Pestilence

Pestilence
Base HP
280
Stage HP
0
Found In
Boss Mini-Boss
Dropped Items
Ball of Bandages Orbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat. Cube of Meat Orbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.

Unlocked By Defeat Mom for the 1st time

The Harbingers

Pestilence is the horseman of Chapter 2.

Behavior

Phase 1

• Pestilence will float around the room, leaving a trail of poison.
• In addition to the trail of poison, it will fire explosive projectiles at Isaac which too, leave poison.
• Pestilence can also summon up to four Chargers or Spitties.

Phase 2

• Pestilence is now headless.
• It will keep firing the explosive projectiles at Isaac.
  
• Instead of Chargers or Spitties, Pestilence will summon Attack Flies.

Champion versions

• White: This version leaves a trail of white creep, which slows the player down and shoots 6 bullets away from itself instead of explosive shots. It spawns Spiders instead of flies in Phase 2.

Gallery

• 

  Pestilence ingame.

• 

  Pestilence in his second phase.

• 

  Pestilence as one of Delirium's forms.

• 

  Pestilence as seen in Isaac's last will.

Unlockable achievements

• The Book of Revelations - Defeat a Harbinger for the 1st time.

• 7 Seals - Defeat all 5 Harbingers.

Trivia

• Pestilence appeared in the original Binding of Isaac.
• Pestilence, while very often portrayed as one of the Four Horsemen of the Apocalypse in popular culture, is actually not present in the Bible at all (see Rev 6:2) and is an example of incorrect interpretation. The canonical Four Horsemen are Conquest (white), War (red), Famine (black) and Death (pale).
• Pestilence means a virulent or fatal disease epidemic.
  • The entirety of Pestilence's offense deals with poison and bugs that are associated with rot.
• Pestilence is the only Harbinger that does not have a charge attack.
• Pestilence’s head resembles The Husk.
• Pestilence makes a "Hey!" sound when launching explosive projectiles at Isaac. Famine makes the same noises when spitting shots at Isaac at its second phase.