Upon picking up all 3 items from the following list, Isaac will heal half of a red heart each time a pile of poop is destroyed.
||Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
- Despite being poop-themed, SkatoleAll types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage., Butt BombsGives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies., and No. 2Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 60 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time. do not count towards the transformation.
- Poop created with Flush!Changes all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie. and E ColiGives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop. do not heal Isaac when he has this transformation.
- This transformation is easier to obtain using ???, since ??? starts with The PoopSpawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop.. However, it is useless because ??? has no red hearts.