||For the boss with a similar name, see Monstro. For the item with a similar name, see Lil Monstro.
| Defeat The Lamb for the 1st timeThe gate is open!|
Ministros, as their name implies, are much smaller versions of Monstro. They are found as early as The Basement, and have a chance to replace Hoppers. Ministro is unlocked by defeating The Lamb for the first time.
Ministros jump around the room in the general direction of Isaac, occasionally pausing to spit a disorganized cluster of red shots, similar to Monstro's main attack.
- When Ministros are Champions, its red shots only deal half a heart of damage, but they still deal a full heart of contact damage.
- If Ministros aren't unlocked yet, they are replaced by Hoppers.