Pandora's Box

Not to be confused with the Box.

Pandora's Box is an unlockable activated item.

Effect[edit | edit source]

Upon use, spawns certain Pickups or Items depending on the floor it is used on. Pandora's Box disappears after use.

Normal Mode	Greed Mode	Items/Pickups
The Basement / The Cellar I Burning Basement I	---	2 Soul Hearts
The Basement / The Cellar II Burning Basement II	The Basement	2 Keys and 2 Bombs
The Caves / The Catacombs I Flooded Caves I	---	1 Boss Room item
The Caves / The Catacombs II Flooded Caves II	The Caves	1 Boss Room item and 2 Soul Hearts
The Depths / Necropolis I Dank Depths I	---	4 Soul Hearts
The Depths / Necropolis II Dank Depths II	The Depths	20 Pennies
Utero / The Womb I Scarred Womb I	Womb	2 Boss Room items
Utero / The Womb II Scarred Womb II	---	The Bible
???	---	Nothing
The Void	---	Nothing
Sheol	Sheol	1 Devil Room item and 1 Black Heart
Dark Room	---	Nothing Unlocks Moving Box
Cathedral	---	1 Angel Room item and 1 Eternal Heart
The Chest	The Shop / Ultra Greed	1 Penny

XL floors count as I floor for Pandora's Box.
If Pandora's Box attempts to spawn an item from an item pool that is empty, it will instead spawn an item from the Treasure Room pool.
Using the ? Card with Pandora's Box will consume both the card and the item with no additional benefit.
Pandora's Box is not doubled by Car Battery.

In Greek legend, Pandora's Box was a box containing all of the evils of the world, given to the first woman created, who opened it, releasing every evil unto the land, besides the last spirit, Elpis, the Spirit of Hope.

PC 1TNY 7MJ0 (Curse Room adjancent to spawn)

PC VKPS 2M1F (Shop in 1st floor)

PC 1TNY 7MJO (Second floor curse room)

Lazarus Unlocks