|Guppy||Beelzebub||Super Bum||Yes Mother?||Bob||Fun Guy||Leviathan||Conjoined|
|Spun||Seraphim||Oh Crap||Bookworm||Spider Baby||Adult||Stompy|
Isaac turns into his cat Guppy after picking up any 3 distinct items from this item pool.
As Guppy, Isaac gains flight and spawns a Blue Fly every time he or his familiars hit an enemy with a tear. Laser attacks from Brimstone, Technology and Tech X also work normally, but Mom's Knife and Technology 2 spawn flies only very rarely. Explosions and non-tear based attacks from familiars do not spawn flies.
Activated Collectibles[edit | edit source]
|Guppy's Head||145||Reusable fly hive||Spawns 2-4 Blue Flies to damage enemies.|
|Guppy's Paw||133||Soul converter||Removes one Red Heart container in exchange for gaining 3 Soul Hearts.|
Passive Collectibles[edit | edit source]
|Dead Cat||81||9 lives||Sets Isaac's Red Heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac respawns with 1 Red Heart in the last safe room.|
|Guppy's Collar||212||Eternal Life?||Grants Isaac a permanent 50% chance to respawn with 1/2 of a Red Heart after death.|
|Guppy's Hair Ball||187||Swing it||Loosely follows behind Isaac. It can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.|
|Guppy's Tail||134||Cursed?||Increases chance of finding Locked Chests and normal Chests, but reduces chance of finding pickups.|
Unlockable Achievements[edit | edit source]
- Guppy's Hairball - Become Guppy.
- Cat Got Your Tongue - Become Guppy.
Trivia[edit | edit source]
- This transformation is a reference to Edmund's first cat, as seen in some of his early videos on his personal channel.
Seeds [edit | edit source]
XWN6 1YWH (The Basement I - Curse Room above spawn contains 2 Red Chests and Bomb Chest, Guppy's Collar, Guppy's Head and Dead Cat respectively)
7TC3 43F1 (The Cellar I - Curse Room above spawn contains 2 Red Chests and Bomb Chest, Guppy's Collar, Guppy's Paw and Guppy's Head respectively
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|