- Rooms contain more advanced enemies and in a higher number.
- Causes champions to spawn 20% of time instead of only 5%; however, they award pickups only 33% of the time.
- You are 65% less likely to receive hearts after completing a room.
- Only champion bosses can drop Red Heart containers; normal bosses will not.
- You are more likely to be cursed on each floor.
- You are more likely to receive a harder version of a floor (e.g. Necropolis or Dank Depths instead of The Depths).
Unlocks for Hard Mode[edit | edit source]
|Character||Mom's Heart||All completion marks|
Trivia[edit | edit source]
- Before update 1.03, the reduced drop-rate affected all pickups (not just Red Hearts).
- Godhead, Smelter, and Marrow are the only items that require playing Hard mode to unlock, with every other unlock being co-op babies.
- Godhead's unlock requirements were extended in the Afterbirth DLC (and further extended in the Afterbirth+ DLC) due to the addition of more completion marks, but it can still be unlocked in the base game using the same method.
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|