Pandora's Box

One time use   Shop Red Chest Shop   (page 3, column 12, line 3) (page 3, column 2, line 10)

Not to be confused with the BoxSpawns 1 of each (non-collectible) item: 1 coin, 1 key, 1 bomb, 1 heart, 1 card, 1 pill, 1 trinket..

Pandora's Box is an unlockable activated item.

Effect

Upon use, spawns certain Pickups or Items depending on the floor it is used on. Pandora's Box disappears after use.

Normal Mode	Greed Mode	Items/Pickups
Basement / Cellar I Burning Basement I	---	2 soul hearts
Basement / Cellar II Burning Basement II	Basement	2 keys and 2 bombs
Caves / Catacombs I Flooded Caves I	---	1 Boss Room item
Caves / Catacombs II Flooded Caves II	Caves	1 Boss Room item and 2 soul hearts
Depths / Necropolis I Dank Depths I	---	4 soul hearts
Depths / Necropolis II Dank Depths II	Depths	20 coins
Utero / Womb I Scarred Womb I	Womb	2 Boss Room items
Utero / Womb II Scarred Womb II	---	The BibleUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
Blue Womb	---	Nothing
The Void	---	Nothing
Sheol	Sheol	1 Devil Room item and 1 black heart
Dark Room	---	Nothing Unlocks Moving Box
Cathedral	---	1 Angel Room item and 1 eternal heart
Chest	The Shop / Ultra Greed	1 coin

Notes

• XL floors count as I floors for Pandora's Box.
• If Pandora's Box attempts to spawn an item from an item pool that is empty, it will instead spawn an item from the Treasure Room Pool.
• Using the with Pandora's Box will consume both the card and the item with no additional benefit.
• Pandora's Box is not doubled by Car BatteryCauses Isaac's activated item to activate twice on each use..
• You can not use Pandora's Box multiple times by absorbing it with Void.

Unlockable Achievements

• 

  Moving Box - Use Pandora's Box in the Dark Room.

Gallery

• 

   3DS  The icon of Pandora's Box as seen on the lower 3DS screen

Notes

• The rewards for Greed Mode changed in patch v.106.J168.

Trivia

• In Greek legend, Pandora's Box was a box containing all of the evils of the world, given to the first woman created, who opened it, releasing every evil unto the land, besides the last spirit, Elpis, the Spirit of Hope.

Seeds

 PC  1TNY 7MJ0 (Curse Room adjancent to spawn)

 PC  1TNY 7MJO (Second floor curse room)