Mom's Hands are tricky foes. When these enemies spawn (either at the start of a room or in a Challenge Room wave, Mom's laugh can be heard and (
) the ground may shake. After this, a disembodied hand will come down to try and grab Isaac, pausing in a stunned state for a brief moment before going back up to repeat this again. Before coming down, a subtle shadow on the floor will indicate where the hand is going to land. They can spawn in groups of up to six in large rooms.
If Isaac is grabbed, he takes half a heart of damage and is sent back to the spawn room of the floor. Any enemies that Isaac damaged or killed before being grabbed will re-spawn at full health when Isaac returns to the room. If a black heart is depleted when Isaac is grabbed, the player will not be teleported and the hand will die instead.
Charmed Mom's Hands are extremely powerful as they can potentially kill any monster they attack in a single move if they manage to grab them and pull them up without getting killed in the process. This can be seen more easily by using the "C0CK FGHT" Special Seed.
Mom's Dead Hands behave similarly to regular Mom's Hands. When they land, they send out several lines of rock waves. Upon death, they spawn several Spiders. Like normal Mom's Hands, if the player is grabbed they will be teleported to the starting room of the floor.
- The Hands are a reference to the Wallmasters from the Legend of Zelda.
- Mom's Hand is the only enemy in the game that can teleport the player.
The Emergency Contact card spawns two Mom's Hands that grab enemies.