No. 2

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No. 2 is a passive item added in the Binding of Isaac: Afterbirth expansion.

Effects

• Continuously firing or charging tears for 3 seconds causes Isaac to drop a Butt Bomb. Only 1 Butt Bomb can be dropped per charging cycle, so you'll need to stop firing and then charge again to drop another Butt Bomb. Taking Damage will interrupt the cycle.
• Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
• Essentially grants unlimited bombs, as you can just reset the charge time over and over to bomb tinted rocks and to get into Secret and Super Secret Rooms.

Interactions

• Bobby-BombGives Isaac 5 Bombs, and causes all dropped bombs to home towards the closest enemy. - Butt Bombs will home in on enemies.
• Glitter BombsGives Isaac 5 bombs, and makes Isaac's bombs have a chance to drop random pickups or charm enemies when they explode. - Butt Bombs can drop pickups.
• MarkedIsaac will now fire tears automatically directed at a red target on the ground which is controlled by the player. This allows for a full 360 degree tear firing radius. Can be overridden by other tear modifiers such as Mom's Knife or Brimstone. - Holding the fire key to move the crosshairs for 3 seconds drops a butt bomb.
• Sad Bombs+5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears. - Butt Bombs will also shoot 10 tears off in every direction.
• PyromaniacIsaac heals 1 heart instead of taking damage from an explosive source. Adds 5 bombs. - Butt Bombs regenerate health.
• Scatter BombsAdds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs. - 2-4 smaller Butt Bombs will spawn after the first detonates.

Notes

• Increases difficulty of poop-themed bosses such as Dingle, as the Butt Bomb restore the boss' hp when they explode.

Trivia

• Number Two is a euphemism for defecation.

Seeds

 PC  1A8Z 43DC (Treasure room adjacent to spawn)

 PC  4X63 T64A (Treasure room adjacent to spawn)

Bombs

Items:

• Anarchist CookbookSpawns six troll bombs around the room.
• Bob's CurseGives 5 bombs and grants all bombs poison effect.
• Bob's Rotten HeadUpon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.
• Bobby-BombGives Isaac 5 Bombs, and causes all dropped bombs to home towards the closest enemy.
• Bomber Boy+5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects troll bombs.
• Boom!Grants 10 bombs.
• Butt BombsGives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
• Curse of the TowerCauses Isaac to spawn 6 troll bombs on the floor every time he gets hit, similar to the Anarchist Cookbook mechanic.
• Dr. FetusTears are replaced by bombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired.
• Fast BombsGrants 7 bombs and allows bombs to be placed rapidly.
• Glitter BombsGives Isaac 5 bombs, and makes Isaac's bombs have a chance to drop random pickups or charm enemies when they explode.
• Hot BombsGrants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
• Mama Mega!Damages all enemies and destroys all obstacles. The effect occurs every time a new room is entered for the rest of the floor. Opens doors to the floor's secret and super secret rooms.
• Mr. BoomDrops a large bomb.
• Mr. MegaGives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
• No. 2Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
• PyroAdds 99 bombs.
• Remote DetonatorBombs you place explode only when you use this item. Gives 5 bombs.
• Sad Bombs+5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears.
• Scatter BombsAdds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs.
• Sticky Bombs+5 bombs. Bombs stick to enemies and spawn 2-4 blue spiders if they kill an enemy.

Trinkets:

• Blasting CapExploding bombs have a chance to drop another bomb pickup.
• Bob's BladderLeaves a pool of green creep under all bombs Isaac places, which damages enemies that walk over it.

Cards:

• XVI - The TowerSpawns 6 troll bombs randomly around the room (same effect as the Anarchist Cookbook).

Poop

Items:

• Butt BombsGives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
• E ColiGives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
• Flush!Changes all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.
• Hallowed GroundSpawns a white poop familiar, which turns into a white poop when Isaac is hurt.
• Midas' TouchEnemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin.
• No. 2Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
• The PoopSpawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop.
• SkatoleAll types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.

Trinkets:

• Brown CapPoop will explode after being destroyed.
• MeconiumPoop has a chance to turn into black poop.
• Mysterious CandyIsaac farts or poops at random intervals. Getting hit can also trigger the effect.
• Petrified PoopGreatly increases the chances of a pickup dropping when destroying poop.
• Used DiaperGrants the Skatole effect in some rooms.

Cards:

• A Card Against HumanityCovers the entire room with poop. The process is not instant, and the room will not get filled if you leave it before it's done filling.