Leprosy

Treasure Room Treasure Room

(page 5, column 20, row 2)

Beat Chapter 3 without taking damageLeprosy

Leprosy is an unlockable passive item added in Booster Pack #2.

Effects

• Upon taking damage, Isaac gains a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with.
  • A maximum of three body parts can be active at once.
  • The body parts will be destroyed if they take enough damage from enemies or enemy shots.
  • The body parts persist between floors.
  • Body parts orbit on the same layer as Blue Flies and Locusts do.

Interactions

• Box of FriendsUpon use, duplicates all of Isaac's familiars for the current room.: Will not multiply orbitals.

Synergies

• Dull RazorHurts Isaac without depleting health, activating any items that trigger upon taking damage.: Allows Isaac to spawn orbitals without reducing health.

Trivia

• Leprosy was inspired by this Steam Workshop item by Bobby Lashley Fangirl #1.
• The item used to be misspelled Leprocy, but was corrected in a later patch.
• Its appearance is changed slightly for The Forgotten due to his lack of skin, making him look like Melting from the game Nuclear Throne.

Gallery

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Booster Packs
#1	Angry Fly Spawns a fly familiar that orbits around a random enemy and deals 5 damage per tick to enemies it comes in contact with. Black Hole Throws a black hole on the ground which sucks in and damages enemies. Bozo Increases damage by a flat 0.1 and grants a soul heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop. Broken Modem Enemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals. Mystery Gift Upon use, spawns a random item from the current room's item pool, with a chance to spawn A Lump of Coal or The Poop instead. Sprinkler Upon use, spawns a sprinkler that rotates and fires tears. Fast Bombs Grants 7 bombs and allows bombs to be placed rapidly. Buddy in a Box Grants a familiar with a random tear effect. The familiar is randomized at the start of each floor. Lil Delirium Grants a familiar that transforms into another random familiar every 10 seconds. HairpinFully recharges Isaac's active item upon entering a boss fight. Wooden CrossGrants a Holy Mantle shield upon entering a new floor, which protects against one hit of damage. Butter!Using an active item will drop it onto a pedestal on the ground. Taking damage may result in dropping a passive item. Huge GrowthMakes Isaac large for the current room, increasing his range and damage. Ancient RecallSpawns 3 random cards. Era WalkFor the current room, enemies are slowed, Isaac's speed is increased, and his shot speed is decreased.
#2	Jumper Cables Grants an active item charge every 15 enemies killed. Coupon Upon use, makes a random item from a shop, devil deal, or black market free. Telekinesis Upon use, for the next two seconds, any enemy shots that come near Isaac are held in place. After the charge is depleted, they are fired back as tears. Moving Box If the box is empty, picks up all items and pickups in a room and stores them. If the box is not empty, places all stored items and pickups in the current room. Technology Zero Connects Isaac's tears with electricity that can damage enemies. Leprosy Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots. Filigree FeatherAngels drop items instead of key pieces when defeated.
#3	7 Seals Grants a random Harbinger familiar that changes every 10 seconds. Mr. ME! Summons a controllable ghost that can perform various tasks depending on what it targets. Angelic Prism Grants a prism orbital with a large orbital radius. Tears that pass through the prism split into four multi-colored tears. Pop! Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle. Door StopThe last door Isaac went through stays open, allowing him to leave the room even if enemies are in it.
#4	Death's List Grants a reward if all enemies in a room are killed in the order they are marked. Haemolacria Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay. Lachryphagy Isaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage. Trisagion Tears are replaced with piercing white blasts of light. Schoolbag Allows Isaac to hold two active items. Extension CordBeams of yellow electricity flow between Isaac and his familiars, damaging any enemies between them.
#5	Blanket Grants one soul heart. Upon entering a boss room, grants a shield that blocks one hit, then disappears. Sacrificial Altar Upon use, sacrifices up to 2 familiars and spawns an item from the Devil Room Pool for each familiar sacrificed. Lil Spewer Spawns a random pill, and grants a small Spewer familiar that charges up and fires different types of creep. Marbles Spawns 3 random trinkets. Taking damage has a small chance to swallow Isaac's currently held trinket, gaining its effect permanently. Mystery Egg Spawns an egg familiar, which cracks and turns into a random friendly enemy when Isaac is hurt. The egg regenerates upon entering a different room. Flat Stone Tears bounce off the floor. Tears that hit an enemy after bouncing deal splash damage to all nearby enemies for 25% of Isaac's tear damage. Marrow Grants one bone heart and spawns three red heart pickups. Slipped Rib Spawns a bone familiar that circles around Isaac and reflects enemy shots. Hallowed Ground Spawns a white poop familiar, which turns into a white poop when Isaac is hurt. Pointy Rib Spawns a bone familiar that can be aimed with the fire buttons and does contact damage. Book of the Dead Upon use, spawns a friendly Bony or an orbital bone for each enemy killed in the current room. Dad's Ring Creates a ring of light around Isaac that petrifies enemies in contact. Divorce Papers Spawns a Mysterious Paper, increases tears, and grants a bone heart. Jaw Bone Spawns a familiar that flies the room while firing, dealing a flat 7 damage to enemies that come in contact and retrieving pickups. Brittle Bones Replaces all red hearts with 6 empty bone hearts. Upon losing a bone heart, Isaac fires bones in 8 directions and permanently gains a tears up. Broken Shovel While held, causes multiple Mom's Foots to come down and stomp on Isaac. One of two parts necessary to create Mom's Shovel. Broken Shovel One of two parts necessary to create Mom's Shovel. Mom's Shovel Spawns a trapdoor that leads to the next floor upon activation. Unlocks The Forgotten when used on a mound of dirt that appears in The Dark Room. Rotten PennySpawns a blue fly every time a coin is picked up. Baby-BenderGrants Isaac's familiars homing shots. Finger BoneGrants a chance to gain a bone heart upon taking damage.