Isaac's Heart

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Font TeamMeat I.pngFont TeamMeat s.pngFont TeamMeat a.pngFont TeamMeat a.pngFont TeamMeat c.pngFont TeamMeat '.pngFont TeamMeat s.png   Font TeamMeat H.pngFont TeamMeat e.pngFont TeamMeat a.pngFont TeamMeat r.pngFont TeamMeat t.png
Item icon
Item altar
 
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276
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Treasure Room Treasure Room
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Added in Afterbirth(page 3, column 11, row 2)
Removed in Afterbirth(page 3, column 1, row 8)
 
Isaac's Heart Defeat Isaac as The LostIsaac's HeartIsaac's Heart

Isaac's Heart is an unlockable passive item.

Effects[edit | edit source]

  • Isaac's body becomes immune to all damage.
  • A heart familiar appears and closely follows Isaac. If the heart is hurt, Isaac is hurt.
    • Most enemies now target the heart instead of Isaac. Eyes and other similar enemies, however, will still target Isaac.

Notes[edit | edit source]

  • Blood donation machines and Demon Beggars can be used for free. Curse Room doors also deal no damage.
    • Added in Afterbirth During The Guardian challenge, Demon Beggars and Blood Donation Machines deal damage to Isaac.
  • Picking up a non-orbital familiar will cause either Isaac's Heart or the other familiar to be layered over the other's sprite. This is due to the heart not taking up the spot that the other familiar follows in.
  • Additional players gain the immunity effect without spawning additional hearts.
  • Removed in Afterbirth Enemy Brimstone shots (such as from The Bloat) will not deal any damage to the heart.
  • The tracking lasers from Hush and light pillars from Isaac (Boss) do not damage the heart.

Tips and strategies[edit | edit source]

Items / trinkets[edit | edit source]

  • Items that activate on contact with enemies retain their ability, allowing Isaac to use them without suffering collision damage.
  • Items that hurt Isaac on activation, such as IV Bag IV BagCollectible IV Bag icon.pngUnlimitedUpon activation, Isaac loses a half-heart (one whole heart in The Womb onwards) for a random amount of coins, similar to the blood donation machine. and Blood Rights Blood RightsCollectible Blood Rights icon.pngUnlimitedDamages all enemies in the room, but deals a heart of damage to Isaac with each use. no longer do so, allowing infinite uses for free.
  • Speed up items are invaluable when having Isaac's heart since the delay between the player moving away and the heart moving as well gets drastically reduced. Avoid speed down items early in the run.
  • Orbital Familiars are invaluable as Isaac can get extremely close to the enemy without fear of contact damage.
  • Flight items are invaluable as the heart can be placed over a rock and Isaac can stick out enough to shoot at enemies without needing spectral tears.
  • Angel Rooms are safer bets for items than Devil Rooms.
  • Use restock boxes in shops as much as possible get as many soul hearts for health but make sure to hold on to at least 5 cents.
  • Get 5 cents as soon as possible so an arcade can show up, blood donation machines and IV Bag IV BagCollectible IV Bag icon.pngUnlimitedUpon activation, Isaac loses a half-heart (one whole heart in The Womb onwards) for a random amount of coins, similar to the blood donation machine. are the best and most common ways to win an Isaac's heart run.
    • Added in Afterbirth † If lucky pennies are unlocked, it may be beneficial to immediately try to gain 10 luck or more via the IV Bag to maximize room drops and enhance tear effects.
  • Consider bombing skulls for a chance to get Dry Baby Dry BabyCollectible Dry Baby icon.pngSpawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering The Necronomicon effect..

Combat and damage[edit | edit source]

  • Hug obstacles to avoid taking damage. Look out for enemies that fly or can jump over rocks, and make sure enemies don't push Isaac far away from his heart to expose it.
  • When dodging, move in semi straight lines as the heart only follows Isaac's movements when he is at a certain distance away, for example, moving in a circle would pull the heart in and make it stay in place in the middle of the arc as Isaac would no longer be moving away from the heart. Moving in a triangle formation would allow the heart to move more.
  • Enemies that fly and charge like One Tooth are extremely hard to dodge and should be killed as soon as possible, take caution since they can appear as early as The Caves The Caves / The Catacombs The Catacombs.
  • Enemies can be pushed away with Isaac's body, while not recommended, it can be used as a last resort.

Synergies[edit | edit source]

  • Added in AfterbirthBox of Friends Box of FriendsCollectible Box of Friends icon.png4 roomsUpon use, duplicates all of Isaac's familiars for the current room.: Box of Friends does not duplicate the heart, making it safe to use.
  • Breath of Life Breath of LifeCollectible Breath of Life icon.png6 secondsGrants a brief moment of invincibility when the charge bar hits zero. If spacebar is held for an additional second after hitting zero, Isaac will take damage.: Isaac can be infinitely invulnerable, as invincibility carries out to the heart without hurting the player. Note that the item needs to be activated for longer than one second for the invulnerability to kick in, however.
  • Dry Baby Dry BabyCollectible Dry Baby icon.pngSpawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering The Necronomicon effect.: If Isaac's Heart is layered over Dry Baby, Dry Baby will block incoming shots and the heart will not be damaged by projectiles. Enemies touching the heart can still do damage.
  • Added in Afterbirth †Duct Tape Duct TapeTrinket Duct Tape icon.pngStops Isaac's familiars from moving.: Makes dodging significantly easier.
  • Gnawed Leaf Gnawed LeafCollectible Gnawed Leaf icon.pngAfter standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.: Invincibility carries over to the heart.
  • Holy Mantle Holy MantleCollectible Holy Mantle icon.pngAutomatically negates first taken damage in every room.: The shield effect carries over to the heart.
  • Kamikaze! Kamikaze!Collectible Kamikaze! icon.pngUnlimitedCreates an explosion in the same area as Isaac, dealing half a heart of damage to him and also damaging all enemies caught in the blast radius.: As long as the heart is away from the blast radius, no damage is taken. Character must be at high enough speed for this.

Interactions[edit | edit source]

  • Added in Afterbirth †King Baby King BabyCollectible King Baby icon.pngSpawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, it stops moving.: The Heart will follow King Baby. This makes it much harder to avoid damage, but also makes other synergies like Kamikaze! Kamikaze!Collectible Kamikaze! icon.pngUnlimitedCreates an explosion in the same area as Isaac, dealing half a heart of damage to him and also damaging all enemies caught in the blast radius. much easier to use.
  • Sharp Plug Sharp PlugSharp Plug Icon.pngUsing an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.: Sharp Plug can no longer be used.
  • The Soul The SoulCollectible The Soul icon.pngGrants two soul hearts. Isaac now repels enemy projectiles.: Isaac's body repels projectiles, but Isaac's Heart doesn't.

In-game footage[edit | edit source]

Trivia[edit | edit source]

  • Isaac's Heart while it's following Isaac fittingly shares the same sprite as Child's Heart Child's HeartTrinket Child's Heart icon.pngIncreases the chance of a heart pickup dropping after clearing a room, and the chance of finding a heart when opening a Chest..
  • The nature of the item is similar to that of a Mask + Heart enemy.
  • Added in Afterbirth This item is used in challenge #30 (The Guardian).

Seeds[edit | edit source]

 PC  TPWZ 7CVR (Treasure Room below of spawn)

 PC  PCJZ 03TG

 PC  Added in Afterbirth † Y8V7 7K4F (Adjacent Treasure Room)

 PS4  W1TD 0BJN (Treasure room south of spawn)

Gallery[edit | edit source]


The Lost Unlocks The Lost Unlocks The Lost Unlocks
Added in Afterbirth Added in Afterbirth †
Isaac's HeartIsaac's HeartDefeat Isaac as The LostThe MindThe MindDefeat Satan as The LostThe BodyThe BodyDefeat ??? as The LostThe SoulThe SoulDefeat The Lamb as The LostThe D100The D100Complete the Boss Rush as The LostGodheadGodheadRemoved in Afterbirth Beat Mom's Heart, Isaac, Satan, ???, and The Lamb and complete the Boss Rush on hard mode as The Lost
Added in Afterbirth Earn all 9 Completion Marks on hard mode as The Lost
-0- Baby-0- BabyDefeat Mom's Heart on hard mode as The Lost
Sworn ProtectorSworn ProtectorDefeat Hush as The LostZodiacZodiacDefeat Ultra Greed as The LostWhite BabyWhite BabyDefeat Mega Satan as The Lost Holy CardHoly CardDefeat Delirium as The LostDad's Lost CoinDad's Lost CoinDefeat Ultra Greedier as The Lost
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets