Plan C does not kill both phases of bosses like The Lamb, Hush, Ultra Greed, and Mega Satan, and is most useful when used during the last phase of these multi-phase bosses. After killing bosses, however, you will not be able to reach the chest or next floor in time. The kill still counts as a victory for Completion Marks, but the run will still end without extra lives.
While using this will technically kill Delirium, his death animation takes longer than 3 seconds, meaning you will die first and it will not count as a Delirium kill. Having extra lives that re-spawn your character outside the room will not help either; you must fight Delirium again.
However, if playing as Lazarus or if Lazarus' Rags is obtained, using Plan C against Delirium will net a very easy kill. One problem with this is that Delirium may quickly become an enemy that will go offscreen and become unkillable; this results in a waste of health and should only be used when low on health.
Invulnerable enemies and closed Hosts will not be killed by Plan C.
Isaac's last will will show his last damage source as the cause of death, not Plan C. If Isaac has not taken damage or lost health from any source, Isaac's face is shown.
Even if Isaac enters a trapdoor immediately after using Plan C, he will still die after arriving at the next floor.
This is a reference to the "Morning After" pill that prevents pregnancy, commonly referred to as "Plan B". It's also a reference to a "cyanide pill" that is fatally poisonous and can be deliberately taken to commit suicide. It's likely that the item is called "Plan C" because it is too late for a "Plan B" to prevent Isaac from being born; so the "next best thing", Plan C, is for Isaac to kill himself. Additionally, the initial of the C is likely a further reference to the aforementioned cyanide pill.
Before the Cathedral is unlocked, the viable method for this item would be to use it on Mom's Heart (or It Lives), which would be another joke around "Plan B."
This item is found in more item pools than any other item in the game.
This page was last edited on 15 October 2020, at 18:25.
Content is available under CC BY-NC-SA 3.0 unless otherwise noted. Game content and materials are trademarks and copyrights of their respective publisher and its licensors. All rights reserved.
This site is a part of Fandom, Inc. and is not affiliated with the game publisher.