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| Defeat Hush as LazarusEmpty Vessel|
Empty Vessel is an unlockable passive item added in Afterbirth.
- Grants 2 Black Hearts on pickup.
- When Isaac has no red hearts:
- Grants flight.
- Every 40 seconds, when in a room with enemies, a shield triggers, nullifying all types of damage for 10 seconds.
- The changed texture of the player's body is the same as The Lost's, but recolored.
- Has no effect on Keeper.
- The Lost, ???: Since these characters can never gain red hearts, Empty Vessel will always be activated.
- AbaddonIncreases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.: Since Abaddon removes all red hearts as well as adding several black hearts, it will immediately activate Empty Vessel's effects.
- Whore of BabylonIncreases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.: Since Whore of Babylon is active at half a red heart or less, it will always be active when Empty Vessel is active.
- Empty vessel is a religious term for having an open mind so God can fill it with his divine wisdom.
Switch 6GW8 CG48 (Basement Devil Room)