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List of curated daily challenges

From Binding of Isaac: Rebirth Wiki
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Date Event, if any Peculiarities
January 1 New Year's Starts with 99 bombs (not Pyro PyroPyro Rebirth Icon.pngAdds 99 bombs.), blindfolded. Only bomb items can be found in Treasure Room Item Pool.
January 14 National Dress Up Your Pet Day Isaac, starts with Guppy's Head Guppy's HeadGuppy's Head Icon.png1 roomsSpawns 2-4 blue flies to damage enemies., Guppy's Collar Guppy's CollarGuppy's Collar Icon.pngGrants Isaac a permanent 50% chance to respawn with 1/2 of a red heart after death., and Guppy's Tail Guppy's TailGuppy's Tail Icon.pngIncreases chance of finding gold chests and normal chests, but reduces chance of finding pickups., no item rooms.
January 16 National Nothing Day Apollyon, no item rooms, no shops.
January 27 Thomas Crapper Day ???, starts with Flush! Flush!Flush! Icon.png6 roomsChanges all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie., Number One Number OneNumber One Icon.png+1.5 tears, -17.62 range, Butt Bombs Butt BombsButt Bombs Icon.pngGives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies., Added in  AfterbirthNo. 2 No. 2No. 2 Icon.pngContinuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 60 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time. and E Coli E ColiE Coli Icon.pngGives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop., no item rooms, no shops.
February 2 Groundhog Day Same seed as the day before.
February 9 National Toothache Day Cain, starts with Monstro's Tooth Monstro's ToothMonstro's Tooth Icon.png3 roomsMonstro jumps onto a random enemy, doing area damage. Can damage/kill the player if summoned in an room without enemies., Added in Afterbirth †Dead Tooth Dead ToothDead Tooth Icon.pngWhile firing, Isaac gains a green aura that poisons nearby enemies., Tough Love Tough LoveTough Love Rebirth Icon.pngAdds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears. and 50 luck, no item rooms.
February 11 National "Don't Cry Over Spilled Milk" Day Magdalene, starts with Added in  AfterbirthMilk! Milk!Milk! Icon.pngA glass of milk follows Isaac and spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the rest of the room. and Soy Milk Soy MilkSoy Milk Icon.pngTears shrink and do much less damage, but fire in very rapid succession..
February 14 Valentine's Day Magdalene, starts with Added in  AfterbirthFriendly Ball Friendly BallFriendly Ball Icon.png3 roomsThrowing the ball at an enemy instantly kills it and captures it. The captured enemy can later be released and will be friendly, fighting for Isaac and persisting between rooms., The Battery The BatteryThe Battery Icon.pngActivated Items can be "overcharged" to allow for an additional use., Mom's Eyeshadow Mom's EyeshadowMom's Eyeshadow Icon.pngTears have a chance to charm enemies. and 7 luck.
February 18 National Battery Day Isaac, starts with 9 Volt 9 Volt9 Volt Icon.pngReduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges., The Battery The BatteryThe Battery Icon.pngActivated Items can be "overcharged" to allow for an additional use., Added in  AfterbirthCharged Baby Charged BabyCharged Baby Icon.pngA familiar that drops a Little Battery every 4 rooms. Has a small chance to freeze all enemies in the room when hit., Mom's Purse Mom's PurseMom's Purse Icon.pngAllows Isaac to hold 1 additional trinket., AAA Battery AAA BatteryAAA Battery Icon.pngAutomatically recharges the last energy slot of an activated item, effectively reducing recharge rates by one. and Added in  AfterbirthWatch Battery Watch BatteryWatch Battery Icon.pngIncreased chance of batteries spawning. Has a chance to add an extra charge to Isaac's activated item upon completing a room..
March 2 Edmund's birthday Isaac to Mega Satan, starts with undroppable The Left Hand The Left HandThe Left Hand Icon.pngReplaces brown chests and golden chests with red chests..
March 4 Holy Experiment Day Magdalene, starts with Added in Afterbirth †Eucharist EucharistEucharist Icon.pngAn Angel Room door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II., Added in  AfterbirthImmaculate Conception Immaculate ConceptionImmaculate Conception Icon.pngUpon picking up a certain amount of health, spawn a permanent angelic familiar., and Added in  AfterbirthSeraphim SeraphimSeraphim Icon.pngAn angel familiar which follows Isaac and fires homing tears which deal 10 damage at -25% shot speed and a reduced fire rate., no Item Rooms.
March 17 St. Patrick's day Cain to Mega Satan, starts with 18 luck.
March 20 National Alien Abduction Day Isaac, starts with Added in Afterbirth †Cone Head Cone HeadCone Head Icon.pngGrants a soul heart. Adds a chance to block enemy shots., The Parasite The ParasiteThe Parasite Icon.pngIsaac's tears split in two when they hit something., and Added in  AfterbirthTractor Beam Tractor BeamTractor Beam Icon.pngIsaac emits a beam from his face. Isaac's tears travel in the path of the beam.. No item rooms.
March 22 National "Goof off" day Isaac, starts with extreme range; tears follow random patterns.
Easter Easter Lazarus, starts with Blood of the Martyr Blood of the MartyrBlood of the Martyr Icon.pngIncreases Damage by 1, and turns Isaac's tears into blood tears., Stigmata StigmataStigmata Icon.pngIncreases damage, and adds 1 heart container., no item rooms.
April 1 April fools Old Man Keeper, random trinkets and items upon pickups.
April 10 National siblings day Lilith, starts with Brother Bobby Brother BobbyBrother Bobby Rebirth Icon.pngFollows Isaac around shooting normal tears., Ghost Baby Ghost BabyGhost Baby Rebirth Icon.pngSpawns a familiar that follows Isaac around and fires spectral tears., Little Gish Little GishLittle Gish Icon.pngSpawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed., Little Steven Little StevenLittle Steven Icon.pngSpawns a familiar that follows Isaac around and fires homing tears., Mongo Baby Mongo BabyMongo Baby Icon.pngSummons a familiar that copies the tears of Isaac's other familiars., and Sister Maggy Sister MaggySister Maggy Rebirth Icon.pngA familiar that follows Isaac around shooting blood tears..
April 15 National That Sucks day Lazarus, starts with Bob's Brain Bob's BrainBob's Brain Icon.pngSpawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds., Added in  AfterbirthCurse of the Tower Curse of the TowerCurse of the Tower Icon.pngCauses Isaac to spawn 6 troll bombs on the floor every time he gets hit, similar to the Anarchist Cookbook mechanic., Cursed Eye Cursed EyeCursed Eye Icon.pngGrants charged tears that can be fired in a tight burst of four. Getting hit while charging will teleport Isaac into another room., Dead Cat Dead CatDead Cat Icon.pngSets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again., and Tick TickTick Icon.pngDrain 15% health of each enemy with more than 60 HP (ie. most bosses). Also restores one red heart of Isaac whenever he enters an uncleared boss room. The Tick cannot be swapped out for another trinket.; no item rooms.
April 22 National Jelly Bean day Maggie, starts with 9 Volt 9 Volt9 Volt Icon.pngReduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges., The Black Bean The Black BeanThe Black Bean Icon.pngWhen taking damage, Isaac farts, causing poison damage to all enemies in range., Added in Afterbirth †Linger Bean Linger BeanLinger Bean Icon.pngAdds a chance to fire a gas cloud that damages nearby enemies., and Added in Afterbirth †Wait What? Wait What?Wait What Icon.png10 secondsIsaac farts, sending out rock waves., no item rooms.
May 4 May the 4th be with you! Isaac, starts with Added in  AfterbirthSpear of Destiny Spear of DestinySpear of Destiny Afterbirth Icon.pngIn addition to tears, Isaac now holds a spear in front of him which deals damage equal to 2 times his tear damage, and occasionally inflicts fear. The spear cannot be thrown, but deals damage while it is in contact with an enemy. and Technology TechnologyTechnology Icon.pngReplaces tears with a piercing laser with unlimited range..
May 8 Mothers' day Isaac, starts with Mom's Lipstick Mom's LipstickMom's Lipstick Icon.pngIncreases range and shot height., Mom's Pad Mom's PadMom's Pad Icon.png3 roomsUpon use, inflicts fear to all enemies in the room for 5 seconds. and Mom's Eye Mom's EyeMom's Eye Rebirth Icon.pngAllows Isaac to fire tears from the back of his head., no item rooms.
May 13 National "Stamp Out Hunger" and Frog Jump day Magdalene, starts with How to Jump How to JumpHow to Jump Icon.pngUnlimitedGives Isaac the ability to jump (over gaps, spikes, etc.). and Thunder Thighs Thunder ThighsThunder Thighs Icon.pngDestroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.. No item rooms.
May 17 National "Pack Rat Day" Isaac, starts with D20 D20D20 Rebirth Icon.png6 roomsRerolls all pickups in the current room. and Added in  AfterbirthSack Head Sack HeadSack Head Icon.pngGreatly increases the chance to find sacks..
May 30 Memorial day The Lost, no tears, 3 familiars and Conjoined.
June 2 Magdalene, starts with Blank Card Blank CardBlank Card Icon.png4 roomsHas the same effect as the card or rune currently held by Isaac., II - The High Priestess II - The High PriestessII - The High Priestess Icon.pngMom's dismembered leg is called down to deal 300 damage to anything it stomps. It will always stomp on the enemy with the most health. If used in an empty room or during the fight with Mom, it will stomp Isaac instead. and undroppable Mom's Toenail Mom's ToenailMom's Toenail Icon.pngMom's foot randomly stomps down somewhere in the room. 1 minute intervals., no item rooms.
June 5 World Environment Day ???, starts with Gnawed Leaf Gnawed LeafGnawed Leaf Icon.pngAfter standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots. and Added in  AfterbirthRestock RestockRestock Icon.pngCauses shops to instantly restock their items when they are bought. Granted by default for every character in Greed Mode..
June 18 Fathers' day Cain, starts with A Dollar A DollarA Dollar Icon.pngGives Isaac 99 coins. Can be found multiple times in a single playthrough..
June 19 Fathers' day Cain, starts with Daddy Longlegs Daddy LonglegsDaddy Longlegs Rebirth Icon.pngDaddy Long Legs' shadow follows Isaac and stomps on enemies. and Dad's Key Dad's KeyDad's Key Icon.png2 roomsOpens all doors in the current room when activated, including doors which require a key to open and entrances to secret rooms. Opens the big doors in the first room of both The Chest and the Dark Room..
June 25 Pride day The Lost, rainbow items.
July 2 I Forgot Day ???, starts with Forget Me Now Forget Me NowForget Me Now Icon.pngOne time useWhen activated, the level ends and is freshly regenerated with new rooms, monsters, and items. Disappears after use.. Permanent Curse of the Lost, Curse of the Blind, and Curse of the Unknown.
July 4 Independence day Samson, starts with Dr. Fetus Dr. FetusDr. Fetus Icon.pngTears are replaced by bombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired. and Added in  AfterbirthScatter Bombs Scatter BombsScatter Bombs Icon.pngAdds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs..
July 11 ???, to Sheol. Starts with Added in Afterbirth †Compost CompostCompost Icon.png2 roomsSpawns a blue spider or fly. Turns pickups in the room into blue spiders or flies., The Mulligan The MulliganThe Mulligan Rebirth Icon.pngTears have a 1/6 chance of spawning allied blue flies when they hit an enemy., and Rotten Baby Rotten BabyRotten Baby Icon.pngA familiar that spawns blue flies.. No Treasure Rooms.
July 13 Embrace Your Geekness Day Lazarus, starts with 20/20 20/2020 20 Rebirth Icon.pngGrants double shot., Monster Manual Monster ManualMonster Manual Icon.png3 roomsSummons a random familiar for the current room. Can summon familiars not yet unlocked., Robo-Baby Robo-BabyRobo-Baby Rebirth Icon.pngFollows Isaac around, shooting enemies with an eye laser similar to Technology., and a Dice Shard. No Treasure Rooms.
August 15 National Relaxation day Magdalene, starts with Brimstone BrimstoneBrimstone Rebirth Icon.pngTears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period., Holy Mantle Holy MantleHoly Mantle Icon.pngAutomatically negates first taken damage in every room., Rubber Cement Rubber CementRubber Cement Icon.pngTears bounce off walls, enemies, and environmental objects., Spoon Bender Spoon BenderSpoon Bender Icon.pngGrants Isaac homing tears., and Tammy's Head Tammy's HeadTammy's Head Icon.png1 roomsShoots 10 tears in a circle around Isaac, which retain the damage, shot speed, and special effects (such as poison) of Isaac's tears.; no item rooms.
August 16 National Tell a Joke day The Keeper to The Womb. Every pill is Explosive Diarrhea.
August 22 National Be an Angel day Isaac to The Dark Room. Starts with Fate FateFate Icon.pngGrants flight and one eternal heart., Added in  AfterbirthHoly Light Holy LightHoly Light Icon.pngIsaac has a random chance to fire a Holy tear, which, when it hits an enemy, will spawn a Crack the Sky-style light beam on the same enemy, dealing damage., and Sacred Heart Sacred HeartSacred Heart Icon.pngIncreases damage and range while reducing shot speed and grants homing tears. Grants a Heart Container and replenishes all Red Hearts..
September 5 National Be Late for Something day Magdalene to Mom. Starts with Broken Watch Broken WatchBroken Watch Icon.pngChance upon entering a room to slow down or speed up every enemy and their attacks. The chance to slow enemies is quite higher than the chance to speed them up., Stop Watch Stop WatchStop Watch Icon.pngRemoved in Afterbirth Automatically inflicts slow to all enemies in every room.
Added in  Afterbirth Upon taking damage, inflicts slow to all enemies for the current room.
, and 0.15 Speed
September 17 National Apple Dumpling day Cain to Mega Satan. Every boss item is Added in Afterbirth †Apple! Apple!Apple! Icon.pngIncreases tears. Adds a chance to fire a high-damage razor blade..
September 22 Elephant Appreciation Day Magdalene to The Chest, starts with Bucket of Lard Bucket of LardBucket of Lard Icon.pngGrants two empty heart containers and heals Isaac by half a heart, but decreases speed by 0.2. and Thunder Thighs Thunder ThighsThunder Thighs Icon.pngDestroys rocks upon contact with Isaac. Adds one heart container and lowers Speed..
October 6 National Mad Hatter day Judas, starts with Dr. Fetus Dr. FetusDr. Fetus Icon.pngTears are replaced by bombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired. and Added in  AfterbirthScatter Bombs Scatter BombsScatter Bombs Icon.pngAdds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs.. Only bomb items can be found in Treasure Room Item Pool.
October 7 Isaac to The Cathedral. Starts with Added in  AfterbirthChaos ChaosChaos Icon.pngChaos causes items to be chosen from random item pools. When picked up, drops between 1-6 random pickups on the floor..
October 31 Halloween Eve, starts with Added in  AfterbirthSack Head Sack HeadSack Head Icon.pngGreatly increases the chance to find sacks..
November 1 Day of the Dead The Lost, starts with Dead Cat Dead CatDead Cat Icon.pngSets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again., without Holy Mantle Holy MantleHoly Mantle Icon.pngAutomatically negates first taken damage in every room. and D4 D4D4 Icon.png6 roomsRerolls all of Isaac's items..
November 11 Veterans' day The Lost, no item rooms.
November 13 World Kindness day Isaac to It Lives; starts with A Quarter A QuarterA Quarter Icon.pngAdds 25 to Isaac's coin count, capping at 99., Blank Card Blank CardBlank Card Icon.png4 roomsHas the same effect as the card or rune currently held by Isaac. + XX - Judgement XX - JudgementXX - Judgement Icon.pngSpawns a Beggar., Habit HabitHabit Rebirth Icon.pngWhen Isaac is hit, 1 point of an item's charge is filled., and PHD PHDPHD Icon.pngConverts all bad pills into good pills, spawns one pill pickup and restores health. Identifies all pills upon pickup..
November 19 National "Have a Bad Day" day ??? to Mega Satan; starts with Bob's Brain Bob's BrainBob's Brain Icon.pngSpawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds., Cursed Eye Cursed EyeCursed Eye Icon.pngGrants charged tears that can be fired in a tight burst of four. Getting hit while charging will teleport Isaac into another room., Added in  AfterbirthCurse of the Tower Curse of the TowerCurse of the Tower Icon.pngCauses Isaac to spawn 6 troll bombs on the floor every time he gets hit, similar to the Anarchist Cookbook mechanic., and Added in  AfterbirthScatter Bombs Scatter BombsScatter Bombs Icon.pngAdds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs.. No item rooms.
November 20 Thanksgiving Starts with Cupid's Arrow Cupid's ArrowCupid's Arrow Rebirth Icon.pngGrants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.. Every boss item is Rotten Meat Rotten MeatRotten Meat Icon.pngAdds one heart container..
December 5 Krampusnacht Isaac to Satan; starts with A Lump of Coal A Lump of CoalA Lump of Coal Icon.pngThe more distance tears travel, the more damage they will do. and Mitre MitreMitre Rebirth Icon.pngGrants a chance of converting any red hearts pickups into soul hearts instead.. Devil Room spawns on first floor with Krampus.
December 6 Satoru Iwata's birthday Iwata's sprite, starts with The Gamekid The GamekidThe Gamekid Icon.png6 roomsUpon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed. and Cartridge CartridgeCartridge Icon.pngChance to trigger The Gamekid effect upon taking damage.. Nintendo-themed items in special rooms.
December 23 National Festivus day Only The Body The BodyThe Body Icon.pngAdds 3 heart containers., The Soul The SoulThe Soul Icon.pngGrants two soul hearts. Isaac now repels enemy projectiles., The Mind The MindThe Mind Icon.pngGrants the combined effects of the Blue Map, Treasure Map, and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms. and Godhead GodheadGodhead Icon.pngIncreases damage and range while reducing tears and shot speed. Grants homing tears and tears gain a damaging halo. can be found in Treasure Room Item Pool.
December 25 Christmas Isaac, starts with A Quarter A QuarterA Quarter Icon.pngAdds 25 to Isaac's coin count, capping at 99., A Lump of Coal A Lump of CoalA Lump of Coal Icon.pngThe more distance tears travel, the more damage they will do., and wearing a Christmas hat. Every item room has 2 items.
December 31 New Year's Eve Isaac, starts with Added in  AfterbirthMore Options More OptionsMore Options Icon.pngTwo items spawn in every Treasure Room. Only one can be taken; the other will disappear. and There's Options There's OptionsThere's Options Icon.pngThere will be 2 items available to choose from after defeating a boss. Choosing 1 item causes the other to disappear..

The full list of the remaining undisclosed dailies isn't published to avoid spoiling content.