Major changes are coming to the Wiki! To learn more and let your voice be heard, please go here.

Additionally, we are currently experiencing some bugs and glitches. We're working on fixing them, but please be aware this means certain images, such as the collection grid for items, will be replaced by errors for the time being.


From Binding of Isaac: Rebirth Wiki
Jump to: navigation, search
Font TeamMeat P.pngFont TeamMeat l.pngFont TeamMeat a.pngFont TeamMeat c.pngFont TeamMeat e.pngFont TeamMeat n.pngFont TeamMeat t.pngFont TeamMeat a.png
Item icon
Item altar
Table dividing line 1.png
Character appearance
Table dividing line 2.png
Boss Boss
Table dividing line 3.png
Added in Afterbirth(page 2, column 15, row 5)
Removed in Afterbirth(page 3, column 5, row 2)

Placenta is a passive item.

Effects[edit | edit source]

  • Grants one full Heart Container when picked up.
  • Isaac has a chance to regenerate half of a red heart every one minute of gameplay.

Notes[edit | edit source]

  • The regeneration can happen multiple times in the same room, so there is no need to move between rooms to continue regeneration.
  • It is possible to regenerate all missing hearts by simply standing in the same room for a while. Players may want to take a short break with the game not paused in order to regenerate all of their health.
  • Regeneration does not occur when standing in a Crawl Space.
  • Added in Afterbirth Regeneration occurs with Keeper; it will restore a full health coin for him.
  • Added in Afterbirth † Regeneration occurs with The Forgotten, restoring a third of a bone heart.
  • Regeneration will not occur for ???, as he only has soul hearts.

Synergies[edit | edit source]

  • Bloody Lust Bloody LustBloody Lust Icon.pngIncreases damage as Isaac receives damage. Damage increase stays for the whole floor.: Isaac can gain up to +6.5 damage if provided with a safe source of damage (e.g. fire or spikes), as he can regenerate health without having to do anything. However, this method is very slow and inefficient.
  • Gnawed Leaf Gnawed LeafGnawed Leaf Icon.pngAfter standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.: Allows Isaac to safely regenerate in any room.
  • IV Bag IV BagIV Bag Icon.pngUnlimitedUpon activation, Isaac loses a half-heart (one whole heart in The Womb onwards) for a random amount of coins, similar to the blood donation machine. / Blood Donation Machine: Allows Isaac to slowly gain coins, but due to the time required, this is very inefficient.

Interactions[edit | edit source]

  • Maggy's Bow Maggy's BowMaggy's Bow Icon.pngGives one heart container and doubles the healing provided by red hearts.: No effect on regen.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • A Placenta is an organ that forms from the mother's uterus during pregnancy that supports the unborn child during development until it is expelled during childbirth. In some cultures, it is a common practice for the mother and/or child to eat the expelled placenta.
    • This, like many other things Isaac does, is medically inadvisable.

Seeds[edit | edit source]

 PC  EPBF FS6M (Basement I boss)

 PC  419H 1DQM (Basement I boss, Gnawed Leaf in first floor item room)

Bugs[edit | edit source]

Bug Bug! Going into a Ventricle Razor portal at the same time the effect of Placenta is triggered will cause the effect to trigger in rapid succesion, effectively healing Isaac to full health.

The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item Pools Item Pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets