Brain

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Added in AfterbirthStage dank depths.pngStage scarred womb.png

Brains move around the room slowly, leaving a trail of Creep that does one full heart of damage to Isaac. They are relatively weak on their own, but can quickly corner Isaac when fought in groups. Brains can also be spawned by Oobs.

Variants[edit | edit source]

Poison Mind[edit | edit source]

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Stage necropolis.pngStage womb.pngStage utero.pngStage scarred womb.png
 
The gate is open! Defeat The Lamb for the 1st timeThe gate is open!The gate is open!
Added in Afterbirth †

Poison Minds behave like regular Brains, but crawl diagonally and leave a trail of green creep.

MemBrain[edit | edit source]

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Stage depths.pngStage womb.pngStage utero.pngStage chest.png
Added in AfterbirthStage dank depths.pngStage scarred womb.png

The MemBrain is a much larger Brain that slowly moves around the room and occasionally hops to fire blood shots in 8 directions. It has a large amount of health, and will split into two Brains upon death.

Notes[edit | edit source]

  • Added in Afterbirth † If Poison Minds aren't unlocked yet, Brains would spawn in their rooms instead.

Trivia[edit | edit source]

  • MemBrains, along with Dingas and Mama Guts, have the second-highest base health of all non-boss enemies, second to Oobs.
  • A MemBrain is a pun on the word membrane, which means a thin, flexible layer of body tissue.


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