Binding of Isaac: Rebirth Wiki
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(there is no "etc", belly button and mom's purse are currently the only items in the game that allow you to hold 2 trinkets (ignoring modded items))
(bold claim and definitely doesn't seem to be true)
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{{pickupHeader}}
 
{{pickupHeader}}
'''Pills''' are [[pickups]] that can provide useful or inhibiting effects. They take up the same [[Item Slot|slot]] as [[cards]] and [[runes]].
 
   
 
'''Pills''' are [[pickup]]s that can provide useful or inhibiting effects. They take up the same [[item slot|slot]] as [[card]]s and [[rune]]s.
At the start of each run, an effect is randomly assigned to each color of pill. The pill effect for that color will remain constant throughout the run. (However, it is possible for {{i|PHD}} or {{i|Virgo}} to reassign some of the effects, such that 2 different colored pills will have the same effect.) The set of pill effects for any given run is usually known as the ''pill pool''.
 
* {{dlc|a}} The pill pool for each run has increased from 9 to 13.
 
   
 
At the start of each run, an effect is randomly assigned to each color of the pill. The pill effect for that color will remain constant throughout the run. (However, it is possible for {{i|PHD}} or {{i|Virgo}} to reassign some of the effects, such that 2 different colored pills will have the same effect). Pills will start the game unidentified (unless the player is holding {{i|PHD}}), their effect is shown as "???" when picked up. Upon using a particular pill for the first time, its effect will be revealed and all subsequent pills with the same color will have their effect shown as well. The set of pill effects for any given run is usually known as the ''pill pool''.
 
* {{dlc|a}} The pill pool for each run has increased from 9 to 13.
   
==Pill Effects==
+
== Pill Effects ==
{| class="mw-collapsible wikitable striped" style="text-align:center;width:100%;height:100%;"
+
{| class="mw-collapsible wikitable striped" style="text-align: center; width: 100%"
|style="background: #45264D; width: 30px; font-size: 10pt; color: #FFFFFF; font-weight: bold" |'''ID'''
+
! style="width: 30px" | '''ID'''
|style="background: #45264D; width: 130px; font-size: 10pt; color: #FFFFFF; font-weight: bold" |'''Pill'''
+
! style="width: 130px" | '''Pill'''
  +
! '''Effect'''
|style="background: #45264D; font-size: 10pt; color: #FFFFFF; font-weight: bold"|'''Effect'''
 
 
|-
 
|-
| 0 || Bad Gas ||<p style="text-align: left;">Isaac farts, [[Status Effects|poisoning]] enemies around him.</p>
+
| 0 || Bad Gas || style="text-align: left" | Isaac farts, dealing 5 damage and [[poison]]ing enemies around him.
 
|-
 
|-
| 1 || Bad Trip ||<p style="text-align: left;">Injures Isaac by a full heart. If a Bad Trip pill is used while Isaac only has a single heart left or less, the pill will turn into a Full Health pill instead. (This damage counts as red heart damage for the purposes of getting a Devil Deal.)</p>
+
| 1 || Bad Trip || style="text-align: left" | Injures Isaac by a full heart. If a Bad Trip pill is used while Isaac only has a single heart left or less, the pill will turn into a Full Health pill instead.
 
|-
 
|-
| 2 || Balls of Steel ||<p style="text-align: left;">Grants Isaac two soul hearts.</p>
+
| 2 || Balls of Steel || style="text-align: left" | Grants Isaac two soul hearts.
 
|-
 
|-
| 3 || Bombs Are Key ||<p style="text-align: left;">Swaps the values of Isaac's bombs and keys.</p>
+
| 3 || Bombs Are Key || style="text-align: left" | Swaps the values of Isaac's bombs and keys.
 
|-
 
|-
| 4 || Explosive Diarrhea ||<p style="text-align: left;">Spawns five active bombs behind Isaac over a period of five seconds, at one a second.</p>
+
| 4 || Explosive Diarrhea || style="text-align: left" | Spawns five active bombs behind Isaac over a period of five seconds, at one a second.
 
|-
 
|-
| 5 || Full Health ||<p style="text-align: left;">Refills every empty [[Red heart]] containers. </p>
+
| 5 || Full Health || style="text-align: left" | Refills every empty [[red heart]] container.
 
|-
 
|-
| 6 || Health Down ||<p style="text-align: left;">Removes one red heart container upon use. While Isaac has one or fewer red heart containers, it will act as a ''Health Up'' pill instead. [[Blue Baby]] can encounter Health Down pills, even though he can't have red heart containers.</p>
+
| 6 || Health Down || style="text-align: left" | Removes one red heart container upon use. While Isaac has one or fewer red heart containers, it will act as a ''Health Up'' pill instead. [[??? (Character)|???]] can encounter Health Down pills, even though he can't have red heart containers.
 
|-
 
|-
| 7 || Health Up ||<p style="text-align: left;">Adds one empty red heart container upon use.</p>
+
| 7 || Health Up || style="text-align: left" | Adds one empty red heart container upon use.
 
|-
 
|-
| 8 || I Found Pills||<p style="text-align: left;">Changes the appearance of Isaac's face. This pill is cosmetic only, {{dlc|na}} and the effect disappears when you leave the room.</p>
+
| 8 || I Found Pills || style="text-align: left" | Changes the appearance of Isaac's face. This pill is cosmetic only, {{dlc|na}}, and the effect disappears when you leave the room.
 
|-
 
|-
| 9 || Puberty ||<p style="text-align: left;">Causes Isaac to grow four hairs from the top of his head and zits on his face. This pill is cosmetic only, and will stay for the rest of the run. <br>{{dlc|a+}} Consuming three puberty pills will grant the [[Adult (Transformation)|Adult]] transformation.</p>
+
| 9 || Puberty || style="text-align: left" | Causes Isaac to grow four hairs from the top of his head and zits on his face. This pill is cosmetic only and will stay for the rest of the run.<br>{{dlc|a+}} Consuming three puberty pills will grant the [[Adult]] transformation, granting one red heart container (one time effect).
 
|-
 
|-
| 10 || [[Familiar#Pretty Fly|Pretty Fly]] ||<p style="text-align: left;">Grants 1 fly orbital that circles the player, blocking projectiles and damaging [[Fly|fly-type]] enemies on touch.</p>
+
| 10 || [[Pretty Fly]] || style="text-align: left" | Grants a fly orbital, up to 3 maximum, that circles the player, blocking projectiles and damaging [[Fly|fly-type]] enemies on touch.
 
|-
 
|-
| 11 || Range Down ||<p style="text-align: left;">Decreases Isaac's range by 2.</p>
+
| 11 || Range Down || style="text-align: left" | Decreases Isaac's range by 2.
 
|-
 
|-
| 12 || Range Up ||<p style="text-align: left;">Increases Isaac's range by 2.5.</p>
+
| 12 || Range Up || style="text-align: left" | Increases Isaac's range by 2.5.
 
|-
 
|-
| 13 || Speed Down ||<p style="text-align: left;">Decreases Isaac's movement speed by 0.12.</p>
+
| 13 || Speed Down || style="text-align: left" | Decreases Isaac's movement speed by 0.12.
 
|-
 
|-
| 14 || Speed Up ||<p style="text-align: left;">Increases Isaac's movement speed by 0.15.</p>
+
| 14 || Speed Up || style="text-align: left" | Increases Isaac's movement speed by 0.15.
 
|-
 
|-
| 15 || Tears Down ||<p style="text-align: left;">Decreases Isaac's tears by 0.28.</p>
+
| 15 || Tears Down || style="text-align: left" | Decreases Isaac's tears by 0.28.
 
|-
 
|-
| 16 || Tears Up ||<p style="text-align: left;">Increases Isaac's tears by 0.35.</p>
+
| 16 || Tears Up || style="text-align: left" | Increases Isaac's tears by 0.35.
 
|-
 
|-
| 17 || Luck Down ||<p style="text-align: left;">Decreases Isaac's luck by 1.</p>
+
| 17 || Luck Down || style="text-align: left" | Decreases Isaac's luck by 1.
 
|-
 
|-
| 18 || Luck Up ||<p style="text-align: left;">Increases Isaac's luck by 1.</p>
+
| 18 || Luck Up || style="text-align: left" | Increases Isaac's luck by 1.
 
|-
 
|-
| 19 || Telepills ||<p style="text-align: left;">Isaac gets teleported to a random room. Has a small chance to teleport Isaac to the [[I AM ERROR]] room, and an extremely small chance to teleport him to the [[Black Market]], like [[Undefined]].</p>
+
| 19 || Telepills || style="text-align: left" | Isaac gets teleported to a random room. Has a small chance to teleport Isaac to the [[I AM ERROR]] room, and an extremely small chance to teleport him to the [[Black Market]], like {{i|Undefined}}. Unobtainable in [[Greed Mode]].
 
|-
 
|-
| 20 || 48 Hour Energy ||<p style="text-align: left;">Drops one to two [[little battery|little batteries]] and fully charges the [[Item#Activated Collectibles|spacebar item]]. {{dlc|a}} Can be used with the [[Placebo]] or [[D1]] to generate infinite batteries.</p>
+
| 20 || 48 Hour Energy || style="text-align: left" | Drops one to two [[little battery|little batteries]] and fully charges the [[activated collectible|spacebar item]]. {{dlc|a}} Can be used with the {{i|Placebo}} or {{i|D1}} to generate infinite batteries.
 
|-
 
|-
| 21 || Hematemesis ||<p style="text-align: left;">Empties all but one red heart container and spawns 1-4 full [[Pickups#Red Hearts|red heart]] pickups. If Isaac only has half of a heart left, it will heal him to one heart. If used without any red heart containers, no health will be deducted, but red hearts will still spawn. If used in a [[Black Heart]] or [[Eternal Heart]]-containing [[Super Secret Room]], it will spawn those types of hearts instead. </p>
+
| 21 || Hematemesis || style="text-align: left" | Empties all but one red heart container and spawns 1-4 [[red heart]]s. If Isaac only has half of a heart left, it will heal him to one heart. If used without any red heart containers, no health will be deducted, but red hearts will still spawn. If used in a [[black heart]] or [[eternal heart]]-containing [[super secret room]], it will spawn those types of hearts instead.
 
|-
 
|-
| 22 || Paralysis ||<p style="text-align: left;">Prevents Isaac from moving for a short duration.</p>
+
| 22 || Paralysis || style="text-align: left" | Prevents Isaac from moving and shooting for 2 seconds.
 
|-
 
|-
| 23 || I can see forever! ||<p style="text-align: left;">Opens all entrances to the [[Secret Room]] and [[Super Secret Room]] for the current floor.</p>
+
| 23 || I can see forever! || style="text-align: left" | Opens all entrances to the [[secret room]] and [[super secret room]] for the current floor.
 
|-
 
|-
| 24 || Pheromones ||<p style="text-align: left;">[[Status Effects|Charms]] all enemies in the room for a short period of time.</p>
+
| 24 || Pheromones || style="text-align: left" | [[Charm]]s all enemies in the room for a short period of time.
 
|-
 
|-
| 25 || Amnesia ||<p style="text-align: left;">Replaces [[HUD#Map|the floor map]] with a ? for the rest of the floor. If no other [[curses]] are active for the floor, the Curse of the Lost will appear under the level name when the map key is held. This effect cannot be negated by [[Black Candle]]. {{dlc|a}} Also the only pill to have its flavour text appear on a piece of paper, like curses do.</p>
+
| 25 || Amnesia || style="text-align: left" | Replaces [[map|the floor map]] with a ? for the rest of the floor. If no other [[curse]]s are active for the floor, the Curse of the Lost will appear under the level name when the map key is held. This effect cannot be negated by {{i|Black Candle}}. {{dlc|a}} Also the only pill to have its flavor text appear on a piece of paper as curses do.
 
|-
 
|-
| 26 || Lemon Party ||<p style="text-align: left;">Spawns a large yellow pool (similar to [[Lemon Mishap]]) around your character. Greatly damages any enemy that steps on it, for 22 damage per tick or 66 damage per second.</p>
+
| 26 || Lemon Party || style="text-align: left" | Spawns a large yellow pool (similar to {{i|Lemon Mishap}}) around your character. Greatly damages any enemy that steps on it, for 22 damage per tick or 66 damage per second.
 
|-
 
|-
| 27 || R U a Wizard? ||<p style="text-align: left;">Tears are shot diagonally outwards for about 30 seconds. This effect does not reset upon exiting the room.</p>
+
| 27 || R U a Wizard? || style="text-align: left" | Tears are shot diagonally outwards for about 30 seconds. This effect does not reset upon exiting the room.
 
 
|-
 
|-
|colspan="3" style="background: #45264D; font-size: 10pt; color: #FFFFFF; font-weight: bold" | '''{{dlc|a}} [[Afterbirth]]'''
+
! colspan="3" | '''{{dlc|a}} [[Afterbirth]]'''
 
|-
 
|-
| 28 || {{unlockable}} Percs! ||<p style="text-align: left;">Gives [[The Wafer]] effect while in the room : reduces all damage taken to half a heart. Unlocked by completing Challenge #24: [[PAY TO PLAY]].</p>
+
| 28 || {{unlockable}} Percs! || style="text-align: left" | Gives {{i|The Wafer}} effect while in the room : reduces all damage taken to half a heart.<br>Unlocked by completing Challenge #24: [[PAY TO PLAY]].
 
|-
 
|-
| 29 || {{unlockable}} Addicted! ||<p style="text-align: left;">Makes Isaac take a full heart of damage from all sources for the current room. Also changes his appearance for the room. Unlocked by completing Challenge #24: [[PAY TO PLAY]].</p>
+
| 29 || {{unlockable}} Addicted! || style="text-align: left" | Makes Isaac take a full heart of damage from all sources for the current room. Also changes his appearance for the room.<br>Unlocked by completing Challenge #24: [[PAY TO PLAY]].
 
|-
 
|-
| 30 || {{unlockable}} Re-Lax ||<p style="text-align: left;">For a short time, poop spawns wherever Isaac moves, like Explosive Diarrhea but with poop. A higher move speed means you can touch more tiles in the same time. A pun on laxatives. Unlocked by completing Challenge #25: [[Have a Heart]].</p>
+
| 30 || {{unlockable}} Re-Lax || style="text-align: left" | For a short time, poop spawns wherever Isaac moves, like Explosive Diarrhea but with poop. A higher move speed means you can touch more tiles in the same time. A pun on laxatives.<br>Unlocked by completing Challenge #25: [[Have a Heart]].
 
|-
 
|-
| 31 || {{unlockable}} ??? ||<p style="text-align: left;">Gives the Curse of the Maze effect for the remainder of the floor. The effect can stack with other [[curses]]. If no other [[curses]] are active for the floor, Curse of the Maze will appear under the level name when Tab is held. This effect cannot be negated by [[Black Candle]]. Unlocked by completing Challenge #25: [[Have a Heart]].</p>
+
| 31 || {{unlockable}} ??? || style="text-align: left" | Gives the Curse of the Maze effect for the remainder of the floor. The effect can stack with other [[curse]]s. If no other [[curse]]s are active for the floor, Curse of the Maze will appear under the level name when Tab is held. This effect cannot be negated by {{i|Black Candle}}. As the pill's name is "???", the same as what unidentified pills are referred to, it is easy to accidentally use it more than once per run. It is recommended to memorize its color upon first using it.<br>Unlocked by completing Challenge #25: [[Have a Heart]].
 
|-
 
|-
| 32 || One makes you larger ||<p style="text-align: left;">Increases Isaac's size and decreases the pitch of his voice. This effect does not increase the size of Isaac's hitbox. {{dlc|a+}} These pills contribute to the [[Stompy (Transformation)|Stompy]] transformation.</p>
+
| 32 || One makes you larger || style="text-align: left" | Increases Isaac's size and decreases the pitch of his voice. This effect does not increase the size of Isaac's hitbox but will increase the size of [[The Forgotten|The Forgotten's]] bone club. {{dlc|a+}} These pills contribute to the [[Stompy]] transformation.
 
|-
 
|-
| 33 || One makes you small ||<p style="text-align: left;">Decreases Isaac's size and increases the pitch of his voice. This effect decreases the size of Isaac's hitbox.</p>
+
| 33 || One makes you small || style="text-align: left" | Decreases Isaac's size and increases the pitch of his voice. This effect decreases the size of Isaac's hitbox.
 
|-
 
|-
| 34 || Infested! ||<p style="text-align: left;">Destroys all poop in the room and spawns a single [[Blue Spider]] under Isaac and on each destroyed poop.</p>
+
| 34 || Infested! || style="text-align: left" | Destroys all poop in the room and spawns a single [[blue spider]] under Isaac and on each destroyed poop.
 
|-
 
|-
| 35 || Infested? ||<p style="text-align: left;">Spawns [[Blue Spider]]s equal to the number of enemies in the room. If there are no enemies in the room, spawns 1-3 Blue Spiders.</p>
+
| 35 || Infested? || style="text-align: left" | Spawns [[blue spider]]s equal to the number of enemies in the room. If there are no enemies in the room, spawns 1-3 Blue Spiders.
 
|-
 
|-
| 36 || Power Pill! ||<p style="text-align: left;">Activates an effect similar to [[The Gamekid]].</p>
+
| 36 || Power Pill! || style="text-align: left" | Temporarily grants invulnerability, inflicts fear on enemies in the room, and lets Isaac deal contact damage, similar to {{i|The Gamekid}}.
 
|-
 
|-
| 37 || Retro Vision ||<p style="text-align: left;">Briefly pixelates the screen 3 times over 30 seconds.</p>
+
| 37 || Retro Vision || style="text-align: left" | Pixelates the screen 3 times over 30 seconds. The effect continues between floors.
 
|-
 
|-
| 38 || Friends Till The End! ||<p style="text-align: left;">Spawns three [[blue fly|blue flies]].</p>
+
| 38 || Friends Till The End! || style="text-align: left" | Spawns three [[blue fly|blue flies]].
   
 
|-
 
|-
|colspan="3" style="background: #45264D; font-size: 10pt; color: #FFFFFF; font-weight: bold" | '''{{dlc|a+}} [[Afterbirth †]]'''
+
! colspan="3" | '''{{dlc|a+}} [[Afterbirth †]]'''
 
|-
 
|-
| 39 || X-Lax ||<p style="text-align: left;">Creates a pool of slippery brown creep underneath Isaac.</p>
+
| 39 || X-Lax || style="text-align: left" | Creates a pool of slippery brown [[creep]] underneath Isaac.
 
|-
 
|-
| 40 || Something's wrong... || <p style="text-align: left;">Creates a pool of black creep beneath Isaac.</p>
+
| 40 || Something's wrong... || style="text-align: left" | Creates a pool of black [[creep]] beneath Isaac that slows enemies.
 
|-
 
|-
| 41 || I'm Drowsy... ||<p style="text-align: left;">Upon use, slows all enemies for the duration of the room.</p>
+
| 41 || I'm Drowsy... || style="text-align: left" | Slows all enemies for the duration of the room.
 
|-
 
|-
| 42 || I'm Excited!!! || <p style="text-align: left;">Upon use, increases the speed of all enemies for the duration of the room. The effect triggers again 30 seconds after use and 60 seconds after use.</p>
+
| 42 || I'm Excited!!! || style="text-align: left" | Increases the speed of all enemies for the duration of the room. The effect triggers again 30 seconds after use and 60 seconds after use.
 
|-
 
|-
| 43 || {{unlockable}} Gulp!|| <p style="text-align: left;">Upon use, any trinkets that the player is holding are destroyed, and their effects are permanently applied to the player. Unlocked by acquiring the [[Achievements|Once More With Feeling!]] achievement.</p>
+
| 43 || {{unlockable}} Gulp! || style="text-align: left" | Any trinkets that the player is holding are destroyed, and their effects are permanently applied to the player.<br>Unlocked by acquiring the [[Once More With Feeling!]] achievement.
 
|-
 
|-
| 44 || {{unlockable}} Horf! || <p style="text-align: left;">Upon use, Isaac shoots an explosive tear with the [[Ipecac]] effect that always deals 200 damage.
+
| 44 || {{unlockable}} Horf! || style="text-align: left" | Isaac shoots an explosive tear with the {{i|Ipecac}} effect that always deals 200 damage.<br>Unlocked by acquiring the [[Dedication]] achievement.
<br>Unlocked by acquiring the [[Achievements|Dedication]] achievement.</p>
 
 
|-
 
|-
| 45 || {{unlockable}} Feels like I'm walking on sunshine! || <p style="text-align: left;">Temporarily makes Isaac invincible, similar to [[Unicorn Stump]].<br>Unlocked by acquiring the [[Achievements|Sin Collector]] achievement.</p>
+
| 45 || {{unlockable}} Feels like I'm walking on sunshine! || style="text-align: left" | Temporarily makes Isaac invincible, similar to {{i|Unicorn Stump}}.<br>Unlocked by acquiring the [[Sin Collector]] achievement.
 
|-
 
|-
| 46 || {{unlockable}} Vurp! || <p style="text-align: left;">Throws up the last pill you used. Will spawn itself if no other pills were taken beforehand.<br>Unlocked by acquiring the [[Achievements|U Broke It!]] achievement.</p>
+
| 46 || {{unlockable}} Vurp! || style="text-align: left" | Throws up the last pill you used. Will spawn itself if no other pills were taken beforehand.<br>Unlocked by acquiring the [[U Broke It!]] achievement.
 
|}
 
|}
   
==Pill Appearances==
+
== Pill appearances ==
 
{| class="mw-collapsible mw-collapsed wikitable striped" style="text-align: center"
 
  +
! '''ID'''
{| class="mw-collapsible wikitable striped" style="text-align:center;"
 
  +
! '''Pill'''
|style="background: #45264D; width: 30px; font-size: 10pt; color: #FFFFFF; font-weight: bold" |'''ID'''
 
|style="background: #45264D; font-size: 10pt; color: #FFFFFF; font-weight: bold" |'''Pill'''
 
 
|-
 
|-
| 1 || [[File:BlueBlue.png|38px]]
+
| 1 || [[file:BlueBlue.png|38px|link=]]
 
|-
 
|-
| 2 || [[File:WhiteBlue.png|38px]]
+
| 2 || [[file:WhiteBlue.png|38px|link=]]
 
|-
 
|-
| 3 || [[File:OrangeOrange.png|38px]]
+
| 3 || [[file:OrangeOrange.png|38px|link=]]
 
|-
 
|-
| 4 || [[File:Pill WhiteWhite.png|38px]]
+
| 4 || [[file:pill WhiteWhite.png|38px|link=]]
 
|-
 
|-
| 5 || [[File:RedSpecled.png|38px]]
+
| 5 || [[file:RedSpecled.png|38px|link=]]
 
|-
 
|-
| 6 || [[File:WhiteRed.png|38px]]
+
| 6 || [[file:WhiteRed.png|38px|link=]]
 
|-
 
|-
| 7 || [[File:BlueCyan.png|38px]]
+
| 7 || [[file:BlueCyan.png|38px|link=]]
 
|-
 
|-
| 8 || [[File:YellowOrange.png|38px]]
+
| 8 || [[file:YellowOrange.png|38px|link=]]
 
|-
 
|-
| 9 || [[File:SpottedwhiteWhite.png|38px]]
+
| 9 || [[file:SpottedwhiteWhite.png|38px|link=]]
 
 
|-
 
|-
|colspan="2" style="background: #45264D; font-size: 10pt; color: #FFFFFF; font-weight: bold" | '''{{dlc|a}} [[Afterbirth]]'''
+
! colspan="2" | '''{{dlc|a}} [[Afterbirth]]'''
 
|-
 
|-
| 10 || [[File:Pill White Cyan.png|38px]]
+
| 10 || [[file:pill White Cyan.png|38px|link=]]
 
|-
 
|-
| 11 || [[File:Pill Black Yellow.png|38px]]
+
| 11 || [[file:pill Black Yellow.png|38px|link=]]
 
|-
 
|-
| 12 || [[File:Pill Black White.png|38px]]
+
| 12 || [[file:pill Black White.png|38px|link=]]
 
|-
 
|-
| 13 || [[File:Pill White Yellow.png|38px]]
+
| 13 || [[file:pill White Yellow.png|38px|link=]]
 
|}
 
|}
   
==Notes==
+
== Notes ==
* Among the [[attribute]] modifying pill effects, only five of the seven [[Attributes#Visible Attributes|visible attributes]] are covered: health, range, tears, speed, and luck. Both shot speed and damage can't be altered by pills.
+
* Among the [[attribute]] modifying pill effects, only five of the seven [[attribute|visible attributes]] are covered: health, range, tears, speed, and luck. Both shot speed and damage can't be altered by pills.
* {{dlc|a}} Pill effects have a chance to be narrated upon use, as do [[cards]] and [[runes]].
+
* {{dlc|a}} Pill effects have a chance to be narrated upon use, as do [[card]]s and [[rune]]s.
 
* {{dlc|a}} Currently, the "Retro Vision" pill effect can crash the game on some machines, resulting in restarting the current floor when the game is continued.
 
* {{dlc|a}} Currently, the "Retro Vision" pill effect can crash the game on some machines, resulting in restarting the current floor when the game is continued.
 
* {{dlc|a}} The "Addicted!" pill will have no effect if Isaac has {{i|The Wafer}}.
 
* {{dlc|a}} The "Addicted!" pill will have no effect if Isaac has {{i|The Wafer}}.
 
** Despite this, if one takes both the "Addicted!" pill with "Percs!" in the same room, Isaac will take a full heart of damage from all sources.
 
** Despite this, if one takes both the "Addicted!" pill with "Percs!" in the same room, Isaac will take a full heart of damage from all sources.
* Having {{i|Midas' Touch}}, {{t|Meconium}}, or {{i|Hallowed Ground}} and using a "Re-Lax" pill has a chance to spawn [[Obstacles#Golden Poop|golden poop]], [[Obstacles#Black Poop|black poop]], or [[Obstacles#White Poop|white poop]], respectively.
+
* Having {{i|Midas' Touch}}, {{t|Meconium}}, or {{i|Hallowed Ground}} and using a "Re-Lax" pill has a chance to spawn [[golden poop]], [[black poop]], or [[white poop]], respectively.
* {{dlc|a}} Using an "Infested!" pill on [[Obstacles#Red Poop|red poop]] will spawn [[Familiars#Blue Spiders|blue spiders]] and the red poop will regenerate.
+
* {{dlc|a}} Using an "Infested!" pill on [[red poop]] will spawn [[blue spider]]s and the red poop will regenerate.
 
* {{dlc|a}} If a Tiny or Large [[Champion]] monster drops a "One Makes You Small"/"Larger" pill and either pill is not in the current pill pool, an existing pill will be overwritten. If the chosen pill was already identified, the new pill will also be.
* {{dlc|a+}} Using a "Gulp!" pill while holding two [[trinkets]] (with {{i|Belly Button|n}} or {{i|Mom's Purse}}) will cause both trinkets to be absorbed.
 
  +
*{{dlc|a}} "R U A Wizard" does not affect [[Lilith]]'s Incubus.
*{{dlc|a}} If a Tiny or Large [[Champion]] monster drops a "One Makes You Small"/"Larger" pill and either pill is not in the current pill pool, an existing pill will be overwritten. If the chosen pill was already identified, the new pill will also be.
 
 
* {{dlc|a+|a}} Using a "Gulp!" pill while holding two [[trinket]]s (with {{i|Belly Button}} or {{i|Mom's Purse}}) will cause both trinkets to be absorbed. {{dlc||r}}
  +
* Isaac's hitbox can be reduced to 30% of original, which is achieved after 6 One Makes You Small pills. Further pills will only make him visually smaller, with no additional benefit.
   
==Strategy==
+
== Strategy ==
 
* Use of unidentified pills is recommended for outside of combat as Hematemesis, R U a Wizard?, Paralysis, {{dlc|a}}Addicted!, {{dlc|a+}} X-Lax, and {{dlc|a+}} I'm Excited!!! can be detrimental mid-fight. However, {{dlc|a+}} I'm Drowsy..., {{dlc|a+}} Something's wrong..., Lemon Party, Bad Gas, and Pheromones are useless outside of combat.
 
* Use of unidentified pills is recommended for outside of combat as Hematemesis, R U a Wizard?, Paralysis, {{dlc|a}}Addicted!, {{dlc|a+}} X-Lax, and {{dlc|a+}} I'm Excited!!! can be detrimental mid-fight. However, {{dlc|a+}} I'm Drowsy..., {{dlc|a+}} Something's wrong..., Lemon Party, Bad Gas, and Pheromones are useless outside of combat.
*{{dlc|a}} Percs! can be used in the [[Sacrifice Room]] to reduce the damage Isaac takes, potentially allowing him to do more sacrifices. However, if Isaac is teleported to the Devil/Angel room, he loses the effect.
+
* {{dlc|a}} Percs! can be used in the [[sacrifice room]] to reduce the damage Isaac takes, potentially allowing him to do more sacrifices. However, if Isaac is teleported to the Devil/Angel room, he loses the effect.
*{{dlc|a}} The invincibility effect from Power Pill and {{dlc|a+}} Feels like I'm walking on sunshine! can be utilized to get into [[Curse Room|Curse Rooms]], play [[Blood Donation Machine|Blood Donation Machines]], or use [[Beggar#Devil Beggar|Devil Beggars]] without taking any damage.
+
* {{dlc|a}} The invincibility effect from Power Pill and {{dlc|a+}} Feels like I'm walking on sunshine! can be utilized to get into [[curse room]]s, play [[blood donation machine]]s, or use [[Devil beggar]]s without taking any damage.
**{{dlc|a}} Percs! can be used to reduce damage from these from [[Chapter 4]] onward.
+
** {{dlc|a}} Percs! can be used to reduce damage from these from [[chapter 4]] onward.
   
 
== Unlockable [[achievement]]s ==
 
== Unlockable [[achievement]]s ==
{{achv|Huge Growth|text}}
+
{{a|Huge Growth|text}}
{{achv|Marbles|text}}
+
{{a|Marbles |text}}
{{achv|Lachryphagy|text}}
+
{{a|Lachryphagy|text}}
{{achv|Lil Spewer|text}}
+
{{a|Lil Spewer |text}}
   
==Trivia==
+
== Trivia ==
* Lemon Party is an internet [[Wikipedia:shock site|shock site]] featuring a group of elderly men performing oral sex.
+
* Lemon Party is an internet [[wikipedia:shock site|shock site]] featuring a group of elderly men performing oral sex.
 
* {{dlc|a+}} The Vurp! pill is a portmanteau of the words vomit and burp.
 
* {{dlc|a+}} The Vurp! pill is a portmanteau of the words vomit and burp.
 
* {{dlc|a}} Power Pills activating the Gamekid effect is a reference to Pac-Man, in which the "Super-Pac" powerup is obtained by eating a Power Pellet.
 
* {{dlc|a}} Power Pills activating the Gamekid effect is a reference to Pac-Man, in which the "Super-Pac" powerup is obtained by eating a Power Pellet.
* "I Found Pills (and Ate Them)," "R U a Wizard?," and "I can see Forever" are all [[Wikipedia:image macro|image macro]] memes.
+
* "I Found Pills (and Ate Them)," "R U a Wizard?," and "I can see Forever" are all [[wikipedia:image macro|image macro]] memes.
 
** Despite being called I Can See Forever, the effects only last for the rest of that floor.
 
** Despite being called I Can See Forever, the effects only last for the rest of that floor.
* {{dlc|a+}} The Feels like I'm walking on sunshine! pill is a reference to the 80s song [[Wikipedia:Walking on Sunshine (Katrina and the Waves song)|Walking on Sunshine]].
+
* {{dlc|a+}} The Feels like I'm walking on sunshine! pill is a reference to the 80s song [[wikipedia:Walking on Sunshine (Katrina and the Waves song)|Walking on Sunshine]].
 
* Balls of Steel is a reference to ''Duke Nukem''; it is one of Duke's more famous quotes.
 
* Balls of Steel is a reference to ''Duke Nukem''; it is one of Duke's more famous quotes.
* Explosive Diarrhea is extremely loud and forceful [[wikipedia:Diarrhea|diarrhea]]. In the original game, the message that displayed when the pill was activated was "Oh No!". The pill name and effect are likely a reference to Atomic Bomberman where a pickup of the same name would cause the player to drop bombs behind them uncontrollably for a short duration.
+
* Explosive Diarrhea is extremely loud and forceful [[wikipedia:diarrhea|diarrhea]]. In the original game, the message that displayed when the pill was activated was "Oh No!". The pill name and effect are likely a reference to Atomic Bomberman where a pickup of the same name would cause the player to drop bombs behind them uncontrollably for a short duration.
*{{dlc|a}} Friends Till the End! was originally in the Wrath of the Lamb but removed in Rebirth, then put back into Afterbirth.
+
* {{dlc|a}} Friends Till the End! was originally in the Wrath of the Lamb but removed in Rebirth, then put back into Afterbirth.
*{{dlc|ana+}} Friends Till The End! is the only non-narrated pill.
+
* {{dlc|ana+}} Friends Till The End! is the only non-narrated pill.
 
* 48 Hour Energy is a reference to the drink 5 Hour Energy.
 
* 48 Hour Energy is a reference to the drink 5 Hour Energy.
*{{dlc|a+}} X-Lax is a reference to the anti-constipation medicine Ex-Lax.
+
* {{dlc|a+}} X-Lax is a reference to the anti-constipation medicine Ex-Lax.
 
* {{dlc|a}} "One makes you larger" and "One makes you small" are references to Alice in Wonderland, and the specific wording is a reference to the song White Rabbit by Jefferson Airplane.
 
* {{dlc|a}} "One makes you larger" and "One makes you small" are references to Alice in Wonderland, and the specific wording is a reference to the song White Rabbit by Jefferson Airplane.
 
* {{dlc|a}} "Percs" is a reference to a street name for the prescription drug Percocet, which is more generically known as Oxycodone. This drug is meant to be used to treat pain, but it is often abused for recreational purposes.
 
* {{dlc|a}} "Percs" is a reference to a street name for the prescription drug Percocet, which is more generically known as Oxycodone. This drug is meant to be used to treat pain, but it is often abused for recreational purposes.
* {{dlc|a}} The "???" is the only pill which has 3 different narrated voice lines.
+
* {{dlc|a}} The "???" is the only pill that has 3 different narrated voice lines.
   
 
== Voiceovers ==
 
== Voiceovers ==
 
{| class="wikitable sortable mw-collapsible mw-collapsed"
 
{| class="wikitable sortable mw-collapsible mw-collapsed"
!Pill
+
! Pill
!Voiceover
+
! Voiceover
 
|-
 
|-
|???
+
| ???
|[[File:3Question_Voiceover1.wav|thumb]]<br/>
+
| [[file:3Question_Voiceover1.wav|thumb]]<br>[[file:3Question_Voiceover2.wav|thumb]]<br>[[file:3Question_Voiceover3.wav|thumb]]
[[File:3Question_Voiceover2.wav|thumb]]<br/>
 
[[File:3Question_Voiceover3.wav|thumb]]<br/>
 
 
|-
 
|-
|48 Hour Energy
+
| 48 Hour Energy
|[[File:48HourEnergyVoiceover.wav.wav|thumb]]
+
| [[file:48HourEnergyVoiceover.wav.wav|thumb]]
 
|-
 
|-
|Addicted
+
| Addicted
|[[File:AddictedVoiceover.wav|thumb]]
+
| [[file:AddictedVoiceover.wav|thumb]]
 
|-
 
|-
|Amnesia
+
| Amnesia
|[[File:Amnesia.wav|thumb]]
+
| [[file:Amnesia.wav|thumb]]
 
|-
 
|-
|Bad Gas
+
| Bad Gas
|[[File:BadGasVoiceover.wav|thumb]]
+
| [[file:BadGasVoiceover.wav|thumb]]
 
|-
 
|-
|Bad Trip
+
| Bad Trip
|[[File:BadTripVoiceover.wav|thumb]]
+
| [[file:BadTripVoiceover.wav|thumb]]
 
|-
 
|-
|Balls of Steel
+
| Balls of Steel
|[[File:BallsOfSteelVoiceover.wav|thumb]]
+
| [[file:BallsOfSteelVoiceover.wav|thumb]]
 
|-
 
|-
|Bombs Are Key
+
| Bombs Are Key
|[[File:BombsAreKeyVoiceover.wav|thumb]]
+
| [[file:BombsAreKeyVoiceover.wav|thumb]]
 
|-
 
|-
|Feels like I'm walking on sunshine!
+
| Feels like I'm walking on sunshine!
|[[File:FeelsLikeImWalkingonSunshine.wav|thumb]]
+
| [[file:FeelsLikeImWalkingonSunshine.wav|thumb]]
 
|-
 
|-
|Friends Till the End!
+
| Friends Till the End!
|[[File:FriendsTillTheEndVoiceover.wav|thumb]]
+
| [[file:FriendsTillTheEndVoiceover.wav|thumb]]
 
|-
 
|-
|Full Health
+
| Full Health
|[[File:FullHealthVoiceover.wav|thumb]]
+
| [[file:FullHealthVoiceover.wav|thumb]]
 
|-
 
|-
|Gulp!
+
| Gulp!
|[[File:GulpVoiceover.wav|thumb]]
+
| [[file:GulpVoiceover.wav|thumb]]
 
|-
 
|-
|Health Down
+
| Health Down
|[[File:HealthDownVoiceover.wav|thumb]]
+
| [[file:HealthDownVoiceover.wav|thumb]]
 
|-
 
|-
|Health Up
+
| Health Up
|[[File:HealthUpVoiceover.wav|thumb]]
+
| [[file:HealthUpVoiceover.wav|thumb]]
 
|-
 
|-
|Hematemesis
+
| Hematemesis
|[[File:HematemisisVoiceover.wav|thumb]]
+
| [[file:HematemisisVoiceover.wav|thumb]]
 
|-
 
|-
|Horf!
+
| Horf!
|[[File:HorfVoiceover.wav|thumb]]
+
| [[file:HorfVoiceover.wav|thumb]]
 
|-
 
|-
|I Can See Forever
+
| I Can See Forever
|[[File:ICanSeeForeverVoiceover1.wav|thumb]]
+
| [[file:ICanSeeForeverVoiceover1.wav|thumb]]<br>[[file:ICanSeeForever2Voiceover.wav|thumb]]
 
[[File:ICanSeeForever2Voiceover.wav|thumb]]
 
 
|-
 
|-
|I Found Pills
+
| I Found Pills
|[[File:IFoundPillsVoiceover.wav|thumb]]
+
| [[file:IFoundPillsVoiceover.wav|thumb]]
 
|-
 
|-
|I'm Drowsy...
+
| I'm Drowsy...
|[[File:I'mDrowsyVoiceover.wav|thumb]]
+
| [[file:I'mDrowsyVoiceover.wav|thumb]]
 
|-
 
|-
|I'm Excited!!!
+
| I'm Excited!!!
|[[File:ImExcitedVoiceover.wav|thumb]]
+
| [[file:ImExcitedVoiceover.wav|thumb]]
 
|-
 
|-
|Infested!
+
| Infested!
|[[File:InfestedExclaimVoiceover.wav|thumb]]
+
| [[file:InfestedExclaimVoiceover.wav|thumb]]
 
|-
 
|-
|Infested?
+
| Infested?
|[[File:InfestedQuestionVoiceover.wav|thumb]]
+
| [[file:InfestedQuestionVoiceover.wav|thumb]]
 
|-
 
|-
|Lemon Party
+
| Lemon Party
|[[File:LemonPartyVoiceover.wav|thumb]]
+
| [[file:LemonPartyVoiceover.wav|thumb]]
 
|-
 
|-
|Luck Down
+
| Luck Down
|[[File:LuckDownVoiceover.wav|thumb]]
+
| [[file:LuckDownVoiceover.wav|thumb]]
 
|-
 
|-
|Luck Up
+
| Luck Up
|[[File:LuckUpVoiceover.wav|thumb]]
+
| [[file:LuckUpVoiceover.wav|thumb]]
 
|-
 
|-
|One Makes You Larger
+
| One Makes You Larger
|[[File:OneMakesYouLarger.wav|thumb]]
+
| [[file:OneMakesYouLarger.wav|thumb]]
 
|-
 
|-
|One Makes You Small
+
| One Makes You Small
|[[File:OneMakesYouSmallVoiceover.wav|thumb]]
+
| [[file:OneMakesYouSmallVoiceover.wav|thumb]]
 
|-
 
|-
|Paralysis
+
| Paralysis
|[[File:ParalysisVoiceover.wav|thumb]]
+
| [[file:ParalysisVoiceover.wav|thumb]]
 
|-
 
|-
|Percs
+
| Percs
|[[File:PercsVoiceover.wav|thumb]]
+
| [[file:PercsVoiceover.wav|thumb]]
 
|-
 
|-
|Pheromones
+
| Pheromones
|[[File:PheromonesVoiceover.wav|thumb]]
+
| [[file:PheromonesVoiceover.wav|thumb]]
 
|-
 
|-
|Power Pill
+
| Power Pill
|[[File:PowerPillVoiceover.wav|thumb]]
+
| [[file:PowerPillVoiceover.wav|thumb]]
 
|-
 
|-
|Pretty Fly
+
| Pretty Fly
|[[File:PrettyFlyVoiceover.wav|thumb]]
+
| [[file:PrettyFlyVoiceover.wav|thumb]]
 
|-
 
|-
|Puberty
+
| Puberty
|[[File:PubertyVoiceover.wav|thumb]]
+
| [[file:PubertyVoiceover.wav|thumb]]
 
|-
 
|-
|R U a Wizard?
+
| R U a Wizard?
|[[File:RUAWizardVoiceover.wav|thumb]]
+
| [[file:RUAWizardVoiceover.wav|thumb]]
 
|-
 
|-
|Range Down
+
| Range Down
|[[File:RangeDownVoiceover.wav|thumb]]
+
| [[file:RangeDownVoiceover.wav|thumb]]
 
|-
 
|-
|Range Up
+
| Range Up
|[[File:RangeUpVoiceover.wav|thumb]]
+
| [[file:RangeUpVoiceover.wav|thumb]]
 
|-
 
|-
|Re-Lax
+
| Re-Lax
|[[File:RelaxVoiceover.wav|thumb]]
+
| [[file:RelaxVoiceover.wav|thumb]]
 
|-
 
|-
|Retro Vision
+
| Retro Vision
|[[File:RetroVisionVoiceover.wav|thumb]]
+
| [[file:RetroVisionVoiceover.wav|thumb]]
 
|-
 
|-
|Something's wrong...
+
| Something's wrong...
|[[File:SomethingsWrongVoiceover.wav|thumb]]
+
| [[file:SomethingsWrongVoiceover.wav|thumb]]
 
|-
 
|-
|Speed Down
+
| Speed Down
|[[File:SpeedDownVoiceover.wav|thumb]]
+
| [[file:SpeedDownVoiceover.wav|thumb]]
 
|-
 
|-
|Speed Up
+
| Speed Up
|[[File:SpeedUpVoiceover.wav|thumb]]
+
| [[file:SpeedUpVoiceover.wav|thumb]]
 
|-
 
|-
|Tears Down
+
| Tears Down
|[[File:TearsDownVoiceover.wav|thumb]]
+
| [[file:TearsDownVoiceover.wav|thumb]]
 
|-
 
|-
|Tears Up
+
| Tears Up
|[[File:TearsUpVoiceover.wav|thumb]]
+
| [[file:TearsUpVoiceover.wav|thumb]]
 
|-
 
|-
|Telepills
+
| Telepills
|[[File:TelepillsVoiceover.wav|thumb]]
+
| [[file:TelepillsVoiceover.wav|thumb]]
 
|-
 
|-
|Vurp!
+
| Vurp!
|[[File:VurpVoiceover.wav|thumb]]
+
| [[file:VurpVoiceover.wav|thumb]]
 
|-
 
|-
|X-Lax
+
| X-Lax
|[[File:XLaxVoiceover.wav|thumb]]
+
| [[file:XLaxVoiceover.wav|thumb]]
 
|}
 
|}
  +
{{nav}}
 
  +
{{nav|fr=pilules}}
[[Category:Mechanics]]
 
[[Category:Objects]]
+
[[category:mechanics]]
[[fr:Pilules]]
+
[[category:objects]]

Revision as of 19:16, 19 January 2021

Pills are pickups that can provide useful or inhibiting effects. They take up the same slot as cards and runes.

At the start of each run, an effect is randomly assigned to each color of the pill. The pill effect for that color will remain constant throughout the run. (However, it is possible for Collectible PHD iconPHD or Collectible Virgo iconVirgo to reassign some of the effects, such that 2 different colored pills will have the same effect). Pills will start the game unidentified (unless the player is holding Collectible PHD iconPHD), their effect is shown as "???" when picked up. Upon using a particular pill for the first time, its effect will be revealed and all subsequent pills with the same color will have their effect shown as well. The set of pill effects for any given run is usually known as the pill pool.

  • (except in Rebirth) The pill pool for each run has increased from 9 to 13.

Pill Effects

ID Pill Effect
0 Bad Gas Isaac farts, dealing 5 damage and poisoning enemies around him.
1 Bad Trip Injures Isaac by a full heart. If a Bad Trip pill is used while Isaac only has a single heart left or less, the pill will turn into a Full Health pill instead.
2 Balls of Steel Grants Isaac two soul hearts.
3 Bombs Are Key Swaps the values of Isaac's bombs and keys.
4 Explosive Diarrhea Spawns five active bombs behind Isaac over a period of five seconds, at one a second.
5 Full Health Refills every empty red heart container.
6 Health Down Removes one red heart container upon use. While Isaac has one or fewer red heart containers, it will act as a Health Up pill instead. ??? can encounter Health Down pills, even though he can't have red heart containers.
7 Health Up Adds one empty red heart container upon use.
8 I Found Pills Changes the appearance of Isaac's face. This pill is cosmetic only, (in Rebirth), and the effect disappears when you leave the room.
9 Puberty Causes Isaac to grow four hairs from the top of his head and zits on his face. This pill is cosmetic only and will stay for the rest of the run.
(in Afterbirth † and Repentance) Consuming three puberty pills will grant the Adult transformation, granting one red heart container (one time effect).
10 Pretty Fly Grants a fly orbital, up to 3 maximum, that circles the player, blocking projectiles and damaging fly-type enemies on touch.
11 Range Down Decreases Isaac's range by 2.
12 Range Up Increases Isaac's range by 2.5.
13 Speed Down Decreases Isaac's movement speed by 0.12.
14 Speed Up Increases Isaac's movement speed by 0.15.
15 Tears Down Decreases Isaac's tears by 0.28.
16 Tears Up Increases Isaac's tears by 0.35.
17 Luck Down Decreases Isaac's luck by 1.
18 Luck Up Increases Isaac's luck by 1.
19 Telepills Isaac gets teleported to a random room. Has a small chance to teleport Isaac to the I AM ERROR room, and an extremely small chance to teleport him to the Black Market, like Collectible Undefined iconUndefined. Unobtainable in Greed Mode.
20 48 Hour Energy Drops one to two little batteries and fully charges the spacebar item. (except in Rebirth) Can be used with the (except in Rebirth)Collectible Placebo iconPlacebo or (in Afterbirth † and Repentance)Collectible D1 iconD1 to generate infinite batteries.
21 Hematemesis Empties all but one red heart container and spawns 1-4 red hearts. If Isaac only has half of a heart left, it will heal him to one heart. If used without any red heart containers, no health will be deducted, but red hearts will still spawn. If used in a black heart or eternal heart-containing super secret room, it will spawn those types of hearts instead.
22 Paralysis Prevents Isaac from moving and shooting for 2 seconds.
23 I can see forever! Opens all entrances to the secret room and super secret room for the current floor.
24 Pheromones Charms all enemies in the room for a short period of time.
25 Amnesia Replaces the floor map with a ? for the rest of the floor. If no other curses are active for the floor, the Curse of the Lost will appear under the level name when the map key is held. This effect cannot be negated by Collectible Black Candle iconBlack Candle. (except in Rebirth) Also the only pill to have its flavor text appear on a piece of paper as curses do.
26 Lemon Party Spawns a large yellow pool (similar to Collectible Lemon Mishap iconLemon Mishap) around your character. Greatly damages any enemy that steps on it, for 22 damage per tick or 66 damage per second.
27 R U a Wizard? Tears are shot diagonally outwards for about 30 seconds. This effect does not reset upon exiting the room.
(except in Rebirth) Afterbirth
28 Needs to be unlocked Percs! Gives Collectible The Wafer iconThe Wafer effect while in the room : reduces all damage taken to half a heart.
Unlocked by completing Challenge #24: PAY TO PLAY.
29 Needs to be unlocked Addicted! Makes Isaac take a full heart of damage from all sources for the current room. Also changes his appearance for the room.
Unlocked by completing Challenge #24: PAY TO PLAY.
30 Needs to be unlocked Re-Lax For a short time, poop spawns wherever Isaac moves, like Explosive Diarrhea but with poop. A higher move speed means you can touch more tiles in the same time. A pun on laxatives.
Unlocked by completing Challenge #25: Have a Heart.
31 Needs to be unlocked ??? Gives the Curse of the Maze effect for the remainder of the floor. The effect can stack with other curses. If no other curses are active for the floor, Curse of the Maze will appear under the level name when Tab is held. This effect cannot be negated by Collectible Black Candle iconBlack Candle. As the pill's name is "???", the same as what unidentified pills are referred to, it is easy to accidentally use it more than once per run. It is recommended to memorize its color upon first using it.
Unlocked by completing Challenge #25: Have a Heart.
32 One makes you larger Increases Isaac's size and decreases the pitch of his voice. This effect does not increase the size of Isaac's hitbox but will increase the size of The Forgotten's bone club. (in Afterbirth † and Repentance) These pills contribute to the Stompy transformation.
33 One makes you small Decreases Isaac's size and increases the pitch of his voice. This effect decreases the size of Isaac's hitbox.
34 Infested! Destroys all poop in the room and spawns a single blue spider under Isaac and on each destroyed poop.
35 Infested? Spawns blue spiders equal to the number of enemies in the room. If there are no enemies in the room, spawns 1-3 Blue Spiders.
36 Power Pill! Temporarily grants invulnerability, inflicts fear on enemies in the room, and lets Isaac deal contact damage, similar to Collectible The Gamekid iconThe Gamekid.
37 Retro Vision Pixelates the screen 3 times over 30 seconds. The effect continues between floors.
38 Friends Till The End! Spawns three blue flies.
(in Afterbirth † and Repentance) Afterbirth †
39 X-Lax Creates a pool of slippery brown creep underneath Isaac.
40 Something's wrong... Creates a pool of black creep beneath Isaac that slows enemies.
41 I'm Drowsy... Slows all enemies for the duration of the room.
42 I'm Excited!!! Increases the speed of all enemies for the duration of the room. The effect triggers again 30 seconds after use and 60 seconds after use.
43 Needs to be unlocked Gulp! Any trinkets that the player is holding are destroyed, and their effects are permanently applied to the player.
Unlocked by acquiring the Once More With Feeling! achievement.
44 Needs to be unlocked Horf! Isaac shoots an explosive tear with the Collectible Ipecac iconIpecac effect that always deals 200 damage.
Unlocked by acquiring the Dedication achievement.
45 Needs to be unlocked Feels like I'm walking on sunshine! Temporarily makes Isaac invincible, similar to Collectible Unicorn Stump iconUnicorn Stump.
Unlocked by acquiring the Sin Collector achievement.
46 Needs to be unlocked Vurp! Throws up the last pill you used. Will spawn itself if no other pills were taken beforehand.
Unlocked by acquiring the U Broke It! achievement.

Pill appearances

ID Pill
1 BlueBlue
2 WhiteBlue
3 OrangeOrange
4 Pill WhiteWhite
5 RedSpecled
6 WhiteRed
7 BlueCyan
8 YellowOrange
9 SpottedwhiteWhite
(except in Rebirth) Afterbirth
10 Pill White Cyan
11 Pill Black Yellow
12 Pill Black White
13 Pill White Yellow

Notes

  • Among the attribute modifying pill effects, only five of the seven visible attributes are covered: health, range, tears, speed, and luck. Both shot speed and damage can't be altered by pills.
  • (except in Rebirth) Pill effects have a chance to be narrated upon use, as do cards and runes.
  • (except in Rebirth) Currently, the "Retro Vision" pill effect can crash the game on some machines, resulting in restarting the current floor when the game is continued.
  • (except in Rebirth) The "Addicted!" pill will have no effect if Isaac has Collectible The Wafer iconThe Wafer.
    • Despite this, if one takes both the "Addicted!" pill with "Percs!" in the same room, Isaac will take a full heart of damage from all sources.
  • Having Collectible Midas' Touch iconMidas' Touch, (in Afterbirth † and Repentance)MeconiumMeconium, or (in Afterbirth † and Repentance)Collectible Hallowed Ground iconHallowed Ground and using a "Re-Lax" pill has a chance to spawn golden poop, black poop, or white poop, respectively.
  • (except in Rebirth) Using an "Infested!" pill on red poop will spawn blue spiders and the red poop will regenerate.
  • (except in Rebirth) If a Tiny or Large Champion monster drops a "One Makes You Small"/"Larger" pill and either pill is not in the current pill pool, an existing pill will be overwritten. If the chosen pill was already identified, the new pill will also be.
  • (except in Rebirth) "R U A Wizard" does not affect Lilith's Incubus.
  • (in Afterbirth † and Repentance) Using a "Gulp!" pill while holding two trinkets (with (in Afterbirth † and Repentance)Collectible Belly Button iconBelly Button or Collectible Mom's Purse iconMom's Purse) will cause both trinkets to be absorbed.
  • Isaac's hitbox can be reduced to 30% of original, which is achieved after 6 One Makes You Small pills. Further pills will only make him visually smaller, with no additional benefit.

Strategy

  • Use of unidentified pills is recommended for outside of combat as Hematemesis, R U a Wizard?, Paralysis, (except in Rebirth)Addicted!, (in Afterbirth † and Repentance) X-Lax, and (in Afterbirth † and Repentance) I'm Excited!!! can be detrimental mid-fight. However, (in Afterbirth † and Repentance) I'm Drowsy..., (in Afterbirth † and Repentance) Something's wrong..., Lemon Party, Bad Gas, and Pheromones are useless outside of combat.
  • (except in Rebirth) Percs! can be used in the sacrifice room to reduce the damage Isaac takes, potentially allowing him to do more sacrifices. However, if Isaac is teleported to the Devil/Angel room, he loses the effect.
  • (except in Rebirth) The invincibility effect from Power Pill and (in Afterbirth † and Repentance) Feels like I'm walking on sunshine! can be utilized to get into curse rooms, play blood donation machines, or use Devil beggars without taking any damage.
    • (except in Rebirth) Percs! can be used to reduce damage from these from chapter 4 onward.

Unlockable achievements

Trivia

  • Lemon Party is an internet shock site featuring a group of elderly men performing oral sex.
  • (in Afterbirth † and Repentance) The Vurp! pill is a portmanteau of the words vomit and burp.
  • (except in Rebirth) Power Pills activating the Gamekid effect is a reference to Pac-Man, in which the "Super-Pac" powerup is obtained by eating a Power Pellet.
  • "I Found Pills (and Ate Them)," "R U a Wizard?," and "I can see Forever" are all image macro memes.
    • Despite being called I Can See Forever, the effects only last for the rest of that floor.
  • (in Afterbirth † and Repentance) The Feels like I'm walking on sunshine! pill is a reference to the 80s song Walking on Sunshine.
  • Balls of Steel is a reference to Duke Nukem; it is one of Duke's more famous quotes.
  • Explosive Diarrhea is extremely loud and forceful diarrhea. In the original game, the message that displayed when the pill was activated was "Oh No!". The pill name and effect are likely a reference to Atomic Bomberman where a pickup of the same name would cause the player to drop bombs behind them uncontrollably for a short duration.
  • (except in Rebirth) Friends Till the End! was originally in the Wrath of the Lamb but removed in Rebirth, then put back into Afterbirth.
  • (in Afterbirth) Friends Till The End! is the only non-narrated pill.
  • 48 Hour Energy is a reference to the drink 5 Hour Energy.
  • (in Afterbirth † and Repentance) X-Lax is a reference to the anti-constipation medicine Ex-Lax.
  • (except in Rebirth) "One makes you larger" and "One makes you small" are references to Alice in Wonderland, and the specific wording is a reference to the song White Rabbit by Jefferson Airplane.
  • (except in Rebirth) "Percs" is a reference to a street name for the prescription drug Percocet, which is more generically known as Oxycodone. This drug is meant to be used to treat pain, but it is often abused for recreational purposes.
  • (except in Rebirth) The "???" is the only pill that has 3 different narrated voice lines.

Voiceovers

Pill Voiceover
???


48 Hour Energy
File:48HourEnergyVoiceover.wav.wav
Addicted
Amnesia
File:Amnesia.wav
Bad Gas
Bad Trip
Balls of Steel
Bombs Are Key
Feels like I'm walking on sunshine!
File:FeelsLikeImWalkingonSunshine.wav
Friends Till the End!
Full Health
Gulp!
Health Down
Health Up
Hematemesis
File:HematemisisVoiceover.wav
Horf!
I Can See Forever

File:ICanSeeForever2Voiceover.wav
I Found Pills
I'm Drowsy...
I'm Excited!!!
File:ImExcitedVoiceover.wav
Infested!
Infested?
Lemon Party
Luck Down
Luck Up
One Makes You Larger
File:OneMakesYouLarger.wav
One Makes You Small
Paralysis
Percs
Pheromones
Power Pill
Pretty Fly
Puberty
R U a Wizard?
Range Down
Range Up
Re-Lax
File:RelaxVoiceover.wav
Retro Vision
Something's wrong...
File:SomethingsWrongVoiceover.wav
Speed Down
Speed Up
Tears Down
Tears Up
Telepills
Vurp!
X-Lax