Epic Fetus

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Item icon
Item altar
Character appearance
Tear appearance
Item Pool Treasure Room.pngTreasure Room
Added in AfterbirthGreed ModeItem Pool Treasure Room.pngTreasure Room
Added in Afterbirth (page 2, column 5, line 3)
Removed in Afterbirth (page 2, column 5, line 7)
Epic Fetus Beat challenge #19

Epic Fetus is a Special unlockable passive item.


  • Isaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.
    • Missiles deal 20 times Isaac's damage.


  • Missiles benefit from most bomb-enhancing effects.
  • Epic Fetus overrides most items in the game and has the highest priority of all of them, over Brimstone and Mom's Knife.
  • On PC, using the mouse and keyboard when obtaining this item can be helpful due to the ability to precisely target a specific area in the room, avoiding the sensitivity of a joystick or the limited directions of the arrow keys.
  • Isaac's tear delay determines how quickly a new missile or missile set can be fired after the previous one has landed. Barring very high tear delay, this has little effect on damage rate due to the delay of the missiles themselves.


  • Added in Afterbirth 20/20 20/20: Makes two missiles drop one after the other.
  • Blood Clot Blood Clot / Chemical Peel Chemical Peel: Each missile has a 50% chance to deal 20 or 40 points more damage, respectively.
  • Bob's Curse Bob's Curse: Grants each missile the poison effect.
    • Bob's Curse + Technology Technology: Lasers turn green, but do not poison enemies like the bombs do.
  • Butt Bombs Butt Bombs: Each missile explosion applies the Butt Bombs effect.
  • Brimstone Brimstone: Fires 10 lasers with each explosion
  • Added in Afterbirth Conjoined (Transformation): Makes three missiles drop one after the other.
  • Added in Afterbirth † Haemolacria Haemolacria: Damage increased by about 31%, though tear delay also increases considerably.
  • Added in Afterbirth Host Hat Host Hat: Isaac becomes immune to his own airstrikes.
  • Added in Afterbirth Monstro's Lung Monstro's Lung: Adds 2 to 4 more crosshairs that orbit the main crosshair and fires a missile onto each crosshair.
  • Mysterious Liquid Mysterious Liquid: Every explosion from a crosshair leave a small, lasting pool of creep.
    • Added in Afterbirth: The explosion leaves a large pool of green creep behind.
  • Added in Afterbirth Strange Attractor Strange Attractor: Enemies get drawn towards the crosshair.
  • Added in Afterbirth Spoon Bender Spoon Bender: Cursor slides towards enemies
  • Added in Afterbirth Technology Technology: Explosion shoots technology beams in all directions, similar to Tammy's Head. When firing/moving the cursor, you still shoot your Technology laser.
  • Added in Afterbirth Technology 2 Technology 2: Both the Technology 2 laser, and the Epic Fetus missiles will be active.
  • Added in Afterbirth Tech X Tech X: Explosion shoots technology beams in all directions, similar to Tammy's Head.


  • Added in Afterbirth 8 Inch Nails 8 Inch Nails: Retains damage and knock back boost.
  • Anti-Gravity Anti-Gravity: Overridden by Epic Fetus.
  • Added in Afterbirth Bomber Boy Bomber Boy: Overridden by Epic Fetus.
  • Brimstone Brimstone: Overridden by Epic Fetus.
    • Added in Afterbirth: Lasers fire in all directions upon impact of a missile.
  • Cursed Eye Cursed Eye: Overridden by Epic Fetus.
  • Dr. Fetus Dr. Fetus: Overridden by Epic Fetus.
  • Fire Mind Fire Mind: Creates a fire every time a shot lands.
  • Homing tears: Overridden by Epic Fetus.
    • Added in Afterbirth: Cross-hair slowly moves towards enemies.
  • Added in Afterbirth Hot Bombs Hot Bombs: Creates a fire every time a shot lands.
  • The Inner Eye The Inner Eye: Slower fire rate, each cross-hair will cause three consecutive air strikes to happen. The cross-hair may still be moved after the first one lands.
  • Ipecac Ipecac: Greatly increases damage and turns missiles poisonous.
  • Added in Afterbirth Lilith: Blindfold is overridden by Epic Fetus.
  • Loki's Horns Loki's Horns: Four cross-hairs are produced around the player, firing four missiles instead of a single one. Having the Mutant Spider or the Inner Eye applies the same effect to each cross-hair.
  • The Ludovico Technique The Ludovico Technique: Overridden by Epic Fetus.
  • Mom's Eye Mom's Eye: A second missile will be symmetrically fired at the player's opposite side.
  • Mom's Knife Mom's Knife: Overridden by Epic Fetus.
    • Added in Afterbirth: Missiles explode into a circle of knives.
  • Mutant Spider Mutant Spider: Slower fire rate, each cross-hair will cause four consecutive air strikes to happen. The cross-hair may still be moved after the first one lands.
  • The Parasite The Parasite: No effect.
  • Added in Afterbirth Sad Bombs Sad Bombs: Missiles fire a burst of tears where they land.
  • Added in Afterbirth Scatter Bombs Scatter Bombs: Overridden by Epic Fetus.
  • Scorpio Scorpio: Missiles become poisonous.
  • Soy Milk Soy Milk: Damage of missiles will be decreased accordingly, but unlike normal tears, the fire-rate will not increase.
  • Tammy's Head Tammy's Head: Fires only normal tears, not missiles.
  • Tiny Planet Tiny Planet: Overridden by Epic Fetus.
  • Added in Afterbirth The Wiz The Wiz: Control of the crosshair is rotated 45 degrees clockwise. Fires 2 missiles in rapid succession.

In-game Footage


  • In the original game it was possible to control the crosshair with the mouse. This was removed in Rebirth.
    • Mouse control can however be re-enabled by editing the options.ini file in C:\Users\<username>\Documents\My Games\Binding of Isaac Afterbirth/Rebirth and changing the line MouseControl=0 into MouseControl=1. Also useful for The Ludovico Technique.
  • The Dr. Fetus and Epic Fetus items are based off of Dr. Fetus, the main villain in Super Meat Boy which is a game by Edmund McMillen (the creator of The Binding of Isaac: Rebirth).
  • This item is used in Challenge #11 (Glass Cannon).


 PC  GOBD W8TB (Treasure Room adjacent to spawn)

 PS4  8ETR M2M9 (First floor treasure room)

 Vita  8G4J JFH8 (Treasure Room adjacent to spawn)

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