Pandora's Box

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Font TeamMeat P.pngFont TeamMeat a.pngFont TeamMeat n.pngFont TeamMeat d.pngFont TeamMeat o.pngFont TeamMeat r.pngFont TeamMeat a.pngFont TeamMeat '.pngFont TeamMeat s.png   Font TeamMeat B.pngFont TeamMeat o.pngFont TeamMeat x.png
Item icon
Item altar
Table dividing line 1.png
Table dividing line 2.png
One time use One time use
Item Pool Shop.png Shop
Item Pool Red Chest.png Red Chest
Added in AfterbirthGreed mode onlyItem Pool Shop.png Shop
Table dividing line 3.png
Added in Afterbirth (page 3, column 12, line 3)
Removed in Afterbirth (page 3, column 2, line 10)

Not to be confused with the Box BoxBox Icon.pngSpawns 1 of each (non-collectible) item: 1 coin, 1 key, 1 bomb, 1 heart, 1 card, 1 pill, 1 trinket..

Pandora's Box is an unlockable activated item.

Effect[edit | edit source]

Upon use, spawns certain Pickups or Items depending on the floor it is used on. Pandora's Box disappears after use.

Normal Mode Added in Afterbirth Greed Mode Items/Pickups
Basement / Cellar I
Added in Afterbirth Burning Basement I
--- 2 soul hearts
Basement / Cellar II
Added in Afterbirth Burning Basement II
Basement 2 keys and 2 bombs
Caves / Catacombs I
Added in Afterbirth Flooded Caves I
--- 1 Boss Room item
Caves / Catacombs II
Added in Afterbirth Flooded Caves II
Caves 1 Boss Room item and 2 soul hearts
Depths / Necropolis I
Added in Afterbirth Dank Depths I
--- 4 soul hearts
Depths / Necropolis II
Added in Afterbirth Dank Depths II
Depths 20 coins
Utero / Womb I
Added in Afterbirth Scarred Womb I
Womb 2 Boss Room items
Utero / Womb II
Added in Afterbirth Scarred Womb II
--- The Bible The BibleThe Bible Icon.png6 roomsUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
Added in Afterbirth Blue Womb --- Nothing
Added in Afterbirth † The Void --- Nothing
Sheol Sheol 1 Devil Room item and 1 black heart
Dark Room --- Nothing

Unlocks Moving Box

Cathedral --- 1 Angel Room item and 1 eternal heart
Chest The Shop / Ultra Greed 1 coin

Notes[edit | edit source]

  • XL floors count as I floors for Pandora's Box.
  • If Pandora's Box attempts to spawn an item from an item pool that is empty, it will instead spawn an item from the Treasure Room Pool.
  • Using the with Pandora's Box will consume both the card and the item with no additional benefit.
  • Pandora's Box is not doubled by Added in AfterbirthCar Battery Car BatteryCar Battery Icon.pngCauses Isaac's activated item to activate twice on each use..
  • You can not use Pandora's Box multiple times by absorbing it with Void.

In-game Footage[edit | edit source]

Unlockable Achievements[edit | edit source]

Gallery[edit | edit source]

Notes[edit | edit source]

  • The rewards for Greed Mode changed in patch v.106.J168.

Trivia[edit | edit source]

  • In Greek legend, Pandora's Box was a box containing all of the evils of the world, given to the first woman created, who opened it, releasing every evil unto the land, besides the last spirit, Elpis, the Spirit of Hope.

Seeds[edit | edit source]

 PC  1TNY 7MJ0 (Curse Room adjancent to spawn) Normal and hard modes only

 PC  Added in Afterbirth † 1TNY 7MJO (Second floor curse room) Hard mode only

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