Ipecac

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Item icon
Item altar
 
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Character appearance
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Treasure Room Treasure Room
Greed mode only Treasure Room Treasure Room
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Added in  Afterbirth(page 2, column 6, row 2)
Removed in Afterbirth(page 2, column 6, row 5)
 
Ipecac Defeat Mom's Heart 6 timesIpecacIpecac

Ipecac is an unlockable passive item.

Effects

  • Replaces tears with explosive and poisoning projectiles fired in an arc.
  • Tears down - (Delay * 2) + 10
  • +13 Shot Height
  • +40 flat damage (See Effective Damage)

Notes

  • As Ipecac's explosion range does not scale with tear size, with enough tear size increasing items (e.g. Death's Touch), it can become nearly impossible to hit enemies with Ipecac's explosions.
  • Ipecac's flat damage upgrade does not increase tear size like standard damage upgrades.
  • Ipecac's damage bonus does not apply to Burn or Poison fully; only +4 is applied to their damage per tick.
  • Character damage multipliers do not apply to Ipecac's flat bonus.
  • Using Ipecac in a Crawl Space will cause the tear to bounce off the ceiling, bounce off the floor at a low height, and eventually explode. The same applies with using it on a Crawl Space wall.

Synergies

  • Chocolate Milk Chocolate MilkChocolate Milk Icon.pngGrants charged tears that deal greater damage when fully charged.: Charged up Ipecac deals expectedly high damage. Rapid fire can be used against weaker enemies or to clear obstacles when necessary.
  • Cricket's Head Cricket's HeadCricket's Head Rebirth Icon.pngIncreases damage by 0.5, and multiplies it by 1.5x. / Eve's Mascara Eve's MascaraEve's Mascara Icon.pngDoubles damage, halves tears stat, and greatly reduces shot speed. / Magic Mushroom Magic MushroomMagic Mushroom Icon.pngIncreases all stats and enlargens Isaac.: The damage multipliers from these items apply to Ipecac's +40 bonus, unlike others.
  • Dr. Fetus Dr. FetusDr. Fetus Icon.pngTears are replaced by bombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired.: Bombs explode on contact, do no damage to Isaac and become Bob's Curse bombs.
    • Dr. Fetus + Monstro's Lung: renders Isaac no longer immune to his own shots, also they will explode as soon as Isaac shoots.
  • Epic Fetus Epic FetusEpic Fetus Icon.pngIsaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.: Missiles turn green and are poisonous. Damage greatly increases as the flat damage bonus stacks with Epic Fetus' explosive multiplier.
  • Mom's Knife Mom's KnifeMom's Knife Rebirth Icon.pngIsaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.: Knife turns green, may poisons enemies, and removes Ipecac's damage increase.
    • Added in Afterbirth † Also adds +4 damage.
  • Monstro's Lung Monstro's LungMonstro's Lung Icon.pngIncreases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.: Isaac fires a barrage of Ipecac shots, with no increase in charge time compared to Monstro's Lung alone.
  • Added in  AfterbirthTractor Beam Tractor BeamTractor Beam Icon.pngIsaac emits a beam from his face. Isaac's tears travel in the path of the beam.: The Ipecac tear will always travel forwards along the beam, even if Isaac is moving forward as well. This makes it less likely for Isaac to get damaged by his own tear.

Interactions

  • Bloody Lust Bloody LustBloody Lust Icon.pngIncreases damage as Isaac receives damage. Damage increase stays for the whole floor. / Added in  AfterbirthCrown of Light Crown of LightCrown of Light Afterbirth Icon.pngGives Isaac a crown that glows blue when active, and turns gray when inactive. While Isaac has no empty red heart containers, Isaac's tears are replaced with blue diamond tears that deal double damage. Regardless of health, the crown will deactivate for the current room when Isaac takes damage. / Polyphemus PolyphemusPolyphemus Rebirth Icon.pngMakes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage. / Proptosis ProptosisProptosis Rebirth Icon.pngTears start out massive with high damage, and then shrink down and become weaker over a short range. / Sacred Heart Sacred HeartSacred Heart Icon.pngIncreases damage and range while reducing shot speed and grants homing tears. Grants a Heart Container and replenishes all Red Hearts.: The damage multipliers from these items do not apply to Ipecac's +40 bonus, resulting in much lower damage increase than expected.
  • Brimstone BrimstoneBrimstone Rebirth Icon.pngTears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.: Blood beam now does poison damage. The character doesn't gain the Damage Up or Tears Down effects.
    • Added in Afterbirth † Isaac shoots Ipecac tears while charging Brimstone. Both Brimstone and Ipecac shots modify Isaac's damage and tear delay stat, meaning that Ipecac fires slower and Brimstone charges slower, but Brimstone does an extra 40*13 damage. Take care to pre-charge Brimstone so that the Ipecac shot is on cooldown as Isaac enters a room. This interaction also applies to Azazel's mini Brimstone.
  • Cricket's Body Cricket's BodyCricket's Body Icon.pngGrants -1 Tear Delay and reduces Range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose Range and Damage scale with Isaac's.: Main tear splits into four explosive splash tears. The splash tears can still damage Isaac.
  • Death's Touch Death's TouchDeath's Touch Icon.pngIncreases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.: Although damage is increased, the tears' hitbox also grows larger which may be detrimental.
  • Added in Afterbirth †Flat Stone Flat StoneFlat Stone Icon.pngTears bounce off the floor. Tears that hit an enemy after bouncing deal splash damage to all nearby enemies for 25% of Isaac's tear damage.: The Ipecac shots cause full-damage explosions instead of lesser splash damage when they bounce off the floor, though they can also harm Isaac.
  • Added in Afterbirth †The Forgotten: The ghost form uses Ipecac as normal. The skeleton form's melee attacks become poisonous and explosive with +4 flat damage; he cannot be hurt by the blasts, but is pushed back by them. The charged boomerang attack is only poisonous.
  • Added in Afterbirth †Ghost Pepper Ghost PepperGhost Pepper Icon.pngAdds a chance to shoot a fire that damages enemies and remains in place until it deals enough damage or the room is left.: If a fire is generated at the same time as a Ipecac shot, the Ipecac shot will explode instantly.
  • Guppy Transformation: Blue flies are no longer spawned on hit.
    • Added in  Afterbirth Ipecac shots now spawn blue flies on hit, both direct and indirect.
  • Lost Contact Lost ContactLost Contact Icon.pngEvery tear has a small shield which will allow it to block one enemy projectile.: Ipecac shots will explode on contact with enemy shots.
  • The Ludovico Technique The Ludovico TechniqueThe Ludovico Technique Icon.pngInstead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.: Tear damage is increased by 4, explodes when killing an enemy, and comes back to Isaac.
    • Added in Afterbirth † +4 damage bonus, no explosion.
  • Mom's Eye Mom's EyeMom's Eye Rebirth Icon.pngAllows Isaac to fire tears from the back of his head. / Loki's Horns Loki's HornsLoki's Horns Icon.pngGives a random chance for projectiles to fire in all 4 cardinal directions.: Occasionally shoots backwards or in all 4 directions, with high risk of self-damage.
  • The Parasite The ParasiteThe Parasite Icon.pngIsaac's tears split in two when they hit something.: The Ipecac tear will spawn two smaller explosive tears when it collides with a solid object, but not with an enemy. These tears can spawn tears on their own as well, potentially leading to huge chain reactions.
  • Piercing tears: Tears will still explode on enemy contact, nullifying piercing.
  • Rubber Cement Rubber CementRubber Cement Icon.pngTears bounce off walls, enemies, and environmental objects.: Tears will bounce off walls and rocks and won't explode until they hit the ground.
  • Soy Milk Soy MilkSoy Milk Icon.pngTears shrink and do much less damage, but fire in very rapid succession.: Though fire rate is greatly increased, the 20% damage multiplier applies resulting in weak explosions.
  • Spectral tears: Ipecac shots no longer explode on contact with obstacles or walls, making accidental self-damage less likely but it's more difficult to open secret doors.
  • Added in  AfterbirthTech X Tech XTech X Icon.pngTears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the size of the ring.: The laser ring becomes poisonous and gains +4 damage.
  • Technology TechnologyTechnology Icon.pngReplaces tears with a piercing laser with unlimited range.: Overridden by Technology.
    • Added in Afterbirth † +4 damage bonus, poisonous laser.
  • Technology 2 Technology 2Technology 2 Icon.pngDecreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.: The +40 damage bonus is not affected by the Technology 2 multiplier making the laser very high powered, but only every other Ipecac shot is actually fired.
  • Added in Afterbirth †Technology Zero Technology ZeroTechnology Zero Icon.pngConnects Isaac's tears with electricity that can damage enemies.: High fire rate needed for explosive shots to be connected.
  • Tiny Planet Tiny PlanetTiny Planet Icon.pngRange up and makes shot tears revolve around Isaac until they drop.: Ipecac tears orbit around Isaac for a very long time. They land far enough to not cause self-damage, but that can be relied on only if Isaac is not moving and do not hit enemies.

In-game Footage

Unlockable Achievements

Trivia

  • "Ipecac" is a shortened name for syrup of ipecac, a powerful emetic (substance used to induce vomiting). This name is itself derived from a shortening of the source plant's name, Ipecacuanha.
  • This item is used in Challenge #7 (Suicide King).

Seeds

 PC  2Q6M EEZQ (First floor treasure room)

 PC  BK3W 93F4 (treasure room adjacent to spawn)

 PC  NNH2 XPNP (treasure room adjacent to spawn)

 PC  Q47Z GX3W (treasure room adjacent to spawn - Normal mode)

 PC  C139 L97X (treasure room adjacent to spawn)

 PS4  HYDG 0PPY (First treasure room)

 Vita  3N3B BFWZ (Treasure room adjacent to spawn)


Mom's Heart  Unlocks Mom's Heart Unlocks Mom's Heart  Unlocks
Added in  Afterbirth Added in Afterbirth †
A NooseA NooseDefeat Mom's Heart 3 timesA QuarterA QuarterDefeat Mom's Heart 8 timesA Fetus in a JarA Fetus in a JarDefeat Mom's Heart 9 times??????Defeat Mom's Heart 10 timesEverything Is Terrible!!!Everything Is Terrible!!!Defeat Mom's Heart 5 timesIt Lives!It Lives!Defeat Mom's Heart 11 timesWire Coat HangerWire Coat HangerDefeat Mom's Heart 4 timesIpecacIpecacDefeat Mom's Heart 6 timesExperimental TreatmentExperimental TreatmentDefeat Mom's Heart 7 timesRubber CementRubber CementDefeat Mom's Heart 2 timesDarkness FallsDarkness FallsDefeat Mom's Heart 11 timesSolar SystemSolar SystemDefeat Mom's Heart 3 timesSuicide KingSuicide KingDefeat Mom's Heart 11 timesDemo ManDemo ManDefeat Mom's Heart 9 timesLost BabyLost BabyDefeat Mom's Heart on hard mode as IsaacCute BabyCute BabyDefeat Mom's Heart on hard mode as MagdaleneCrow BabyCrow BabyDefeat Mom's Heart on hard mode as EveShadow BabyShadow BabyDefeat Mom's Heart on hard mode as JudasGlass BabyGlass BabyDefeat Mom's Heart on hard mode as CainWrapped BabyWrapped BabyRemoved in Afterbirth † Defeat Mom's Heart on hard mode as Azazel
Added in Afterbirth † Defeat Mom's Heart on hard mode as Lazarus
Begotten BabyBegotten BabyRemoved in Afterbirth † Defeat Mom's Heart on hard mode as Lazarus
Added in Afterbirth † Defeat Mom's Heart on hard mode as Azazel
Dead BabyDead BabyDefeat Mom's Heart on hard mode as ???-0- Baby-0- BabyDefeat Mom's Heart on hard mode as The LostGlitch BabyGlitch BabyDefeat Mom's Heart on hard mode as EdenFighting BabyFighting BabyDefeat Mom's Heart on hard mode as Samson
Goat Head BabyGoat Head BabyDefeat Mom's Heart on hard mode as LilithBlue WombBlue WombDefeat Mom's Heart 10 timesSuper Greed BabySuper Greed BabyDefeat Mom's Heart on hard mode as KeeperBlue BomberBlue BomberDestroy 10 tinted rocks and defeat Mom's Heart 11 times Pokey MansPokey MansDefeat Mom's Heart 11 timesSmelterSmelterDefeat Mom's Heart or It Lives! on hard mode as ApollyonBurning BasementBurning BasementDefeat Mom's Heart 11 timesMarrowMarrowDefeat Mom's Heart or It Lives! on hard mode as The Forgotten
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