Pestilence

Boss Degraded Boss
Ball of Bandages Cube of Meat
Defeat Mom

Pestilence is the horseman of Chapter 2.

Behavior

Phase 1

• Pestilence will float around the room, leaving a trail of damaging Green Creep.
• In addition to the trail of Green Creep, it will fire explosive projectiles at Isaac which too, leave Green Creep.
• Pestilence can summon two Chargers or Spitties, and can have a maximum of either four Chargers, Four Spities, or two of each.

After taking enough damage, Pestilence's head will explode, beginning the second phase.

Phase 2

• Pestilence will keep firing the explosive projectiles at Isaac.
• Instead of Chargers or Spitties, Pestilence will summon two Attack Flies.

Champion Versions

• Pale Grey: This version leaves a trail of slowing White Creep instead of Green Creep, shoots 6 bullets in all directions instead of explosive shots and spawns Trites instead of Chargers or Spitties. It spawns Spiders instead of Attack Flies in Phase 2.

Gallery

• 

  Pestilence ingame.

• 

  Pestilence in his second phase.

• 

  Pale Grey Champion Pestilence.

• 

  Pale Grey Champion Pestilence in his second phase.

• 

  Pestilence as one of Delirium's forms.

• 

  Pestilence as seen in Isaac's last will.

Unlockable achievements

• 

  The Book of Revelations - Defeat a Harbinger.

• 

  7 Seals - Defeat all 5 Harbingers.

Trivia

• Pestilence appeared in the original The Binding of Isaac.
• Pestilence, while very often portrayed as one of the Four Horsemen of the Apocalypse in popular culture, is not present in the Bible at all (see Rev 6:2) and is an example of incorrect interpretation. The canonical Four Horsemen are Conquest (white), War (red), Famine (black), and Death (pale).
• Pestilence means a fatal disease epidemic.
  • The entirety of Pestilence's offense deals with poison and bugs that are associated with rot.
• Pestilence is the only Harbinger that does not have a charge attack.
• Pestilence’s head resembles The Husk.
• Pestilence makes a "Hey!" sound when launching explosive projectiles at Isaac. Famine makes the same noises when spitting shots at Isaac at its second phase.