Leprosy

Treasure Room

(page 5, column 18, row 2)(page , column , row )

Beat Chapter 3 without taking damageLeprosy

Leprosy is an unlockable passive item added in Booster Pack #2.

Effects

• Upon taking damage, Isaac gains a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with.
  • A maximum of three body parts can be active at once.
  • The body parts will be destroyed if they take enough damage from enemies or enemy shots.
  • The body parts persist between floors.
  • Body parts orbit on the same layer as Blue Flies and Locusts do.

Synergies

• Dull RazorHurts Isaac without depleting health, activating any items that trigger upon taking damage.: Allows Isaac to spawn orbitals without reducing health.

Trivia

• Leprosy is based on this Steam Workshop item by Extreme Ninja Home Makeover.
  • Originally, this item added a chance to shoot limbs instead of tears which increased Isaac's movement speed.
• The pickup quote is a reference to Rebel Wilson’s well known line “You’re tearing me apart!”.
  • It could also be argued that the quote is referencing The Room's infamous line "You are tearing me apart Lisa!"
• The item is a reference to the disease leprosy; one of its notable symptoms is the loss of extremities.
• The item used to be misspelled Leprocy, but was corrected in a later patch.
• Its appearance is changed slightly for The Forgotten due to his lack of skin, making him look like Melting from the game Nuclear Throne.

Gallery

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Booster Packs
#1	Angry FlySpawns a fly familiar that orbits around a random enemy and deals 5 damage per tick to enemies it comes in contact with. Black HoleThrows a black hole on the ground which sucks in and damages enemies. BozoIncreases damage by a flat 0.1 and grants a soul heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop. Broken ModemEnemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals. Mystery GiftUpon use, spawns a random item from the current room's item pool, with a chance to spawn A Lump of Coal or The Poop instead. SprinklerUpon use, spawns a sprinkler that rotates and fires tears. Fast BombsGrants 7 bombs and allows bombs to be placed rapidly. Buddy in a BoxGrants a familiar with a random tear effect. The familiar is randomized at the start of each floor. Lil DeliriumGrants a familiar that transforms into another random familiar every 10 seconds. HairpinFully recharges Isaac's active item upon entering a boss fight. Wooden CrossGrants a Holy Mantle shield upon entering a new floor, which protects against one hit of damage. Butter!Using an active item will drop it onto a pedestal on the ground. Taking damage may result in dropping a passive item. Huge GrowthMakes Isaac large for the current room, increasing his range and damage. Ancient RecallSpawns 3 random cards. Era WalkFor the current room, enemies are slowed, Isaac's speed is increased, and his shot speed is decreased.
#2	Jumper CablesGrants an active item charge every 15 enemies killed. CouponUpon use, makes a random item from a shop, devil deal, or black market free. TelekinesisUpon use, for the next two seconds, any enemy shots that come near Isaac are held in place. After the charge is depleted, they are fired back as tears. Moving BoxIf the box is empty, picks up all items and pickups in a room and stores them. If the box is not empty, places all stored items and pickups in the current room. Technology ZeroConnects Isaac's tears with electricity that can damage enemies. LeprosyUpon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots. Filigree FeatherAngels drop items instead of key pieces when defeated.
#3	7 SealsGrants a random Harbinger familiar that changes every 10 seconds. Mr. ME!Summons a controllable ghost that can perform various tasks depending on what it targets. Angelic PrismGrants a prism orbital with a large orbital radius. Tears that pass through the prism split into four multi-colored tears. Pop!Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle. Door StopThe last door Isaac went through stays open, allowing him to leave the room even if enemies are in it.
#4	Death's ListGrants a reward if all enemies in a room are killed in the order they are marked. HaemolacriaTears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay. LachryphagyIsaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage. TrisagionTears are replaced with piercing white blasts of light. SchoolbagAllows Isaac to hold two active items. Extension CordBeams of yellow electricity flow between Isaac and his familiars, damaging any enemies between them.
#5	BlanketGrants one soul heart. Upon entering a boss room, grants a shield that blocks one hit, then disappears. Sacrificial AltarUpon use, sacrifices up to 2 familiars and spawns an item from the Devil Room Pool for each familiar sacrificed. Lil SpewerSpawns a random pill, and grants a small Spewer familiar that charges up and fires different types of creep. MarblesSpawns 3 random trinkets. Taking damage has a small chance to swallow Isaac's currently held trinket, gaining its effect permanently. Mystery EggSpawns an egg familiar, which cracks and turns into a random charmed enemy when Isaac is hurt. The egg regenerates upon entering a different room. Flat StoneTears bounce off the floor. Tears that hit an enemy after bouncing deal splash damage to all nearby enemies for 25% of Isaac's tear damage. MarrowGrants one bone heart and spawns three red heart pickups. Slipped RibSpawns a bone familiar that circles around Isaac and reflects enemy shots. Hallowed GroundSpawns a white poop familiar, which turns into a white poop when Isaac is hurt. Pointy RibSpawns a bone familiar that can be aimed with the fire buttons and does contact damage. Book of the DeadUpon use, spawns a charmed Bony or an orbital bone for each enemy killed in the current room. Dad's RingCreates a ring of light around Isaac that petrifies enemies in contact. Divorce PapersSpawns a Mysterious Paper, increases tears, and grants a bone heart. Jaw BoneSpawns a familiar that flies the room while firing, dealing double Isaac's tear damage to enemies that come in contact and retrieving pickups. Brittle BonesReplaces all red hearts with 6 empty bone hearts. Upon losing a bone heart, Isaac fires bones in 8 directions and permanently gains a tears up. Broken ShovelWhile held, causes multiple Mom's Foots to come down and stomp on Isaac. One of two parts necessary to create Mom's Shovel. Broken ShovelOne of two parts necessary to create Mom's Shovel. Mom's ShovelSpawns a trapdoor that leads to the next floor upon activation. Unlocks The Forgotten when used on a mound of dirt that appears in The Dark Room. Rotten PennySpawns a blue fly every time a coin is picked up. Baby-BenderGrants Isaac's familiars homing shots. Finger BoneGrants a chance to gain a bone heart upon taking damage.