E Coli

Treasure Room Treasure Room   (page 2, column 12, line 6) (page 3, column 2, line 4)

E Coli is a passive item.

Effect

• Enemies that touch Isaac are turned into Poop.

Notes

• Poop created by this item is not axis-aligned, and flashes red when hit, similar to damaging Monsters.
• If you touch the middle section of a Grub with E Coli, it will then split and become two heads (rather than destroying and spawning Maggots).
• Mullibooms can be turned into poop without taking damage.
• This item belongs to the Oh Crap set. Collecting all three items from this set will transform Isaac into a walking pile of poop.

Synergies

• Midas' TouchEnemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin. - Enemies touched are turned into Golden Poop.
• Unicorn StumpUpon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears. - Provides invincibility during which enemies can be touched.
• Isaac's HeartIsaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt. - Isaac can turn enemies into poop without taking damage.
• Petrified PoopGreatly increases the chances of a pickup dropping when destroying poop. - Isaac can get pick up items from poop

Trivia

• Escherichia coli is a type of intestinal bacteria present naturally in the human intestinal system. However, some harmful strains of E coli can cause food poisoning.
• This item is used in Challenge #2 (High Brow).

Seeds

 PC  DXGN OP4D (treasure room adjacent to spawn)

 PS4  F1WD FBBN (treasure room adjacent to spawn)

 Switch  8YRM FTHE (First Golden Treasure Room)