E Coli

Treasure Room Treasure Room

(page 2, column 12, row 6)(page 3, column 2, row 4)

E Coli is a passive item.

Effect

• Enemies that touch Isaac are turned into Poop.

Notes

• Poop created by this item is not grid-aligned, and flashes red when hit, similar to damaging Monsters.
  • Does not work on bosses.
• If you touch the middle section of a Grub with E Coli, it will then split and become two heads (rather than destroying and spawning Maggots).
• Mullibooms can be turned into poop without taking damage.
• The poops vanish if the room is left and then returned to.

Interactions

• Hallowed GroundSpawns a white poop familiar, which turns into a white poop when Isaac is hurt.: The generated poops cannot be white.
• MeconiumPoop has a chance to turn into black poop.: The generated poops cannot be black.

Synergies

• Isaac's HeartIsaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.: Isaac can turn enemies into poop without taking damage.
• Midas' TouchEnemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin.: Enemies touched are turned into Golden Poop.
• Unicorn StumpUpon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears.: Provides invincibility during which enemies can be touched.

Trivia

• Escherichia coli is a type of intestinal bacteria present naturally in the human intestinal system. However, some harmful strains of E coli can cause food poisoning.
• This item is used in Challenge #2 (High Brow).

Seeds

 PC  DXGN OP4D (treasure room adjacent to spawn)

 PS4  F1WD FBBN (treasure room adjacent to spawn)

 Switch  8YRM FTHE (First Golden Treasure Room)

Poop

Items:

• Butt BombsGives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
• E ColiGives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
• Flush!Changes all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.
• Hallowed GroundSpawns a white poop familiar, which turns into a white poop when Isaac is hurt.
• Midas' TouchEnemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin.
• No. 2Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 60 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
• The PoopSpawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop.
• SkatoleAll types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.

Trinkets:

• Brown CapPoop will explode after being destroyed.
• MeconiumPoop has a chance to turn into black poop.
• Mysterious CandyIsaac farts or poops at random intervals. Getting hit can also trigger the effect.
• Petrified PoopGreatly increases the chances of a pickup dropping when destroying poop.
• Used DiaperGrants the Skatole effect in some rooms.

Cards:

• A Card Against HumanityCovers the entire room with poop. The process is not instant, and the room will not get filled if you leave it before it's done filling.