Pandora's Box

	;
	One time use
	Defeat The Lamb as LazarusPandora's Box

Not to be confused with the BoxSpawns 1 of each (non-collectible) item: 1 coin, 1 key, 1 bomb, 1 heart, 1 card, 1 pill, 1 trinket..

Pandora's Box is an unlockable activated item.

Effect[edit | edit source]

Upon use, spawns certain Pickups or Items depending on the floor it is used on. Pandora's Box disappears after use.

Normal Mode	Greed Mode		Items/Pickups
Normal Mode			Items/Pickups
The Basement / The Cellar I Burning Basement I	The Basement	---	2 soul hearts
The Basement II/ The Cellar II Burning Basement II	The Caves	The Basement	2 keys and 2 bombs
The Caves / The Catacombs I Flooded Caves I	The Depths	---	1 Boss Room item
The Caves II/ The Catacombs II Flooded Caves II	The Womb	The Caves	1 Boss Room item and 2 soul hearts
The Depths / Necropolis I Dank Depths I	Sheol	---	4 soul hearts
The Depths II/ Necropolis II Dank Depths II	The Shop	The Depths	20 coins
Utero / The Womb I Scarred Womb I	Ultra Greed	The Womb	2 Boss Room items
Utero II/ The Womb II Scarred Womb II	---	---	The BibleUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
Blue Womb / The Void	---	---	Nothing
Sheol	---	Sheol	1 Devil Room item and 1 black heart
Dark Room	---	---	Nothing Unlocks Moving BoxIf the box is empty, picks up all items and pickups in a room and stores them. If the box is not empty, places all stored items and pickups in the current room.
Cathedral	---	---	1 Angel Room item and 1 eternal heart
The Chest	---	The Shop / Ultra Greed	1 coin

XL floors count as I floors for Pandora's Box.
If Pandora's Box attempts to spawn an item from an item pool that is empty, it will instead spawn an item from the Treasure Room Pool.
Using the ? CardWhen used, copies the effect of Isaac's currently held activated collectible item. with Pandora's Box will consume both the card and the item with no additional benefit.
Pandora's Box is not doubled by Car BatteryCauses Isaac's activated item to activate twice on each use..
You can not use Pandora's Box multiple times by absorbing it with Void.
The rewards for Greed Mode changed in patch v1.06.J168.
On consoles (Switch, PS4), Moving Box is unlocked by opening Pandora's Box in the Chest, not in the Dark Room, where it does not do anything.

In Greek legend, Pandora's Box was a box containing all of the evils of the world, given to the first woman created, who opened it, releasing every evil unto the land, besides the last spirit, Elpis, the Spirit of Hope.

PC 1TNY 7MJ0 (Curse Room adjancent to spawn)

PC 1TNY 7MJO (Second floor curse room)