E Coli

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E Coli is a passive item.

Effect[edit | edit source]

Poop created by this item is not axis-aligned, and flashes red when hit, similar to damaging Monsters.
If you touch the middle section of a Grub with E Coli, it will then split and become two heads (rather than destroying and spawning Maggots).
Mullibooms can be turned into poop without taking damage.
This item belongs to the Oh Crap set. Collecting all three items from this set will transform Isaac into a walking pile of poop.

Midas' Touch
Enemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin.
- Enemies touched are turned into Golden Poop.
Unicorn Stump
Upon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears.
- Provides invincibility during which enemies can be touched.
Isaac's Heart
Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.
- Isaac can turn enemies into poop without taking damage.
Petrified Poop
Greatly increases the chances of a pickup dropping when destroying poop.
- Isaac can get pick up items from poop

Escherichia coli is a type of intestinal bacteria present naturally in the human intestinal system. However, some harmful strains of E coli can cause food poisoning.
This item is used in Challenge #2 (High Brow).

PC DXGN OP4D (treasure room adjacent to spawn)

PS4 F1WD FBBN (treasure room adjacent to spawn)

Switch 8YRM FTHE (First Golden Treasure Room)