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Item icon
Item altar

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Character appearance
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Item Pool Treasure Room.png Treasure Room
Greed mode onlyItem Pool Treasure Room.png Treasure Room
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(page 5, column 20, line 2)
Leprosy Beat Chapter 3 without taking damageLeprosyLeprosy
Added in Afterbirth †

Leprosy is an unlockable passive item added in Booster Pack #2.

Effects[edit | edit source]

  • Upon taking damage, Isaac gains a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with.
    • A maximum of three body parts can be active at once.
    • The body parts will be destroyed if they take enough damage from enemies or enemy shots.
    • The body parts persist between floors.
    • Body parts orbit on the same layer as Blue Flies and Locusts do.

Synergies[edit | edit source]

  • Dull Razor Dull RazorDull Razor Icon.png2 roomsHurts Isaac without depleting health, activating any items that trigger upon taking damage.: Allows Isaac to spawn orbitals without reducing health.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • Leprosy is based on this Steam Workshop item by Extreme Ninja Home Makeover.
    • Originally, this item added a chance to shoot limbs instead of tears which increased Isaac's movement speed.
  • The pickup quote is a reference to Rebel Wilson’s well known line “You’re tearing me apart!”.
    • It could also be argued that the quote is referencing The Room's infamous line "You are tearing me apart Lisa!"
  • The item is a reference to the disease leprosy; one of its notable symptoms is the loss of extremities.
  • The item used to be misspelled Leprocy, but was corrected in a later patch.
  • Its appearance is changed slightly for The Forgotten due to his lack of skin, making him look like Melting from the game Nuclear Throne.

Gallery[edit | edit source]

The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op MainPageItems Small.png Items Item Pools Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets