Pestilence

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Boss Pestilence name.png
Boss versus screen image
 
 
Table dividing line 1.png
 
In-game appearance
Table dividing line 2.png
 
Boss
Stage The Caves icon.pngStage The Catacombs icon.pngStage Flooded Caves icon.png
Super Secret Room Icon.png
Degraded Boss
Stage Cathedral icon.pngStage Sheol icon.png
Stage The Chest icon.pngStage Dark Room icon.png
Table dividing line 3.png
 
Ball of Bandages Ball of BandagesBall of Bandages Icon.pngOrbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.
Cube of Meat Cube of MeatCube of Meat Icon.pngOrbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.
 
The Harbingers Defeat Mom for the 1st timeThe HarbingersThe Harbingers

Pestilence is the horseman of Chapter 2.

Behavior[edit | edit source]

Phase 1[edit | edit source]

  • Pestilence will float around the room, leaving a trail of poison.
  • In addition to the trail of poison, it will fire explosive projectiles at Isaac which too, leave poison.
  • Pestilence can also summon up to four Chargers or Spitties.

Phase 2[edit | edit source]

  • Pestilence is now headless.
  • It will keep firing the explosive projectiles at Isaac.
  • Instead of Chargers or Spitties, Pestilence will summon Attack Flies.

Champion versions[edit | edit source]

  • White: This version leaves a trail of white creep, which slows the player down, shoots 6 bullets away from itself instead of explosive shots and spawns Trites instead of Chargers or Spitties. It spawns Spiders instead of flies in Phase 2.

Gallery[edit | edit source]

Unlockable achievements[edit | edit source]

Trivia[edit | edit source]

  • Pestilence appeared in the original The Binding of Isaac.
  • Pestilence, while very often portrayed as one of the Four Horsemen of the Apocalypse in popular culture, is actually not present in the Bible at all (see Rev 6:2) and is an example of incorrect interpretation. The canonical Four Horsemen are Conquest (white), War (red), Famine (black) and Death (pale).
  • Pestilence means a virulent or fatal disease epidemic.
    • The entirety of Pestilence's offense deals with poison and bugs that are associated with rot.
  • Pestilence is the only Harbinger that does not have a charge attack.
  • Pestilence’s head resembles The Husk.
  • Pestilence makes a "Hey!" sound when launching explosive projectiles at Isaac. Famine makes the same noises when spitting shots at Isaac at its second phase.



Bosses Boss Monstro.png
Chapter 1
Stage The Basement icon.pngStage The Cellar icon.pngStage Burning Basement icon.png
Blighted OvumDingleThe Duke of FliesFamineFistulaGeminiGurglingsThe HauntLarry Jr.MonstroPinStevenWidowThe FallenThe Headless Horseman
Added in  Afterbirth DangleLittle HornRag ManTurdlings
Chapter 2
Stage The Caves icon.pngStage The Catacombs icon.pngStage Flooded Caves icon.png
Carrion QueenC.H.A.D.ChubDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusThe WretchedThe FallenThe Headless Horseman
Added in  Afterbirth The ForsakenThe FrailThe Stain
Added in Afterbirth † Big HornRag Mega
Chapter 3
Stage The Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png
The AdversaryThe BloatThe CageThe GateGishLokiMask Of InfamyMonstro IIWarThe FallenThe Headless HorsemanMom
Added in  Afterbirth Brownie
Added in Afterbirth † Sisters Vis
Chapter 4
Stage The Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png
BlastocystThe BloatConquestDaddy Long LegsDeathLokiiMama GurdyMr. FredScolexTeratomaTriachnidThe FallenThe Headless HorsemanMom's HeartIt Lives
Added in Afterbirth † Sisters VisThe Matriarch
Added in  Afterbirth Blue Womb
???
Added in  Afterbirth Hush
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png
SatanIsaac
Chapter 6
Stage Dark Room icon.pngStage The Chest icon.png
???The LambMega Satan
Added in Afterbirth † The Void
Stage The Void icon.png
Added in Afterbirth † Delirium
Added in  Afterbirth Greed Mode
Ultra Greed
Added in  Afterbirth Ultra Greed
Added in Afterbirth † Ultra Greedier
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