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Hard mode
Hard mode changes the gameplay compared to Normal in some ways to make it more difficult.
When playing in hard mode, a small red pentagram (
) appears on the HUD, below the consumables.
- Rooms contain more advanced enemies and in a higher number.
- Causes champions to spawn more often; however, they award fewer pickups.
- You are 65% less likely to receive hearts after completing a room.
- Only champion bosses can drop red hearts; normal bosses will not.
- You are more likely to be cursed on each floor.
- You are more likely to receive a harder version of a floor (e.g. Necropolis or
Dank Depths instead of The Depths).
Unlocks for Hard Mode[edit | edit source]
Defeat 
Defeat 
Beat 
Trivia[edit | edit source]
- Prior to update 1.03, the reduced drop-rate affected all Pickups (not just Red Hearts).
Godhead
Increases damage and range while reducing tears and shot speed. Grants homing tears and tears gain a damaging halo.'s unlock requirements were extended in the Afterbirth DLC (and further extended in the Afterbirth+ DLC) due to the addition of more completion marks, but it can still be unlocked in the base game using the same method.
 The Binding of Isaac: Rebirth
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 Achievements
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 Attributes
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 Bosses
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 Cards and Runes
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 Challenges
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 Chapters
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 Characters
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 Co-op
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 Items
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 Item Pools
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 Monsters
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 Objects
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 Pickups
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 Pills
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 Rooms
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 Seeds
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 Transformations
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 Trinkets
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