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Temporary Buffs

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Player Effects
Attributes Flight Temporary Buffs Death

Temporary buffs are effects applied to the player character that expire after a timed duration or on leaving a room.

Effects[edit | edit source]

Effect Appearance Description
Invulnerability Invincibility App.gif Negates all types of damage for five seconds, including health loss from Blood Donation Machines and Devil Beggars, environmental hazards like spikes, and Curse Rooms doors and Sacrifice Rooms, but does not prevent heart container or Soul Heart loss from Health Down Pills, Devil Room deals, or spawning a baby.

While under the effects of invulnerability, the character has increased speed, loses the ability to shoot tears, flashes in multiple colors, and the music of the game speeds up. However, all invulnerability-granting items except for the Unicorn Stump also grant the character the ability to damage enemies by contact for the duration of the effect.

Shield Book of Shadows App.png Negates all types of damage for a variable amount of time, depending on the item it's granted by, including health loss from Blood Donation Machines and Devil Beggars, environmental hazards like spikes, and Curse Rooms doors and Sacrifice Rooms, but does not prevent heart container or Soul Heart loss from Health Down Pills, Devil Room deals, or spawning a baby.

Unlike invulnerability, the shield does not prevent the character from attacking.

Invulnerability[edit | edit source]

Activated Items that grant invulnerability[edit | edit source]

Name ID Icon Quote Description
My Little Unicorn 77
My Little Unicorn
6 rooms
Temporary badass Upon use, grants invulnerability and increased speed for five seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
The Gamekid 93
The Gamekid
6 rooms
Temporary Man-Pac Upon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed.
Unicorn Stump 298
Unicorn Stump
1 rooms
You feel stumped Upon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears.

Passive Items that grant invulnerability[edit | edit source]

Name ID Icon Quote Description
Taurus 299 Taurus Speed down + rage is building Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.

Trinkets that grant invulnerability[edit | edit source]

Name ID Icon Quote Description
Cartridge 8 Cartridge I remember these Chance to trigger The Gamekid effect upon taking damage.

Cards that grant invulnerability[edit | edit source]

Name ID Icon Message Effect
VII - The Chariot 8 VII - The Chariot Icon.png May nothing stand before you Grants the temporary invulnerability effect of My Little Unicorn.

Shield[edit | edit source]

Activated Items that grant a shield[edit | edit source]

Name ID Icon Quote Description
Book of Shadows 58
Book of Shadows
3 rooms
Temporary Invincibility Upon use, creates a protective shield nullifying all types of damage for 10 seconds.

Passive Items that grant a shield[edit | edit source]

Name ID Icon Quote Description
Celtic Cross 162 Celtic Cross You feel blessed Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
Added in Afterbirth Empty Vessel 409 Empty Vessel I reward an empty vessel While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.
The Polaroid 327 The Polaroid Fate Chosen If the character has half a red heart or no red hearts after taking damage, it triggers the Book Of Shadows effect, creating a shield that nullifies all types of damage for 5 seconds. Also allows entrance into The Chest.
Virgo 303 Virgo You feel refreshed and protected Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills".

Runes that grant a shield[edit | edit source]

Rune ID Icon Unlock method Message Effect
Algiz 39 Algiz Icon.png Resistance Grants a shield which lasts for 30 seconds.


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