Pestilence

Boss Degraded Boss
Ball of Bandages Cube of Meat
Defeat Mom for the 1st timeThe Harbingers

Pestilence is the horseman of Chapter 2.

Behavior

Phase 1

• Pestilence will float around the room, leaving a trail of poison.
• In addition to the trail of poison, it will fire explosive projectiles at Isaac which too, leave poison.
• Pestilence can also summon up to four Chargers or Spitties.

Phase 2

• Pestilence is now headless.
• It will keep firing the explosive projectiles at Isaac.
• Instead of Chargers or Spitties, Pestilence will summon Attack Flies.

Champion Versions

• Grey: This version leaves a trail of white creep, which slows the player down, shoots 6 bullets away from itself instead of explosive shots and spawns Trites instead of Chargers or Spitties. It spawns Spiders instead of flies in Phase 2.

Gallery

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  Pestilence ingame.

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  Pestilence in his second phase.

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  Grey champion Pestilence.

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  Grey champion Pestilence in his second phase.

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  Pestilence as one of Delirium's forms.

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  Pestilence as seen in Isaac's last will.

Unlockable achievements

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  The Book of Revelations - Defeat a Harbinger for the 1st time.

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  7 Seals - Defeat all 5 Harbingers.

Trivia

• Pestilence appeared in the original The Binding of Isaac.
• Pestilence, while very often portrayed as one of the Four Horsemen of the Apocalypse in popular culture, is not present in the Bible at all (see Rev 6:2) and is an example of incorrect interpretation. The canonical Four Horsemen are Conquest (white), War (red), Famine (black) and Death (pale).
• Pestilence means a fatal disease epidemic.
  • The entirety of Pestilence's offense deals with poison and bugs that are associated with rot.
• Pestilence is the only Harbinger that does not have a charge attack.
• Pestilence’s head resembles The Husk.
• Pestilence makes a "Hey!" sound when launching explosive projectiles at Isaac. Famine makes the same noises when spitting shots at Isaac at its second phase.