Items in this pool can appear in
Locked Chests, Bomb Chests, and Vaults.
A familiar that mirrors the player's movements and shoots in the opposite direction.
Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Increases damage by 0.5, and multiplies it by 1.5x.
Grants flight and one Eternal Heart.
He accepts your offering
A Devil Room / Angel Room Door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Chance to block projectiles coming from any direction.
Your fate beside you
A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage.
Head of the Keeper
Isaac's tears become coins and now have a chance to drop Pennies on the floor upon successfully hitting an enemy.
Increases damage by 1.
Grants one full Red Heart container, restores 4 Red Hearts, and increases speed by 0.3.
Isaac is followed by a small bag that drops a Bomb, a Double Bomb, a Troll Bomb, or a Golden Bomb every 3 rooms.
Extra pill room
Isaac can hold 2 pills at once and all cards are replaced by pills.
Spawns a familiar that drops a heart, coin, bomb, or key every 5-6 rooms.
A bag that follows Isaac and drops a random rune every 5-6 rooms.
Sack of Pennies
Isaac is followed by a small bag that drops a coin every 2 rooms.
Sack of Sacks
Spawns a sack familiar that drops a sack every 5-6 rooms cleared.
"Bag" and "sack" items were added to the Locked Chest pool, which previously contained only "head" items.