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Font TeamMeat P.pngFont TeamMeat l.pngFont TeamMeat a.pngFont TeamMeat c.pngFont TeamMeat e.pngFont TeamMeat b.pngFont TeamMeat o.png
Item icon
Item altar
Table dividing line 1.png
Table dividing line 2.png
4 rooms 4  rooms
Shop Shop
Greed mode only Shop Shop
Table dividing line 3.png
(page 3, column 3, row 6)
Added in Afterbirth

Placebo is an activated item added in Afterbirth.

Effect[edit | edit source]

  • Mimics the effect of Isaac's held pill, like Blank Card Blank CardCollectible Blank Card icon.png4 roomsHas the same effect as the card or rune currently held by Isaac. does with cards or runes.
    • Does not consume Isaac's held pill.
    • Will not mimic cards or runes.

Synergies[edit | edit source]

  • Balls Of Steel + Sharp Plug Sharp PlugSharp Plug Icon.pngUsing an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.: The player can gain functional invincibility.

Interactions[edit | edit source]

  • Starter Deck Starter DeckStarter Deck Icon.pngIsaac can hold 2 cards at once and all pills are replaced by cards.: All pills are replaced by cards, rendering Placebo useless.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • Placebo is a medicine or procedure prescribed for the psychological benefit to the patient rather than for any physiological effect.

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