Pandora's Box

	;
	One time use
	None
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Not to be confused with the BoxSpawns 1 of each (non-collectible) item: 1 coin, 1 key, 1 bomb, 1 heart, 1 card, 1 pill, 1 trinket..

Pandora's Box is an unlockable activated item.

Effect[edit | edit source]

Upon use, spawns certain Pickups or Items depending on the floor it is used on. Pandora's Box disappears after use.

Normal Mode	Greed Mode	Items/Pickups
Basement / Cellar I Burning Basement I	---	2 soul hearts
Basement / Cellar II Burning Basement II	Basement	2 keys and 2 bombs
Caves / Catacombs I Flooded Caves I	---	1 Boss Room item
Caves / Catacombs II Flooded Caves II	Caves	1 Boss Room item and 2 soul hearts
Depths / Necropolis I Dank Depths I	---	4 soul hearts
Depths / Necropolis II Dank Depths II	Depths	20 coins
Utero / Womb I Scarred Womb I	Womb	2 Boss Room items
Utero / Womb II Scarred Womb II	---	The BibleUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
Blue Womb	---	Nothing
The Void	---	Nothing
Sheol	Sheol	1 Devil Room item and 1 black heart
Dark Room	---	Nothing Unlocks Moving Box
Cathedral	---	1 Angel Room item and 1 eternal heart
Chest	The Shop / Ultra Greed	1 coin

XL floors count as I floors for Pandora's Box.
If Pandora's Box attempts to spawn an item from an item pool that is empty, it will instead spawn an item from the Treasure Room Pool.
Using the ? Card with Pandora's Box will consume both the card and the item with no additional benefit.
Pandora's Box is not doubled by Car BatteryCauses Isaac's activated item to activate twice on each use..
You can not use Pandora's Box multiple times by absorbing it with Void.

In Greek legend, Pandora's Box was a box containing all of the evils of the world, given to the first woman created, who opened it, releasing every evil unto the land, besides the last spirit, Elpis, the Spirit of Hope.

PC 1TNY 7MJ0 (Curse Room adjancent to spawn)

PC 1TNY 7MJO (Second floor curse room)

Lazarus Unlocks

Missing No.Complete the Boss Rush as LazarusLazarus' RagsDefeat Isaac as LazarusBroken AnkhDefeat Satan as LazarusStore CreditDefeat ??? as LazarusPandora's BoxDefeat The Lamb as LazarusWrapped Baby Defeat Mom's Heart on hard mode as Azazel Defeat Mom's Heart on hard mode as LazarusBegotten Baby Defeat Mom's Heart on hard mode as Lazarus Defeat Mom's Heart on hard mode as Azazel	Empty VesselDefeat Hush as LazarusKey BumDefeat Ultra Greed as LazarusLong BabyDefeat Mega Satan as LazarusDripping BabyEarn all hard mode completion marks as Lazarus	Compound FractureDefeat Delirium as LazarusPlan CDefeat Ultra Greedier as Lazarus