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Guppy Beelzebub Added in Afterbirth Super Bum Added in Afterbirth Yes Mother? Added in Afterbirth Bob Added in Afterbirth Fun Guy Added in Afterbirth Leviathan Added in Afterbirth Conjoined
Added in Afterbirth Spun Added in Afterbirth Seraphim Added in Afterbirth Oh Crap Added in Afterbirth † Bookworm Added in Afterbirth † Spider Baby Added in Afterbirth † Adult Added in Afterbirth † Stompy


Isaac turns into his cat Guppy after picking up any three distinct items in the following list. In this form, Isaac gains flight and will spawn one blue fly every time an enemy is hit with a tear. Flies do not spawn when dealing damage without tears (except Brimstone BrimstoneCollectible Brimstone Rebirth icon.pngTears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.), such as with Mom's Knife Mom's KnifeCollectible Mom's Knife Rebirth icon.pngIsaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power. or Epic Fetus Epic FetusCollectible Epic Fetus icon.pngIsaac's tears are replaced with guided missiles, like those used by the Doctor's Remote..

Activated collectibles[edit | edit source]

Name ID Icon Quote Description
Guppy's Head 145
Guppy's Head
1 rooms
Reusable fly hive Spawns 2-4 blue flies to damage enemies.
Guppy's Paw 133
Guppy's Paw
Soul converter Removes one red heart container in exchange for gaining 3 Soul Hearts.

Passive collectibles[edit | edit source]

Name ID Icon Quote Description
Dead Cat 81 Dead Cat 9 lives Sets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again.
Guppy's Collar 212 Guppy's Collar Eternal Life? Grants Isaac a permanent 50% chance to respawn with 1/2 of a red heart after death.
Guppy's Tail 134 Guppy's Tail Cursed? Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Guppy's Hair Ball 187 Guppy's Hair Ball Swing it Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.

Unlockable achievements[edit | edit source]

Trivia[edit | edit source]

Seeds Disables achievements[edit | edit source]

 PC  Normal mode only XWN6 1YWH (Basement I - Curse Room above spawn contains 2 Red Chests and Stone Chest, Guppy's Collar, Guppy's Head and Dead Cat respectively)

 PC  Normal mode only 7TC3 43F1 (Cellar I - Curse Room above spawn contains 2 Red Chests and Stone Chest, Guppy's Collar, Guppy's Paw and Guppy's Head respectively

 PC  Added in Afterbirth Greed mode only W82M ZL3F (Basement, Eden only - Start with Guppy's Head, golden treasure room contains Guppy's Paw, silver treasure room contains Guppy's Tail)

 3DS  Hard mode only F4GJ 7ZHK (Caves II, Boss Challenge Room, three red chests with Guppy's Tail, Guppy's Head and Guppy's Paw)

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