Guppy's Head

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Item icon
Item altar
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1 rooms 1  rooms
Curse Room Curse Room
Devil Room Devil Room
Golden Chest Golden Chest
Red Chest Red Chest
Greed mode only Curse Room Curse Room
Greed mode only Devil Room Devil Room
Greed mode only Golden Chest Golden Chest
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Added in Afterbirth(page 2, column 2, row 2)
Removed in Afterbirth(page 2, column 2, row 5)

Guppy's Head is an activated item.

Effects[edit | edit source]

  • Spawns 2-4 friendly blue flies.
  • This item belongs to the GuppyGuppy App.pngGrants flight and spawns a blue fly each time a tear hits an enemy. set. Collecting three items from this set will transform Isaac into Guppy.

Notes[edit | edit source]

  • Each blue fly deals double Isaac's damage.
  • Box of Spiders Box of SpidersCollectible Box of Spiders Rebirth icon.png2 roomsSummons 2-4 blue spiders. is essentially the spider equivalent to Guppy's Head, but can be activated less often.

Synergies[edit | edit source]

  • Added in AfterbirthCar Battery Car BatteryCollectible Car Battery icon.pngCauses Isaac's activated item to activate twice on each use.: Spawns more flies per use.
  • Hive Mind Hive MindCollectible Hive Mind icon.pngIncreases the size of blue spiders and blue flies and doubles the amount of damage they deal.: Increases size and damage of blue flies.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • This item is used in Challenge #8 (Cat Got Your Tongue).

Gallery[edit | edit source]

Seeds[edit | edit source]

 PC  TK1W XHLH (first curse room)

 PS4  J304 8T8Y (first curse room)

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