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|Rebirth||Suicide King||Chaos Card||Credit Card||Rules Card||A Card Against Humanity|
|Afterbirth||? Card||Get out of Jail Free Card||Emergency Contact||Dice Shard|
|Afterbirth †||Holy Card||Huge Growth||Ancient Recall||Era Walk|
The Holy Card is a Special Card.
Effects[edit | edit source]
- Grants Holy MantleAutomatically negates first taken damage in every room. effect for one room.
- Has a 25% chance to display the message "You Are Blessed!" and spawn another Holy Card.
|The Lost Unlocks|
|Isaac's HeartDefeat Isaac as The LostThe MindDefeat Satan as The LostThe BodyDefeat ??? as The LostThe SoulDefeat The Lamb as The LostThe D100Complete the Boss Rush as The LostGodheadRemoved in Afterbirth Beat Mom's Heart, Isaac, Satan, ???, and The Lamb and complete the Boss Rush on hard mode as The Lost
Added in Afterbirth Earn all 9 Completion Marks on hard mode as The Lost-0- BabyDefeat Mom's Heart on hard mode as The Lost
|Sworn ProtectorDefeat Hush as The LostZodiacDefeat Ultra Greed as The LostWhite BabyDefeat Mega Satan as The Lost||Holy CardDefeat Delirium as The LostDad's Lost CoinDefeat Ultra Greedier as The Lost|
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|