Flight is an ability that can be gained by Isaac upon pick up of various items. When Isaac has flight, he can pass over all obstacles, including rocks, poop, and pits, and won't be damaged by hazards such as creep or spikes (except Sacrifice Room spikes). He can still be damaged by Fire Places and spike blocks. Azazel and The Lost start with the ability to fly.
Passively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies.
Upon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
Separates Isaac's head and body for the current room. Isaac's head, which now has flight, will be under the player's control, while his body will seek out enemies to attack by contact damage.
Passively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies while also casting the effect of Crack the Sky.
Note: The Pony and White Pony passively grant flight while they are in Isaac's possession.
While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any Red Hearts, these benefits will disappear.