Fly

Flies are very common enemies, found in almost all floors. They can naturally spawn in The Basement, and can be spawned by the Duke of Flies, The Husk, Hives, Swarmers, Gurdy, and Pestilence. Skatole changes behavior of all types of flies, except Boom Flies and Red Boom flies. The Lord of The Flies transformation also change turns most types of flies to passive behavior while also converting some of them into friendly blue-types.

Black Fly

Black flies buzz around the room randomly, often moving away from the player. They cannot damage Isaac at all, even by touch, making them completely harmless. However, they can turn into relatively dangerous Pooters if they fly around Poop for too long.

Attack Fly

Attack Flies are red and black flashing flies that will follow Isaac relentlessly until killed. Their only way of damaging Isaac is by contact, and they move rather slowly, making them easy to kill. However, they can be dangerous when found in groups, as they can swarm around Isaac quickly.

Attack Flies turn into regular Black Flies if Isaac has Skatole. They take a small amount of time to convert into Black Flies, so it is possible for Isaac to be damaged if the player is not careful.

Large Attack Fly

These have the exact same behavior as regular attack flies, and move at the same speed. However, they're larger and have more health than regular Attack Flies.

Large Attack Flies are unaffected by Skatole.

Moter

Moters appear as two Attack Flies joined together. They behave similarly to regular Attack Flies, but split into two Attack Flies upon being killed. Their split is very wide and unpredictable and can easily shave off half a heart. It is recommended to kill faster flies and other small monsters before it as the two flies it spawns are actually more dangerous in many ways. Running between them just as they split is also a very good way to dodge.

If Isaac has Skatole, or uses a bomb, killing a Moter will not make them split into two Attack Flies.

Eternal Fly

The Eternal Fly is a white Fly that can be found on any floor in the game. They usually circle Corn Poop or enemies like Holy Leeches and the Hanger and will not stop circling them until their hosts are destroyed. Before that, they will deal damage to Isaac if he touches them and are completely immune to all forms of damage. When their hosts are destroyed, they convert into Attack Flies.

If Eternal Flies are circling Corn Poop and there are no other enemies around, you can leave the room at will. This is true even if they have already been converted into large attack flies: they will simply disappear when you return into the room.

Ring Fly

Ring Flies are a new addition to Rebirth. They are pink flies that, upon entering the room, will cluster together into a circular formation and orbit rapidly while moving towards you. They will hold formation even when you destroy all but one fly. These flies are fast and take up a large amount of space, so it may be recommended to hold these on higher danger priority.

Blue Fly

Blue Flies are familiars that will orbit around Isaac and rush towards an enemy if they are in sight, dealing massive damage. Damage dealt by blue fly scale on Isaac's actual damage.

Boom Fly

Boom Flies roam around the room diagonally, dealing touch damage and exploding with a large blast radius upon death. They are unaffected by Skatole. They also spawn from blue champion bosses such as Teratoma and Fistula.

Red Boom Fly

Flies around the room diagonally, dealing touch damage and exploding into 6 directional blood shots upon death.

Level 2 Fly

The Level 2 Fly flies towards Isaac somewhat erratically, dealing touch damage.

Full Fly

The Full Fly behaves similarly to the Large Fly, but explodes into 6 blood shots upon death.

Gallery

• 

  Attack Fly on Isaac's Last Will.

Bugs

• If the host of an Eternal Fly is destroyed while it is frozen due to the use of items such as Mom's Bra, the fly will simply sit in the same spot without doing anything, being pushed by any tears shot at it.

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