Clotties (or Clottys) are enemies that wander around the room, randomly shooting blood shots in the four cardinal directions. These can be particularly difficult to deal with early on if the player isn't careful.
Clots are an alternate version of Clotties that shoot tar shots in the four diagonal directions. They appear similar to Gish, who spawns them. As they do not shoot tar shots in the cardinal directions, they are considerably easier to defeat.
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Chance To Replace Clotties and Clots |
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An even rarer form of the Clotty is the I.Blob. It is an Isaac-like Clot head that shoots tears in 8 directions, combining the attacks of both the normal Clot and the Clotty.
The Mega Clotty slowly moves around the room, occasionally hopping. When it hops, it will usually fire six blood shots around itself, but it can also alternatively leave a small pool of red creep near itself. Even more rarely, the hop may spawn a Clotty or a collapsed Globin. Upon death, it’ll split into two Clotties. Even though the sprite shows three conjoined Clotties, it always creates two upon death, and will never spawn three.
The Binding of Isaac: Rebirth 
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