Effects

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Effects are one major mechanic of The Binding of Isaac: Rebirth. There are a number of different items that alter the type of tears and the status effects they inflict.

Contents

Status Effects[edit | edit source]

Status Effects are special effects that can be inflicted on an enemy from a variety of sources, such as tears, bombs, and items. Each status effect has a colour and symbol/effect associated with them for easy identification. These colourations are not to be confused with champions.

Effect Appearance Description
Burn Burn Effect.png Afflicted enemies take 4 to 6 fire damage over time, like poison. Afflicted enemies will be tinted orange for the duration and have a fire symbol above them.

DLC Indicator.png Afflicted enemies will sustain double Isaac's tear damage over time.

Charm Charm Effect.png Afflicted enemies will temporarily fight on Isaac's side, running toward other enemies and damaging them. If no other enemies are in the room, a charmed enemy will instead run towards Isaac. (Charmed enemies can still hurt Isaac.) Afflicted enemies will be tinted pink for the duration and have a heart symbol above them. Most enemies with ranged attacks will not fire them.
Confusion Confusion Effect.png Afflicted enemies are slowed and walk around randomly. While confused, most non-boss enemies will be unable to attack. Afflicted enemies will be tinted pale gray and have stars above them.
Fear Fear Effect.png Afflicted enemies are scared of Isaac and will run away from him. While scared, most non-boss enemies will be unable to attack or charge towards Isaac. Afflicted enemies will be tinted purple and have a skull symbol above them.
Petrified Stop Effect.png Afflicted enemies are stopped in place. They cannot move or attack. Afflicted enemies will be shaded brown-gray, as if turned to stone (unless petrified by Midas' Touch, in which case they will be shaded gold).
Poison Poison Effect.gif Afflicted enemies sustain 4 to 6 damage over time. Afflicted enemies will be tinted green and have a bubbly effect surrounding them.

DLC Indicator.png Afflicted enemies will sustain double Isaac's tear damage over time.

Slow Slow Effect.gif Afflicted enemies are slowed down. Any projectiles they shoot will also be slowed down. Attacks that end when the enemy runs out of momentum, such as the charging attacks of Gurdy Jr. and Dingle, will be vastly shortened in duration. Depending on the item that triggers the slow effect, afflicted enemies will be tinted black or white with a snail icon above them.
DLC Indicator.png
Shrink
Gaper.png Afflicted enemies are shrunken and will run away from Isaac. Isaac can walk over shrunken enemies to kill them.
Afterbirth† Indicator.png
Bleed
50px Afflicted enemies take damage equal to 10% of their maximum health every 5 seconds.

Notes[edit | edit source]

  • Host-type enemies will take burn and poison damage even if their skull is down, and all status effects can be applied by tears even if their skulls are down.

Burn[edit | edit source]

Passive Items that cause burning[edit | edit source]

Name ID Icon Quote Description
Fire Mind 257 Fire Mind Icon.png Flaming tears Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.

Charm[edit | edit source]

Activated Items that cause charming[edit | edit source]

Name ID Icon Quote Description Recharge
Friendly Ball DLC Indicator.png 382 Friendly Ball Icon.png Gotta fetch 'em all! Throwing the ball at an enemy instantly kills it and captures it. The captured enemy can later be released and will be charmed until it dies, persisting between floors. 3
Kidney Bean DLC Indicator.png 421 Kidney Bean Icon.png Love toots! Upon use, Isaac farts, charming all nearby enemies. 2

Passive Items that cause charming[edit | edit source]

Name ID Icon Quote Description
Ball of Bandages 207 Ball of Bandages Icon.png Gotta lick 'em all! Orbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.
Betrayal DLC Indicator.png 391 Betrayal Icon.png Turn your enemy Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
Glitter Bombs DLC Indicator.png 432 Glitter Bombs Icon.png Prize Bombs! Gives Isaac 5 bombs, and makes Isaac's bombs have a chance to drop random pickups or charm enemies when they explode.
Mom's Eyeshadow 200 Mom's Eyeshadow Icon.png Charm tears Tears have a chance to charm enemies.

Notes[edit | edit source]

  • First stage of Ball of Bandages cannot charm enemies. See Ball of Bandages for details.
  • Charmed enemies will still target Isaac if they are the only enemy in the room.

Pills that cause charming[edit | edit source]

Pill Effect
Pheromones

Charms all enemies in the room for a short period of time.

Confusion[edit | edit source]

Passive Items that cause confusion[edit | edit source]

Name ID Icon Quote Description
Butt Bombs 209 Butt Bombs Icon.png Toxic blast +5 bombs Gives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
Iron Bar 201 Iron Bar Icon.png Concussive tears Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.

Trinkets that cause confusion[edit | edit source]

Name ID Icon Quote Description
Faded Polaroid DLC Indicator.png 69 Faded Polaroid Icon.png You feel faded Occasionally causes Isaac to blend into the ground, which briefly confuses all enemies in the room.

Fear[edit | edit source]

Activated Items that cause fear[edit | edit source]

Name ID Icon Quote Description Recharge
The Gamekid 93 The Gamekid Icon.png Temporary Man-Pac Upon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed. 6
Mom's Pad 41 Mom's Pad Icon.png Gross... Upon use, inflicts fear to all enemies in the room for 5 seconds. 3

Passive Items that cause fear[edit | edit source]

Name ID Icon Quote Description
Abaddon 230 Abaddon Icon.png Evil + DMG up + fear shot Increases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.
Dark Matter 259 Dark Matter Icon.png Fear shot Increases Damage by 1 and adds a chance to shoot fear tears.
Mom's Perfume 228 Mom's Perfume Icon.png Fear shot Adds a chance to shoot fear tears and decreases tear delay by 1.
My Shadow DLC Indicator.png 433 My Shadow Icon.png Me! And my shaaaadow! Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black Charger familiar that will attack enemies. The Charger will be killed if it is damaged too much.
Spear of Destiny DLC Indicator.png 400 Spear of Destiny Icon.png Your destiny In addition to tears, Isaac now holds a spear in front of him which deals damage equal to 2 times his tear damage, and occasionally inflicts fear. The spear cannot be thrown, but deals damage while it is in contact with an enemy.

Petrification[edit | edit source]

Activated Items that petrify enemies[edit | edit source]

Name ID Icon Quote Description Recharge
The Boomerang 338 The Boomerang Icon.png It will never leave you Throws a short-range boomerang which does a bit of damage and has a high chance to stun the enemy for 2 seconds. Can also be used to grab pickups. 4 seconds
Mega Bean DLC Indicator.png 351 Mega Bean Icon.png Giga fart! When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies near Isaac, and send a wave of spikes that deals 10 damage across the room in the direction Isaac is facing. 3
Mom's Bra 39 Mom's Bra Icon.png Mass Fear Upon use, petrifies all enemies in the current room for approximately 4 seconds. 3

Passive Items that petrify enemies[edit | edit source]

Name ID Icon Quote Description
Charged Baby DLC Indicator.png 372 Charged Baby Icon.png Bbbzzzzzt! A familiar baby that drops a battery every 4 rooms. Has a small chance to freeze all enemies in the room when hit.
Eye of Greed Afterbirth† Indicator.png 450 Eye of Greed Icon.png Gold tears! Adds a chance to fire tears that temporarily stun enemies and turn them into gold. Any enemy killed while in this state will drop coins.
Midas' Touch 202 Midas' Touch Icon.png Golden touch Enemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin.
Mom's Contacts 110 Mom's Contacts Icon.png Freeze effect Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.

Poison[edit | edit source]

Activated Items that poison enemies[edit | edit source]

Name ID Icon Quote Description Recharge
The Bean 111 The Bean Icon.png Toot on command Isaac releases bad gas, poisoning any enemy in close vicinity. 1
Bob's Rotten Head 42 Bob's Rotten Head Icon.png Reusable ranged bomb Upon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact. 3
Mega Bean DLC Indicator.png 351 Mega Bean Icon.png Giga fart! When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies near Isaac, and send a wave of spikes that deals 10 damage across the room in the direction Isaac is facing. 3

Passive Items that poison enemies[edit | edit source]

Name ID Icon Quote Description
The Black Bean 180 The Black Bean Icon.png Toot on touch When taking damage, Isaac farts, causing poison damage to all enemies in range.
Bob's Brain 273 Bob's Brain Icon.png Explosive thoughts Spawns a familiar that charges forward when shooting tears, explodes upon contact with an enemy and poisons them. Respawns after few seconds.
Bob's Curse 140 Bob's Curse Icon.png +5 poison bombs Gives 5 bombs and grants all bombs poison effect.
The Common Cold 103 The Common Cold Icon.png Poison Damage Adds a chance to shoot poison tears, dealing damage over time when inflicted.
Ipecac 149 Ipecac Icon.png Explosive shots Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Scorpio 305 Scorpio Icon.png Poison tears Grants poison tears, which deal damage over time when inflicted.
Serpent's Kiss DLC Indicator.png 393 Serpent's Kiss Icon.png The kiss of death Tears now have a random chance to apply a poison effect, causing 4 or 6 damage per tick to enemies (Similar to The Common Cold item). Isaac now deals poison damage on contact with enemies similar to The Virus item (Damage over time 4 or 6 per tick). Enemies that were poisoned have a chance to drop a black heart when killed.
Toxic Shock DLC Indicator.png 350 Toxic Shock Icon.png Mass poison Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short lasting pool of green creep on the ground.
The Virus 13 The Virus Icon.png Poison touch Inflicts poison to enemies who make contact with Isaac. Speed down.

Trinkets that grant poison tears[edit | edit source]

Name ID Icon Quote Description
Pinky Eye 30 Pinky Eye Icon.png Poison shots Adds a 10% chance to shoot a poison tear, dealing damage over time when inflicted.

Pills that poison enemies[edit | edit source]

Pill Effect
Bad Gas

Isaac farts, poisoning enemies around him.

Slow[edit | edit source]

Activated Items that slow enemies[edit | edit source]

Name ID Icon Quote Description Recharge
The Hourglass 66 The Hourglass Icon.png Temporary enemy slowdown Upon activation, enemies and their projectiles are slowed down for a short duration. 2
Spider Butt 171 Spider Butt Icon.png Mass enemy slowdown + damage Damages all enemies in the room and slows them and their projectiles down. 2

Passive Items that slow enemies[edit | edit source]

Name ID Icon Quote Description
Ball of Tar 231 Ball of Tar Icon.png Sticky feet... Adds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
Broken Watch 337 Broken Watch Icon.png I think it's broken Chance upon entering a room to slow down or speed up every enemy and their attacks. The chance to slow enemies is quite higher than the chance to speed them up.
Censer DLC Indicator.png 387 Censer Icon.png Peace be with you Gives Isaac a golden censer familiar which creates a huge aura of light that slows down any enemies and enemy shots inside it.
Juicy Sack 266 Juicy Sack Icon.png Sticky babies A familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.
Little Gish 99 Little Gish Icon.png Sticky friend Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Night Light DLC Indicator.png 425 Night Light Icon.png Scared of the dark? A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots.
Spider Bite 89 Spider Bite Icon.png Slow effect Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Stop Watch 232 Stop Watch Icon.png Let's slow this down a bit NoDLC Indicator.png Automatically inflicts slow to all enemies in every room.
DLC Indicator.png Upon taking damage, inflicts slow to all enemies for the current room.

Notes[edit | edit source]

Shrink DLC Indicator.png[edit | edit source]

Passive Items that grant shrinking tears[edit | edit source]

Name ID Icon Quote Description
God's Flesh DLC Indicator.png 398 God's Flesh Icon.png Shrink shot Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.

Bleed Afterbirth† Indicator.png[edit | edit source]

Active items that inflict bleed[edit | edit source]

Passive Items that inflict bleed[edit | edit source]

Name ID Icon Quote Description
Backstabber Afterbirth† Indicator.png 506 Backstabber Icon.png Watch your back! Has a chance to fire tears that inflict bleeding on enemies, causing them to slowly take damage over time.

Random[edit | edit source]

These items inflict random status effects on enemies.

Passive Items that inflict random effects[edit | edit source]

Name ID Icon Quote Description
GB Bug DLC Indicator.png 405 GB Bug Icon.png Game breaking bug, right away! A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with and has a chance to re-roll pickups that it passes over.
Spider Mod DLC Indicator.png 403 Spider Mod Icon.png Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.

Tear Effects[edit | edit source]

Disambig.png This article is about Isaac's primary weapon. For the attribute of the same name that governs rate of fire, see Attributes.

Tear Effects modify the player character's primary weapon — tears. A few of the most common tear effects are listed below.

Homing Tears[edit | edit source]

Homing Tears slightly divert from their path and seek nearby enemies. The distance homing tears can travel is determined by the range stat.

Activated Items that grant homing tears[edit | edit source]

Name ID Icon Quote Description Recharge
Telepathy for Dummies 192 Telepathy for Dummies Icon.png Temporary psychic shot Upon activation, grants homing tears for the current room. 2

Passive Items that grant homing tears[edit | edit source]

Name ID Icon Quote Description
Sacred Heart 182 Sacred Heart Icon.png Homing shots + DMG up Increases damage and range while reducing shot speed and grants homing tears. Grants a Heart Container and replenishes all Red Hearts.
Spoon Bender 3 Spoon Bender Icon.png Homing shots Grants Isaac homing tears.
Godhead 331 Godhead Icon.png God tears Increases damage and range while reducing tears and shot speed. Grants homing tears and tears gain a damaging halo.

Familiars that fire homing tears[edit | edit source]

Name ID Icon Quote Description
Little Steven 100 Little Steven Icon.png Psychic friend Spawns a familiar that follows Isaac around and fires homing tears.
Seraphim DLC Indicator.png 390 Seraphim Icon.png Sworn friend An angel familiar which follows Isaac and fires homing tears which deal 10 damage at -25% shot speed and a reduced fire rate.

Cards that grant homing tears[edit | edit source]

Name ID Icon Message Effect
I - The Magician 2 I - The Magician Icon.png May you never miss your goal Grants homing tears for the current room.

Piercing Tears[edit | edit source]

Piercing tears travel through enemies (but not obstacles) instead of breaking on impact with them. While they do not directly increase damage, piercing tears can allow the character to deal a greater amount of damage per second due to the multiple impact calculations on large bosses and the possibility to hit multiple enemies at once.
The downside of piercing tears is that they remove knockback.

Passive Items that grant piercing tears[edit | edit source]

Name ID Icon Quote Description
Cupid's Arrow 48 Cupid's Arrow Icon.png Piercing shots Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
Dead Onion 336 Dead Onion Icon.png Toxic aura tears Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed.
Death's Touch 237 Death's Touch Icon.png Penetrative shot + damage up Increases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.
Eye of Belial Afterbirth† Indicator.png 462 Eye of Belial Icon.png Possessed tears! Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.
Sagittarius 306 Sagittarius Icon.png Penetrative shot + speed up Increases speed by +0.2 and grants piercing tears.

Trinkets that grant piercing tears[edit | edit source]

Name ID Icon Quote Description
Push Pin 31 Push Pin Icon.png Piercing shots Adds a 10% chance to shoot a piercing and spectral tear.

Spectral Tears[edit | edit source]

Spectral tears travel through obstacles (but not enemies) instead of breaking on impact with them. Spectral tears can be used to safely dispatch most types of monsters from behind obstacles, or over them in combination with flying.

Passive Items that grant spectral tears[edit | edit source]

Name ID Icon Quote Description
Dead Dove 185 Dead Dove Icon.png Flight + spectral tears Grants spectral tears and flight.
Dead Onion 336 Dead Onion Icon.png Toxic aura tears Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed.
Ouija Board 115 Ouija Board Icon.png Spectral tears Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.
Pupula Duplex DLC Indicator.png 379 Pupula Duplex Icon.png Wide shot Transforms Isaac's tears into a wide arc shape which gives them a much larger hitbox. Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).
Spirit of the Night 159 Spirit of the Night Icon.png Scary Grants spectral tears and flight.

Familiars that fire spectral tears[edit | edit source]

Name ID Icon Quote Description
Ghost Baby 163 Ghost Baby Icon.png Spectral buddy Spawns a familiar that follows Isaac around and fires spectral tears.

Trinkets that grant spectral tears[edit | edit source]

Name ID Icon Quote Description
Ouroboros Worm Afterbirth† Indicator.png 96 Ouroboros Worm Icon.png Foop foop! Tears travel in a large spiral pattern and become spectral.
Push Pin 31 Push Pin Icon.png Piercing shots Adds a 10% chance to shoot a piercing and spectral tear.

Temporary Buffs[edit | edit source]

Temporary buffs are beneficial effects applied to the player character that will expire after a timed duration or on leaving a room, and are not tear effects.

Invulnerability[edit | edit source]

Invulnerability negates all types of damage for five seconds, including health loss from Blood Donation Machines and Devil Beggars, environmental hazards like spikes, and Curse Rooms doors and Sacrifice Rooms, but does not prevent heart container or Soul Heart loss from Health Down Pills, Devil Room deals, or spawning a baby.
While under the effects of invulnerability, the character has increased speed, loses the ability to shoot tears, flashes in multiple colors, and the music of the game speeds up. However, all invulnerability-granting items except for the Unicorn Stump also grant the character the ability to damage enemies by contact for the duration of the effect.

Activated Items that grant invulnerability[edit | edit source]

Name ID Icon Quote Description Recharge
My Little Unicorn 77 My Little Unicorn Icon.png Temporary badass Upon use, grants invulnerability and increased speed for five seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies. 6
The Gamekid 93 The Gamekid Icon.png Temporary Man-Pac Upon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed. 6
Unicorn Stump 298 Unicorn Stump Icon.png You feel stumped Upon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears. 1

Passive Items that grant invulnerability[edit | edit source]

Name ID Icon Quote Description
Taurus 299 Taurus Icon.png Speed down + rage is building Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.

Trinkets that grant invulnerability[edit | edit source]

Name ID Icon Quote Description
Cartridge 8 Cartridge Icon.png I remember these Chance to trigger The Gamekid effect upon taking damage.

Cards that grant invulnerability[edit | edit source]

Name ID Icon Message Effect
VII - The Chariot 8 VII - The Chariot Icon.png May nothing stand before you Grants the temporary invulnerability effect of My Little Unicorn.

Shield[edit | edit source]

A shield negates all types of damage for a variable amount of time, depending on the item it's granted by, including health loss from Blood Donation Machines and Devil Beggars, environmental hazards like spikes, and Curse Rooms doors and Sacrifice Rooms, but does not prevent heart container or Soul Heart loss from Health Down Pills, Devil Room deals, or spawning a baby.
Unlike invulnerability, the shield does not prevent the character from attacking.

Activated Items that grant a shield[edit | edit source]

Name ID Icon Quote Description Recharge
Book of Shadows 58 Book of Shadows Icon.png Temporary Invincibility Upon use, creates a protective shield nullifying all types of damage for 10 seconds. 3

Passive Items that grant a shield[edit | edit source]

Name ID Icon Quote Description
Celtic Cross 162 Celtic Cross Icon.png You feel blessed Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
Empty Vessel DLC Indicator.png 409 Empty Vessel Icon.png I reward an empty vessel While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.
The Polaroid 327 The Polaroid Icon.png Fate Chosen If the character has half a red heart or no red hearts after taking damage, it triggers the Book Of Shadows effect, creating a shield that nullifies all types of damage for 5 seconds. Also allows entrance into The Chest.
Virgo 303 Virgo Icon.png You feel refreshed and protected Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills".

Runes that grant a shield[edit | edit source]

Rune ID Icon Unlock method Message Effect
Algiz 39 Algiz Icon.png Rune of Algiz Beat challenge #8 Resistance Grants a shield which lasts for 30 seconds.

SmallIsaac.png The Binding of Isaac: Rebirth SmallIsaac.png

MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op Magic Mushroom Icon.png Items Isaac's Tears Icon.png Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets