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Item icon
Item altar
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Character appearance
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Added in Afterbirth †(page 4, column 3, row 1)
Removed in Afterbirth †(page 4, column 3, row 1)
Added in Afterbirth

Epiphora is a passive item added in The Binding of Isaac: Afterbirth.

Effects[edit | edit source]

  • Tear delay gradually decreases as the player shoots in one direction. Accuracy also decreases as the fire rate increases.
    • At max "charge", it will reduce tear delay by half, rounding down.
  • Rate of fire returns to its original value if Isaac stops firing, changes firing directions, uses an active item, or is hit.
    • Added in Afterbirth † Being hit, changing rooms, and using items no longer reset the Epiphora bonus.
      • During the delay when transitioning between rooms, picking up an item, or using an active item, it's possible to change the firing direction without resetting the bonus.

Notes[edit | edit source]

  • Epiphora technically works with items that require a charge (such as Monstro's Lung Monstro's Lung) but requires releasing the key or button, causing players to lose the effect.

Synergies[edit | edit source]

  • Continuum Continuum: Reduces the need to change firing direction allowing Isaac to maintain the increased rate of fire.
  • Dr. Fetus Dr. Fetus / Ipecac Ipecac: Firing bombs continually will decrease tear delay, although doing so is not recommended since it increases the risk of self-damage.
  • The Forgotten: When tapping the attack button in a single direction repeatedly, the Ephiphora effect will cause the bone swings to speed up.
  • How to Jump How to Jump: Changing firing direction while jumping does not reset the bonus, similar to when changing rooms.
  • Incubus Incubus: Incubus's fire rate will match Isaac's.
  • The Ludovico Technique The Ludovico Technique: Fire rate increases while moving the tear in one direction; it has a negligible effect during normal gameplay.
  • Marked Marked: Rate of fire only increases so long as the mark is continuously moved in one direction.
  • Rubber Cement Rubber Cement: Reduces the need to change firing direction allowing Isaac to maintain the increased rate of fire.
  • Tractor Beam Tractor Beam: Fire rate still increases when shooting in one direction, but will stay on the line (i.e. no loss in accuracy).
  • Loki's Horns Loki's Horns / Mom's Eye Mom's Eye: Allows for firing in multiple directions at once, decreasing need to change firing direction.

Interactions[edit | edit source]

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • Epiphora is an overflow of tears onto the face.

Seeds[edit | edit source]

 PC  Normal and hard modes only 0RK6 FCRZ (Treasure room adjacent to spawn)

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