Coins

Pickups

Hearts

Coins

Bombs

Keys

Batteries

Pills

Cards/Runes

Chests

Sacks

Coins serve as the currency for shops, the payment for the Donation Machine in shops, and payment for the slot machines, fortune telling machines, shell game, beggars, and Restock Boxes. They are also consumed to use a few activated items (most notably Magic Fingers and Portable Slot). Keeper can also pick up coins to refill his health.

Coin	Image	Worth	Additional Info	Unlocked By
Penny		1	Humbling BundleGives one extra pickup (1+1 Free version) of Red Hearts, pennies, bombs, and keys. Does not work with blue, black, and half red hearts, nickels, and dimes. and Equality!Turns pickups into their doubled versions while Isaac's numbers of coins, bombs, and keys are equal. can replace this with a 1+1 Free Penny.
1+1 Free Penny		2	Doesn't spawn naturally. Can only be found by using certain items or encountering certain rooms.
Nickel		5
Dime		10
Lucky Penny		1	Increases Luck by 1 when picked up. Humbling BundleGives one extra pickup (1+1 Free version) of Red Hearts, pennies, bombs, and keys. Does not work with blue, black, and half red hearts, nickels, and dimes. and Equality!Turns pickups into their doubled versions while Isaac's numbers of coins, bombs, and keys are equal. will not double this. Bumbo and Bum Friend will pick this up, but will not give Isaac any luck.	Donate 1 coin to the Greed machineLucky Pennies
Sticky Nickel		5	Will flip upside-down when Isaac tries to collect it. Afterwards, it will get stuck on the ground, unable to be picked up unless blasted off the ground with an explosion. Bumbo and Bum Friend are unable to pick this up; they instead hover over them attempting to pick them up.	Complete the Boss Rush as KeeperSticky Nickels

Notes

• Unlocking Sticky Nickels doesn't reduce the spawn rate of regular Nickels; rather, Pennies have an additional chance to become Sticky Nickels.

Trivia

• Booster Pack #5 added a green glow to Lucky Pennies, making them easier to spot. This was from this Steam Workshop mod by piber20.

Unlockable Achievements

• 

  Cain - Hold 55 coins at one time.

• 

  It's the Key - Defeat The Lamb without taking hearts, coins, and bombs through an entire run.