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Little Baggy is a passive item.
- Allows Isaac to carry two pills. Tap the Drop button to cycle through the two pills.
- Spawns a random pill.
- Changes all card and rune drops into pills.
- Any Tarot card or rune held when picking this item up will change into a pill.
- Dice ShardUpon use, activates the effects of the D6 and the D20 at the same time. counts as a card and will be converted.
- Crystal BallReveals the map (except the Super Secret Room) and drops a random Tarot Card or soul heart. - Generates pills instead of cards upon use.
- Deck of CardsGives Isaac a random Tarot Card. - Generates pills instead of cards upon use, similar to Mom's Bottle of Pills.
- Mom's Bottle of PillsGives Isaac a random pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough. - Allows Isaac to store excess pills produced for later use.
- PHDConverts all bad pills into good pills, spawns one pill pickup and restores health. Identifies all pills upon pickup./ VirgoGrants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills". - Most negative pills will be converted to their positive counterparts.