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Item icon
Item altar
Character appearance
Item Pool Treasure Room.pngTreasure Room
Added in AfterbirthGreed ModeItem Pool Treasure Room.pngTreasure Room
Added in Afterbirth (page 2, column 6, line 3)
Removed in Afterbirth (page 2, column 6, line 7)

Polyphemus is a Special passive item.

Effects[edit | edit source]

  • Greatly increased damage: (Damage + 4) * 2
  • Tears down: (Delay * 2.1) + 3
  • If a tear kills an enemy, the tear travels on with the leftover damage.

Synergies[edit | edit source]

  • 20/20 20/20: Fires 2 Polyphemus tears instead of one.
  • Brimstone Brimstone: Greatly increases damage and charge time.
  • Chocolate Milk Chocolate Milk: Greatly increases damage of each shot. Charge time seems unaffected.
  • Eve's Mascara Eve's Mascara: Makes tears even larger with increased damage. Fire rate will be extremely low but the large tear can kill most enemies in one shot.
  • Ipecac Ipecac: Slightly increases damage, large decrease in fire rate.
  • Mom's Knife Mom's Knife: Massively increased damage while decreasing charge rate.
  • Monstro's Lung Monstro's Lung: Increases charge time and damage.
  • Piercing shots: Tears do not lose strength upon piercing enemies.
  • Proptosis Proptosis: Very large, high-damage tears with a short range.
  • Added in Afterbirth Pupula Duplex Pupula Duplex: Widens tear shots and adds Spectral Tear effect.
  • Rotten Baby Rotten Baby: Greatly increases flies damage.
  • Rubber Cement Rubber Cement: Tears bounce off of enemies without losing strength.
  • Sacred Heart Sacred Heart: Greatly increases the damage and the size of the tear making the tear extremely big.
  • Tech.5 Tech.5: Frequently fires a very high damage laser.
  • Technology Technology: Greatly increases damage while decreasing rate of fire.

Interactions[edit | edit source]

  • The Inner Eye The Inner Eye / Mutant Spider Mutant Spider: Fires 3 / 4 Polyphemus tears instead of one. Tear rate is not lowered further, but the effect on damage becomes a flat +5 bonus instead.
  • Lost Contact Lost Contact: Isaac's tears will block enemy shots and continue on, but lose 10 damage. If the tear had less than 10 damage left, it disappears.
  • A second Polyphemus: No effect.

Ingame Footage[edit | edit source]

Seeds[edit | edit source]

 PC  01LE JSFZ (Treasure room adjacent to spawn)

 PC  CRCR 2DRH (Treasure room north of spawn)

 PC  Z9EF 3B2H (Treasure room adjacent to spawn)

 PC  KWG7 MXZR (Treasure room adjacent to spawn)

 PC  4S8J GX6L (Treasure room adjacent to spawn) (Normal mode only)

 PC  NKV1 BPSK (Treasure room adjacent to spawn) (Normal mode only)

 PC  6DA4 KK71 (Treasure room adjacent to spawn)

 PS4  0ZT7 0K1A (First floor treasure room)

 Vita  YAXZ H2WD (Treasure room adjacent to spawn)

 3DS  WARH B6XF (Treasure room adjacent to spawn)

 3DS  3KDZ DYK1 (First floor treasure room; Curse of the Blind)

 3DS  919A H73A (Treasure room adjacent to spawn)

Trivia[edit | edit source]

  • Polyphemus, ancient Greek for "The much vaunted", is a Cyclops. He is the son of Poseidon and the sea nymph Thoosa.
  • This item is used in Challenge #15 (Slow Roll).

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