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Difficulty[edit | edit source]
Because there are no Treasure Rooms, it is harder to find items. While this is standard for most challenges, Isaac also doesn't start with any items.
Strategy[edit | edit source]
- Other special rooms become much more important.
- Bombs are much more valuable when hunting for Secret Rooms as these can provide free items.
- Curse Rooms guarantee damage and can lower the chances of Devil Rooms. However, if Isaac has a full Soul Heart, Black Heart, or Bone Heart, the reward can outweigh the damage and still allow Isaac to access a Devil Room. Alternatively, wait to enter the Curse Room until after visiting the Devil Room.
- The BibleUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan. can be used to instantly win the boss fights against Mom, which can be used to preserve key health, and Mom's Heart/It Lives, which will complete the challenge.
Reward[edit | edit source]
|The WombDefeat Mom for the 1st timeThe HarbingersDefeat Mom for the 1st timeA Cube of MeatDefeat Mom for the 1st timeA HaloDefeat Mom using The BiblePuristDefeat Mom for the first time||XXXXXXXXLDefeat Mom for the 1st timeSPEED!Defeat Mom for the 1st timeHave a HeartDefeat Mom for the 1st timePRIDE DAY!Defeat Mom for the 1st timeOnan's StreakDefeat Mom for the 1st timeThe GuardianDefeat Mom for the 1st time||Aprils foolDefeat Mom for the 1st time|
|1.||Pitch Black||2.||High Brow||3.||Head Trauma||4.||Darkness Falls||5.||The Tank||6.||Solar System||7.||Suicide King||8.||Cat Got Your Tongue|
|9.||Demo Man||10.||Cursed!||11.||Glass Cannon||12.||When Life Gives You Lemons||13.||Beans!||14.||It's in the Cards||15.||Slow Roll||16.||Computer Savvy|
|17.||Waka Waka||18.||The Host||19.||The Family Man||20.||Purist|
|21.||XXXXXXXXL||22.||SPEED!||23.||Blue Bomber||24.||PAY TO PLAY||25.||Have a Heart||26.||I RULE!||27.||BRAINS!||28.||PRIDE DAY!|
|29.||Onan's Streak||30.||The Guardian|
|31.||Backasswards||32.||Aprils Fool||33.||Pokey Mans||34.||Ultra Hard||35.||Pong|
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|