Rebirth Collection Page

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Collection Page
Removed in Afterbirth
Rebirth
Added in Afterbirth
Afterbirth
Added in Afterbirth †
Afterbirth †

The table below is a recreation of what each page looks like without any DLC installed and all 341 items have been obtained.

Pages[edit | edit source]

(Click images to open the corresponding item page)

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The Sad OnionThe Sad OnionIncreases Tears by 0.7.The Inner EyeThe Inner EyeGrants triple shot but decreases tears.Spoon BenderSpoon BenderGrants Isaac homing tears.Cricket's HeadCricket's HeadIncreases damage by 0.5, and multiplies it by 1.5x.My ReflectionMy ReflectionGives Isaac's tears a boomerang effect, and increases range and shot speed.Number OneNumber One+1.5 tears, -15.77 rangeBlood of the MartyrBlood of the MartyrIncreases Damage by 1, and turns Isaac's tears into blood tears.Brother BobbyBrother BobbyFollows Isaac around shooting normal tears.SkatoleSkatoleAll types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.Halo of FliesHalo of FliesSpawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
1up!1up!Gives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1up!.Magic MushroomMagic MushroomIncreases all stats and enlargens Isaac.The VirusThe VirusInflicts poison to enemies who make contact with Isaac. Speed down.Roid RageRoid RageIncreases speed by 0.6, range by 5.25, and tear height by 0.5.<3<3Grants Isaac one red heart container and fully restores Isaac's health.Raw LiverRaw LiverGrants 2 Heart Containers and completely restores health.Skeleton KeySkeleton KeySets your key count to the maximum of 99.A DollarA DollarGives Isaac 99 coins. Can be found multiple times in a single playthrough.Boom!Boom!Grants 10 bombs.TranscendenceTranscendenceGrants flight.
The CompassThe CompassReveals all special rooms (except secret rooms of any kind).LunchLunchAdds 1 heart container.DinnerDinnerAdds 1 heart container.DessertDessertGrants Isaac one full red heart container.BreakfastBreakfastGrants Isaac one full red heart container.Rotten MeatRotten MeatAdds one heart container.Wooden SpoonWooden SpoonIncreases speed by 0.3.The BeltThe BeltIncreases speed by 0.3.Mom's UnderwearMom's UnderwearIncreases range.Mom's HeelsMom's HeelsIncreases range.
Mom's LipstickMom's LipstickIncreases range and shot height.Wire Coat HangerWire Coat HangerIncreases Tears by 0.7.The BibleThe BibleUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.The Book of BelialThe Book of BelialUpon use increases damage by 2 for the current room and by a further +50% if the character also has the Blood of the Martyr.
Removed in Afterbirth Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it, or Added in Afterbirth increases the chance by 12.5%.
The NecronomiconThe NecronomiconDamages all enemies in the room significantly.The PoopThe PoopSpawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop.Mr. BoomMr. BoomDrops a large bomb.Tammy's HeadTammy's HeadShoots 10 tears in a circle around Isaac, which retain the damage, shot speed, and special effects (such as poison) of Isaac's tears.Mom's BraMom's BraUpon use, petrifies all enemies in the current room for approximately 4 seconds.Kamikaze!Kamikaze!Creates an explosion in the same area as Isaac, dealing half a heart of damage to him and also damaging all enemies caught in the blast radius.
Mom's PadMom's PadUpon use, inflicts fear to all enemies in the room for 5 seconds.Bob's Rotten HeadBob's Rotten HeadUpon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.TeleportTeleportTeleports you to a random room on the level.Yum HeartYum HeartRestores 1 whole red heart.Lucky FootLucky Foot+1 Luck. Increases chance of winning Shell Game Beggar. (Independent of luck stat)Doctor's RemoteDoctor's RemoteSets a big red target on the ground (similar to the Epic Fetus item) which can be controlled with tear controls. After 6 seconds or by pressing space again, a huge explosive missile hits it, which damages all enemies caught in its blast radius.Cupid's ArrowCupid's ArrowGrants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.Shoop Da Whoop!Shoop Da Whoop!Fires a laser from Isaac's mouth.StevenStevenIncreases Damage by 1.PentagramPentagramIncreases damage and increases the chance for a Devil or Angel Room to appear.
Dr. FetusDr. FetusTears are replaced by bombs that benefit from bomb-enhancing effects and slide a fixed range after being fired.MagnetoMagnetoPulls pickups towards Isaac.Treasure MapTreasure MapReveals all rooms for every floor. However, it does not reveal icons or secret rooms.Mom's EyeMom's EyeAllows Isaac to fire tears from the back of his head.Lemon MishapLemon MishapCreates a small yellow pool of creep, which damages enemies that cross it.Distant AdmirationDistant AdmirationA red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.Book of ShadowsBook of ShadowsUpon use, creates a protective shield nullifying all types of damage for 10 seconds.The LadderThe LadderAllows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections.Charm of the VampireCharm of the VampireHeals the character for half of a red heart for every 13 monsters killed.The BatteryThe BatteryActivated Items can be "overcharged" to allow for an additional use.
Steam SaleSteam SaleReduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup.Anarchist CookbookAnarchist CookbookSpawns six troll bombs around the room.The HourglassThe HourglassUpon activation, enemies and their projectiles are slowed down for a short duration.Sister MaggySister MaggyA familiar that follows Isaac around shooting blood tears.TechnologyTechnologyReplaces tears with a piercing laser with unlimited range.Chocolate MilkChocolate MilkGrants charged tears that deal greater damage when fully charged.Growth HormonesGrowth HormonesIncreases damage by 1 and speed by 0.4.Mini MushMini MushIncreases Speed and Shot Height and decreases Isaac's size, but lowers Range.RosaryRosaryAdds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.Cube of MeatCube of MeatOrbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.
A QuarterA QuarterAdds 25 to Isaac's coin count, capping at 99.PHDPHDConverts all bad pills into good pills, spawns one pill pickup and restores health. Identifies all pills upon pickup.X-Ray VisionX-Ray VisionReveals and opens all Secret Room and Super Secret Room entrances.My Little UnicornMy Little UnicornUpon use, grants invulnerability and increased speed for five seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.Book of RevelationsBook of RevelationsAdds 1 soul heart, increases the chance for a Devil or Angel Room to appear, and increases the chance for the next boss to be a Horseman (except on XL floors and floors with fixed bosses such as Mom).The MarkThe MarkIncreases Damage and Speed, plus adds one Soul Heart.The PactThe PactIncreases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.Dead CatDead CatSets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again.Lord of the PitLord of the PitGrants flight and increases speed.The NailThe NailAdds one soul heart and allows the breaking of rocks and damaging enemies by simply walking over them. Increases damage and decreases speed. All effects except for the Soul Heart wear off upon leaving the room.
We Need to Go Deeper!We Need to Go Deeper!Creates a trapdoor to go to the next floor. If used in The Womb, it will create a trapdoor to Sheol, even if the player hasn't unlocked it.Deck of CardsDeck of CardsGives Isaac a random Tarot Card.Monstro's ToothMonstro's ToothMonstro jumps onto a random enemy, doing area damage. Can damage/kill the player if summoned in an room without enemies.Loki's HornsLoki's HornsGives a random chance for projectiles to fire in all 4 cardinal directions.Little ChubbyLittle ChubbyA familiar that charges forward and deals touch damage to any enemies in its path.Spider BiteSpider BiteAdds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.The Small RockThe Small RockIncreases damage by 1, increases tears by 0.2, and decreases speed by 0.1.Spelunker HatSpelunker HatReveals type of adjacent rooms, including location for secret rooms and super secret rooms.Super BandageSuper BandageGrants one Heart Container and gives 2 Soul Hearts.The GamekidThe GamekidUpon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed.
Sack of PenniesSack of PenniesIsaac is followed by a small bag that drops a coin every 2 rooms.Robo-BabyRobo-BabyFollows Isaac around, shooting enemies with an eye laser similar to Technology.Little C.H.A.D.Little C.H.A.D.A familiar who will drop a half red heart every 2 rooms.The Book of SinThe Book of SinSpawns a random pickup, pill, card, or trinket.The RelicThe RelicIsaac is followed by a small blue cross that will drop a Soul Heart every 4 rooms.Little GishLittle GishSpawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.Little StevenLittle StevenSpawns a familiar that follows Isaac around and fires homing tears.The HaloThe HaloGrants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.Mom's Bottle of PillsMom's Bottle of PillsGives Isaac a random pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough.The Common ColdThe Common ColdAdds a chance to shoot poison tears, dealing damage over time when inflicted.

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The ParasiteThe ParasiteIsaac's tears split in two when they hit something.The D6The D6Allows Isaac to re-roll collectible items in the current room into other items, depending on the current room's Item Pool.Mr. MegaMr. MegaGives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.The Pinking ShearsThe Pinking ShearsSeparates Isaac's head and body for the current room. Isaac's head, which now has flight, will be under the player's control, while his body will seek out enemies to attack by contact damage.The WaferThe WaferAll sources of damage that would cause more than one half heart of damage are reduced to one half heart instead.Money = PowerMoney = PowerIncreases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins.Mom's ContactsMom's ContactsAdds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.The BeanThe BeanIsaac releases bad gas, poisoning any enemy in close vicinity.Guardian AngelGuardian AngelSpawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies, and increases the speed of all orbital familiars.Demon BabyDemon BabyFollows Isaac and automatically fires at enemies in its reach.
Mom's KnifeMom's KnifeIsaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.Ouija BoardOuija BoardGrants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.9 Volt9 VoltReduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.Dead BirdDead BirdSpawns a flying familiar for the current room that chases enemies whenever Isaac takes damage.BrimstoneBrimstoneTears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.Blood BagBlood BagGrants one red heart container, restores 5 red hearts, and increases speed by 0.3.Odd MushroomOdd Mushroom+1.7 tears, +0.3 speed, reduces damage.Odd MushroomOdd MushroomGrants an empty heart container. Increases damage, range and shot height while reducing speed.Whore of BabylonWhore of BabylonIncreases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.Monster ManualMonster ManualSummons a random familiar for the current room. Can summon familiars not yet unlocked.
Dead Sea ScrollsDead Sea ScrollsTriggers the effect of a random activated item from a list of possible options (not every activated item is included).Bobby-BombBobby-BombGives Isaac 5 Bombs, and causes all dropped bombs to home towards the closest enemy.Razor BladeRazor BladeUpon use, deals one heart of damage to Isaac and grants +1.2 damage for the current room.Forget Me NowForget Me NowWhen activated, the level ends and is freshly regenerated with new rooms, monsters, and items. Disappears after use.Forever AloneForever AloneSpawns a blue attack fly that orbits a long distance from Isaac.Bucket of LardBucket of LardGrants two empty heart containers and heals Isaac by half a heart, but decreases speed by 0.2.A PonyA PonyPassively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies.Bomb BagBomb BagIsaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms.A Lump of CoalA Lump of CoalThe more distance tears travel, the more damage they will do.Guppy's PawGuppy's PawRemoves one red heart container in exchange for gaining 3 Soul Hearts.
Guppy's TailGuppy's TailIncreases chance of finding gold chests and normal chests, but reduces chance of finding pickups.IV BagIV BagUpon activation, Isaac loses a half-heart (one whole heart in The Womb onwards) for a random amount of coins, similar to the blood donation machine.Best FriendBest FriendDeploys a decoy Isaac that eventually explodes with an increased blast radius.Remote DetonatorRemote DetonatorBombs you place explode only when you use this item. Gives 5 bombs.StigmataStigmataIncreases damage, and adds 1 heart container.Mom's PurseMom's PurseAllows Isaac to hold 1 additional trinket.Bob's CurseBob's CurseGives 5 bombs and grants all bombs poison effect.Pageant BoyPageant BoySpawns several coins around Isaac.ScapularScapularOnce per room, when Isaac is reduced to his last half red Heart, the aura around his head temporarily vanishes and he is granted one Soul Heart.Speed BallSpeed BallIncreases speed by 0.3 and shot speed by 20%.
Bum FriendBum FriendA portable beggar who follows Isaac, picks up coins for himself, and occasionally drops a pickup after collecting a coin. Does not spawn collectibles.Guppy's HeadGuppy's HeadSpawns 2-4 blue flies to damage enemies.Prayer CardPrayer CardGrants an eternal heart per use.Notched AxeNotched AxeIsaac holds the axe above his head for as long as the spacebar button is held (or until he leaves the room). While holding the axe, Isaac can break any rock he touches, but cannot attack or pick up other items.InfestationInfestation1-3 Blue flies randomly spawn every time Isaac gets hit.IpecacIpecacReplaces tears with explosive and poisoning projectiles fired in an arc from the mouth.Tough LoveTough LoveAdds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears.The MulliganThe MulliganTears have a 1/6 chance of spawning allied blue flies when they hit an enemy.Technology 2Technology 2Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.Mutant SpiderMutant SpiderGrants quadruple shot but decreases tears.
Chemical PeelChemical PeelTears fired from left eye do increased damage.The PeeperThe PeeperSpawns a familiar that floats slowly around the room on a zig-zag pattern similar to Boom Flies damaging enemies it passes through.HabitHabitWhen Isaac is hit, 1 point of an item's charge is filled.Bloody LustBloody LustIncreases damage as Isaac receives damage. Damage increase stays for the whole floor.Crystal BallCrystal BallReveals the map (except the Super Secret Room) and drops a random Tarot Card or soul heart.Spirit of the NightSpirit of the NightGrants spectral tears and flight.Crack the SkyCrack the SkySummons multiple beams of light in random locations around the room, dealing a large amount of damage to any enemy that touches them.AnkhAnkhUpon death, the player will respawn as ??? with 3 soul hearts.Celtic CrossCeltic CrossGrants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.Ghost BabyGhost BabySpawns a familiar that follows Isaac around and fires spectral tears.
The CandleThe CandleThrows out a blue flame that can pass over gaps (but not through rocks). The flame damages anything in its path.Cat-O-Nine-TailsCat-O-Nine-TailsIncreases Shot Speed and damage.D20D20Rerolls all pickups in the current room.Harlequin BabyHarlequin BabySpawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.Epic FetusEpic FetusIsaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.PolyphemusPolyphemusMakes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage.Daddy LonglegsDaddy LonglegsDaddy Long Legs' shadow follows Isaac and stomps on enemies.Spider ButtSpider ButtDamages all enemies in the room and slows them and their projectiles down.Sacrificial DaggerSacrificial DaggerDagger orbits Isaac, dealing very high damage.MitreMitreGrants a chance of converting any red hearts pickups into soul hearts instead.
Rainbow BabyRainbow BabySpawns a familiar that follows Isaac around and fires tears with random effects.Dad's KeyDad's KeyOpens all doors in the current room when activated, including doors which require a key to open and entrances to secret rooms. Opens the big doors in the first room of both The Chest and the Dark Room.Stem CellsStem CellsAdds one filled heart container and increases Shot Speed.Portable SlotPortable SlotUpon activation, 1 coin will be consumed, and a random pickup may drop, similar to the slot machine.Holy WaterHoly WaterWhen Isaac receives damage, the bottle breaks and a puddle of blue creep forms, which damages non-flying enemies, similar to Lemon Mishap. The bottle is reformed upon entering a different room.FateFateGrants flight and one eternal heart.The Black BeanThe Black BeanWhen taking damage, Isaac farts, causing poison damage to all enemies in range.White PonyWhite PonyPassively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies while also casting the effect of Crack the Sky.Sacred HeartSacred HeartIncreases damage and range while reducing shot speed and grants homing tears. Grants a Heart Container and replenishes all Red Hearts.ToothpicksToothpicks+0.7 tears, +16% shot speed.
Holy GrailHoly GrailGrants flight and one heart container.Dead DoveDead DoveGrants spectral tears and flight.Blood RightsBlood RightsDamages all enemies in the room, but deals a heart of damage to Isaac with each use.Guppy's Hair BallGuppy's Hair BallLoosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.AbelAbelA familiar that mirrors the player's movements and shoots in the opposite direction.SMB Super FanSMB Super FanIncreases all stats.PyroPyroAdds 99 bombs.3 Dollar Bill3 Dollar BillGives Isaac a random tear effect every room.
Removed in Afterbirth The effect given changes upon entering a room.
Added in Afterbirth The effect changes every 3 seconds.
Telepathy for DummiesTelepathy for DummiesUpon activation, grants homing tears for the current room.MEAT!MEAT!Adds a heart container and increases damage.
Magic 8 BallMagic 8 BallIncreases Shot Speed, and drops a Tarot Card when picked up.Mom's Coin PurseMom's Coin PurseSpawns 4 random pills around Isaac.SqueezySqueezyIncreases tears by 0.4, and spawns 2 Soul Hearts pickups.Jesus JuiceJesus JuiceIncreases Damage and Range.BoxBoxSpawns 1 of each (non-collectible) item: 1 coin, 1 key, 1 bomb, 1 heart, 1 card, 1 pill, 1 trinket.Mom's KeyMom's KeySpawns 2 keys. Generates additional pickups from chests.Mom's EyeshadowMom's EyeshadowTears have a chance to charm enemies.Iron BarIron BarIncreases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.Midas' TouchMidas' TouchEnemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin.Humbling BundleHumbling BundleGives one extra pickup (1+1 Free version) of Red Hearts, pennies, bombs, and keys. Does not work with blue, black, and half red hearts, nickels, and dimes.

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Fanny PackFanny PackHas a chance to drop a random pickup when Isaac takes damage.Sharp PlugSharp PlugUsing an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.GuillotineGuillotineIsaac's head is removed from his body and floats around him. Increases Damage by 1 and grants -1 Tear Delay.Ball of BandagesBall of BandagesOrbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.Champion BeltChampion BeltIncreases damage, but also increases the chance of champion enemies appearing.Butt BombsButt BombsGives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.Gnawed LeafGnawed LeafAfter standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.Spider BabySpider BabyWhen hit, spawns up to 2 blue spiders.Guppy's CollarGuppy's CollarGrants Isaac a permanent 50% chance to respawn with 1/2 of a red heart after death.Lost ContactLost ContactEvery tear has a small shield which will allow it to block one enemy projectile.
AnemicAnemic+5 range. After Isaac is damaged, a trail of red creep will be left behind Isaac until he leaves the current room.Goat HeadGoat HeadA Devil Room / Angel Room Door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.Ceremonial RobesCeremonial RobesAdds 3 black hearts and increases Damage by 1.Mom's WigMom's WigAdds a chance to spawn blue spiders when firing tears. Restores 1 red heart.PlacentaPlacentaGrants a full heart container, and a chance to regenerate a half-heart of health every minute of gameplay.Old BandageOld BandageAdds one empty heart container. Whenever Isaac takes damage there's a chance that a Red Heart may drop.Sad BombsSad Bombs+5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears.Rubber CementRubber CementTears bounce off walls, enemies, and environmental objects.Anti-GravityAnti-Gravity-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.PyromaniacPyromaniacIsaac heals 1 heart instead of taking damage from an explosive source. Adds 5 bombs.
Cricket's BodyCricket's BodyGrants -1 Tear Delay and reduces Range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose Range and Damage scale with Isaac's.GimpyGimpyHas a chance of spawning a soul heart or black heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.Black LotusBlack LotusGrants the player one red heart container, one soul heart, and one black heart.Piggy BankPiggy BankGives 3 pennies on pick-up. Every time Isaac is damaged, he will drop one additional penny.Mom's PerfumeMom's PerfumeAdds a chance to shoot fear tears and decreases tear delay by 1.Monstro's LungMonstro's LungIncreases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.AbaddonAbaddonIncreases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.Ball of TarBall of TarAdds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed.Stop WatchStop WatchRemoved in Afterbirth Automatically inflicts slow to all enemies in every room.
Added in Afterbirth Upon taking damage, inflicts slow to all enemies for the current room.
Tiny PlanetTiny PlanetRange up and makes shot tears revolve around Isaac until they drop.
Infestation 2Infestation 2Spawns allied blue spiders from killed enemies.E ColiE ColiGives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.Death's TouchDeath's TouchIncreases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.Key Piece 1Key Piece 1Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.Key Piece 2Key Piece 2Combined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.Experimental TreatmentExperimental TreatmentRandomly increases and decreases some of the character's stats. There will always be at least one stat increase and one decrease and the same stats can be increased/decreased multiple times.Contract From BelowContract From BelowDoubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.InfamyInfamyChance to block projectiles coming from any direction.Trinity ShieldTrinity ShieldIsaac gains a shield that protects him from enemy shots.Tech.5Tech.5Grants a unlimited range piercing laser with random rate of fire that does not replace tears. The laser might occasionally fire with the effect of a random item or trinket, such as Hook Worm, Spoon Bender or Tiny Planet.
20/2020/20Grants double shot.Blue MapBlue MapShows secret and super secret room locations on the map.BFFS!BFFS!Increases the size and damage of familiars.Hive MindHive MindIncreases the size of blue spiders and Blue Flies and doubles the amount of damage they deal.There's OptionsThere's OptionsThere will be 2 items available to choose from after defeating a boss. Choosing 1 item causes the other to disappear.Bogo BombsBogo BombsAll standard bomb pickups become 1+1 bomb pickups.Starter DeckStarter DeckIsaac can hold 2 cards at once and all pills are replaced by cards.Little BaggyLittle BaggyIsaac can hold 2 pills at once and all cards are replaced by pills.Magic ScabMagic ScabIncreases luck and HP by 1.Blood ClotBlood ClotIncreases damage by 1 and range by 5 for tears fired from the left eye.
ScrewScrew+0.5 tears up, +0.2 shot speed up.Hot BombsHot BombsGrants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.Fire MindFire MindGrants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.Missing No.Missing No.Randomizes all passive items upon pickup and at the start of each succeeding floor.Dark MatterDark MatterIncreases Damage by 1 and adds a chance to shoot fear tears.Black CandleBlack CandlePrevents curses. Grants one black heart. Increases the chance for a Devil or angel room to appear.ProptosisProptosisTears start out massive with high damage, and then shrink down and become weaker over a short range.Missing Page 2Missing Page 2Gives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room.Smart FlySmart FlyAfter Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.Dry BabyDry BabySpawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering The Necronomicon effect.
Juicy SackJuicy SackA familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.Robo-Baby 2.0Robo-Baby 2.0Fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears.Rotten BabyRotten BabyA familiar that spawns blue flies.Headless BabyHeadless BabyFamiliar that follows Isaac, leaving blood creep on the ground.LeechLeechSpawns a friendly familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one.Mystery SackMystery SackSpawns a familiar that follows Isaac around and has a chance to drop a heart, coin, bomb, or key after clearing a room.BBFBBFSpawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.Bob's BrainBob's BrainSpawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.Best BudBest BudWhen hit, summons a white attack fly similar to Distant Admiration for the current room.Lil BrimstoneLil BrimstoneA Familiar that shoots a thin Brimstone beam. Must charge like Brimstone before shooting.
Isaac's HeartIsaac's HeartIsaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.Lil HauntLil HauntA familiar that damages enemies by chasing them as well as inducing the fear effect.Dark BumDark BumSpawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.Big FanBig FanSpawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.Sissy LonglegsSissy LonglegsWanders about the room, occasionally spawning blue spiders.Punching BagPunching BagSpawns a Mulligan Familiar that will wander the room randomly. Enemies will attack the Mulligan if it's closer.How to JumpHow to JumpGives Isaac the ability to jump (over gaps, spikes, etc.).D100D100Upon use, rerolls all passive items on Isaac like the D4, every pedestal item in the room like The D6, and every pickup like the D20.D4D4Rerolls all of Isaac's items.D10D10Rerolls the enemies in a room. Only rerolls enemies that are still alive (does not spawn new enemies).
Blank CardBlank CardHas the same effect as the card or rune currently held by Isaac.Book of SecretsBook of SecretsUpon use, gives the effect of Treasure Map, The Compass, or Blue Map for the duration of the current floor.Box of SpidersBox of SpidersSummons 2-4 blue spiders.Red CandleRed CandleThrows a persistent flame that deals high damage and diminishes as it damages enemies or blocks shots.The JarThe JarWhen at full health, up to 4 extra hearts can be stored in the jar.Flush!Flush!Changes all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.Satanic BibleSatanic BibleUpon activation, Isaac gains a black heart.Head of KrampusHead of KrampusFires a cross-patterned brimstone shot, just like The Fallen and Krampus shoot.Butter BeanButter BeanIsaac farts and pushes back nearby enemies.Magic FingersMagic FingersFor 1 coin, damages all enemies in the room.
ConverterConverterWhen used, converts two soul hearts into a heart container.Pandora's BoxPandora's BoxUpon use, spawns certain pickups or items depending on the floor it is used on. Single-use.Unicorn StumpUnicorn StumpUpon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears.TaurusTaurusSpeed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.AriesAries+0.25 Speed. Running into enemies while at a high speed will deal 18 points of damage. Does not prevent contact damage.CancerCancerAdds 3 soul hearts. Grants The Wafer effect for the current room upon taking damage.LeoLeoAllows you to crush rocks when you walk over them.VirgoVirgoGrants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills".LibraLibraGives 6 coins, 6 bombs, and 6 keys and balances out all attributes.ScorpioScorpioGrants poison tears, which deal damage over time when inflicted.

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SagittariusSagittariusIncreases speed by +0.2 and grants piercing tears.CapricornCapricornAll stats up.AquariusAquariusA trail of blue creep is left behind Isaac, which damages enemies.PiscesPisces-1 Tear Delay, adds knock-back shots and increases tear size.Eve's MascaraEve's MascaraDoubles damage, halves tears stat, and greatly reduces shot speed.Judas' ShadowJudas' ShadowAdds an extra life; upon death, it respawns Isaac as Black Judas with only two black hearts.Maggy's BowMaggy's BowGives one heart container and doubles the healing provided by red hearts.Holy MantleHoly MantleAutomatically negates first taken damage in every room.Thunder ThighsThunder ThighsDestroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.Strange AttractorStrange AttractorPickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
Cursed EyeCursed EyeGrants charged tears that can be fired in a tight burst of four. Getting hit while charging will teleport Isaac into another room.Mysterious LiquidMysterious LiquidTears leave a small, short lasting pool of creep on impact or when their range is depleted.GeminiGeminiSuture becomes attached to Isaac, and does touch damage to enemies within its attacking range.Cain's Other EyeCain's Other EyeSpawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and shoots normal tears in the same direction as Isaac.???'s Only Friend???'s Only FriendSummons a big attack fly that can be controlled with the shooting direction-keys.Samson's ChainsSamson's ChainsPull a chain and ball behind you that will damage enemies on contact and is able to break stones.Mongo BabyMongo BabySummons a familiar that copies the tears of Isaac's other familiars.Isaac's TearsIsaac's TearsShoots 8 tears around Isaac, which retain the damage, shot speed, and special effects of his tears. Each tear shot by Isaac increases item charge by one.UndefinedUndefinedTeleports Isaac to either the Secret Room, Super Secret Room, Treasure Room, or I AM ERROR.ScissorsScissorsUpon use, turns Isaac's head into a stationary familiar for the current room which fires normal tears that deal 3.5 damage.
Breath of LifeBreath of LifeGrants a brief moment of invincibility when the charge bar hits zero. If spacebar is held for an additional second after hitting zero, Isaac will take damage.The PolaroidThe PolaroidIf the character has half a red heart or no red hearts after taking damage, it triggers the Book Of Shadows effect, creating a shield that nullifies all types of damage for 5 seconds. Also allows entrance into The Chest.The NegativeThe NegativeIf the character has half a red heart or no red hearts after taking damage, it triggers The Necronomicon effect, damaging all enemies in the room. Also allows entrance into the Dark Room.The Ludovico TechniqueThe Ludovico TechniqueInstead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.Soy MilkSoy MilkTears shrink and do much less damage, but fire in very rapid succession.GodheadGodheadIncreases damage and range while reducing tears and shot speed. Grants homing tears and tears gain a damaging halo.Lazarus' RagsLazarus' RagsUpon dying, resurrect as Revived Lazarus with one heart container and Anemic item.The MindThe MindGrants the combined effects of the Blue Map, Treasure Map, and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms.The BodyThe BodyAdds 3 heart containers.The SoulThe SoulGrants two soul hearts. Isaac now repels enemy projectiles.
Dead OnionDead OnionGrants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed.Broken WatchBroken WatchChance upon entering a room to slow down or speed up every enemy and their attacks. The chance to slow enemies is quite higher than the chance to speed them up.The BoomerangThe BoomerangThrows a short-range boomerang which does a bit of damage and has a high chance to stun the enemy for 2 seconds. Can also be used to grab pickups.Safety PinSafety PinIncreases range and shot speed, while adding 1 Black Heart.Caffeine PillCaffeine PillIncreases speed and reduces character size. Also gives a random pill.Torn PhotoTorn PhotoTears + Shot speed up.Blue CapBlue CapGrants 1 heart container and increases tears, but decreases shot speed.Latch KeyLatch KeyIncreases Luck by 1, grants 1 Soul Heart and spawns 2 Keys.Match BookMatch BookGrants Isaac 1 Black Heart and 3 bombs. Can also give troll bombs.SynthoilSynthoilIncreases damage by 1, range by 5.25, and tear height by 0.5.
A SnackA SnackGrants one full red heart container.


The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op MainPageItems Small.png Items Item Pools Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets