List of curated daily challenges

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Date Event, if any Peculiarities
January 1st New Years Bomb pool, starting with Pyro, no tears
January 14th Starting as Guppy, no item rooms
January 16th National Nothing Day No item rooms, no shops
January 27th No item rooms, no shops, Poop pool
February 2nd Groundhog day Same seed as the day before
February 9th National Toothache Day 51 luck, Tooth items, no item rooms
February 11th National "Don't Cry Over Spilled Milk" Day Starting with Soy Milk and Milk!
February 14th Valentine's day High luck, Mom's items
February 18th National Battery Day Starting with battery-related items
March 2nd Edmund's birthday Isaac to Mega Satan, Undroppable The Left Hand
March 4th Holy Experiment Day Maggie to Mom. No Item Rooms, starting with Immaculate Conception, Eucharist and Seraphim
March 17th St. Patrick's day Cain to Mega Satan via The Chest, starts with high luck
March 20th National Alien Abduction Day Isaac, starts with Cone Head, The Parasite and Tractor Beam. No item rooms.
March 22nd National "Goof off" day Isaac, starts with extreme range; tears follow random patterns
Easter Easter Lazarus, Blood of the Martyr, Stigmata, no item rooms
April 1st April fools Old Keeper, random trinkets and items upon pickups
April 10th National siblings day Lilith, starts with Mongo Baby, Little Steven, Little Gish, Ghost Baby, Brother Bobby and Sister Maggy
April 15th Lazarus, starts with Tick, Bob's Brain, Dead Cat, Curse of the Tower and Cursed Eye; no item rooms
April 22nd National Jelly Bean day Maggie to Sheol, starts with Wait What?, Linger Bean, The Black Bean and 9 Volt; no item rooms
May 4th May the 4th be with you! Isaac to The Womb, starts with Technology and the Spear of Destiny
May 8th Mothers' day Isaac, Mom transformation, no item rooms
May 13th National "Stamp Out Hunger" and Frog Jump day Maggie, starts with Thunder Thighs and How to Jump. No item rooms
May 17th National "Pack Rat Day" Isaac, starts with Sack Head and D20
May 30th Memorial day The Lost, no tears, 3 familiars and Conjoined
June 2nd Maggie, starting with Blank Card and High Priestess, no item rooms
June 5th ???, starting Restock and Gnawed Leaf
June 18th Fathers' day Cain, A Dollar
June 19th Fathers' day Cain, Daddy Longlegs, Dad's Key
June 25th Pride day The Lost, rainbow items
July 2nd ???, starts with Forget Me Now and "Ultra Hard" difficulty
July 4th Independence day Samson, Dr. Fetus, bomb pool
July 11th ???, to Sheol. Starts with Compost, Rotten Baby and The Mulligan
July 13th Lazarus, to Mom. Starts with Monster Manual, Robo-Baby and 20/20
August 15th National Relaxation day Maggie to The Dark Room. Starts with Brimstone, Rubber Cement, Holy Mantle, Spoon Bender, Tammy's Head; no item rooms.
August 16th National Tell a Joke day The Keeper to The Womb. Every pill is Explosive Diarrhea,
August 22nd Isaac to The Dark Room. Starts with Holy Light, Sacred Heart and Fate
September 5th Magdalene to Mom. Starts with Stop Watch, Broken Watch and 0.15 Speed
September 17th National Apple Dumpling day Cain to Mega Satan. Every boss item is Apple!
September 22nd Elephant Appreciation Day Magdalene to The Chest, starts with Bucket Of Lard and Thunder Thighs
October 6th National Mad Hatter day Judas to The Dark Room. Starts with Dr. Fetus and Scatter Bombs
October 7th Isaac to The Cathedral. Starts with Chaos
October 31st Halloween Eve, Sack Head
November 1st Day of the dead The Lost w/o Holy Mantle, Dead Cat
November 11th Veterans' day The Lost, no item rooms
November 13th World Kindness day Isaac to It Lives; starts with Blank Card + XX - Judgement, PHD, A Quarter, Habit
November 20th Thanksgiving Cupid's Arrow, Rotten Meat
December 5th
December 6th Satoru Iwata's birthday Iwata's sprite, The Gamekid
December 25th Christmas A Quarter, A Lump of Coal, Xmas hat

The full list of the remaining undisclosed dailies isn't published to avoid spoiling content.