Pestilence

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Boss Pestilence name.png
Boss versus screen image
 
 
Table dividing line 1.png
 
In-game appearance
Table dividing line 2.png
 
Boss
Stage The Caves icon.pngStage The Catacombs icon.pngStage Flooded Caves icon.png
Super Secret Room Icon.png
Degraded Boss
Stage Cathedral icon.pngStage Sheol icon.png
Stage The Chest icon.pngStage Dark Room icon.png
Table dividing line 3.png
 
Ball of Bandages Ball of Bandages
Cube of Meat Cube of Meat
 
The Harbingers Defeat Mom

Pestilence is the horseman of Chapter 2.

Behavior[edit | edit source]

Phase 1[edit | edit source]

  • Pestilence will float around the room, leaving a trail of damaging Green Creep.
  • In addition to the trail of Green Creep, it will fire explosive projectiles at Isaac which too, leave Green Creep.
  • Pestilence can summon two Chargers or Spitties, and can have a maximum of either four Chargers, Four Spities, or two of each.

After taking enough damage, Pestilence's head will explode, beginning the second phase.

Phase 2[edit | edit source]

  • Pestilence will keep firing the explosive projectiles at Isaac.
  • Instead of Chargers or Spitties, Pestilence will summon two Attack Flies.

Champion Versions Needs to be unlocked[edit | edit source]

Gallery[edit | edit source]

Unlockable achievements[edit | edit source]

Trivia[edit | edit source]

  • Pestilence appeared in the original The Binding of Isaac.
  • Pestilence, while very often portrayed as one of the Four Horsemen of the Apocalypse in popular culture, is not present in the Bible at all (see Rev 6:2) and is an example of incorrect interpretation. The canonical Four Horsemen are Conquest (white), War (red), Famine (black), and Death (pale).
  • Pestilence means a fatal disease epidemic.
    • The entirety of Pestilence's offense deals with poison and bugs that are associated with rot.
  • Pestilence is the only Harbinger that does not have a charge attack.
  • Pestilence’s head resembles The Husk.
  • Pestilence makes a "Hey!" sound when launching explosive projectiles at Isaac. Famine makes the same noises when spitting shots at Isaac at its second phase.



Bosses Boss Monstro.png
Chapter 1
Stage The Basement icon.pngStage The Cellar icon.pngStage Burning Basement icon.png
GeminiStevenBlighted OvumDingleThe Duke of FliesFamineFistulaGurglingsThe HauntLarry Jr.MonstroPinWidowThe FallenThe Headless Horseman
DangleLittle HornRag ManTurdlings
Chapter 2
Stage The Caves icon.pngStage The Catacombs icon.pngStage Flooded Caves icon.png
ChubC.H.A.D.Carrion QueenDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusThe WretchedThe FallenThe Headless Horseman
The ForsakenThe FrailThe Stain
Big HornRag Mega
Chapter 3
Stage The Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png
The AdversaryThe BloatThe CageThe GateMonstro IIGishLokiMask of InfamyWarThe FallenThe Headless HorsemanMom
Brownie
Sisters Vis
Chapter 4
Stage The Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png
BlastocystThe BloatConquestDaddy Long LegsTriachnidDeathLokiiMama GurdyMr. FredScolexTeratomaThe FallenThe Headless HorsemanMom's HeartIt Lives
Sisters VisThe Matriarch
Blue Womb
???
Hush
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png
SatanIsaac
Chapter 6
Stage Dark Room icon.pngStage The Chest icon.png
???The LambMega Satan
The Void
Stage The Void icon.png
Delirium
Greed Mode
Ultra Greed
Ultra Greed
Ultra Greedier
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