Pandora's Box

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Font TeamMeat P.pngFont TeamMeat a.pngFont TeamMeat n.pngFont TeamMeat d.pngFont TeamMeat o.pngFont TeamMeat r.pngFont TeamMeat a.pngFont TeamMeat '.pngFont TeamMeat s.png   Font TeamMeat B.pngFont TeamMeat o.pngFont TeamMeat x.png
Item icon
Item altar
Table dividing line 1.png
 
5.100.297
Table dividing line 2.png
 
One time use One time use
 
Red Chest Red Chest
Shop Shop
Greed mode only Shop Shop
Table dividing line 3.png
 
Added in Afterbirth(page 3, column 12, row 3)
Removed in Afterbirth(page 3, column 2, row 10)
 
Pandora's Box Defeat The Lamb as Lazarus

Not to be confused with the Box Box.

Pandora's Box is an unlockable activated item.

Effect[edit | edit source]

Upon use, spawns certain Pickups or Items depending on the floor it is used on. Pandora's Box disappears after use.

Normal Mode Added in Afterbirth Greed Mode Items/Pickups
The Basement The Basement / The Cellar The Cellar I
Added in Afterbirth Burning Basement Burning Basement I
--- 2 Soul Hearts
The Basement The Basement / The Cellar The Cellar II
Added in Afterbirth Burning Basement Burning Basement II
The Basement The Basement 2 Keys and 2 Bombs
The Caves The Caves / The Catacombs The Catacombs I
Added in Afterbirth Flooded Caves Flooded Caves I
--- 1 Boss Room item
The Caves The Caves / The Catacombs The Catacombs II
Added in Afterbirth Flooded Caves Flooded Caves II
The Caves The Caves 1 Boss Room item and 2 Soul Hearts
The Depths The Depths / Necropolis Necropolis I
Added in Afterbirth Dank Depths Dank Depths I
--- 4 Soul Hearts
The Depths The Depths / Necropolis Necropolis II
Added in Afterbirth Dank Depths Dank Depths II
The Depths The Depths 20 Pennies
Utero Utero / The Womb The Womb I
Added in Afterbirth Scarred Womb Scarred Womb I
The Womb The Womb 2 Boss Room items
Utero Utero / The Womb The Womb II
Added in Afterbirth Scarred Womb Scarred Womb II
--- The Bible The Bible
Added in Afterbirth ??? ??? --- Nothing
Added in Afterbirth † The Void The Void --- Nothing
Sheol Sheol Sheol Sheol 1 Devil Room item and 1 Black Heart
Dark Room Dark Room --- Nothing
Added in Afterbirth † Unlocks Moving Box Moving Box
Cathedral Cathedral --- 1 Angel Room item and 1 Eternal Heart
The Chest The Chest The Shop The Shop / Ultra Greed 1 Penny

Notes[edit | edit source]

  • XL floors count as I floor for Pandora's Box.
  • If Pandora's Box attempts to spawn an item from an item pool that is empty, it will instead spawn an item from the Treasure Room pool.
  • Using the ? Card with Pandora's Box will consume both the card and the item with no additional benefit.
  • Pandora's Box is not doubled by Added in AfterbirthCar Battery Car Battery.

In-game Footage[edit | edit source]

Unlockable Achievements[edit | edit source]

Gallery[edit | edit source]

Notes[edit | edit source]

  • The rewards for Greed Mode changed in patch v1.06.J168.

Trivia[edit | edit source]

  • In Greek legend, Pandora's Box was a box containing all of the evils of the world, given to the first woman created, who opened it, releasing every evil unto the land, besides the last spirit, Elpis, the Spirit of Hope.

Seeds[edit | edit source]

 PC  Normal and hard modes only 1TNY 7MJ0 (Curse Room adjancent to spawn)

 PC  Added in Afterbirth † Normal mode only VKPS 2M1F (Shop in 1st floor)

 PC  Added in Afterbirth † Hard mode only 1TNY 7MJO (Second floor curse room)


Lazarus Unlocks Lazarus Unlocks Lazarus Unlocks
Missing No.Lazarus' RagsBroken AnkhStore CreditPandora's BoxWrapped BabyBegotten Baby Empty VesselKey BumLong BabyDripping Baby Compound FracturePlan C
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets