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Guppy's Head

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Guppy's Head is an activated item.

Effects[edit | edit source]

Notes[edit | edit source]

  • Each blue fly deals double Isaac's damage.
  • Box of Spiders Box of SpidersBox of Spiders Icon.png2 roomsSummons 2-4 blue spiders. is essentially the spider equivalent to Guppy's Head, but can be activated less often.

Synergies[edit | edit source]

  • Hive Mind Hive MindHive Mind Icon.pngIncreases the size of blue spiders and Blue Flies and doubles the amount of damage they deal.: Increases size and damage of blue flies.
  • Ipecac IpecacIpecac Icon.pngReplaces tears with explosive and poisoning projectiles fired in an arc from the mouth., Polyphemus PolyphemusPolyphemus Icon.pngMakes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage., and other high-Damage items: Significantly increases the damage dealt by blue flies.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • This item is used in Challenge #8 (Cat Got Your Tongue).

Gallery[edit | edit source]

Seeds[edit | edit source]

 PC  TK1W XHLH (first curse room)

 PS4  J304 8T8Y (first curse room)

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