Major changes are coming to the Wiki! To learn more and let your voice be heard, please go here.

Additionally, we are currently experiencing some bugs and glitches. We're working on fixing them, but please be aware this means certain images, such as the collection grid for items, will be replaced by errors for the time being.

High Brow

From Binding of Isaac: Rebirth Wiki
Jump to: navigation, search
Font TeamMeat H.pngFont TeamMeat i.pngFont TeamMeat g.pngFont TeamMeat h.png   Font TeamMeat B.pngFont TeamMeat r.pngFont TeamMeat o.pngFont TeamMeat w.png
IsaacIsaac
Full red heartFull red heartFull red heart
Table dividing line 1.png
 
 
Number One Number OneNumber One Icon.png+1.5 tears, -17.62 range
E Coli E ColiE Coli Icon.pngGives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Butt Bombs Butt BombsButt Bombs Icon.pngGives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
Flush! Flush!Flush! Icon.png6 roomsChanges all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.

Petrified Poop Petrified PoopPetrified Poop Icon.pngGreatly increases the chances of a pickup dropping when destroying poop.
 
Item Pool Treasure Room.png: no          Item Pool Shop.png: yes
Boss Mom.png
Rune of Jera Rune of JeraRune of JeraComplete challenge #2

High Brow is challenge #2. Isaac begins this challenge with Number One Number OneNumber One Icon.png+1.5 tears, -17.62 range, E Coli E ColiE Coli Icon.pngGives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop., Butt Bombs Butt BombsButt Bombs Icon.pngGives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies., Flush! Flush!Flush! Icon.png6 roomsChanges all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie., and Petrified Poop Petrified PoopPetrified Poop Icon.pngGreatly increases the chances of a pickup dropping when destroying poop.. The goal is to defeat Mom. This challenge is unlocked by default.

Difficulty[edit | edit source]

Starting with Number One limits Isaac's range significantly. Getting close to enemies is required to defeat them.

Strategy[edit | edit source]

  • Flush! can be powerful when dealing with a large number of enemies, such as in a 2x2 room. Turning all the enemies into poop allows for rapid clearing of rooms, and Petrified Poop increases the chance of those poops containing pickups.
  • E. Coli can turn enemies into poop. Given the short range granted by Number One, enemies will be more likely to deal contact damage. Enemies that do not deal contact damage (Black Flies, Mulligan, Hosts etc) are valuable, as they can be transformed into poop with no drawbacks.
    • Skatole SkatoleSkatole Icon.pngAll types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage. is a highly useful item, due to the amount of black flies it creates that can be transformed into poop.
  • Butt Bombs gives 5 extra bombs to start with, which can make items or secret rooms easier to find in the first 2 levels.
  • Because of Number One's synergy with Brimstone BrimstoneBrimstone Rebirth Icon.pngTears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period., it is highly recommended, despite the Health cost.
  • While it is slow, Mysterious Candy Mysterious CandyMysterious Candy Icon.pngIsaac farts or poops at random intervals. Getting hit can also trigger the effect. can be helpful if resources are scarce in a run.

Unlockable achievements[edit | edit source]


MainPageChallenges.png Challenges MainPageChallenges.png

Rebirth
1. Pitch Black 2. High Brow 3. Head Trauma 4. Darkness Falls 5. The Tank 6. Solar System 7. Suicide King 8. Cat Got Your Tongue
9. Demo Man 10. Cursed! 11. Glass Cannon 12. When Life Gives You Lemons 13. Beans! 14. It's in the Cards 15. Slow Roll 16. Computer Savvy
17. Waka Waka 18. The Host 19. The Family Man 20. Purist
Afterbirth
21. XXXXXXXXL 22. SPEED! 23. Blue Bomber 24. PAY TO PLAY 25. Have a Heart 26. I RULE! 27. BRAINS! 28. PRIDE DAY!
29. Onan's Streak 30. The Guardian
Afterbirth †
31. Backasswards 32. Aprils Fool 33. Pokey Mans 34. Ultra Hard 35. Pong
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item Pools Item Pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets