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Item icon
Item altar

Character appearance
Item Pool Treasure Room.png Treasure Room
Added in AfterbirthGreed mode onlyItem Pool Treasure Room.png Treasure Room
Added in Afterbirth (page 2, column 6, line 3)
Removed in Afterbirth (page 2, column 6, line 7)

Polyphemus is a special passive item.

Effects[edit | edit source]

  • Greatly increased damage: (Damage + 4) * 2
  • Tears down: (Delay * 2.1) + 3
  • If a tear kills an enemy, the tear travels on with the leftover damage.

Synergies[edit | edit source]

  • 20/20 20/2020 20 Icon.pngGrants double shot.: Fires 2 Polyphemus tears instead of one.
  • Brimstone BrimstoneBrimstone Icon.pngTears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.: Greatly increases damage and charge time.
  • Chocolate Milk Chocolate MilkChocolate Milk Icon.pngGrants charged tears that deal greater damage when fully charged.: Greatly increases damage of each shot. Charge time seems unaffected.
  • Cricket's Body Cricket's BodyCricket's Body Icon.pngGrants -1 Tear Delay and reduces Range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose Range and Damage scale with Isaac's. / The Parasite The ParasiteThe Parasite Icon.pngIsaac's tears split in two when they hit something. / Added in Afterbirth †Compound Fracture Compound FractureCompound Fracture Icon.pngIncreases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.: When split tears kill an enemy, they can continue to travel with leftover damage.
  • Epic Fetus Epic FetusEpic Fetus Icon.pngIsaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.: Isaac fires less frequent missiles that do massive damage.
  • Added in Afterbirth †Euthanasia EuthanasiaEuthanasia Icon.pngAdds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.: Burst needles that kill enemies can continue to travel with their leftover damage.
  • Eve's Mascara Eve's MascaraEve's Mascara Icon.pngDoubles damage, halves tears stat, and greatly reduces shot speed.: Makes tears even larger with increased damage. Fire rate will be extremely low but the large tear can kill most enemies in one shot.
  • Ipecac IpecacIpecac Icon.pngReplaces tears with explosive and poisoning projectiles fired in an arc from the mouth.: Slightly increases damage, large decrease in fire rate.
  • Added in Afterbirth †Lachryphagy LachryphagyLachryphagy Icon.pngIsaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage.: Increases tear delay and greatly increases how big the fed tear can grow.
  • Mom's Knife Mom's KnifeMom's Knife Icon.pngIsaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.: Massively increased damage while decreasing charge rate.
  • Monstro's Lung Monstro's LungMonstro's Lung Icon.pngIncreases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.: Increases charge time and damage.
  • Piercing tears: Tears do not lose strength upon piercing enemies.
  • Proptosis ProptosisProptosis Icon.pngTears start out massive with high damage, and then shrink down and become weaker over a short range.: Very large, high-damage tears with a short range.
  • Added in AfterbirthPupula Duplex Pupula DuplexPupula Duplex Icon.pngTransforms Isaac's tears into a wide arc shape which gives them a much larger hitbox. Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).: Widens tear shots and adds Spectral Tear effect.
  • Rotten Baby Rotten BabyRotten Baby Icon.pngA familiar that spawns blue flies.: Greatly increases flies damage.
  • Rubber Cement Rubber CementRubber Cement Icon.pngTears bounce off walls, enemies, and environmental objects.: Tears bounce off of enemies without losing strength.
  • Sacred Heart Sacred HeartSacred Heart Icon.pngIncreases damage and range while reducing shot speed and grants homing tears. Grants a Heart Container and replenishes all Red Hearts.: Greatly increases the damage and the size of the tear making the tear extremely big.
  • Tech.5 Tech.5Tech.5 Icon.pngGrants a unlimited range piercing laser with random rate of fire that does not replace tears. The laser might occasionally fire with the effect of a random item or trinket, such as Hook Worm, Spoon Bender or Tiny Planet.: Frequently fires a very high damage laser.
  • Technology TechnologyTechnology Icon.pngReplaces tears with a piercing laser with unlimited range.: Greatly increases damage while decreasing rate of fire.

Interactions[edit | edit source]

  • Dr. Fetus Dr. FetusDr. Fetus Icon.pngTears are replaced by bombs that benefit from bomb-enhancing effects and slide a fixed range after being fired.: Increases tear delay, and after the first bomb explodes, a second bomb appears where the first one exploded, doing roughly half the damage of the first.
  • The Inner Eye The Inner EyeThe Inner Eye Icon.pngGrants triple shot but decreases tears. / Mutant Spider Mutant SpiderMutant Spider Icon.pngGrants quadruple shot but decreases tears.: Fires 3 / 4 Polyphemus tears instead of one. Tear rate is not lowered further, but the effect on damage becomes a flat +5 bonus instead.
  • Lost Contact Lost ContactLost Contact Icon.pngEvery tear has a small shield which will allow it to block one enemy projectile.: Isaac's tears will block enemy shots and continue on, but lose 10 damage. If the tear had less than 10 damage left, it disappears.
  • A second Polyphemus - No effect.
  • Soy Milk Soy MilkSoy Milk Icon.pngTears shrink and do much less damage, but fire in very rapid succession.: Due to the fact that Soy Milk has the opposite effect of Polyphemus, the resulting combination will make Isaac's tears relatively normal.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • Polyphemus, ancient Greek for "The much vaunted", is a Cyclops. He is the son of Poseidon and the sea nymph Thoosa.
  • This item is used in Challenge #15 (Slow Roll).

Gallery[edit | edit source]

Seeds[edit | edit source]

 PC  01LE JSFZ (Treasure room adjacent to spawn)

 PC  CRCR 2DRH (Treasure room north of spawn)

 PC  Z9EF 3B2H (Treasure room adjacent to spawn)

 PC  KWG7 MXZR (Treasure room adjacent to spawn)

 PC  Normal mode only 4S8J GX6L (Treasure room adjacent to spawn)

 PC  Normal mode only NKV1 BPSK (Treasure room adjacent to spawn)

 PC  6DA4 KK71 (Treasure room adjacent to spawn)

 PS4  0ZT7 0K1A (First floor treasure room)

 Vita  YAXZ H2WD (Treasure room adjacent to spawn)

 3DS  WARH B6XF (Treasure room adjacent to spawn)

 3DS  3KDZ DYK1 (First floor treasure room; Curse of the Blind)

 3DS  919A H73A (Treasure room adjacent to spawn)

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