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Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki
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in: Modified in Repentance, Modified in Afterbirth, Modified in Afterbirth+,
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Changes: Pills

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(→‎Notes: Updated the Retro Vision effect, now cancels a run if you exit and try to restart to negate.)
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(Not needed since it's already in a Repentance section.)
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{{pickupHeader}}
  
{{pickupHeader}}
   
−
'''Pills''' are [[pickup]]s that can provide useful or inhibiting effects. They take up the same [[item slot|slot]] as [[card]]s and [[rune]]s.
 +
'''Pills''' are [[pickup]]s that can provide useful or inhibiting effects. They take up the same [[item slot|slot]] as [[cards and runes]].
   
−
At the start of each run, an effect is randomly assigned to each color of the pill. The pill effect for that color will remain constant throughout the run. (However, it is possible for {{i|PHD}} or {{i|Virgo}} to reassign some of the effects, such that 2 different colored pills will have the same effect). Pills will start the game unidentified (unless the player is holding {{i|PHD}}), their effect is shown as "???" when picked up. Upon using a particular pill for the first time, its effect will be revealed and all subsequent pills with the same color will have their effect shown as well. The set of pill effects for any given run is usually known as the ''pill pool''.
 +
At the start of each run, an effect is randomly assigned to each color of pill. The pill effect for each color will remain constant throughout the run. (However, it is possible for {{i|PHD}}, {{i|Virgo}}, {{I|false PHD}}, or {{dlc|r}}{{I|Lucky Foot}} to reassign some of the effects, such that 2 different colored pills will have the same effect.) Pills start the game unidentified (unless the player is holding {{i|PHD}} or {{I|False PHD}}); their effect is shown as "???" when picked up. Upon using a particular pill for the first time, its effect will be revealed and all subsequent pills with the same color will have their effect shown as well. The set of pill effects for any given run is usually known as the ''pill pool''.
 
* {{dlc|a}} The pill pool for each run has increased from 9 to 13.
  
* {{dlc|a}} The pill pool for each run has increased from 9 to 13.
   
 
== Pill Effects ==
  
== Pill Effects ==
−
{| class="mw-collapsible wikitable striped" style="text-align: center; width: 100%"
 +
{| class="mw-collapsible wikitable striped" style="width: 100%"
 
! style="width: 30px" | '''ID'''
  
! style="width: 30px" | '''ID'''
 
! style="width: 130px" | '''Pill'''
  
! style="width: 130px" | '''Pill'''
−
! '''Effect'''
 +
! {{dlc|r}} '''Polarity'''
  +
!{{dlc|r}} '''Class'''
  +
! style="width: 50%" |'''Effect'''
  +
! style="width: 50%" |{{dlc|r}} '''Horse Pill Effect'''
  +
|- id="Bad Gas"
  +
|0||Bad Gas
  +
| style="text-align:center;" | N
  +
|1|| Isaac farts, dealing 5 damage and [[Status Effects#Poison|poisoning]] enemies around him.
  +
|| The poison affects all enemies in the room.
  +
|- id="Bad Trip"
  +
|1||Bad Trip
  +
| style="text-align:center; background-color: #6C2121;" | -
  +
|2||Deals a full heart of damage to Isaac. Using a Bad Trip pill while Isaac only has a single heart left or less turns it into a Full Health pill.<br>{{dlc|r}} This doesn't count as damage for the purposes of {{R|Devil Room}}/{{R|Angel Room}} generation odds or score reduction.
  +
||Deals two hearts of damage. If Isaac would not survive, the pill becomes Full Health.
  +
|- id="Balls of Steel"
  +
|2||Balls of Steel
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|2||Grants Isaac two soul hearts.
  +
||Grants four soul hearts.
  +
|- id="Bombs Are Key"
  +
|3||Bombs Are Key
  +
| style="text-align:center;" |N
  +
|2|| Swaps the values of Isaac's {{E|bomb}}s and {{E|key}}s.<br>{{dlc|r}}The effects of {{E|Golden Bomb}}s and {{E|Golden Key}}s are also swapped.
  +
||The number of bombs and keys is increased by 50% while swapping.
  +
|- id="Explosive Diarrhea"
  +
|4||Explosive Diarrhea
  +
| style="text-align:center;" | N
  +
|1||Spawns a lit bomb behind Isaac every second for five seconds.
  +
||Spawns more bombs with the effects of {{i|Mr. Mega}} and {{i|Bobby-Bomb}}.
  +
|- id="Full Health"
  +
|5||Full Health
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|2||Refills every empty [[Health#Red Heart Containers|red heart]] container.
  +
||Fully heals and grants 3 soul hearts.
  +
|- id="Health Down"
  +
|6||Health Down
  +
| style="text-align:center; background-color: #6C2121;" | -
  +
|3||Removes one red heart container. Acts as a ''Health Up'' pill if Isaac has one or fewer red heart containers. Characters who cannot have red heart containers will lose one heart.
  +
|| Removes two heart containers. if Isaac has 0 or 1 heart containers, the pill becomes Health Up and if he has 2 with no other types of health, they are removed and he is given half a soul heart.
  +
|- id="Health Up"
  +
|7||Health Up
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|3||Adds one empty red heart container.
  +
|| Adds two empty red heart containers.
  +
|- id="I Found Pills"
  +
|8||I Found Pills
  +
| style="text-align:center;" |N
  +
|0||Changes the appearance of Isaac's face. This pill is cosmetic only, {{dlc|na}}and the effect disappears when Isaac leaves the room.
  +
||Isaac's face gets a permanent, very exaggerated expression resembling a horse.
  +
|- id="Puberty"
  +
|9||Puberty
  +
| style="text-align:center;" | N
  +
|0||Causes Isaac to grow four hairs from the top of his head and zits on his face. This pill is cosmetic only and will stay for the rest of the run.<br>{{dlc+|a+}} Consuming three puberty pills will grant the {{tf|Adult}} transformation, granting one red heart container and making Isaac's voice slightly deeper (one time effect).{{dlc-}}
  +
||Isaac gains very fluffy hair covering his entire head and even face.
  +
|- id="Pretty Fly"
  +
|10||[[Pretty Fly]]
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|2||Grants a fly orbital, up to 3 maximum, that circles the player, blocking projectiles and damaging [[Fly|fly-type]] enemies on touch.
  +
||Spawns a {{i|Big Fan}}. There is no upper limit. These Big Fans do not contribute towards the {{tf|Beelzebub}} transformation.
  +
  +
|- id="Range Down"
  +
|11||Range Down
  +
| style="text-align:center; background-color: #6C2121;" | -
  +
|3||{{dlc|nr}}-2.00 [[range]].<br />{{dlc|r}}-1.00 range.
  +
|| -2.00 range.
  +
|- id="Range Up"
  +
|12||Range Up
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|3||{{dlc|nr}}+2.50 range.<br />{{dlc|r}}+1.25 range.
  +
|| +2.50 range.
  +
|- id="Speed Down"
  +
|13|| Speed Down
  +
| style="text-align:center; background-color: #6C2121;" | -
  +
| 3||-0.12 [[speed]].
  +
|| -0.24 speed.
  +
|- id="Speed Up"
  +
|14||Speed Up
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|3||+0.15 speed.
  +
|| +0.30 speed.
  +
|- id="Tears Down"
  +
|15||Tears Down
  +
| style="text-align:center; background-color: #6C2121;" | -
  +
|3||-0.28 [[tears]].
  +
|| -0.56 tears.
  +
|- id="Tears Up"
  +
|16||Tears Up
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|3||+0.35 tears.
  +
|| +0.70 tears.
  +
|- id="Luck Down"
  +
|17||Luck Down
  +
| style="text-align:center; background-color: #6C2121;" | -
  +
|3|| -1 [[luck]].
  +
|| -2 luck.
  +
|- id="Luck Up"
  +
|18||Luck Up
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|3||+1 luck.
  +
|| +2 luck.
  +
|- id="Telepills"
  +
|19|| Telepills
  +
| style="text-align:center;" | N
  +
|1|| Teleports Isaac to a random [[room]]. Has a small chance to teleport Isaac to the {{R|I AM ERROR}} room, and an extremely small chance to teleport him to the {{R|Black Market}}, like {{i|Undefined}}. {{Dlc|nr}}Unobtainable in [[Greed Mode]].
  +
{{dlc|r}} Using a Telepills in the mirrored version of {{S|Downpour}}/{{S|Dross}} II has a chance to teleport Isaac to an {{R|Ultra Secret Room}}.
  +
||No difference.
  +
|- id="48 Hour Energy"
  +
|20||48 Hour Energy
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|2||Drops one to two {{E|Lil' Battery|display=Lil' Batteries}} and fully charges the [[activated collectible|spacebar item]]. {{dlc|anr}} Can be used with {{i|Placebo|x}} or {{i|D1}} to generate infinite batteries.
  +
||Spawns 3-4 batteries.
  +
|- id="Hematemesis"
  +
|21||Hematemesis
  +
| style="text-align:center;" |N
  +
|2||Sets Isaac's red heart health to 1, then spawns 1-4 {{E|Red Heart}}s. This fills Isaac's first red heart container (even if Isaac's red health is less than 1) and empties the rest, including {{E|Bone Heart}}s. This effect does not count as damage. If used without any red heart containers, no health will be deducted, but red hearts will still spawn. If used in a{{R|Super Secret Room}} containing a{{E|Black Heart}} or {{E|Eternal Heart}}, it will spawn those types of hearts instead.
  +
||Spawns 4-7 hearts.
  +
|- id="Paralysis"
  +
|22 ||Paralysis
  +
| style="text-align:center; background-color: #6C2121;" | -
  +
| 1||Prevents Isaac from moving and shooting for 2 seconds.
  +
||The effect lasts 4 seconds.
  +
|- id="I can see forever!"
  +
|23||I can see forever!
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|2||Opens all entrances to the {{R|Secret Room}} and {{R|Super Secret Room}} for the current floor.
  +
||In addition to the normal effect, fully reveals the map like {{i|The Mind}}.
  +
|- id="Pheromones"
  +
|24||Pheromones
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|1||[[Status Effects#Charm|Charms]] all enemies in the room for a short period of time.
  +
||The charm is permanent, turning the enemies [[Status Effects#Friendly|friendly]].
  +
|- id="Amnesia"
  +
|25 ||Amnesia
  +
| style="text-align:center; background-color: #6C2121;" | -
  +
| 2||Replaces [[map|the floor map]] with a ? for the rest of the floor, identical to the effect of Curse of the Lost. If no other [[curse]]s are active for the floor, the Curse of the Lost will appear under the level name when the map key is held. This effect can be negated by picking up {{i|Black Candle}}, but will not prevent future uses of the Amnesia pill from giving the Curse of the Lost effect. {{dlc|a}} Also the only pill to have its flavor text appear on a piece of paper as curses do.
  +
||No difference.
  +
|- id="Lemon Party"
  +
|26|| Lemon Party
  +
| style="text-align:center;" |N
  +
|3||Spawns [[Creep#Yellow Creep|a large yellow pool]] (similar to {{i|Lemon Mishap}}) around Isaac. Greatly damages any enemy that steps on it, for 22 damage per tick or 66 damage per second.
  +
||The puddle is larger, covering nearly the entire room if used near the center.
  +
|- id="R U a Wizard?"
  +
|27||R U a Wizard?
  +
| style="text-align:center; background-color: #6C2121;" | -
  +
|1||Tears are shot diagonally outwards for 30 seconds, making it much harder to aim. This effect will persist between rooms until it wears off.
  +
||The effect lasts for 60 seconds.
 
|-
  
|-
  +
! colspan="6" |'''{{dlc|a}} [[Afterbirth]]'''
−
| 0 || Bad Gas || style="text-align: left" | Isaac farts, dealing 5 damage and [[poison]]ing enemies around him.
  
  +
|- id="Percs!"
  +
| 28||{{unlockable}} {{Anchor|Percs!}}
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
| 1|| For the duration of the room, taking damage only removes a half-heart from Isaac's HP, regardless of the source of the damage. (Similar effect to{{i|The Wafer}}'s)<br />Unlocked by: {{A|2 new pills|unlock}}.
  +
||No difference.
  +
|- id="Addicted!"
  +
|29||{{unlockable}} Addicted!
  +
| style="text-align:center; background-color: #6C2121;" | -
  +
|1||For the duration of the room, taking damage removes a full heart from Isaac's HP, regardless of the source of the damage. Also changes Isaac's appearance for the room.<br />Unlocked by: {{A|2 new pills|unlock}}.
  +
||No difference.
  +
|- id="Re-Lax"
  +
| 30||{{unlockable}} Re-Lax
  +
| style="text-align:center;" |N
  +
| 0|| Spawns {{E|Poop}} at Isaac's position for a few seconds. A higher speed stat means Isaac can cover more tiles in poop in the same time. A pun on laxatives.<br />Unlocked by: {{A|2 new pills 2|unlock}}.
  +
||The effect lasts much longer.
  +
|- id="???"
  +
| 31||{{unlockable}} ???
  +
| style="text-align:center; background-color: #6C2121;" | -
  +
|1||Gives the Curse of the Maze effect for the remainder of the floor. The effect can stack with other [[curse]]s. If no other [[curse]]s are active for the floor, Curse of the Maze will appear under the level name when Tab is held. This effect can be negated by picking up {{i|Black Candle}}, but will not prevent future uses of the ??? pill from giving the Curse of the Maze effect. As the pill's name is "???", the same as what unidentified pills are referred to, it is easy to accidentally use it more than once per run. It is recommended to memorize its color upon first using it.<br />Unlocked by: {{A|2 new pills 2|unlock}}.
  +
||No difference.
  +
|- id="One makes you larger"
  +
| 32||One makes you larger
  +
| style="text-align:center;" |N
  +
|1||Increases Isaac's size and decreases the pitch of his voice. This effect does not increase the size of Isaac's hitbox, but increases the size of {{C|The Forgotten}}'s bone club. {{dlc|a+}} These pills contribute to the [[Stompy]] transformation.
  +
||Size increases by two steps.
  +
|- id="One makes you small"
  +
|33|| One makes you small
  +
| style="text-align:center;" |N
  +
|1||Decreases Isaac's size and increases the pitch of his voice. This effect decreases the size of Isaac's hitbox; a small enough hitbox allows Isaac to walk "under" certain projectiles to avoid them.
  +
||Size decreases by two steps.
  +
|- id="Infested!"
  +
|34||Infested!
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|1||Destroys all poop in the room and spawns a single [[blue spider]] under Isaac and on each destroyed poop.
  +
||Double the number of spiders spawned.
  +
|- id="Infested?"
  +
|35 ||Infested?
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
  +
|1
  +
|Spawns [[blue spider]]s equal to the number of enemies in the room. If there are no enemies in the room, spawns 1-3 Blue Spiders.
  +
||Double the number of spiders spawned.
  +
|- id="Power Pill!"
  +
| 36||Power Pill!
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|1|| Temporarily grants [[invulnerability]], inflicts [[Status Effects#Fear|fear]] on enemies in the room, lets Isaac deal contact damage, and has a chance to replenish a {{e|Half Red Heart}} every time an enemy is killed, similar to {{i|The Gamekid}}.
  +
||In addition to the normal effect, grants {{p|Huge Growth}} for +7 flat damage and +3 range. The Huge Growth bonus persists after the Gamekid wears off.
  +
|- id="Retro Vision"
  +
| 37||Retro Vision
  +
| style="text-align:center; background-color: #6C2121;" | -
  +
| 1||{{dlc|nr}}Applies a pixelating filter on the screen 3 times over 30 seconds. The effect continues between floors.
  +
{{dlc|r}}Pixelates the screen and degrades colors for 30 seconds.
  +
||The effect lasts 90 seconds, with no breaks.
  +
|- id="Friends Till The End!"
  +
|38||Friends Till The End!
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|1||Spawns three [[blue fly|blue flies]].
  +
||Spawns 12 blue flies.
 
|-
  
|-
  +
! colspan="6" |'''{{dlc|a+}} [[Afterbirth †]]'''
−
| 1 || Bad Trip || style="text-align: left" | Injures Isaac by a full heart. If a Bad Trip pill is used while Isaac only has a single heart left or less, the pill will turn into a Full Health pill instead.
  
  +
|- id="X-Lax"
  +
|39||X-Lax
  +
| style="text-align:center; background-color: #6C2121;" | -
  +
|0||Creates a pool of slippery [[Creep#Brown Creep|brown creep]] underneath Isaac.
  +
||The pool lasts much longer.
  +
|- id="Something's wrong..."
  +
|40||Something's wrong...
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
| 0||Creates a pool of [[Creep#Black Creep|black creep]] beneath Isaac that slows enemies.
  +
||The pool lasts much longer.
  +
|- id="I'm Drowsy..."
  +
|41||I'm Drowsy...
  +
| style="text-align:center;" |N
  +
|1||{{dlc|nr}} Slows all enemies for the duration of the room.<br>{{dlc|r}} Applies the {{i|Stop Watch}} effect, slowing all enemies, Isaac, and the background music as well as additionally applying the Slowness status effect on every enemy for the duration of the room.
  +
||No difference.
  +
|- id="I'm Excited!!!"
  +
|42||I'm Excited!!!
  +
| style="text-align:center;" |N
  +
|1||{{dlc|nr}} Increases the speed of all enemies for the duration of the room.<br>{{dlc|r}} Increases the speed of all enemies, Isaac, and the background music for the duration of the room.<br>The effect triggers again three additional times.
  +
||No difference.
  +
|- id="Gulp!"
  +
|43||{{unlockable}} {{Anchor|Gulp!}}
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|2||Destroys any [[trinkets]] held by Isaac and grants their effects permanently.<br />Unlocked by: {{A|Once More with Feeling!|unlock}}.
  +
|| Heals one red heart per gulped trinket (Up to 2 at the same time with {{i|Mom's purse}}). No effect for characters who cannot have red hearts. This counts for two gulp pills toward the {{I|Marbles}} achievement.
  +
|- id="Horf!"
  +
|44||{{unlockable}} Horf!
  +
| style="text-align:center;" |N
  +
|0||Isaac shoots an explosive tear with the {{i|Ipecac}} effect that always deals 200 damage.<br />Unlocked by: {{A|Dedication|unlock}}.
  +
||Isaac shoots a cluster of 6 Horf! tears with 150-400 damage per tear, resulting in an average of 1650 damage if all tears or their explosions hit.
  +
|- id="Feels like I'm walking on sunshine!"
  +
|45 ||{{unlockable}} Feels like I'm walking on sunshine!
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|1||Temporarily makes Isaac invincible, similar to {{I|Unicorn Stump}}.<br />Unlocked by: {{A|Sin Collector|unlock}}.
  +
||The effect is upgraded to {{i|The Gamekid}}'s.
  +
|- id="Vurp!"
  +
|46||{{unlockable}} Vurp!
  +
| style="text-align:center; background-color: #124b1b;" | +
  +
|2||Spawns the last pill used. Will spawn itself if no other pills were taken beforehand, or if Vurp! was the last pill used.<br />Unlocked by: {{A|U Broke It!|unlock}}.
  +
||If the last pill was a normal pill, it becomes a horse pill. No further difference on horse pills themselves.
 
|-
  
|-
  +
! colspan="6" |'''{{dlc|r}} [[Repentance]]'''
−
| 2 || Balls of Steel || style="text-align: left" | Grants Isaac two soul hearts.
  
  +
|- id="Shot Speed Down"
−
|-
  
  +
|47||Shot Speed Down
−
| 3 || Bombs Are Key || style="text-align: left" | Swaps the values of Isaac's bombs and keys.
  
  +
| style="text-align:center; background-color: #6C2121;" | -
−
|-
  
  +
|1||-0.15 [[shot speed]].
−
| 4 || Explosive Diarrhea || style="text-align: left" | Spawns five active bombs behind Isaac over a period of five seconds, at one a second.
  
  +
|| -0.30 shot speed.
−
|-
  
  +
|- id="Shot Speed Up"
−
| 5 || Full Health || style="text-align: left" | Refills every empty [[red heart]] container.
  
  +
|48||Shot Speed Up
−
|-
  
  +
| style="text-align:center; background-color: #124b1b;" | +
−
| 6 || Health Down || style="text-align: left" | Removes one red heart container upon use. While Isaac has one or fewer red heart containers, it will act as a ''Health Up'' pill instead. [[??? (Character)|???]] can encounter Health Down pills, even though he can't have red heart containers.
  
  +
| 1||+0.15 shot speed.
−
|-
  
  +
|| +0.30 shot speed.
−
| 7 || Health Up || style="text-align: left" | Adds one empty red heart container upon use.
  
  +
|- id="Experimental Pill"
−
|-
  
  +
|49 ||Experimental Pill
−
| 8 || I Found Pills || style="text-align: left" | Changes the appearance of Isaac's face. This pill is cosmetic only, {{dlc|na}}, and the effect disappears when you leave the room.
  
  +
| style="text-align:center;" |N
−
|-
  
  +
|3||Increases one [[attribute]] and decreases another randomly, with the same power as normal attribute up/down pills. Will not reduce any attributes if taken with {{i|Lucky Foot}}, {{I|PHD}} or {{i|Virgo}}. Will not increase any attribute if taken with {{I|False PHD|n}}. If a pill-improving item is combined with False PHD, the pill gives an attribute increase, a decrease and a damage up.
−
| 9 || Puberty || style="text-align: left" | Causes Isaac to grow four hairs from the top of his head and zits on his face. This pill is cosmetic only and will stay for the rest of the run.<br>{{dlc|a+}} Consuming three puberty pills will grant the [[Adult]] transformation, granting one red heart container (one time effect).
  
  +
||The two effects are doubled in power.
−
|-
  
  +
|}
−
| 10 || [[Pretty Fly]] || style="text-align: left" | Grants a fly orbital, up to 3 maximum, that circles the player, blocking projectiles and damaging [[Fly|fly-type]] enemies on touch.
  
−
|-
  
−
| 11 || Range Down || style="text-align: left" | Decreases Isaac's range by 2.
  
−
|-
  
−
| 12 || Range Up || style="text-align: left" | Increases Isaac's range by 2.5.
  
−
|-
  
−
| 13 || Speed Down || style="text-align: left" | Decreases Isaac's movement speed by 0.12.
  
−
|-
  
−
| 14 || Speed Up || style="text-align: left" | Increases Isaac's movement speed by 0.15.
  
−
|-
  
−
| 15 || Tears Down || style="text-align: left" | Decreases Isaac's tears by 0.28.
  
−
|-
  
−
| 16 || Tears Up || style="text-align: left" | Increases Isaac's tears by 0.35.
  
−
|-
  
−
| 17 || Luck Down || style="text-align: left" | Decreases Isaac's luck by 1.
  
−
|-
  
−
| 18 || Luck Up || style="text-align: left" | Increases Isaac's luck by 1.
  
−
|-
  
−
| 19 || Telepills || style="text-align: left" | Isaac gets teleported to a random room. Has a small chance to teleport Isaac to the [[I AM ERROR]] room, and an extremely small chance to teleport him to the [[Black Market]], like {{i|Undefined}}. Unobtainable in [[Greed Mode]].
  
−
|-
  
−
| 20 || 48 Hour Energy || style="text-align: left" | Drops one to two [[little battery|little batteries]] and fully charges the [[activated collectible|spacebar item]]. {{dlc|a}} Can be used with the {{i|Placebo}} or {{i|D1}} to generate infinite batteries.
  
−
|-
  
−
| 21 || Hematemesis || style="text-align: left" | Empties all but one red heart container and spawns 1-4 [[red heart]]s. If Isaac only has half of a heart left, it will heal him to one heart. If used without any red heart containers, no health will be deducted, but red hearts will still spawn. If used in a [[black heart]] or [[eternal heart]]-containing [[super secret room]], it will spawn those types of hearts instead.
  
−
|-
  
−
| 22 || Paralysis || style="text-align: left" | Prevents Isaac from moving and shooting for 2 seconds.
  
−
|-
  
−
| 23 || I can see forever! || style="text-align: left" | Opens all entrances to the [[secret room]] and [[super secret room]] for the current floor.
  
−
|-
  
−
| 24 || Pheromones || style="text-align: left" | [[Charm]]s all enemies in the room for a short period of time.
  
−
|-
  
−
| 25 || Amnesia || style="text-align: left" | Replaces [[map|the floor map]] with a ? for the rest of the floor. If no other [[curse]]s are active for the floor, the Curse of the Lost will appear under the level name when the map key is held. This effect cannot be negated by {{i|Black Candle}}. {{dlc|a}} Also the only pill to have its flavor text appear on a piece of paper as curses do.
  
−
|-
  
−
| 26 || Lemon Party || style="text-align: left" | Spawns a large yellow pool (similar to {{i|Lemon Mishap}}) around your character. Greatly damages any enemy that steps on it, for 22 damage per tick or 66 damage per second.
  
−
|-
  
−
| 27 || R U a Wizard? || style="text-align: left" | Tears are shot diagonally outwards for about 30 seconds. This effect does not reset upon exiting the room.
  
−
|-
  
−
! colspan="3" | '''{{dlc|a}} [[Afterbirth]]'''
  
−
|-
  
−
| 28 || {{unlockable}} Percs! || style="text-align: left" | Gives {{i|The Wafer}} effect while in the room : reduces all damage taken to half a heart.<br>Unlocked by completing Challenge #24: [[PAY TO PLAY]].
  
−
|-
  
−
| 29 || {{unlockable}} Addicted! || style="text-align: left" | Makes Isaac take a full heart of damage from all sources for the current room. Also changes his appearance for the room.<br>Unlocked by completing Challenge #24: [[PAY TO PLAY]].
  
−
|-
  
−
| 30 || {{unlockable}} Re-Lax || style="text-align: left" | For a short time, poop spawns wherever Isaac moves, like Explosive Diarrhea but with poop. A higher move speed means you can touch more tiles in the same time. A pun on laxatives.<br>Unlocked by completing Challenge #25: [[Have a Heart]].
  
−
|-
  
−
| 31 || {{unlockable}} ??? || style="text-align: left" | Gives the Curse of the Maze effect for the remainder of the floor. The effect can stack with other [[curse]]s. If no other [[curse]]s are active for the floor, Curse of the Maze will appear under the level name when Tab is held. This effect cannot be negated by {{i|Black Candle}}. As the pill's name is "???", the same as what unidentified pills are referred to, it is easy to accidentally use it more than once per run. It is recommended to memorize its color upon first using it.<br>Unlocked by completing Challenge #25: [[Have a Heart]].
  
−
|-
  
−
| 32 || One makes you larger || style="text-align: left" | Increases Isaac's size and decreases the pitch of his voice. This effect does not increase the size of Isaac's hitbox but will increase the size of [[The Forgotten|The Forgotten's]] bone club. {{dlc|a+}} These pills contribute to the [[Stompy]] transformation.
  
−
|-
  
−
| 33 || One makes you small || style="text-align: left" | Decreases Isaac's size and increases the pitch of his voice. This effect decreases the size of Isaac's hitbox.
  
−
|-
  
−
| 34 || Infested! || style="text-align: left" | Destroys all poop in the room and spawns a single [[blue spider]] under Isaac and on each destroyed poop.
  
−
|-
  
−
| 35 || Infested? || style="text-align: left" | Spawns [[blue spider]]s equal to the number of enemies in the room. If there are no enemies in the room, spawns 1-3 Blue Spiders.
  
−
|-
  
−
| 36 || Power Pill! || style="text-align: left" | Temporarily grants invulnerability, inflicts fear on enemies in the room, and lets Isaac deal contact damage, similar to {{i|The Gamekid}}.
  
−
|-
  
−
| 37 || Retro Vision || style="text-align: left" | Pixelates the screen 3 times over 30 seconds. The effect continues between floors.
  
−
|-
  
−
| 38 || Friends Till The End! || style="text-align: left" | Spawns three [[blue fly|blue flies]].
  
   
  +
==Pill Appearances ==
  +
{| class="mw-collapsible mw-collapsed wikitable striped" style="text-align: center"
  +
! colspan="2" |'''Normal Pills'''
  +
! colspan="2" |{{dlc|r}}'''Horse Pills'''
 
|-
  
|-
  +
!'''ID'''
−
! colspan="3" | '''{{dlc|a+}} [[Afterbirth †]]'''
  
  +
!'''Appearance'''
  +
!'''ID'''
  +
!'''Appearance'''
 
|-
  
|-
  +
|{{ghost|5.70.}}1||[[file:BlueBlue.png|38px|link=]]||{{ghost|5.70.}}2049||[[file:Horse Pill Blue-Blue icon.png|50px|link=]]
−
| 39 || X-Lax || style="text-align: left" | Creates a pool of slippery brown [[creep]] underneath Isaac.
  
 
|-
  
|-
  +
|{{ghost|5.70.}}2||[[file:WhiteBlue.png|38px|link=]]||{{ghost|5.70.}}2050||[[file:Horse Pill White-Blue icon.png|50px|link=]]
−
| 40 || Something's wrong... || style="text-align: left" | Creates a pool of black [[creep]] beneath Isaac that slows enemies.
  
 
|-
  
|-
  +
|{{ghost|5.70.}}3||[[file:OrangeOrange.png|38px|link=]]||{{ghost|5.70.}}2051||[[file:Horse Pill Orange-Orange icon.png|50px|link=]]
−
| 41 || I'm Drowsy... || style="text-align: left" | Slows all enemies for the duration of the room.
  
 
|-
  
|-
  +
|{{ghost|5.70.}}4||[[file:pill WhiteWhite.png|38px|link=]]||{{ghost|5.70.}}2052||[[file:Horse Pill White-White icon.png|50px|link=]]
−
| 42 || I'm Excited!!! || style="text-align: left" | Increases the speed of all enemies for the duration of the room. The effect triggers again 30 seconds after use and 60 seconds after use.
  
 
|-
  
|-
  +
|{{ghost|5.70.}}5||[[file:RedSpecled.png|38px|link=]]||{{ghost|5.70.}}2053||[[file:Horse Pill Dots-Red icon.png|50px|link=]]
−
| 43 || {{unlockable}} Gulp! || style="text-align: left" | Any trinkets that the player is holding are destroyed, and their effects are permanently applied to the player.<br>Unlocked by acquiring the [[Once More With Feeling!]] achievement.
  
 
|-
  
|-
  +
|{{ghost|5.70.}}6||[[file:WhiteRed.png|38px|link=]]||{{ghost|5.70.}}2054||[[file:Horse Pill Pink-Red icon.png|50px|link=]]
−
| 44 || {{unlockable}} Horf! || style="text-align: left" | Isaac shoots an explosive tear with the {{i|Ipecac}} effect that always deals 200 damage.<br>Unlocked by acquiring the [[Dedication]] achievement.
  
 
|-
  
|-
  +
|{{ghost|5.70.}}7||[[file:BlueCyan.png|38px|link=]]||{{ghost|5.70.}}2055||[[file:Horse Pill Blue-Cadetblue icon.png|50px|link=]]
−
| 45 || {{unlockable}} Feels like I'm walking on sunshine! || style="text-align: left" | Temporarily makes Isaac invincible, similar to {{i|Unicorn Stump}}.<br>Unlocked by acquiring the [[Sin Collector]] achievement.
  
 
|-
  
|-
  +
|{{ghost|5.70.}}8||[[file:YellowOrange.png|38px|link=]]||{{ghost|5.70.}}2056||[[file:Horse Pill Yellow-Orange icon.png|50px|link=]]
−
| 46 || {{unlockable}} Vurp! || style="text-align: left" | Throws up the last pill you used. Will spawn itself if no other pills were taken beforehand.<br>Unlocked by acquiring the [[U Broke It!]] achievement.
  
−
|}
  
−  
−
== Pill appearances ==
  
−
{| class="mw-collapsible mw-collapsed wikitable striped" style="text-align: center"
  
−
! '''ID'''
  
−
! '''Pill'''
  
 
|-
  
|-
−
| 1 || [[file:BlueBlue.png|38px|link=]]
+
|{{ghost|5.70.}}9||[[file:SpottedwhiteWhite.png|38px|link=]]||{{ghost|5.70.}}2057||[[file:Horse Pill Dots-White icon.png|50px|link=]]
 
|-
  
|-
  +
! colspan="4" |'''{{dlc|a}} [[Afterbirth]]'''
−
| 2 || [[file:WhiteBlue.png|38px|link=]]
  
 
|-
  
|-
  +
|{{ghost|5.70.}}10||[[file:pill White Cyan.png|38px|link=]]||{{ghost|5.70.}}2058||[[file:Horse Pill White-Azure icon.png|50px|link=]]
−
| 3 || [[file:OrangeOrange.png|38px|link=]]
  
 
|-
  
|-
−
| 4 || [[file:pill WhiteWhite.png|38px|link=]]
 +
|{{ghost|5.70.}}11||[[file:pill Black Yellow.png|38px|link=]]||{{ghost|5.70.}}2059||[[file:Horse Pill Black-Yellow icon.png|50px|link=]]
 
|-
  
|-
  +
|{{ghost|5.70.}}12||[[file:pill Black White.png|38px|link=]]||{{ghost|5.70.}}2060||[[file:Horse Pill White-Black icon.png|50px|link=]]
−
| 5 || [[file:RedSpecled.png|38px|link=]]
  
 
|-
  
|-
  +
|{{ghost|5.70.}}13||[[file:Pill White Yellow.png|38px|link=]]||{{ghost|5.70.}}2061||[[file:Horse Pill White-Yellow icon.png|50px|link=]]
−
| 6 || [[file:WhiteRed.png|38px|link=]]
  
 
|-
  
|-
  +
! colspan="4" |'''{{dlc|r}} [[Repentance]]'''
−
| 7 || [[file:BlueCyan.png|38px|link=]]
  
 
|-
  
|-
  +
|{{ghost|5.70.}}14 ||[[file:Golden Pill icon.png|38px|link=]]||{{ghost|5.70.}}2062||[[file:Golden Horse Pill icon.png|50px|link=]]
−
| 8 || [[file:YellowOrange.png|38px|link=]]
  
−
|-
  
−
| 9 || [[file:SpottedwhiteWhite.png|38px|link=]]
  
−
|-
  
−
! colspan="2" | '''{{dlc|a}} [[Afterbirth]]'''
  
−
|-
  
−
| 10 || [[file:pill White Cyan.png|38px|link=]]
  
−
|-
  
−
| 11 || [[file:pill Black Yellow.png|38px|link=]]
  
−
|-
  
−
| 12 || [[file:pill Black White.png|38px|link=]]
  
−
|-
  
−
| 13 || [[file:pill White Yellow.png|38px|link=]]
  
 
|}
  
|}
   
−
== Notes ==
 +
=={{Dlc+|r}} Pill Classes ==
  +
[[Repentance]] introduces the mechanic of pill classes. Internally, pills are given a class from 0 to 3 and a polarity that reflects their influence:
  +
  +
Pills in class 0 have little to no impact on a run overall, while pills in higher classes are correspondingly more influential, class 3 pills having effects as significant as permanent stat changes.
  +
Classes that end with + or - denote a positive or negative effect, otherwise considered neutral.
  +
  +
This mechanic is used to balance the pill pool and avoid having too many negative or positive pills. Polarity is used by certain items to determine which pills to convert.
  +
  +
{{dlc-}}
  +
  +
=={{dlc+|r}} Gold Pills==
  +
  +
[[Repentance]] introduces '''Gold Pills''' (or Golden Pills). Using them will give a random pill effect. Gold pills only have a chance to be "used up" upon using them, which means that you can often use them many times before they finally disappear.
  +
  +
*Unlocked by: {{a|Gold Pill|unlock}}.
  +
* The possible effects are all effects that aren't in the run's pill pool, which means if you see an effect from a normal pill, you will never see it from a golden pill.
  +
*Items such as {{I|PhD}} or {{I|Lucky Foot}} which alter pill effects also work on the effects of this pill, allowing many beneficial effects to be stacked with little risk. Effects altered by these items may overlap with the effects in the run's pill pool; for example, a run might have Tears Up in the pill pool and Tears Down outside of the pill pool, which will be turned into Tears Up due to the effects of the item.
  +
*Gold Pills have an ID of 5.70.14.
  +
*A Gold Pill can also be a Horse Pill. Golden Horse Pills use the Horse Pill effect on every use.
  +
*Golden horse pills are most likely the rarest pickup in the game with a 0.06% chance of spawning instead of a normal pill.
  +
*If a Golden Pill uses the 'Vurp' effect, and no other pill was used prior, another golden pill will drop.
  +
  +
{{dlc-}}
  +
  +
=={{dlc+|r}} Horse Pills==
  +
  +
''[[Repentance]]'' introduces '''Horse Pills'''. These are larger versions of the standard pills with a more powerful effect, but only appear very rarely. Unique sound effects can be heard when they are used, and the narrator's normal spoken voice lines are instead shouted using a different voice.
  +
  +
*Unlocked by: {{a|Horse Pill|unlock}}.
  +
*All items that work with pills work identically with horse pills.
  +
*A horse pill with a given effect has the same color as the normal pill does.
  +
*Horse pills have an ID of the normal ID + 2048 (i.e. 1 << 11). For example, a white-blue pill has an ID of 2, so the horse pill version would have an ID of 5.70.2050.
  +
*It is also possible to have a golden horse pill. (It has an ID of 5.70.2062.)
  +
{{dlc-}}
  +
  +
==Probabilities==
  +
  +
Pills that spawn with a sub-type of 0 (i.e. a random pill) will have the following probabilities:
  +
  +
*Random normal pill - 97.86%
  +
*Specific normal pill - 7.53%
  +
*Gold pill - 0.7%
  +
*Random horse pill - 1.43%
  +
*Specific horse pill - 0.11%
  +
*Horse gold pill - 0.01%
  +
  +
==Notes==
 
* Among the [[attribute]] modifying pill effects, only five of the seven [[attribute|visible attributes]] are covered: health, range, tears, speed, and luck. Both shot speed and damage can't be altered by pills.
  
* Among the [[attribute]] modifying pill effects, only five of the seven [[attribute|visible attributes]] are covered: health, range, tears, speed, and luck. Both shot speed and damage can't be altered by pills.
  +
**{{dlc|r}} Shot speed can now be altered with pills. Damage can now also be altered with pills with {{I|False PHD|force=x}}.
−
* {{dlc|a}} Pill effects have a chance to be narrated upon use, as do [[card]]s and [[rune]]s.
  
  +
*If a "Health up" pill is used while Isaac has 11 empty red hearts and one non-red heart, The non-red heart will be replaced with an empty container, killing Isaac.
−
* {{dlc|a}} Currently, the "Retro Vision" pill effect can crash the game on some machines, resulting in restarting the current floor when the game is continued. The old trick to negate the effect of the pill now cancels your run and you must start fresh to prevent people cheesing out of the effect.
  
  +
*Having {{i|Midas' Touch}}, {{t|Meconium}}, or {{i|Hallowed Ground}} and using a "Re-Lax" pill has a chance to spawn {{E|Golden Poop}}, {{E|Black Poop}}, or {{E|White Poop}}, respectively.
−
* {{dlc|a}} The "Addicted!" pill will have no effect if Isaac has {{i|The Wafer}}.
  
  +
* If the item {{i|PHD}} is picked up and then lost in any way, such as rerolling by the {{i|D4}} or a {{R|Dice Room}}, or dropping it as {{dlc|r}}{{c|Tainted Isaac}}, pills will remain fully identified for the rest of the run, but negative pills will not be converted.
−
** Despite this, if one takes both the "Addicted!" pill with "Percs!" in the same room, Isaac will take a full heart of damage from all sources.
  
  +
*{{dlc|a}} Pill effects have a chance to be narrated upon use, as do [[card]]s and [[rune]]s.
−
* Having {{i|Midas' Touch}}, {{t|Meconium}}, or {{i|Hallowed Ground}} and using a "Re-Lax" pill has a chance to spawn [[golden poop]], [[black poop]], or [[white poop]], respectively.
  
−
* {{dlc|a}} Using an "Infested!" pill on [[red poop]] will spawn [[blue spider]]s and the red poop will regenerate.
 +
*{{dlc|a}} Currently, the "Retro Vision" pill effect can crash the game on some machines, resulting in restarting the current floor when the game is continued.
  +
*{{dlc|a}} The "Addicted!" pill will have no effect if Isaac has {{i|The Wafer}}.
−
* {{dlc|a}} If a Tiny or Large [[Champion]] monster drops a "One Makes You Small"/"Larger" pill and either pill is not in the current pill pool, an existing pill will be overwritten. If the chosen pill was already identified, the new pill will also be.
  
  +
**Despite this, if one takes both the "Addicted!" pill with "Percs!" in the same room, Isaac will take a full heart of damage from all sources.
−
*{{dlc|a}} "R U A Wizard" does not affect [[Lilith]]'s Incubus.
  
−
* {{dlc|a+|a}} Using a "Gulp!" pill while holding two [[trinket]]s (with {{i|Belly Button}} or {{i|Mom's Purse}}) will cause both trinkets to be absorbed. {{dlc||r}}
 +
* {{dlc|a}} Using an "Infested!" pill on {{E|red poop}} will spawn [[blue spider]]s and the red poop will regenerate.
  +
*{{dlc|a}} If a Tiny or Large [[Champion]] monster drops a "One Makes You Small"/"Larger" pill and either pill is not in the current pill pool, an existing pill will be overwritten. If the chosen pill was already identified, the new pill will also be.
−
* Isaac's hitbox can be reduced to 30% of original, which is achieved after 6 One Makes You Small pills. Further pills will only make him visually smaller, with no additional benefit.
  
  +
*{{dlc|a}} "R U A Wizard" does not affect {{C|Lilith}}'s Incubus.
  +
*{{dlc|a}}Isaac's hitbox can be reduced to 30% of original, which is achieved after 6 One Makes You Small pills. Further pills will only make him visually smaller, with no additional benefit.
  +
*{{dlc|a+|a}} Using a "Gulp!" pill while holding two [[trinket]]s (with {{i|Belly Button}} or {{i|Mom's Purse}}) will cause both trinkets to be absorbed. {{dlc||r}}
  +
*{{c|Magdalene}}'s starting pill will override one of the pills in the current run's pill set if it doesn't exist in it (Speed Up for ''Afterbirth+'', or Full Health in ''Repentance''). The pill that is converted is dependent on the run's seed.
  +
**This only applies if the run is started as Magdalene or if Magdalene is chosen as a [[Co-op|Co-op partner]], not if Isaac turns into Magdalene using {{i|Clicker}}.
  +
* {{dlc|r}}All golden pills in the run have a shared sequence of effects they activate, so reversing the effects of one golden pill through {{i|Glowing Hourglass}} and consuming another golden pill will activate the same effects.
  +
*{{dlc|r}} If a Vurp! effect is activated by a golden pill, it will spawn the last non-golden pill taken by Isaac, or a golden pill if no non-golden pills have been taken by Isaac in the run.
  +
* {{dlc|r}}If a [[Rocks#Marked Skulls|Marked Skull]] is destroyed while Isaac is holding {{i|Little Baggy}}, it will spawn a Telepill instead of {{p|0 - The Fool}}. If Telepills doesn't exist in the current run's pill set, one of the pills in the run's set will be turned into Telepills. The pill that is converted is dependent on the run's seed.
  +
**All other pills with the same color as the Telepill spawned will also be converted into Telepills for the rest of the run, even if they're currently being held by Isaac. This can also override Magdalene's starting Full Health pill.
  +
* {{dlc|r}} While transformed into{{C|The Lost}} by a [[Fire Places#White Fire Place|White Fireplace]], Health Down pills turn into Health Up pills, regardless of Isaac's number of red heart containers.
   
−
== Strategy ==
 +
==Strategy==
  +
*{{dlc|r}} There are 24 good effects, 14 neutral (sometimes good/sometimes bad) effects, and 12 negative effects. This means taking mystery pills is usually beneficial. However, you should consider not taking one if an effect like Hematemesis or Tears Down would ruin your run.
−
* Use of unidentified pills is recommended for outside of combat as Hematemesis, R U a Wizard?, Paralysis, {{dlc|a}}Addicted!, {{dlc|a+}} X-Lax, and {{dlc|a+}} I'm Excited!!! can be detrimental mid-fight. However, {{dlc|a+}} I'm Drowsy..., {{dlc|a+}} Something's wrong..., Lemon Party, Bad Gas, and Pheromones are useless outside of combat.
  
  +
*Use of unidentified pills is recommended for outside of combat as Hematemesis, R U a Wizard?, Paralysis, {{dlc|a}}Addicted!, {{dlc|a+}} X-Lax, and {{dlc|a+}} I'm Excited!!! can be detrimental mid-fight. However, {{dlc|a+}} I'm Drowsy..., {{dlc|a+}} Something's wrong..., Lemon Party, Bad Gas, and Pheromones are useless outside of combat.
−
* {{dlc|a}} Percs! can be used in the [[sacrifice room]] to reduce the damage Isaac takes, potentially allowing him to do more sacrifices. However, if Isaac is teleported to the Devil/Angel room, he loses the effect.
  
−
* {{dlc|a}} The invincibility effect from Power Pill and {{dlc|a+}} Feels like I'm walking on sunshine! can be utilized to get into [[curse room]]s, play [[blood donation machine]]s, or use [[Devil beggar]]s without taking any damage.
 +
*{{dlc|a}} Percs! can be used in the {{R|Sacrifice Room}} to reduce the damage Isaac takes, potentially allowing him to do more sacrifices. However, if Isaac is teleported to the Devil/Angel room, he loses the effect.
  +
*{{dlc|a}} The invincibility effect from Power Pill and {{dlc|a+}} Feels like I'm walking on sunshine! can be utilized to get into {{R|Curse Room}}s, play {{Machine|Blood Donation Machine}}s and {{Machine|Confessional}}s, or use {{Machine|Devil Beggar}}s and {{Machine|Hell Game}}s without taking any damage.
−
** {{dlc|a}} Percs! can be used to reduce damage from these from [[chapter 4]] onward.
  
  +
**{{dlc|a}} Percs! can be used to reduce damage from these from [[chapter 4]] onward.
  +
* {{dlc|r}}{{t|Endless Nameless}} can be used to effectively generate infinite golden pills, as the trinket's ability to respawn collectibles applies with every use.
  +
*{{dlc|r}} Taking only golden pills in a run can allow for infinite golden pill generation by repeatedly activating the Vurp! effect.
   
−
== Unlockable [[achievement]]s ==
 +
==Unlockable [[Achievement]]s==
 
{{a|Huge Growth|text}}
  
{{a|Huge Growth|text}}
 
{{a|Marbles |text}}
  
{{a|Marbles |text}}
Line 171: Line 404:
 
{{a|Lil Spewer |text}}
  
{{a|Lil Spewer |text}}
   
−
== Trivia ==
 +
== Trivia==
  +
−
* Lemon Party is an internet [[wikipedia:shock site|shock site]] featuring a group of elderly men performing oral sex.
  
−
* {{dlc|a+}} The Vurp! pill is a portmanteau of the words vomit and burp.
 +
*{{dlc|a+}} The Vurp! pill is a portmanteau of the words vomit and burp.
 
* {{dlc|a}} Power Pills activating the Gamekid effect is a reference to Pac-Man, in which the "Super-Pac" powerup is obtained by eating a Power Pellet.
  
* {{dlc|a}} Power Pills activating the Gamekid effect is a reference to Pac-Man, in which the "Super-Pac" powerup is obtained by eating a Power Pellet.
−
* "I Found Pills (and Ate Them)," "R U a Wizard?," and "I can see Forever" are all [[wikipedia:image macro|image macro]] memes.
 +
*"I Found Pills (and Ate Them)," "R U a Wizard?," and "I can see Forever" are all [[wikipedia:image macro|image macro]] memes.
  +
*{{dlc|a+}} The Feels like I'm walking on sunshine! pill is a reference to the 80s song [[wikipedia:Walking on Sunshine (Katrina and the Waves song)|Walking on Sunshine]].
−
** Despite being called I Can See Forever, the effects only last for the rest of that floor.
  
−
* {{dlc|a+}} The Feels like I'm walking on sunshine! pill is a reference to the 80s song [[wikipedia:Walking on Sunshine (Katrina and the Waves song)|Walking on Sunshine]].
 +
**Furthermore, creator Edmund McMillen made in 2010 [https://www.youtube.com/watch?v=eMIXDlvD_Yw a video with the same name], although it doesn't feature the actual Walking on Sunshine song.
−
* Balls of Steel is a reference to ''Duke Nukem''; it is one of Duke's more famous quotes.
 +
*Balls of Steel is a reference to ''Duke Nukem''; it is one of Duke's more famous quotes.
−
* Explosive Diarrhea is extremely loud and forceful [[wikipedia:diarrhea|diarrhea]]. In the original game, the message that displayed when the pill was activated was "Oh No!". The pill name and effect are likely a reference to Atomic Bomberman where a pickup of the same name would cause the player to drop bombs behind them uncontrollably for a short duration.
 +
*Explosive Diarrhea is extremely loud and forceful [[wikipedia:diarrhea|diarrhea]]. In the original game, the message that displayed when the pill was activated was "Oh No!". The pill name and effect are likely a reference to Atomic Bomberman where a pickup of the same name would cause the player to drop bombs behind them uncontrollably for a short duration.
  +
*Shot speed effects were introduced in The Binding of Isaac: Eternal Edition, after the release of Rebirth. They were finally added to Rebirth in the Repentance DLC.
  +
*Hematemesis is a medical term for [https://muschealth.org/medical-services/ddc/patients/symptoms-and-conditions/hematemesis vomiting blood].
  +
*Lemon Party is a reference to internet shock site featuring a group of elderly men performing oral sex, peeing on each other.
  +
*"Puberty" having a negative sound effect is a tongue in cheek connotation to how unpleasant that period in life can be.
 
* {{dlc|a}} Friends Till the End! was originally in the Wrath of the Lamb but removed in Rebirth, then put back into Afterbirth.
  
* {{dlc|a}} Friends Till the End! was originally in the Wrath of the Lamb but removed in Rebirth, then put back into Afterbirth.
−
* {{dlc|ana+}} Friends Till The End! is the only non-narrated pill.
 +
*{{dlc|ana+}} Friends Till The End! is the only non-narrated pill.
−
* 48 Hour Energy is a reference to the drink 5 Hour Energy.
 +
*48 Hour Energy is a reference to the drink 5 Hour Energy.
−
* {{dlc|a+}} X-Lax is a reference to the anti-constipation medicine Ex-Lax.
 +
*{{dlc|a+}} X-Lax is a reference to the anti-constipation medicine Ex-Lax.
 
* {{dlc|a}} "One makes you larger" and "One makes you small" are references to Alice in Wonderland, and the specific wording is a reference to the song White Rabbit by Jefferson Airplane.
  
* {{dlc|a}} "One makes you larger" and "One makes you small" are references to Alice in Wonderland, and the specific wording is a reference to the song White Rabbit by Jefferson Airplane.
−
* {{dlc|a}} "Percs" is a reference to a street name for the prescription drug Percocet, which is more generically known as Oxycodone. This drug is meant to be used to treat pain, but it is often abused for recreational purposes.
 +
*{{dlc|a}} "Percs" is a reference to a street name for the prescription drug Percocet, which is more generically known as Oxycodone. This drug is meant to be used to treat pain, but it is often abused for recreational purposes.
−
* {{dlc|a}} The "???" is the only pill that has 3 different narrated voice lines.
 +
*{{dlc|a}} The "???" is the only pill that has 3 different narrated voice lines.
  +
*{{dlc|r}} "Horse pills" is a slang term used to refer to large, hard to swallow pills, hence their sprites being larger than those of regular pills.
   
−
== Voiceovers ==
 +
==Voiceovers ==
−
{| class="wikitable sortable mw-collapsible mw-collapsed"
 +
{| class="wikitable sortable mw-collapsible mw-collapsed striped"
−
! Pill
 +
!Pill
−
! Voiceover
 +
! class="unsortable" |Voiceover (Standard Pills)
  +
! class="unsortable" |Voiceover (Horse Pills)
 
|-
  
|-
 
| ???
  
| ???
−
| [[file:3Question_Voiceover1.wav|thumb]]<br>[[file:3Question_Voiceover2.wav|thumb]]<br>[[file:3Question_Voiceover3.wav|thumb]]
 +
|[[file:3Question_Voiceover1.wav|thumb]][[file:3Question_Voiceover2.wav|thumb]][[file:3Question_Voiceover3.wav|thumb]]
  +
|[[File:3Question_Voiceover1HorsePill.wav|thumb]][[File:3Question_Voiceover2HorsePill.wav|thumb]][[File:3Question_Voiceover3HorsePill.wav|thumb]]
 
|-
  
|-
−
| 48 Hour Energy
 +
|48 Hour Energy
−
| [[file:48HourEnergyVoiceover.wav.wav|thumb]]
 +
|[[file:48HourEnergyVoiceover.wav|thumb]]
  +
|[[File:48HourEnergyVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
−
| Addicted
 +
|Addicted
−
| [[file:AddictedVoiceover.wav|thumb]]
 +
|[[file:AddictedVoiceover.wav|thumb]]
  +
|[[File:AddictedVoiceoverHorsePill.wav|thumb]]
  +
 
|-
  
|-
−
| Amnesia
 +
|Amnesia
−
| [[file:Amnesia.wav|thumb]]
 +
|[[file:AmnesiaVoiceover.wav|thumb]]
  +
|[[File:AmnesiaVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
−
| Bad Gas
 +
|Bad Gas
−
| [[file:BadGasVoiceover.wav|thumb]]
 +
|[[file:BadGasVoiceover.wav|thumb]]
  +
|[[File:BadGasVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
−
| Bad Trip
 +
|Bad Trip
−
| [[file:BadTripVoiceover.wav|thumb]]
 +
|[[file:BadTripVoiceover.wav|thumb]]
  +
|[[File:BadTripVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
−
| Balls of Steel
 +
|Balls of Steel
−
| [[file:BallsOfSteelVoiceover.wav|thumb]]
 +
|[[file:BallsOfSteelVoiceover.wav|thumb]]
  +
|[[File:BallsOfSteelVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
−
| Bombs Are Key
 +
|Bombs Are Key
−
| [[file:BombsAreKeyVoiceover.wav|thumb]]
 +
|[[file:BombsAreKeyVoiceover.wav|thumb]]
  +
|[[File:BombsAreKeyVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Experimental Pill
−
| Feels like I'm walking on sunshine!
  
−
| [[file:FeelsLikeImWalkingonSunshine.wav|thumb]]
 +
|[[File:ExperimentalPillVoiceover.wav|thumb]]
  +
|[[File:ExperimentalPillVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Explosive Diarrhea
−
| Friends Till the End!
  
−
| [[file:FriendsTillTheEndVoiceover.wav|thumb]]
 +
|[[file:ExplosiveDiahrreaVoiceover.wav|thumb]]
  +
|[[file:ExplosiveDiahrreaVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Feels like I'm walking on sunshine!
−
| Full Health
  
−
| [[file:FullHealthVoiceover.wav|thumb]]
 +
|[[file:FeelsLikeI'mWalkingonSunshine.wav|thumb]]
  +
|[[File:FeelsLikeI'mWalkinOnSunshineVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Friends Till the End!
−
| Gulp!
  
−
| [[file:GulpVoiceover.wav|thumb]]
 +
|[[file:FriendsTillTheEndVoiceover.wav|thumb]]
  +
|[[File:FriendsTillTheEndVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
−
| Health Down
 +
|Full Health
  +
|
−
| [[file:HealthDownVoiceover.wav|thumb]]
  
  +
[[file:FullHealthVoiceover.wav|thumb]]
  +
|[[File:FullHealthVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Gulp!
−
| Health Up
  
−
| [[file:HealthUpVoiceover.wav|thumb]]
 +
|[[file:GulpVoiceover.wav|thumb]]
  +
|[[File:GulpVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Health Down
−
| Hematemesis
  
−
| [[file:HematemisisVoiceover.wav|thumb]]
 +
|[[file:HealthDownVoiceover.wav|thumb]]
  +
|[[File:HealthDownVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Health Up
−
| Horf!
  
−
| [[file:HorfVoiceover.wav|thumb]]
 +
|[[file:HealthUpVoiceover.wav|thumb]]
  +
|[[File:HealthUpVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Hematemesis
−
| I Can See Forever
  
−
| [[file:ICanSeeForeverVoiceover1.wav|thumb]]<br>[[file:ICanSeeForever2Voiceover.wav|thumb]]
 +
|[[file:HematemesisVoiceover.wav|thumb]]
  +
|[[File:HematemesisVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Horf!
−
| I Found Pills
  
−
| [[file:IFoundPillsVoiceover.wav|thumb]]
 +
|[[file:HorfVoiceover.wav|thumb]]
  +
|[[File:HorfVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|I Can See Forever
−
| I'm Drowsy...
  
−
| [[file:I'mDrowsyVoiceover.wav|thumb]]
 +
|[[file:ICanSeeForeverVoiceover1.wav|thumb]][[file:ICanSeeForeverVoiceover2.wav|thumb]]
  +
|[[File:ICanSeeForeverVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|I Found Pills
−
| I'm Excited!!!
  
−
| [[file:ImExcitedVoiceover.wav|thumb]]
 +
|[[file:IFoundPillsVoiceover.wav|thumb]]
  +
|[[File:IFoundPillsVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|I'm Drowsy...
−
| Infested!
  
−
| [[file:InfestedExclaimVoiceover.wav|thumb]]
 +
|[[file:I'mDrowsyVoiceover.wav|thumb]]
  +
|[[File:I'mDrowsyVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|I'm Excited!!!
−
| Infested?
  
−
| [[file:InfestedQuestionVoiceover.wav|thumb]]
 +
|[[file:I'mExcitedVoiceover.wav|thumb]]
  +
|[[File:I'mExcitedVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Infested!
−
| Lemon Party
  
−
| [[file:LemonPartyVoiceover.wav|thumb]]
 +
|[[file:InfestedExclaimVoiceover.wav|thumb]]
  +
|[[File:InfestedExclaimVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Infested?
−
| Luck Down
  
−
| [[file:LuckDownVoiceover.wav|thumb]]
 +
|[[file:InfestedQuestionVoiceover.wav|thumb]]
  +
|[[File:InfestedQuestionVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Lemon Party
−
| Luck Up
  
−
| [[file:LuckUpVoiceover.wav|thumb]]
 +
|[[file:LemonPartyVoiceover.wav|thumb]]
  +
|[[File:LemonPartyVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Luck Down
−
| One Makes You Larger
  
−
| [[file:OneMakesYouLarger.wav|thumb]]
 +
|[[file:LuckDownVoiceover.wav|thumb]]
  +
|[[File:LuckDownVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Luck Up
−
| One Makes You Small
  
  +
|
−
| [[file:OneMakesYouSmallVoiceover.wav|thumb]]
  
  +
[[file:LuckUpVoiceover.wav|thumb]]
  +
|[[File:LuckUpVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|One Makes You Larger
−
| Paralysis
  
−
| [[file:ParalysisVoiceover.wav|thumb]]
 +
|[[file:OneMakesYouLargerVoiceover.wav|thumb]]
  +
|[[File:OneMakesYouLargerVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|One Makes You Small
−
| Percs
  
−
| [[file:PercsVoiceover.wav|thumb]]
 +
|[[file:OneMakesYouSmallVoiceover.wav|thumb]]
  +
|[[File:OneMakesYouSmallVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Paralysis
−
| Pheromones
  
−
| [[file:PheromonesVoiceover.wav|thumb]]
 +
|[[file:ParalysisVoiceover.wav|thumb]]
  +
|[[File:ParalysisVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Percs
−
| Power Pill
  
−
| [[file:PowerPillVoiceover.wav|thumb]]
 +
|[[file:PercsVoiceover.wav|thumb]]
  +
  +
|[[File:PercsVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Pheromones
−
| Pretty Fly
  
−
| [[file:PrettyFlyVoiceover.wav|thumb]]
 +
|[[file:PheromonesVoiceover.wav|thumb]]
  +
|[[File:PheromonesVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Power Pill
−
| Puberty
  
−
| [[file:PubertyVoiceover.wav|thumb]]
 +
|[[file:PowerPillVoiceover.wav|thumb]]
  +
|[[File:PowerPillVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Pretty Fly
−
| R U a Wizard?
  
−
| [[file:RUAWizardVoiceover.wav|thumb]]
 +
|[[file:PrettyFlyVoiceover.wav|thumb]]
  +
|[[File:PrettyFlyVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Puberty
−
| Range Down
  
−
| [[file:RangeDownVoiceover.wav|thumb]]
 +
|[[file:PubertyVoiceover.wav|thumb]]
  +
|[[File:PubertyVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|R U a Wizard?
−
| Range Up
  
−
| [[file:RangeUpVoiceover.wav|thumb]]
 +
|[[file:RUAWizardVoiceover.wav|thumb]]
  +
|[[File:RUAWizardVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Range Down
−
| Re-Lax
  
−
| [[file:RelaxVoiceover.wav|thumb]]
 +
|[[file:RangeDownVoiceover.wav|thumb]]
  +
|[[File:RangeDownVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Range Up
−
| Retro Vision
  
−
| [[file:RetroVisionVoiceover.wav|thumb]]
 +
|[[file:RangeUpVoiceover.wav|thumb]]
  +
|[[File:RangeUpVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Re-Lax
−
| Something's wrong...
  
−
| [[file:SomethingsWrongVoiceover.wav|thumb]]
 +
|[[file:ReLaxVoiceover.wav|thumb]]
  +
|[[File:ReLaxVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Retro Vision
−
| Speed Down
  
−
| [[file:SpeedDownVoiceover.wav|thumb]]
 +
|[[file:RetroVisionVoiceover.wav|thumb]]
  +
|[[File:RetroVisionVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
−
| Speed Up
 +
|Shot Speed Down
−
| [[file:SpeedUpVoiceover.wav|thumb]]
 +
|[[File:ShotSpeedDownVoiceover.wav|thumb]]
  +
|[[File:ShotSpeedDownVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Shot Speed Up
−
| Tears Down
  
−
| [[file:TearsDownVoiceover.wav|thumb]]
 +
|[[File:ShotSpeedUpVoiceover.wav|thumb]]
  +
|[[File:ShotSpeedUpVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Something's wrong...
−
| Tears Up
  
−
| [[file:TearsUpVoiceover.wav|thumb]]
 +
|[[file:Something'sWrongVoiceover.wav|thumb]]
  +
|[[File:Something'sWrongVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Speed Down
−
| Telepills
  
−
| [[file:TelepillsVoiceover.wav|thumb]]
 +
|[[file:SpeedDownVoiceover.wav|thumb]]
  +
|[[File:SpeedDownVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
  +
|Speed Up
−
| Vurp!
  
−
| [[file:VurpVoiceover.wav|thumb]]
 +
|[[file:SpeedUpVoiceover.wav|thumb]]
  +
|[[File:SpeedUpVoiceoverHorsePill.wav|thumb]]
  +
|-
  +
|Tears Down
  +
|[[file:TearsDownVoiceover.wav|thumb]]
  +
|[[File:TearsDownVoiceoverHorsePill.wav|thumb]]
  +
|-
  +
|Tears Up
  +
|[[file:TearsUpVoiceover.wav|thumb]]
  +
|[[File:TearsUpVoiceoverHorsePill.wav|thumb]]
  +
|-
  +
|Telepills
  +
|[[file:TelepillsVoiceover.wav|thumb]]
  +
|[[File:TelepillsVoiceoverHorsePill.wav|thumb]]
  +
|-
  +
|Vurp!
  +
|[[file:VurpVoiceover.wav|thumb]]
  +
|[[File:VurpVoiceoverHorsePill.wav|thumb]]
 
|-
  
|-
 
| X-Lax
  
| X-Lax
−
| [[file:XLaxVoiceover.wav|thumb]]
 +
|[[file:XLaxVoiceover.wav|thumb]]
  +
|[[File:XLaxVoiceoverHorsePill.wav|thumb]]
 
|}
  
|}
   
  +
==Gallery==
−
{{nav|fr=pilules}}
  
  +
*[https://youtu.be/7nA5y4ODeCk YouTube - Pills in Repentance - What is New? What Has Changed?]
−
[[category:mechanics]]
  
  +
*[https://youtu.be/kO9n3oV-ZUk YouTube - All Horse Pills/Giant Pills (With Sound)]
−
[[category:objects]]
  
  +
* [https://youtu.be/wuqJlLRzFYU YouTube - NEW Horse Pills]
  +
  +
==Bugs==
  +
{{bug|dlc=a|Any blue flies and blue spiders created by pill effects can be multiplied when {{i|Glowing Hourglass|n}} teleports Isaac in a way that does not move him to a different room from the one he is currently in (such as by teleporting to the previous room then using it again).{{dlc-}}}}
  +
  +
{{nav|fr=pilules|mega satan unlock|tainted cain unlock|tainted eve unlock}}
  +
[[Category:Mechanics]]
  +
[[Category:Objects]]

Latest revision as of 06:07, 5 February 2024

Pickups
Hearts Coins Bombs Keys Batteries Pills Cards/Runes Chests (except in Rebirth) Sacks

Pills are pickups that can provide useful or inhibiting effects. They take up the same slot as cards and runes.

At the start of each run, an effect is randomly assigned to each color of pill. The pill effect for each color will remain constant throughout the run. (However, it is possible for Collectible PHD iconPHD, Collectible Virgo iconVirgo, (in Repentance)Collectible False PHD iconFalse PHD, or (in Repentance)Collectible Lucky Foot iconLucky Foot to reassign some of the effects, such that 2 different colored pills will have the same effect.) Pills start the game unidentified (unless the player is holding Collectible PHD iconPHD or (in Repentance)Collectible False PHD iconFalse PHD); their effect is shown as "???" when picked up. Upon using a particular pill for the first time, its effect will be revealed and all subsequent pills with the same color will have their effect shown as well. The set of pill effects for any given run is usually known as the pill pool.

  • (except in Rebirth) The pill pool for each run has increased from 9 to 13.

Pill Effects[ | ]

ID Pill (in Repentance) Polarity (in Repentance) Class Effect (in Repentance) Horse Pill Effect
0 Bad Gas N 1 Isaac farts, dealing 5 damage and poisoning enemies around him. The poison affects all enemies in the room.
1 Bad Trip - 2 Deals a full heart of damage to Isaac. Using a Bad Trip pill while Isaac only has a single heart left or less turns it into a Full Health pill.
(in Repentance) This doesn't count as damage for the purposes of Devil RoomDevil Room/Angel RoomAngel Room generation odds or score reduction. 		Deals two hearts of damage. If Isaac would not survive, the pill becomes Full Health.
2 Balls of Steel + 2 Grants Isaac two soul hearts. Grants four soul hearts.
3 Bombs Are Key N 2 Swaps the values of Isaac's BombBombs and KeyKeys.
(in Repentance)The effects of (except in Rebirth) Golden BombGolden Bombs and Golden KeyGolden Keys are also swapped. 		The number of bombs and keys is increased by 50% while swapping.
4 Explosive Diarrhea N 1 Spawns a lit bomb behind Isaac every second for five seconds. Spawns more bombs with the effects of Collectible Mr. Mega iconMr. Mega and Collectible Bobby-Bomb iconBobby-Bomb.
5 Full Health + 2 Refills every empty red heart container. Fully heals and grants 3 soul hearts.
6 Health Down - 3 Removes one red heart container. Acts as a Health Up pill if Isaac has one or fewer red heart containers. Characters who cannot have red heart containers will lose one heart. Removes two heart containers. if Isaac has 0 or 1 heart containers, the pill becomes Health Up and if he has 2 with no other types of health, they are removed and he is given half a soul heart.
7 Health Up + 3 Adds one empty red heart container. Adds two empty red heart containers.
8 I Found Pills N 0 Changes the appearance of Isaac's face. This pill is cosmetic only, (in Rebirth)and the effect disappears when Isaac leaves the room. Isaac's face gets a permanent, very exaggerated expression resembling a horse.
9 Puberty N 0 Causes Isaac to grow four hairs from the top of his head and zits on his face. This pill is cosmetic only and will stay for the rest of the run.
(in Afterbirth † and Repentance) Consuming three puberty pills will grant the AdultAdult transformation, granting one red heart container and making Isaac's voice slightly deeper (one time effect). 		Isaac gains very fluffy hair covering his entire head and even face.
10 Pretty Fly + 2 Grants a fly orbital, up to 3 maximum, that circles the player, blocking projectiles and damaging fly-type enemies on touch. Spawns a Collectible Big Fan iconBig Fan. There is no upper limit. These Big Fans do not contribute towards the BeelzebubBeelzebub transformation.
11 Range Down - 3 (except in Repentance)-2.00 range.
(in Repentance)-1.00 range. 		-2.00 range.
12 Range Up + 3 (except in Repentance)+2.50 range.
(in Repentance)+1.25 range. 		+2.50 range.
13 Speed Down - 3 -0.12 speed. -0.24 speed.
14 Speed Up + 3 +0.15 speed. +0.30 speed.
15 Tears Down - 3 -0.28 tears. -0.56 tears.
16 Tears Up + 3 +0.35 tears. +0.70 tears.
17 Luck Down - 3 -1 luck. -2 luck.
18 Luck Up + 3 +1 luck. +2 luck.
19 Telepills N 1 Teleports Isaac to a random room. Has a small chance to teleport Isaac to the I AM ERRORI AM ERROR room, and an extremely small chance to teleport him to the Black MarketBlack Market, like Collectible Undefined iconUndefined. (except in Repentance)Unobtainable in Greed Mode.

(in Repentance) Using a Telepills in the mirrored version of (in Repentance)DownpourDownpour/(in Repentance)DrossDross II has a chance to teleport Isaac to an Ultra Secret RoomUltra Secret Room.

No difference.
20 48 Hour Energy + 2 Drops one to two Lil' BatteryLil' Batteries and fully charges the spacebar item. (in Afterbirth and Afterbirth †) Can be used with Collectible Placebo iconPlacebo or (in Afterbirth † and Repentance)Collectible D1 iconD1 to generate infinite batteries. Spawns 3-4 batteries.
21 Hematemesis N 2 Sets Isaac's red heart health to 1, then spawns 1-4 Red HeartRed Hearts. This fills Isaac's first red heart container (even if Isaac's red health is less than 1) and empties the rest, including (in Afterbirth † and Repentance) Bone HeartBone Hearts. This effect does not count as damage. If used without any red heart containers, no health will be deducted, but red hearts will still spawn. If used in aSuper Secret RoomSuper Secret Room containing a Black HeartBlack Heart or Eternal HeartEternal Heart, it will spawn those types of hearts instead. Spawns 4-7 hearts.
22 Paralysis - 1 Prevents Isaac from moving and shooting for 2 seconds. The effect lasts 4 seconds.
23 I can see forever! + 2 Opens all entrances to the Secret RoomSecret Room and Super Secret RoomSuper Secret Room for the current floor. In addition to the normal effect, fully reveals the map like Collectible The Mind iconThe Mind.
24 Pheromones + 1 Charms all enemies in the room for a short period of time. The charm is permanent, turning the enemies friendly.
25 Amnesia - 2 Replaces the floor map with a ? for the rest of the floor, identical to the effect of Curse of the Lost. If no other curses are active for the floor, the Curse of the Lost will appear under the level name when the map key is held. This effect can be negated by picking up Collectible Black Candle iconBlack Candle, but will not prevent future uses of the Amnesia pill from giving the Curse of the Lost effect. (except in Rebirth) Also the only pill to have its flavor text appear on a piece of paper as curses do. No difference.
26 Lemon Party N 3 Spawns a large yellow pool (similar to Collectible Lemon Mishap iconLemon Mishap) around Isaac. Greatly damages any enemy that steps on it, for 22 damage per tick or 66 damage per second. The puddle is larger, covering nearly the entire room if used near the center.
27 R U a Wizard? - 1 Tears are shot diagonally outwards for 30 seconds, making it much harder to aim. This effect will persist between rooms until it wears off. The effect lasts for 60 seconds.
(except in Rebirth) Afterbirth
28 Needs to be unlocked Percs! + 1 For the duration of the room, taking damage only removes a half-heart from Isaac's HP, regardless of the source of the damage. (Similar effect toCollectible The Wafer iconThe Wafer's)
Unlocked by: (except in Rebirth)2 new pills Complete PAY TO PLAY (challenge #24). 		No difference.
29 Needs to be unlocked Addicted! - 1 For the duration of the room, taking damage removes a full heart from Isaac's HP, regardless of the source of the damage. Also changes Isaac's appearance for the room.
Unlocked by: (except in Rebirth)2 new pills Complete PAY TO PLAY (challenge #24). 		No difference.
30 Needs to be unlocked Re-Lax N 0 Spawns PoopPoop at Isaac's position for a few seconds. A higher speed stat means Isaac can cover more tiles in poop in the same time. A pun on laxatives.
Unlocked by: (except in Rebirth)2 new pills Complete Have a Heart (challenge #25). 		The effect lasts much longer.
31 Needs to be unlocked ??? - 1 Gives the Curse of the Maze effect for the remainder of the floor. The effect can stack with other curses. If no other curses are active for the floor, Curse of the Maze will appear under the level name when Tab is held. This effect can be negated by picking up Collectible Black Candle iconBlack Candle, but will not prevent future uses of the ??? pill from giving the Curse of the Maze effect. As the pill's name is "???", the same as what unidentified pills are referred to, it is easy to accidentally use it more than once per run. It is recommended to memorize its color upon first using it.
Unlocked by: (except in Rebirth)2 new pills Complete Have a Heart (challenge #25). 		No difference.
32 One makes you larger N 1 Increases Isaac's size and decreases the pitch of his voice. This effect does not increase the size of Isaac's hitbox, but increases the size of Character The Forgotten iconThe Forgotten's bone club. (in Afterbirth † and Repentance) These pills contribute to the Stompy transformation. Size increases by two steps.
33 One makes you small N 1 Decreases Isaac's size and increases the pitch of his voice. This effect decreases the size of Isaac's hitbox; a small enough hitbox allows Isaac to walk "under" certain projectiles to avoid them. Size decreases by two steps.
34 Infested! + 1 Destroys all poop in the room and spawns a single blue spider under Isaac and on each destroyed poop. Double the number of spiders spawned.
35 Infested? + 1 Spawns blue spiders equal to the number of enemies in the room. If there are no enemies in the room, spawns 1-3 Blue Spiders. Double the number of spiders spawned.
36 Power Pill! + 1 Temporarily grants invulnerability, inflicts fear on enemies in the room, lets Isaac deal contact damage, and has a chance to replenish a Half Red HeartHalf Red Heart every time an enemy is killed, similar to Collectible The Gamekid iconThe Gamekid. In addition to the normal effect, grants (in Afterbirth † and Repentance)Huge GrowthHuge Growth for +7 flat damage and +3 range. The Huge Growth bonus persists after the Gamekid wears off.
37 Retro Vision - 1 (except in Repentance)Applies a pixelating filter on the screen 3 times over 30 seconds. The effect continues between floors.

(in Repentance)Pixelates the screen and degrades colors for 30 seconds.

The effect lasts 90 seconds, with no breaks.
38 Friends Till The End! + 1 Spawns three blue flies. Spawns 12 blue flies.
(in Afterbirth † and Repentance) Afterbirth †
39 X-Lax - 0 Creates a pool of slippery brown creep underneath Isaac. The pool lasts much longer.
40 Something's wrong... + 0 Creates a pool of black creep beneath Isaac that slows enemies. The pool lasts much longer.
41 I'm Drowsy... N 1 (except in Repentance) Slows all enemies for the duration of the room.
(in Repentance) Applies the Collectible Stop Watch iconStop Watch effect, slowing all enemies, Isaac, and the background music as well as additionally applying the Slowness status effect on every enemy for the duration of the room. 		No difference.
42 I'm Excited!!! N 1 (except in Repentance) Increases the speed of all enemies for the duration of the room.
(in Repentance) Increases the speed of all enemies, Isaac, and the background music for the duration of the room.
The effect triggers again three additional times. 		No difference.
43 Needs to be unlocked Gulp! + 2 Destroys any trinkets held by Isaac and grants their effects permanently.
Unlocked by: (in Afterbirth † and Repentance)Once More with Feeling! Complete a Victory Lap, defeating The Lamb. 		Heals one red heart per gulped trinket (Up to 2 at the same time with Collectible Mom's Purse iconMom's Purse). No effect for characters who cannot have red hearts. This counts for two gulp pills toward the (in Afterbirth † and Repentance)Collectible Marbles iconMarbles achievement.
44 Needs to be unlocked Horf! N 0 Isaac shoots an explosive tear with the Collectible Ipecac iconIpecac effect that always deals 200 damage.
Unlocked by: (in Afterbirth † and Repentance)Dedication Participate in 31 Daily Challenges (they don't have to be consecutive; it will still count if Isaac dies in the first room). 		Isaac shoots a cluster of 6 Horf! tears with 150-400 damage per tear, resulting in an average of 1650 damage if all tears or their explosions hit.
45 Needs to be unlocked Feels like I'm walking on sunshine! + 1 Temporarily makes Isaac invincible, similar to Collectible Unicorn Stump iconUnicorn Stump.
Unlocked by: (in Afterbirth † and Repentance)Sin collector Collect every entry in the Bestiary (bugged v190 - Mobs that don't exist in the bestiary are being counted. This allows Sin Collector to be unlocked without a complete bestiary). 		The effect is upgraded to Collectible The Gamekid iconThe Gamekid's.
46 Needs to be unlocked Vurp! + 2 Spawns the last pill used. Will spawn itself if no other pills were taken beforehand, or if Vurp! was the last pill used.
Unlocked by: (in Afterbirth † and Repentance)U Broke It! Obtain 50 items in a run (duplicate passive items/familiars count towards the total, e.g., multiple Collectible Breakfast iconBreakfast). 		If the last pill was a normal pill, it becomes a horse pill. No further difference on horse pills themselves.
(in Repentance) Repentance
47 Shot Speed Down - 1 -0.15 shot speed. -0.30 shot speed.
48 Shot Speed Up + 1 +0.15 shot speed. +0.30 shot speed.
49 Experimental Pill N 3 Increases one attribute and decreases another randomly, with the same power as normal attribute up/down pills. Will not reduce any attributes if taken with Collectible Lucky Foot iconLucky Foot, Collectible PHD iconPHD or Collectible Virgo iconVirgo. Will not increase any attribute if taken with Collectible False PHD iconFalse PHD. If a pill-improving item is combined with False PHD, the pill gives an attribute increase, a decrease and a damage up. The two effects are doubled in power.

Pill Appearances[ | ]

Normal Pills (in Repentance)Horse Pills
ID Appearance ID Appearance
5.70.1 BlueBlue 5.70.2049 Horse Pill Blue-Blue icon
5.70.2 WhiteBlue 5.70.2050 Horse Pill White-Blue icon
5.70.3 OrangeOrange 5.70.2051 Horse Pill Orange-Orange icon
5.70.4 Pill WhiteWhite 5.70.2052 Horse Pill White-White icon
5.70.5 RedSpecled 5.70.2053 Horse Pill Dots-Red icon
5.70.6 WhiteRed 5.70.2054 Horse Pill Pink-Red icon
5.70.7 BlueCyan 5.70.2055 Horse Pill Blue-Cadetblue icon
5.70.8 YellowOrange 5.70.2056 Horse Pill Yellow-Orange icon
5.70.9 SpottedwhiteWhite 5.70.2057 Horse Pill Dots-White icon
(except in Rebirth) Afterbirth
5.70.10 Pill White Cyan 5.70.2058 Horse Pill White-Azure icon
5.70.11 Pill Black Yellow 5.70.2059 Horse Pill Black-Yellow icon
5.70.12 Pill Black White 5.70.2060 Horse Pill White-Black icon
5.70.13 Pill White Yellow 5.70.2061 Horse Pill White-Yellow icon
(in Repentance) Repentance
5.70.14 Golden Pill icon 5.70.2062 Golden Horse Pill icon

(in Repentance) Pill Classes[ | ]

Repentance introduces the mechanic of pill classes. Internally, pills are given a class from 0 to 3 and a polarity that reflects their influence:

Pills in class 0 have little to no impact on a run overall, while pills in higher classes are correspondingly more influential, class 3 pills having effects as significant as permanent stat changes. Classes that end with + or - denote a positive or negative effect, otherwise considered neutral.

This mechanic is used to balance the pill pool and avoid having too many negative or positive pills. Polarity is used by certain items to determine which pills to convert.

(in Repentance) Gold Pills[ | ]

Repentance introduces Gold Pills (or Golden Pills). Using them will give a random pill effect. Gold pills only have a chance to be "used up" upon using them, which means that you can often use them many times before they finally disappear.

  • Unlocked by: Gold Pill Defeat Mega Satan as Character Tainted Cain iconTainted Cain.
  • The possible effects are all effects that aren't in the run's pill pool, which means if you see an effect from a normal pill, you will never see it from a golden pill.
  • Items such as Collectible PHD iconPHD or Collectible Lucky Foot iconLucky Foot which alter pill effects also work on the effects of this pill, allowing many beneficial effects to be stacked with little risk. Effects altered by these items may overlap with the effects in the run's pill pool; for example, a run might have Tears Up in the pill pool and Tears Down outside of the pill pool, which will be turned into Tears Up due to the effects of the item.
  • Gold Pills have an ID of 5.70.14.
  • A Gold Pill can also be a Horse Pill. Golden Horse Pills use the Horse Pill effect on every use.
  • Golden horse pills are most likely the rarest pickup in the game with a 0.06% chance of spawning instead of a normal pill.
  • If a Golden Pill uses the 'Vurp' effect, and no other pill was used prior, another golden pill will drop.

(in Repentance) Horse Pills[ | ]

Repentance introduces Horse Pills. These are larger versions of the standard pills with a more powerful effect, but only appear very rarely. Unique sound effects can be heard when they are used, and the narrator's normal spoken voice lines are instead shouted using a different voice.

  • Unlocked by: Horse Pill Defeat Mega Satan as Character Tainted Eve iconTainted Eve.
  • All items that work with pills work identically with horse pills.
  • A horse pill with a given effect has the same color as the normal pill does.
  • Horse pills have an ID of the normal ID + 2048 (i.e. 1 << 11). For example, a white-blue pill has an ID of 2, so the horse pill version would have an ID of 5.70.2050.
  • It is also possible to have a golden horse pill. (It has an ID of 5.70.2062.)

Probabilities[ | ]

Pills that spawn with a sub-type of 0 (i.e. a random pill) will have the following probabilities:

  • Random normal pill - 97.86%
  • Specific normal pill - 7.53%
  • Gold pill - 0.7%
  • Random horse pill - 1.43%
  • Specific horse pill - 0.11%
  • Horse gold pill - 0.01%

Notes[ | ]

  • Among the attribute modifying pill effects, only five of the seven visible attributes are covered: health, range, tears, speed, and luck. Both shot speed and damage can't be altered by pills.
    • (in Repentance) Shot speed can now be altered with pills. Damage can now also be altered with pills with Collectible False PHD iconFalse PHD.
  • If a "Health up" pill is used while Isaac has 11 empty red hearts and one non-red heart, The non-red heart will be replaced with an empty container, killing Isaac.
  • Having Collectible Midas' Touch iconMidas' Touch, (in Afterbirth † and Repentance)MeconiumMeconium, or (in Afterbirth † and Repentance)Collectible Hallowed Ground iconHallowed Ground and using a "Re-Lax" pill has a chance to spawn Golden PoopGolden Poop, (except in Rebirth) Black PoopBlack Poop, or (in Afterbirth † and Repentance) White PoopWhite Poop, respectively.
  • If the item Collectible PHD iconPHD is picked up and then lost in any way, such as rerolling by the Collectible D4 iconD4 or a Dice RoomDice Room, or dropping it as (in Repentance) Character Tainted Isaac iconTainted Isaac, pills will remain fully identified for the rest of the run, but negative pills will not be converted.
  • (except in Rebirth) Pill effects have a chance to be narrated upon use, as do cards and runes.
  • (except in Rebirth) Currently, the "Retro Vision" pill effect can crash the game on some machines, resulting in restarting the current floor when the game is continued.
  • (except in Rebirth) The "Addicted!" pill will have no effect if Isaac has Collectible The Wafer iconThe Wafer.
    • Despite this, if one takes both the "Addicted!" pill with "Percs!" in the same room, Isaac will take a full heart of damage from all sources.
  • (except in Rebirth) Using an "Infested!" pill on Red PoopRed Poop will spawn blue spiders and the red poop will regenerate.
  • (except in Rebirth) If a Tiny or Large Champion monster drops a "One Makes You Small"/"Larger" pill and either pill is not in the current pill pool, an existing pill will be overwritten. If the chosen pill was already identified, the new pill will also be.
  • (except in Rebirth) "R U A Wizard" does not affect Character Lilith iconLilith's Incubus.
  • (except in Rebirth)Isaac's hitbox can be reduced to 30% of original, which is achieved after 6 One Makes You Small pills. Further pills will only make him visually smaller, with no additional benefit.
  • (in Afterbirth † and Repentance) Using a "Gulp!" pill while holding two trinkets (with (in Afterbirth † and Repentance)Collectible Belly Button iconBelly Button or Collectible Mom's Purse iconMom's Purse) will cause both trinkets to be absorbed.
  • Character Magdalene iconMagdalene's starting pill will override one of the pills in the current run's pill set if it doesn't exist in it (Speed Up for Afterbirth+, or Full Health in Repentance). The pill that is converted is dependent on the run's seed.
    • This only applies if the run is started as Magdalene or if Magdalene is chosen as a Co-op partner, not if Isaac turns into Magdalene using (in Afterbirth † and Repentance)Collectible Clicker iconClicker.
  • (in Repentance)All golden pills in the run have a shared sequence of effects they activate, so reversing the effects of one golden pill through (except in Rebirth)Collectible Glowing Hourglass iconGlowing Hourglass and consuming another golden pill will activate the same effects.
  • (in Repentance) If a Vurp! effect is activated by a golden pill, it will spawn the last non-golden pill taken by Isaac, or a golden pill if no non-golden pills have been taken by Isaac in the run.
  • (in Repentance)If a Marked Skull is destroyed while Isaac is holding Collectible Little Baggy iconLittle Baggy, it will spawn a Telepill instead of 0 - The Fool0 - The Fool. If Telepills doesn't exist in the current run's pill set, one of the pills in the run's set will be turned into Telepills. The pill that is converted is dependent on the run's seed.
    • All other pills with the same color as the Telepill spawned will also be converted into Telepills for the rest of the run, even if they're currently being held by Isaac. This can also override Magdalene's starting Full Health pill.
  • (in Repentance) While transformed into Character The Lost iconThe Lost by a White Fireplace, Health Down pills turn into Health Up pills, regardless of Isaac's number of red heart containers.

Strategy[ | ]

  • (in Repentance) There are 24 good effects, 14 neutral (sometimes good/sometimes bad) effects, and 12 negative effects. This means taking mystery pills is usually beneficial. However, you should consider not taking one if an effect like Hematemesis or Tears Down would ruin your run.
  • Use of unidentified pills is recommended for outside of combat as Hematemesis, R U a Wizard?, Paralysis, (except in Rebirth)Addicted!, (in Afterbirth † and Repentance) X-Lax, and (in Afterbirth † and Repentance) I'm Excited!!! can be detrimental mid-fight. However, (in Afterbirth † and Repentance) I'm Drowsy..., (in Afterbirth † and Repentance) Something's wrong..., Lemon Party, Bad Gas, and Pheromones are useless outside of combat.
  • (except in Rebirth) Percs! can be used in the Sacrifice RoomSacrifice Room to reduce the damage Isaac takes, potentially allowing him to do more sacrifices. However, if Isaac is teleported to the Devil/Angel room, he loses the effect.
  • (except in Rebirth) The invincibility effect from Power Pill and (in Afterbirth † and Repentance) Feels like I'm walking on sunshine! can be utilized to get into Curse RoomCurse Rooms, play Blood Donation MachineBlood Donation Machines and (in Repentance) ConfessionalConfessionals, or use Devil BeggarDevil Beggars and (in Repentance) Hell GameHell Games without taking any damage.
    • (except in Rebirth) Percs! can be used to reduce damage from these from chapter 4 onward.
  • (in Repentance)(except in Rebirth)Endless NamelessEndless Nameless can be used to effectively generate infinite golden pills, as the trinket's ability to respawn collectibles applies with every use.
  • (in Repentance) Taking only golden pills in a run can allow for infinite golden pill generation by repeatedly activating the Vurp! effect.

Unlockable Achievements[ | ]

Trivia[ | ]

  • (in Afterbirth † and Repentance) The Vurp! pill is a portmanteau of the words vomit and burp.
  • (except in Rebirth) Power Pills activating the Gamekid effect is a reference to Pac-Man, in which the "Super-Pac" powerup is obtained by eating a Power Pellet.
  • "I Found Pills (and Ate Them)," "R U a Wizard?," and "I can see Forever" are all image macro memes.
  • (in Afterbirth † and Repentance) The Feels like I'm walking on sunshine! pill is a reference to the 80s song Walking on Sunshine.
    • Furthermore, creator Edmund McMillen made in 2010 a video with the same name, although it doesn't feature the actual Walking on Sunshine song.
  • Balls of Steel is a reference to Duke Nukem; it is one of Duke's more famous quotes.
  • Explosive Diarrhea is extremely loud and forceful diarrhea. In the original game, the message that displayed when the pill was activated was "Oh No!". The pill name and effect are likely a reference to Atomic Bomberman where a pickup of the same name would cause the player to drop bombs behind them uncontrollably for a short duration.
  • Shot speed effects were introduced in The Binding of Isaac: Eternal Edition, after the release of Rebirth. They were finally added to Rebirth in the Repentance DLC.
  • Hematemesis is a medical term for vomiting blood.
  • Lemon Party is a reference to internet shock site featuring a group of elderly men performing oral sex, peeing on each other.
  • "Puberty" having a negative sound effect is a tongue in cheek connotation to how unpleasant that period in life can be.
  • (except in Rebirth) Friends Till the End! was originally in the Wrath of the Lamb but removed in Rebirth, then put back into Afterbirth.
  • (in Afterbirth) Friends Till The End! is the only non-narrated pill.
  • 48 Hour Energy is a reference to the drink 5 Hour Energy.
  • (in Afterbirth † and Repentance) X-Lax is a reference to the anti-constipation medicine Ex-Lax.
  • (except in Rebirth) "One makes you larger" and "One makes you small" are references to Alice in Wonderland, and the specific wording is a reference to the song White Rabbit by Jefferson Airplane.
  • (except in Rebirth) "Percs" is a reference to a street name for the prescription drug Percocet, which is more generically known as Oxycodone. This drug is meant to be used to treat pain, but it is often abused for recreational purposes.
  • (except in Rebirth) The "???" is the only pill that has 3 different narrated voice lines.
  • (in Repentance) "Horse pills" is a slang term used to refer to large, hard to swallow pills, hence their sprites being larger than those of regular pills.

Voiceovers[ | ]

Pill Voiceover (Standard Pills) Voiceover (Horse Pills)
???
48 Hour Energy
Addicted
Amnesia
Bad Gas
Bad Trip
Balls of Steel
Bombs Are Key
Experimental Pill
Explosive Diarrhea
Feels like I'm walking on sunshine!
Friends Till the End!
Full Health
Gulp!
Health Down
Health Up
Hematemesis
Horf!
I Can See Forever
I Found Pills
I'm Drowsy...
I'm Excited!!!
Infested!
Infested?
Lemon Party
Luck Down
Luck Up
One Makes You Larger
One Makes You Small
Paralysis
Percs
Pheromones
Power Pill
Pretty Fly
Puberty
R U a Wizard?
Range Down
Range Up
Re-Lax
Retro Vision
Shot Speed Down
Shot Speed Up
Something's wrong...
Speed Down
Speed Up
Tears Down
Tears Up
Telepills
Vurp!
X-Lax

Gallery[ | ]

Bugs[ | ]

Bug Bug! (except in Rebirth) Any blue flies and blue spiders created by pill effects can be multiplied when Collectible Glowing Hourglass iconGlowing Hourglass teleports Isaac in a way that does not move him to a different room from the one he is currently in (such as by teleporting to the previous room then using it again).


Tainted Cain Unlocks Tainted Cain Unlocks Tainted Cain Unlocks
(in Repentance)
Blue KeyWheel of FortuneGilded KeyLucky SackBag of CraftingGold PillSoul of Cain
Tainted Eve Unlocks Tainted Eve Unlocks Tainted Eve Unlocks
(in Repentance)
HeartbreakThe EmpressStrange KeyLil ClotSumptoriumHorse PillSoul of Eve
Mega Satan Unlocks Mega Satan Unlocks Mega Satan Unlocks
(except in Rebirth)
Cry BabyRed BabyGreen BabyBrown BabyBlue BabyLil' BabyRage BabyBlack BabyLong BabyYellow BabyWhite BabyBig BabyNoose BabyI RULE!Mega 		(in Afterbirth † and Repentance)
BackasswardsUltra HardMort BabyApollyonBound Baby 		(in Repentance)
Glowing BabyIllusion BabyMega ChestQueen of HeartsGold PillBlack SackCharming PoopHorse PillCrane GameHell GameWooden ChestWild CardHaunted ChestFool's GoldGolden PennyRotten BeggarGolden BatteryConfessionalGolden Trinket
SmallIsaacThe Binding of Isaac: RebirthSmallIsaac
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