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| Beat Mom's Heart, Isaac, Satan, ???, and The Lamb and complete the Boss Rush on hard mode as The Lost|
Earn all 9 Completion Marks on hard mode as The LostGodhead
- +0.5 Damage.
- -0.3 Tears.
- +1.2 Range.
- -30% Shot Speed.
- +0.8 Shot Height.
- Grants homing tears.
- Tears gain a damaging aura.
- BrimstoneTears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.: Brimstone laser becomes slightly stronger and homes towards enemies. Laser does not receive the damaging aura.
- Chocolate MilkGrants charged tears that deal greater damage when fully charged.: Charging shots increases the size of the aura but does not affect its damage.
- Compound FractureIncreases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle./ Cricket's BodyGrants -1 Tear Delay and reduces Range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose Range and Damage scale with Isaac's./ The ParasiteIsaac's tears split in two when they hit something.: Main tears and burst tears retain all effects.
- Death's TouchIncreases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.: Tears replaced by scythes, increasing damage and causing the damaging aura to grow in size.
- Epic FetusIsaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.: Causes the crosshair to home in upon enemies, and hits harder. Missiles do not have a damaging aura.
- ExplosivoIsaac's tears have a chance to stick to enemies and explode.: Causes damaging aura to grow once attached to an enemy.
- EuthanasiaAdds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.: When needles are fired, they retain homing and damaging aura.
- Glass CannonWhen used, reduces Isaac's health to half a heart (including soul and black hearts) and fires one large piercing spectral tear that does a lot of damage. The damage done by Glass Cannon scales with Isaac's damage (at base damage it does 45 damage).: The huge tear gains the homing ability and fully scaled damaging aura, able to cover most of the screen with extreme damage.
- IpecacReplaces tears with explosive and poisoning projectiles fired in an arc from the mouth.: Explosive projectile tears become slower and smaller, but retain the damaging aura and homing effect.
- LachryphagyIsaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage.: Fired tears and burst tears retain aura and homing effect.
- The Ludovico TechniqueInstead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.: Tear increases in size and gains the damaging aura effect.
- A Lump of CoalThe more distance tears travel, the more damage they will do.: The size and damage of the aura increases as long as the tear is on screen.
- Pop!Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.: Tears retain damaging aura and homing effect.
- Rubber CementTears bounce off walls, enemies, and environmental objects.: Tears stay longer on screen, increasing the amount of the damage the aura can do.
- Soy MilkTears shrink and do much less damage, but fire in very rapid succession.: Every tear has a tiny aura around it. Also retains homing effect.
- Spectral Tears: Similar to the piercing effect, items which provide a spectral effect allow tears to pass through objects, giving the aura more time to cause damage.
- Dr. FetusTears are replaced by bombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired.: Bombs retain all effect expect damaging aura.
- HaemolacriaTears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.: Main tear retains all effects, but burst tears do not.
- Mom's KnifeIsaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.: Does not get the damaging aura, but does get all other effects.
- Piercing Tears: Once the tear hits the enemy, the aura also ceases to do damage to that particular target.
- TechnologyReplaces tears with a piercing laser with unlimited range.: Gets the homing effect but not the aura.
- Technology 2Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.: Laser only gets the homing effect, while the tear gets all its effects.
- Tech XTears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the size of the ring.: Only gets the homing effect.
- Sinus InfectionAdds a chance to fire a booger which sticks to enemies and poisons them.: The aura on booger tears stuck to an enemy won't hurt that particular enemy. Other enemies passing through it still take damage.
- Spear of DestinyIn addition to tears, Isaac now holds a spear in front of him which deals damage equal to 2 times his tear damage, and occasionally inflicts fear. The spear cannot be thrown, but deals damage while it is in contact with an enemy.: Overrides Godhead.
- TrisagionTears are replaced with piercing white blasts of light.: Trisagion causes Godhead's aura to visually disappear; however, the aura is still there and can still damage enemies.
- Godhead is another term for Godhood, or overall Divine nature.
- The Godhead bears strong resemblance to the Eye of Providence, Eye of God, or The Eye That Sees All, a common religious symbol also used in Christian religions. The three edges of the triangle may represent each part of the Holy Trinity.
- Godhead is arguably the hardest/most grueling item to unlock in Rebirth and Afterbirth, as it requires having to kill every final boss, on hard mode, with The Lost.
- The three triangles on the corners of the Godhead icon may be a reference to The MindGrants the combined effects of the Blue Map, Treasure Map, and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms., The BodyAdds 3 heart containers., and The SoulGrants two soul hearts. Isaac now repels enemy projectiles. items.
- This item appears in the Afterbirth† release date trailer.
G2KQ M1J1 (Angel Room in Catacombs I in a damageless run)
|The Lost Unlocks|
|Isaac's HeartDefeat Isaac as The LostThe MindDefeat Satan as The LostThe BodyDefeat ??? as The LostThe SoulDefeat The Lamb as The LostThe D100Complete the Boss Rush as The LostGodhead Beat Mom's Heart, Isaac, Satan, ???, and The Lamb and complete the Boss Rush on hard mode as The Lost
Earn all 9 Completion Marks on hard mode as The Lost-0- BabyDefeat Mom's Heart on hard mode as The Lost
|Sworn ProtectorDefeat Hush as The LostZodiacDefeat Ultra Greed as The LostWhite BabyDefeat Mega Satan as The Lost||Holy CardDefeat Delirium as The LostDad's Lost CoinDefeat Ultra Greedier as The Lost|
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|