Pestilence

	Boss; ; ; Mini-Boss; ;
	Orbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.
	Orbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.
	The Harbingers

Pestilence is the horseman of Chapter 2.

Behavior[edit | edit source]

Pestilence will float around the room, leaving a trail of poison.
In addition to the trail of poison, it will fire explosive projectiles at Isaac which too, leave poison.
Pestilence can also summon up to four Chargers or Spitties.

White: This version leaves a trail of white creep, which slows the player down and shoots 6 bullets away from itself instead of explosive shots. It spawns Spiders instead of flies in Phase 2.

Pestilence appeared in the original Binding of Isaac.
Pestilence, while very often portrayed as one of the Four Horsemen of the Apocalypse in popular culture, is actually not present in the Bible at all (see Rev 6:2) and is an example of incorrect interpretation. The canonical Four Horsemen are Conquest (white), War (red), Famine (black) and Death (pale).
Pestilence means a virulent or fatal disease epidemic.
- The entirety of Pestilence's offense deals with poison and bugs that are associated with rot.
Pestilence is the only Harbinger that does not have a charge attack.
Pestilence’s head resembles The Husk.
Pestilence makes a "Hey!" sound when launching explosive projectiles at Isaac. Famine makes the same noises when spitting shots at Isaac at its second phase.

Bosses
Chapter 1	Blighted Ovum • Dingle • The Duke of Flies • Famine • Fistula • Gemini • Gurglings • The Haunt • Larry Jr. • Monstro • Pin • Steven • Widow Dangle • Little Horn • Rag Man • Turdlings
Chapter 2	Carrion Queen • C.H.A.D. • Chub • Dark One • Gurdy • Gurdy Jr. • The Hollow • The Husk • Mega Fatty • Mega Maw • Peep • Pestilence • Polycephalus • The Wretched The Forsaken • The Frail • The Stain Big Horn • Rag Mega
Chapter 3	The Adversary • The Bloat • The Cage • The Gate • Gish • Loki • Mask Of Infamy • Monstro II • War • Mom Brownie Sisters Vis
Chapter 4	Blastocyst • The Bloat • Conquest • Daddy Long Legs • Death • Lokii • Mama Gurdy • Mr. Fred • Scolex • Teratoma • Triachnid • Mom's Heart • It Lives Sisters Vis • The Matriarch
Blue Womb	Hush
Chapter 5	Satan • Isaac
Chapter 6	??? • The Lamb • Mega Satan
Greed Mode	Ultra Greed Ultra Greedier
The Void	Delirium
Chapters 1-4	The Fallen • The Headless Horseman