In Greed Mode, it will always generate its 2nd floor drops for each Chapter that is before the Womb, such as 20 pennies in the Depths, etc.
The Womb is the exception, generating its 1st floor drop: 2 Boss Room items.
Synergies[ | ]
The Book of Belial + Birthright as Judas / Dark Judas: In addition to the item's expected reward, spawns one of the following demonic familiars: [[{{{page}}}|Blood Puppy]], [[{{{page}}}|Dark Bum]], [[{{{page}}}|Demon Baby]], [[{{{page}}}|Incubus]], [[{{{page}}}|Lil Abaddon]], [[{{{page}}}|Lil Brimstone]], [[{{{page}}}|Succubus]], or [[{{{page}}}|Twisted Pair]].
Book of Virtues: Spawns floor - 1 regular wisps with no unique effect, up to a maximum of 8. No wisps are spawned on the first floor.
Strange Key: Instead of its normal effect, Pandora's Box spawns six items from a set of item pools. Both items are consumed.
This will prevent unlocking Moving Box if it hasn't already been unlocked, when used in Dark Room.
The icon of Pandora's Box as seen on the lower 3DS screen.
Trivia[ | ]
In Greek legend, Pandora's Box is a jar containing all of the evils of the world. It was given to the first woman created, who, in her curiosity, opened it, releasing every evil unto the land. Once the evils were released, the only thing that remained was Elpis, the Spirit of Hope.