High Brow

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High Brow
Challenge number
2
Character
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starting Items
Number One Number OneNumber One Icon.png+1.5 tears, -15.77 range
E Coli E ColiE Coli Icon.pngGives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Butt Bombs Butt BombsButt Bombs Icon.pngGives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
Flush! Flush!Flush! Icon.png6 roomsChanges all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.
Trinket:
Petrified Poop Petrified PoopPetrified Poop Icon.pngGreatly increases the chances of a pickup dropping when destroying poop.
Available rooms
Item Pool Treasure Room.png: no          Item Pool Shop.png: yes
Goal
Boss Mom.png
Unlocks
Rune of Jera Rune of JeraRune of JeraComplete challenge #2

High Brow is challenge #2. This challenge starts you with Number One Number OneNumber One Icon.png+1.5 tears, -15.77 range, E Coli E ColiE Coli Icon.pngGives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop., Butt Bombs Butt BombsButt Bombs Icon.pngGives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies., Flush! Flush!Flush! Icon.png6 roomsChanges all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie., and Petrified Poop Petrified PoopPetrified Poop Icon.pngGreatly increases the chances of a pickup dropping when destroying poop.. Your goal is to defeat Mom. This challenge is unlocked by default.

Difficulty[edit | edit source]

Starting with Number One Number OneNumber One Icon.png+1.5 tears, -15.77 range gives you a much shorter range for your tears. You'll need to get closer to your enemies to defeat them.

Strategy[edit | edit source]

  • Flush! Flush!Flush! Icon.png6 roomsChanges all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie. can be powerful when dealing with a large number of enemies, such as in a 2x2 room. Turning all the enemies into poop can save you quite a bit of time, and Petrified Poop Petrified PoopPetrified Poop Icon.pngGreatly increases the chances of a pickup dropping when destroying poop. can then increase your chances of valuable pickups.
  • E Coli E ColiE Coli Icon.pngGives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop. can turn enemies into poop. Given the short range because of Number One Number OneNumber One Icon.png+1.5 tears, -15.77 range, you will have an increased chance of contact damage. Try to touch every enemy that doesn't damage you (Black Flies, Mulligan, Hosts etc). They will still be transformed into poop. This works well with Petrified Poop Petrified PoopPetrified Poop Icon.pngGreatly increases the chances of a pickup dropping when destroying poop..
    • This also works well with Skatole SkatoleSkatole Icon.pngAll types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.. Attack flies are instantly transformed into harmless black flies that can be touched and transformed into poop.
  • Butt Bombs Butt BombsButt Bombs Icon.pngGives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies. gives you 5 extra bombs to start with, which can make getting some items or secret rooms easier to find in the first 2 levels.
  • Because of Number One Number OneNumber One Icon.png+1.5 tears, -15.77 range's synergy with Brimstone BrimstoneBrimstone Icon.pngTears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period., it is highly recommended if the deal is available.
  • Slow but potentially useful synergy with Petrified Poop if you find Mysterious Candy. Good if you find yourself strapped for coins, especially early on.

Unlockable achievements[edit | edit source]


The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op MainPageItems Small.png Items Item Pools Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets