Items in this pool can appear in Locked Chests , Bomb Chests , and Vaults .
Name
ID
Icon
Quote
Description
Bob's Rotten Head
5.100. 42
Reusable ranged bomb
Upon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.
Guppy's Head
5.100. 145
Reusable fly hive
Spawns 2-4 Blue Flies to damage enemies.
Tammy's Head
5.100. 38
Reusable tear burst
Shoots 10 tears in a circle around Isaac, which retain the damage , shot speed , and special effects (such as poison ) of Isaac's tears.
IV Bag
5.100. 135
Portable blood bank
Upon activation, Isaac loses a half-heart (one whole heart in The Womb onwards) for a random amount of coins, similar to the Blood Donation Machine .
Name
ID
Icon
Quote
Description
Abel
5.100. 188
Mirrored buddy
A familiar that mirrors the player's movements and shoots in the opposite direction.
Bob's Brain
5.100. 273
Explosive thoughts
Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Cricket's Head
5.100. 4
DMG up
Increases damage by 0.5, and multiplies it by 1.5x.
Fate
5.100. 179
Flight eternal
Grants flight and one Eternal Heart .
Goat Head
5.100. 215
He accepts your offering
A Devil Room / Angel Room Door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Infamy
5.100. 242
Damage Reduction
Chance to block projectiles coming from any direction.
Fate's Reward
5.100. 361
Your fate beside you
A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage.
Head of the Keeper
5.100. 429
Penny tears!
Isaac's tears become coins and now have a chance to drop Pennies on the floor upon successfully hitting an enemy.
Steven
5.100. 50
DMG up
Increases damage by 1.
Blood Bag
5.100. 119
HP up
Grants one full Red Heart container , restores 4 Red Hearts, and increases speed by 0.3.
Bomb Bag
5.100. 131
Gives bombs
Isaac is followed by a small bag that drops a Bomb, a Double Bomb, a Troll Bomb, or a Golden Bomb every 3 rooms.
Little Baggy
5.100. 252
Extra pill room
Isaac can hold 2 pills at once and all cards are replaced by pills.
Mystery Sack
5.100. 271
?
Spawns a familiar that drops a heart , coin , bomb , or key every 5-6 rooms.
Rune Bag
5.100. 389
Rune generator
A bag that follows Isaac and drops a random rune every 5-6 rooms.
Sack of Pennies
5.100. 94
Gives money
Isaac is followed by a small bag that drops a coin every 2 rooms.
Sack of Sacks
5.100. 500
Gives sacks
Spawns a sack familiar that drops a sack every 5-6 rooms cleared.
"Bag" and "sack" items were added to the Locked Chest pool, which previously contained only "head" items.