Isaac's Heart

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Font TeamMeat I.pngFont TeamMeat s.pngFont TeamMeat a.pngFont TeamMeat a.pngFont TeamMeat c.pngFont TeamMeat '.pngFont TeamMeat s.png   Font TeamMeat H.pngFont TeamMeat e.pngFont TeamMeat a.pngFont TeamMeat r.pngFont TeamMeat t.png
Item icon
Item altar
Item Pool Treasure Room.pngTreasure Room
Added in Afterbirth (page 3, column 11, line 2)
Removed in Afterbirth (page 3, column 1, line 8)
Isaac's Heart Defeat Isaac as The Lost

Isaac's Heart is a secret unlockable passive item.

Effect[edit | edit source]

  • Isaac's body becomes immune to all damage.
  • A heart familiar appears and closely follows Isaac. If the heart is hurt, Isaac is hurt.
    • Most enemies now target the heart instead of Isaac. Eyes and other similar enemies, however, will still target Isaac.

Notes[edit | edit source]

  • Items that activate on contact with enemies retain their ability, allowing Isaac to use them without suffering collision damage.
  • Isaac can use Blood Donation Machines and Demon Beggars without taking damage.
    • Added in Afterbirth During The Guardian challenge, Demon Beggars and Blood Donation Machines deal damage to Isaac.
  • Curse Rooms don't deal damage when entered. When used properly, it can allow The Lost to enter and exit Curse Rooms without risk of death.
  • Even if Isaac himself can't fly, the heart will hover over ground hazards, making Isaac immune to all damaging creep and spikes. However, the spikes in a Sacrifice Room can still damage it.
  • Picking up a non-orbital familiar will cause either Isaac's Heart or the other familiar to be layered over the other's sprite. This is due to the heart not taking up the spot that the other familiar follows in.
  • Enemy Brimstone shots (such as from The Bloat) will not deal any damage to the heart.
    • Added in Afterbirth Brimstone shots will damage the heart.
  • Additional players gain the immunity effect without spawning additional hearts.
  • Enemy beams of light (similar to Crack the Sky Crack the Sky) will not deal any damage to the heart.

Synergies[edit | edit source]

  • Aries Aries - Isaac can cause contact damage without taking damage.
  • Blood Rights Blood Rights - Isaac can use Blood Rights infinitely without taking damage.
  • Breath of Life Breath of Life - Isaac can be infinitely invulnerable, as invincibility carries out to the heart without hurting the player. Note that the item needs to be activated for longer than one second for the invulnerability to kick in, however.
  • Blank Card Blank Card + XIV - Temperance - Isaac can use the Temperance card indefinitely to get infinite money.
  • Dry Baby Dry Baby - If Isaac's Heart is layered over Dry Baby, Dry Baby will block incoming shots and the heart will not be damaged by projectiles. Enemies touching the heart can still do damage.
  • E Coli E Coli - Isaac can turn enemies into poop without taking damage.
  • Gnawed Leaf Gnawed Leaf - Invincibility carries over to the heart.
  • Holy Mantle Holy Mantle - The shield effect carries over to the heart.
  • IV Bag IV Bag - Isaac can use the bag without taking damage, effectively granting infinite money.
  • Kamikaze! Kamikaze! - As long as the heart is away from the blast radius, no damage is taken. Character must be at high enough speed for this.
  • Midas' Touch Midas' Touch - Isaac can turn enemies into coins on contact without taking damage.
  • Razor Blade Razor Blade - Isaac cannot take damage from the Razor Blade, allowing for infinite uses of the item.
  • The Nail The Nail - Demon Isaac can cause contact damage without taking damage.
  • The Virus The Virus - Isaac can poison enemies on contact without taking damage.

Interactions[edit | edit source]

  • Added in Afterbirth Box of Friends Box of Friends - Box of Friends does not duplicate the heart.
  • BFFS! BFFS! - BFFS! will make the heart bigger, making it easier to get hit.
  • Sharp Plug Sharp Plug - Sharp Plug can no longer be used.
  • The Soul The Soul - Isaac's body repels projectiles, but Isaac's Heart doesn't.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • Isaac's Heart while it's following Isaac fittingly shares the same sprite as Child's Heart Child's Heart.
  • The nature of the item is similar to that of a Mask + Heart enemy.
  • Added in Afterbirth This item is used in Challenge #30 (The Guardian).

Seeds[edit | edit source]

 PC  TPWZ 7CVR (Treasure Room below of spawn)

 PC  PCJZ 03TG (Adjacent Treasure Room)

 PS4  W1TD 0BJN (Treasure room south of spawn)

Gallery[edit | edit source]

SmallIsaac.png The Binding of Isaac: Rebirth SmallIsaac.png

MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op Magic Mushroom Icon.png Items Isaac's Tears Icon.png Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets
Promotional Content