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Endings are cutscenes at the end of each successfully completed run. They are all different and some depend on the player's route through the game. There are 16 endings in Rebirth, with 2 more added in Afterbirth and another 2 added in Afterbirth+. They can be unlocked by killing the boss at the end of chapters 3-6. They can be viewed in the 'stats' section of the menu.
- The Credits are played after any ending.
- Epilogue is available after defeating Mom for the first time.
- Endings 1 - 11 are available after defeating Mom's Heart. Each time you defeat the boss, a new ending is unlocked.
- Ending 12 is unlocked by beating Sheol.
- Ending 13 is unlocked by beating The Cathedral.
- Ending 14 is unlocked by beating The Chest.
- Ending 15 is unlocked by beating The Dark Room.
- Ending 16 is unlocked by defeating Mega Satan.
- Ending 17 is unlocked by defeating Hush for the first time.
- Ending 18 is unlocked by defeating Ultra Greed in Greed Mode.
- Ending 19 is unlocked by defeating Ultra Greed in Greedier Mode.
- Final Ending is unlocked by defeating Delirium.
- 1 Endings
- 1.1 Epilogue
- 1.2 Ending 1
- 1.3 Ending 2
- 1.4 Ending 3
- 1.5 Ending 4
- 1.6 Ending 5
- 1.7 Ending 6
- 1.8 Ending 7
- 1.9 Ending 8
- 1.10 Ending 9
- 1.11 Ending 10
- 1.12 Ending 11
- 1.13 Ending 12
- 1.14 Ending 13
- 1.15 Ending 14
- 1.16 Ending 15
- 1.17 Ending 16
- 1.18 Ending 17
- 1.19 Ending 18 (Greed Mode Ending)
- 1.20 Ending 19 (Greedier Mode Ending)
- 1.21 Final Ending
- 2 Gallery
- 3 Trivia
Isaac's mother closes in, trapping Isaac in a corner, preparing to kill him, when The Bible drops down from above and kills her. Isaac is victorious. Unfortunately, this turns out to be just a story that Isaac has written — and seconds later, the door to Isaac's room busts open and Mom appears again with a knife in her hand.
Isaac opens and falls into the chest, which closes, locking him inside. The chest rattles a few times, and then a bright light comes out of it. Isaac then emerges from it as Eden. This unlocks said character, who has randomized starting items and stats.
Isaac opens the chest and finds Rubber Cement inside of it. He then uses it, and looks at the camera with white eyes and his eyelids stretched out. This unlocks said item, a passive item which makes your tears bounce off of enemies, objects, and walls.
Isaac opens the chest and finds a noose inside of it. He then hangs himself with it. This unlocks the item Transcendence, a passive item which gives Isaac flight.
Isaac opens the chest and finds a Wire Coat Hanger inside of it. He is then shown with it jammed into his head. This unlocks said item, a passive item which increases Isaac's Tears stat.
Isaac opens the chest. His mother is heard yelling his name. Her arm then comes out of the chest, punches Isaac, grabs him, and locks him inside of it. Mom's muffled laugh is then heard. This unlocks the achievement "Everything is Terrible", which makes the game harder in several ways.
Isaac opens the chest, but before he can reveal what he found, he becomes nauseated and vomits into the chest, creating several explosions. This unlocks the item Ipecac, a passive item which makes Isaac spit explosive projectiles.
Isaac opens the chest and finds a syringe with a yellow liquid inside of it. He is then shown deformed and happy. This unlocks the item Experimental Treatment, a passive item which randomly increases and decreases Isaac's stats.
Isaac opens the chest and finds a Quarter. This unlocks said item, a passive item which instantly gives Isaac 25 cents.
Isaac opens the chest and finds Dr. Fetus inside of it. He is then seen holding it wearing Dr. Fetus' characteristic top hat and monocle. This unlocks said item, a passive item which turns Isaac's tears into bombs.
Isaac opens the chest and finds ??? lying inside of it. ??? sits up and smiles at him, which terrifies Isaac. This unlocks said character, who starts with The Poop and can only have soul hearts or black hearts.
Isaac opens the chest, and It Lives appears behind him. It Lives then growls and smiles at him. This unlocks said boss, a harder version of Mom's Heart which permanently replaces it.
Isaac opens the chest, which has a bright light coming out of it. The screen then cycles through various scenes of different characters in different places, before finally cycling to his room. Isaac then gets into the chest and closes it.
Isaac is shown reading a Bible, and then he looks up at his mirror, which shows him with red eyes and black skin. Believing he is full of sin, Isaac closes the Bible and shamefully looks at a large chest in the corner of his room.
Various pictures are shown of Isaac and his family, showing various events such as Isaac having a demonic shadow, his father leaving, and his angry mother holding a knife. The screen then fades to black and says "The End" with a chest next to it.
The camera slowly pans to the Missing Poster attached to a pole with Isaac's mother looking around in the background.
Isaac is shown curled up inside of a chest with Guppy's paw visible. His breathing gradually increases while pictures of a demonic Isaac flash onto the screen, until he makes the demonic transformation. A heartbeat can be heard in the background.
The cinematic begins showing the Missing Poster from Ending 15, with Isaac's home being in the background. The scene is changed to Isaac's chest, with his mother's shadow over it. The chest is popped open and multiple flies leave it. The chest is then opened up further, showing Isaac's skeletal remains. A spider can be seen crawling inside the eye hole of Isaac's skull and a fly zooms into the camera, then the scene switches over to a dull-colored ghastly landscape. Isaac pops out of a red chest, and a large shadow forms behind him. The shadow then grows fangs and red eyes as the scene blacks out accompanied with Devil Room ambiance.
Ending 18 (Greed Mode Ending)
Isaac is shown inside a small cave, followed by Isaac turning around to see the cave entrance collapsing, trapping him and a few flies inside it. The screen then cuts back to the same cave, with the rocks being cleared to show a rotting shopkeeper. The shopkeeper suddenly smiles at the camera and the scene ends.
Ending 19 (Greedier Mode Ending)
Isaac is shown inside a small cave, followed by Isaac turning around to see the cave entrance collapsing, trapping him and a few flies inside it. The screen then cuts back to the same cave, with the rocks being cleared to show a rotting shopkeeper.
The shopkeeper suddenly smiles at the camera, his head falls off, and he begins to spew out a geyser of spiders.
Isaac is shown lying inside his toy chest, breathing heavily. In a memory he is shown drawing and smiling (but still nude), but is distracted by noise (presumably his parents fighting), and looks at one of his drawings of his house with a caption saying "WE LIVED HERE". He remembers seeing his mother crying in front of the TV. His breathing gets faster as he remembers looking at a burnt version of The Polaroid, or the Torn Photo, with his father's face being partially burnt away, standing in front of his toy chest which is filled with polaroid photos. His breathing slows down, Isaac is shown turning blue in the chest, and a wall is shown. The pictures hanging on the wall are (from right to left): Isaac with his parents; Isaac's house; Isaac with Guppy; Isaac playing with his father; Isaac watching his parents fight; Isaac with his mother; Isaac with a wig / Magdalene; Isaac's mother with a knife, angry; a demon with the word "bad" written on it with red ink; a smiling demon with the words "I'm the devil" written on it (as well as a little arrow labeled "me" pointing at it); a pentagram, once again with the word "bad" written on it; and finally, a demon which is shown above Isaac's dead and blood-covered parents, laughing. The left side of the wall is also covered with the words "bad", "evil", and "I'm the devil". As the wall is shown, the noises of an argument in the background get louder, culminating in a man's voice audibly saying "I'm outta here!" After a cut to black, Isaac's skeleton is shown lying in the chest, covered in cobwebs. The chest is opened, and the Missing Poster from Ending 15 is shown falling off the telephone pole outside Isaac's house. Finally, Isaac is shown roaming the dull-colored ghastly landscape from Ending 17.
Experimental Treatment in Ending 7.
The Polaroid in Ending 14.
The Missing Poster in Ending 15.
Isaac lying in The Chest in Final Ending.
- The item and character appearance for Dr. Fetus, unlocked in Ending 9, is one of many references to another game named Meat Boy. The Binding of Isaac as well as Meat Boy are just two of the games that Edmund McMillen worked on. Meat Boy was followed by a successor called Super Meat Boy.
- Ending 9, especially the dramatic camera shot of Isaac dressed as Dr. Fetus, may also be a reference to the popular meme Dramatic chipmunk.
- The Ghastly landscape at the end of Ending 17 and 20 are confirmed by Edmund to be Purgatory.
- The music that is played throughout Ending 20 (Final) is titled Sepulcrum. Sepulcrum is the Latin word for "Grave" or "Burial".
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