Infestation 2

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Font TeamMeat I.pngFont TeamMeat n.pngFont TeamMeat f.pngFont TeamMeat e.pngFont TeamMeat s.pngFont TeamMeat t.pngFont TeamMeat a.pngFont TeamMeat t.pngFont TeamMeat i.pngFont TeamMeat o.pngFont TeamMeat n.png   Font TeamMeat 2.png
Item icon
Item altar
Table dividing line 1.png
Character appearance
Table dividing line 2.png
Treasure Room Treasure Room
Greed mode only Treasure Room Treasure Room
Table dividing line 3.png
Added in  Afterbirth(page 2, column 11, row 6)
Removed in Afterbirth(page 3, column 1, row 4)

Infestation 2 is a passive item.

Effects[edit | edit source]

Notes[edit | edit source]

  • Enemies do not spawn spiders when killed by anything not controlled by Isaac (environmental hazards, charmed enemies, death upon clearing room, etc).
  • Enemies do not spawn spiders when killed by blue spiders.
  • Blue flies can also spawn spiders.
  • Enemies killed by familiars will spawn blue spiders.
  • Destroying dead shopkeepers will spawn blue spiders.
  • Killing Pin will give one spider for each of his segments.
  • Killing Chub will spawn a lot of blue spiders.
  • Killing a Homunculus or a Begotten will sometimes spawn a blue spider for each segment in the chains holding them to the wall.
  • Added in  Afterbirth Black Balls spawned by Little Horn can also drop blue spiders upon death.

Synergies[edit | edit source]

  • Daddy Longlegs Daddy LonglegsDaddy Longlegs Rebirth Icon.pngDaddy Long Legs' shadow follows Isaac and stomps on enemies.: All kills from the Daddy Longlegs will count as kills from the player, causing Infestation 2 to activate.

In-game Footage[edit | edit source]

Seeds[edit | edit source]

 PS4  AV4D 6SA4

 Vita  F2YP 4L9V (Treasure room adjacent to spawn)

 PC  KLFM X14Z (First floor treasure room)

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