Pandora's Box

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Font TeamMeat P.pngFont TeamMeat a.pngFont TeamMeat n.pngFont TeamMeat d.pngFont TeamMeat o.pngFont TeamMeat r.pngFont TeamMeat a.pngFont TeamMeat '.pngFont TeamMeat s.png   Font TeamMeat B.pngFont TeamMeat o.pngFont TeamMeat x.png
Item icon
Item altar
Table dividing line 1.png
Table dividing line 2.png
one time  rooms one time  rooms
Red Chest Red Chest
Shop Shop
Greed mode only Shop Shop
Table dividing line 3.png
Added in  Afterbirth(page 3, column 12, row 3)
Removed in Afterbirth(page 3, column 2, row 10)
Pandora's Box Defeat The Lamb as LazarusPandora's BoxPandora's Box

Not to be confused with the Box BoxBox Rebirth Icon.pngSpawns 1 of each (non-collectible) item: 1 coin, 1 key, 1 bomb, 1 heart, 1 card, 1 pill, 1 trinket..

Pandora's Box is an unlockable activated item.

Effect[edit | edit source]

Upon use, spawns certain Pickups or Items depending on the floor it is used on. Pandora's Box disappears after use.

Normal Mode Added in  Afterbirth Greed Mode Items/Pickups
Basement / Cellar I
Added in  Afterbirth Burning Basement I
--- 2 soul hearts
Basement / Cellar II
Added in  Afterbirth Burning Basement II
Basement 2 keys and 2 bombs
Caves / Catacombs I
Added in  Afterbirth Flooded Caves I
--- 1 Boss Room item
Caves / Catacombs II
Added in  Afterbirth Flooded Caves II
Caves 1 Boss Room item and 2 soul hearts
Depths / Necropolis I
Added in  Afterbirth Dank Depths I
--- 4 soul hearts
Depths / Necropolis II
Added in  Afterbirth Dank Depths II
Depths 20 coins
Utero / Womb I
Added in  Afterbirth Scarred Womb I
Womb 2 Boss Room items
Utero / Womb II
Added in  Afterbirth Scarred Womb II
--- The Bible The BibleThe Bible Icon.png6 roomsUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
Added in  Afterbirth Blue Womb --- Nothing
Added in Afterbirth † The Void --- Nothing
Sheol Sheol 1 Devil Room item and 1 black heart
Dark Room --- Nothing

Added in Afterbirth † UnlocksMoving Box Moving BoxMoving Box Icon.png4 roomsIf the box is empty, picks up all items and pickups in a room and stores them. If the box is not empty, places all stored items and pickups in the current room.

Cathedral --- 1 Angel Room item and 1 eternal heart
Chest The Shop / Ultra Greed 1 coin

Notes[edit | edit source]

  • XL floors count as I floors for Pandora's Box.
  • If Pandora's Box attempts to spawn an item from an item pool that is empty, it will instead spawn an item from the Treasure Room Pool.
  • Using the ? Card with Pandora's Box will consume both the card and the item with no additional benefit.
  • Pandora's Box is not doubled by Added in  AfterbirthCar Battery Car BatteryCar Battery Icon.pngCauses Isaac's activated item to activate twice on each use..
  • You can not use Pandora's Box multiple times by absorbing it with Void.

In-game Footage[edit | edit source]

Unlockable Achievements[edit | edit source]

Gallery[edit | edit source]

Notes[edit | edit source]

  • The rewards for Greed Mode changed in patch v1.06.J168.

Trivia[edit | edit source]

  • In Greek legend, Pandora's Box was a box containing all of the evils of the world, given to the first woman created, who opened it, releasing every evil unto the land, besides the last spirit, Elpis, the Spirit of Hope.

Seeds[edit | edit source]

 PC  Normal and hard modes only 1TNY 7MJ0 (Curse Room adjancent to spawn)

 PC  Added in Afterbirth † Hard mode only 1TNY 7MJO (Second floor curse room)

Lazarus  Unlocks Lazarus Unlocks Lazarus  Unlocks
Added in  Afterbirth Added in Afterbirth †
Missing No.Missing No.Complete the Boss Rush as LazarusLazarus' RagsLazarus' RagsDefeat Isaac as LazarusBroken AnkhBroken AnkhDefeat Satan as LazarusStore CreditStore CreditDefeat ??? as LazarusPandora's BoxPandora's BoxDefeat The Lamb as LazarusWrapped BabyWrapped BabyRemoved in Afterbirth † Defeat Mom's Heart on hard mode as Azazel
Added in Afterbirth † Defeat Mom's Heart on hard mode as Lazarus
Begotten BabyBegotten BabyRemoved in Afterbirth † Defeat Mom's Heart on hard mode as Lazarus
Added in Afterbirth † Defeat Mom's Heart on hard mode as Azazel
Empty VesselEmpty VesselDefeat Hush as LazarusKey BumKey BumDefeat Ultra Greed as LazarusLong BabyLong BabyDefeat Mega Satan as LazarusDripping BabyDripping BabyEarn all hard mode completion marks as Lazarus Compound FractureCompound FractureDefeat Delirium as LazarusPlan CPlan CDefeat Ultra Greedier as Lazarus
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Characters Characters MainPageBabies.png Co-op Items Items Item Pools Item Pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets