Mega Blast

12 rooms   Devil Room Devil Room   (page 4, column 16, line 4)   Defeat Mega Satan as every character Mega

Mega Blast is a secret unlockable activated item added in Afterbirth.

Effects

• Upon use, Isaac fires a giant, incredibly powerful blood laser, similar to the one used by Mega Satan, for 15 seconds.
  • The beam deals Isaac's current damage multiplied by 5 per tick.
  • The beam has enough power to push Isaac backwards while being fired, and will last between rooms, and across multiple floors.
  • The beam has spectral and piercing effects.
  • The beam can be moved while firing in many angles diagonally.
  • While Mega Blast is being fired, Isaac cannot:
    • Open chests.
    • Pick up a Little Battery, collectibles, pills, trinkets, or cards or runes.
    • Pick up the trophy or enter the chest that spawns after defeating Isaac or ???.
    • Sleep in a bed.
  • The laser extinguishes fires, detonates TNT, and destroys poop.

Notes

• Picking up a Little Battery with this item will not fully charge it. Instead, it will add 3 to its charge, meaning that 4 batteries are required to fully recharge the item.
  • A charged key will only add 3 charges as well.
• Using a 48 Hour Energy pill with this item will fully charge it.
• Mega Blast has an 80% decreased item pool weight, making it less likely to appear than other collectibles.
• In order to unlock Mega Blast, Mega Satan must be defeated with all characters including secret characters (The Forgotten, The Lost and, Keeper).

Synergies

• 9 Volt

  Reduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.

  : Reduces number of charges by 1.
• Euthanasia

  Adds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.

  : Adds a chance for beams to fire with triple damage.
• Homing Tears: Beam curves toward nearby enemies.
• A Lump of Coal

  The more distance tears travel, the more damage they will do.

  : Increases the damage of the laser the farther that it travels. Also colors the laser black and makes it wider as it travels.
• Ipecac

  Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.

  : Massively increases damage, poisons enemies, and turns the beam dark red.
• Polyphemus

  Makes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage.

  : Quadruples beam's damage.
• Rubber Cement

  Tears bounce off walls, enemies, and environmental objects.

  : Beam bounces off walls like Brimstone

  Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.

  would.
• Schoolbag

  Allows Isaac to hold two active items.

  : Beam will continue to fire when switching to another active item. Other active item can be used while beam is firing.
• Tiny Planet

  Range up and makes shot tears revolve around Isaac until they drop.

  : Beam rotates around the player like Brimstone would.
• Void

  Consumes all pedestal items in the room. Active items will have their effects added to Void, and passive items will grant stat upgrades.

  : Allows the item to be used every 6 rooms instead of 12 and batteries will fully charge the item.

Interactions

• 20/20

  Grants double shot.

  / The Inner Eye

  Grants triple shot but decreases tears.

  / Mutant Spider

  Grants quadruple shot but decreases tears.

  : No effect on Mega Blast.
• Angelic Prism

  Grants a prism orbital with a large orbital radius. Tears that pass through the prism split into four multi-colored tears.

  : Laser beam will only split and change color when Isaac is directly against a wall.
• Anti-Gravity

  -2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.

  : No effect on Mega Blast.
• Car Battery

  Causes Isaac's activated item to activate twice on each use.

  : No effect.
• Chocolate Milk

  Grants charged tears that deal greater damage when fully charged.

  : No effect on Mega Blast. Laser beams turn a light brown color.
• Compound Fracture

  Increases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.

  / Cricket's Body

  Grants -1 Tear Delay and reduces Range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose Range and Damage scale with Isaac's.

  / The Parasite

  Isaac's tears split in two when they hit something.

  : No effect on Mega Blast.
• Continuum

  +2.25 Range Up. +1.5 Tear Height. Isaac's tears travel through walls and appear out of the opposite wall. Isaac's tears also travel over rocks and objects.

  : No effect on Mega Blast.
• Dr. Fetus

  Tears are replaced by bombs that benefit from bomb-enhancing effects and slide a fixed range after being fired.

  : No effect.
• Epic Fetus

  Isaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.

  : No effect.
• Godhead

  Increases damage and range while reducing tears and shot speed. Grants homing tears and tears gain a damaging halo.

  : Multiplies beam damage by 1.2, retains homing effect. The beam does not have a damaging aura.
• Haemolacria

  Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.

  : Multiplies beam damage by 1.3. No other effects.
• Incubus

  A demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects.

  : Familiar fires normal tears while Mega Blast is in use.
• The Ludovico Technique

  Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.

  : No effect.
• Mom's Eye

  Allows Isaac to fire tears from the back of his head.

  / Loki's Horns

  Gives a random chance for projectiles to fire in all 4 cardinal directions.

  : Will not fire other beams even with high luck.
• Mom's Knife

  Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.

  : No effect.
• Monstro's Lung

  Increases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.

  : No effect.
• My Reflection

  Gives Isaac's tears a boomerang effect, and increases range and shot speed.

  : Causes the beam to curve while moving.
• Proptosis

  Tears start out massive with high damage, and then shrink down and become weaker over a short range.

  : The beam does massively increased damage at close range but does nearly no damage from afar.
• Sharp Plug

  Using an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.

  : Fully recharges the item upon use at the cost of 2 hearts.
• Soy Milk

  Tears shrink and do much less damage, but fire in very rapid succession.

  : Reduces beam's damage to Isaac's base damage.
• Technology

  Replaces tears with a piercing laser with unlimited range.

  : No effect.
• Technology 2

  Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.

  : Decreases beam's damage.
• Tech X

  Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the size of the ring.

  : No effect.
• Trisagion

  Tears are replaced with piercing white blasts of light.

  : No effect on Mega Blast.

Seeds

 PC  WCB1 YZ39 (First floor Devil Room)

 PC  TQWA 6TQD (Curse room adjacent to spawn, chest teleports to devil deal)

 PC  3KY4 LSVL (Second floor Devil Room)

 PC  RZL2 6MQ0 (Starting item as Eden, and will also start with Godhead

Increases damage and range while reducing tears and shot speed. Grants homing tears and tears gain a damaging halo.

)

 PC  MKNJ 711R (Third floor Devil Room)

 PC  W3BZ BBB2 (Starting item as Eden)

 PC  PGH7 BMRT (Starting item as Eden)

 PC  L6B9 ZZ22 (Starting item as Eden)

 PC  NZ7T 4RAJ (Starting item as Eden)

Gallery

• 

  The notification after unlocking Mega Blast.