Binding of Isaac: Rebirth Wiki
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Experimental Treatment is an unlockable passive item.

Effects[ | ]

  • (in Rebirth and Afterbirth) Randomly increases at least 1 and decreases 1-3 of Isaac's stats. The same stats can be increased/decreased multiple times.
  • (in Afterbirth † and Repentance) Randomly increases 4 and decreases 2 of Isaac's stats.
  • Each increase or decrease for a stat will change it by a fixed value:
  • If a stat that is already at an upper or lower limit is chosen, there is no visible effect.
  • (except in Rebirth) This item belongs to the SpunSpun set. Collecting three items from this set will transform Isaac into a buff berserker.

Notes[ | ]

The stat changes are permanent and will not go away if the item is removed.

  • (in Repentance) This makes the item especially useful for Character Tainted Isaac iconTainted Isaac, since he gets to keep the stats while having the option to switch Experimental Treatment for another item and the transformation progress isn't lost in the process.

(in Repentance) The tears up from this item is allowed to go past the normal tear cap of 5.0. However if it decreases tears, the normal tear cap will also be decreased.

In-game Footage[ | ]

Unlockable Achievements[ | ]

Trivia[ | ]

(except in Repentance) Prior to Repentance, this item's description was "All stats up... then shuffled".

  • Despite the item's old description, the item did not increase all stats or shuffle them.

Gallery[ | ]


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