Brain

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Entity image

 
 
Table dividing line 1.png
 
32.0
Table dividing line 1.png
 
Stage The Depths icon.pngStage Necropolis icon.pngStage The Womb icon.pngStage Utero icon.png
Added in AfterbirthStage Dank Depths icon.pngStage Scarred Womb icon.png

Brains move around the room slowly, leaving a trail of Creep that does half heart of damage to the player, though they do 1 heart worth of contact damage. They are relatively weak on their own, but can quickly corner Isaac when fought in groups. Two of them are spawned by MemBrains upon death. Brains can also be spawned by Oobs.

Variants[edit | edit source]

Poison Mind[edit | edit source]

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Entity image

 
 
Table dividing line 1.png
 
301.0
Table dividing line 1.png
 
Stage Necropolis icon.pngStage The Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png
Chance To Replace Brains
 
The gate is open! Defeat The Lamb for the 1st timeThe gate is open!The gate is open!
Added in Afterbirth †

Poison Minds behave like regular Brains, but crawl diagonally and leave a trail of green creep.

Black Globin's Head[edit | edit source]

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Entity image

 
 
Table dividing line 1.png
 
279.0
Table dividing line 1.png
 
Stage The Cellar icon.pngStage The Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.pngStage Sheol icon.pngCurse Room Icon.pngSecret Room Icon.png
Added in Afterbirth

Black Globin's Heads slide towards Isaac, leaving behind a trail of damaging red creep.

Notes[edit | edit source]

  • Added in Afterbirth † If Poison Minds aren't unlocked yet, they are replaced by Brains.
  • Added in Afterbirth † Black Globin's Heads can spawn in Super Secret Rooms.


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