Pestilence

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Pestilence
Boss Pestilence.png
Base HP
280
Stage HP
0
Found In
Boss
Stage caves.pngStage catacombs.pngStage flooded caves.png
Super Secret Room Icon.png
Mini-Boss
Stage cathedral.pngStage sheol.png
Stage chest.pngStage dark room.png
Dropped Items
Ball of Bandages Ball of Bandages
Ball of Bandages Icon.pngOrbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.

Cube of Meat Cube of Meat
Cube of Meat Icon.pngOrbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.

Unlocked By The Harbingers Defeat Mom for the 1st time
The HarbingersThe Harbingers

Pestilence is the horseman of Chapter 2.

Behavior[edit | edit source]

Phase 1[edit | edit source]

  • Pestilence will float around the room, leaving a trail of poison.
  • In addition to the trail of poison, it will fire explosive projectiles at Isaac which too, leave poison.
  • Pestilence can also summon up to four Chargers or Spitties.

Phase 2[edit | edit source]

  • Pestilence is now headless.
  • It will keep firing the explosive projectiles at Isaac.
  • Instead of Chargers or Spitties, Pestilence will summon Attack Flies.

Champion versions[edit | edit source]

  • White: This version leaves a trail of white creep, which slows the player down and shoots 6 bullets away from itself instead of explosive shots. It spawns Spiders instead of flies in Phase 2.

Unlockable achievements[edit | edit source]

Gallery[edit | edit source]

Trivia[edit | edit source]

  • Pestilence appeared in the original Binding of Isaac.
  • Pestilence, while very often portrayed as one of the Four Horsemen of the Apocalypse in popular culture, is actually not present in the Bible at all (see Rev 6:2) and is an example of incorrect interpretation. The canonical Four Horsemen are Conquest (white), War (red), Famine (black) and Death (pale).
  • Pestilence means a virulent or fatal disease epidemic.
    • The entirety of Pestilence's offense deals with poison and bugs that are associated with rot.
  • Pestilence is the only Harbinger that does not have a charge attack.
  • Pestilence’s head resembles The Husk.
  • Pestilence makes a "Hey!" sound when launching explosive projectiles at Isaac. Famine makes the same noises when spitting shots at Isaac at its second phase.


Bosses Boss Monstro.png
Chapter 1 Blighted OvumDingleThe Duke of FliesFamineFistulaGeminiGurglingsThe HauntLarry Jr.MonstroPinStevenWidow
Added in Afterbirth DangleLittle HornRag ManTurdlings
Chapter 2 C.H.A.D.ChubDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusCarrion QueenThe Wretched
Added in Afterbirth The ForsakenThe FrailThe Stain
Added in Afterbirth † Big HornRag Mega
Chapter 3 The AdversaryThe BloatThe CageThe GateGishLokiMask of InfamyMonstro IIWarMom
Added in Afterbirth Brownie
Added in Afterbirth † Sisters Vis
Chapter 4 BlastocystThe BloatConquestDaddy Long LegsDeathIt LivesLokiiMama GurdyMom's HeartMr. FredScolexTeratomaTriachnid
Added in Afterbirth † Sisters VisThe Matriarch
Added in Afterbirth Blue Womb Added in Afterbirth Hush
Chapter 5 SatanIsaac
Chapter 6 ???The LambMega Satan
Added in Afterbirth Greed Mode Added in Afterbirth Ultra Greed
Added in Afterbirth † Ultra Greedier
Added in Afterbirth † The Void Added in Afterbirth † Delirium
Chapters 1-4 The FallenThe Headless Horseman


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