Cards and Runes

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Pickups
Hearts Coins Bombs Keys Batteries Pills Cards Chests Added in Afterbirth  Sacks

Cards and runes are usable items with a wide variety of effects. They take up the same slot as pills.

Runes and special cards are unlocked by completing challenges.

Cards[edit | edit source]

Major Arcana Cards[edit | edit source]

When on the ground, these cards look like: TarotCard.png


Name ID Icon Message Effect
0 - The Fool 1 0 - The Fool Icon.png Where journey begins Teleports you back to the starting room of a floor.
I - The Magician 2 I - The Magician Icon.png May you never miss your goal Grants homing tears for the current room.
II - The High Priestess 3 II - The High Priestess Icon.png Mother is watching you Mom's dismembered leg is called down to deal 300 damage to anything it stomps. It will always stomp on the enemy with the most health. If used in an empty room or during the fight with Mom, it will stomp Isaac instead.
III - The Empress 4 III - The Empress Icon.png May your rage bring power Triggers the Whore of Babylon effect.
IV - The Emperor 5 IV - The Emperor Icon.png Challenge me! Teleports you into the Boss Room of a floor.
V - The Hierophant 6 V - The Hierophant Icon.png Two prayers for the lost Spawns 2 soul hearts.
VI - The Lovers 7 VI - The Lovers Icon.png May you prosper and be in good health Drops 2 full red hearts. If used in a black heart or eternal heart-containing Super Secret Room, it will spawn those types of hearts instead.
VII - The Chariot 8 VII - The Chariot Icon.png May nothing stand before you Grants the temporary invulnerability effect of My Little Unicorn.
VIII - Justice 9 VIII - Justice Icon.png May your future become balanced Spawns one of each consumable drop (a heart, a key, a bomb, and a coin).
IX - The Hermit 10 IX - The Hermit Icon.png May you see what life has to offer Teleports you to the shop. If there is no shop, this will act as a random teleport. If the shop has not yet been accessed, this card will unlock the door without requiring a key (as long as the player exits through the main entrance).
X - Wheel of Fortune 11 X - Wheel of Fortune Icon.png Spin the wheel of destiny Spawns an arcade machine (Slot Machine or Fortune Teller).
XI - Strength 12 XI - Strength Icon.png May your power bring rage Upon use, increases all of Isaac's stats except tears and adds one (temporary) heart container for the current room.
XII - The Hanged Man 13 XII - The Hanged Man Icon.png May you find enlightenment Removes Isaac's body, allowing him to fly around for the duration of the room, similar to Transcendence.
XIII - Death 14 XIII - Death Icon.png Lay waste to all that oppose you Deals 40 damage to all enemies in the room.
XIV - Temperance 15 XIV - Temperance Icon.png May you be pure in heart Spawns a blood donation machine.
Added in Afterbirth Spawns a devil beggar in Greed Mode.
XV - The Devil 16 XV - The Devil Icon.png Revel in the power of darkness Increases your damage by 2 until you leave the room (same effect as the Book of Belial).
XVI - The Tower 17 XVI - The Tower Icon.png Destruction brings creation Spawns 6 troll bombs randomly around the room.
XVII - The Stars 18 XVII - The Stars Icon.png May you find what you desire Teleports the player to the Treasure Room. If there is no Treasure Room, this will act as a random teleport. Randomly chooses a Treasure Room on Curse of the Labyrinth. If the Treasure Room has not yet been accessed, this card will unlock the door without requiring a key (as long as the player exits through the main entrance).
XVIII - The Moon 19 XVIII - The Moon Icon.png May you find all you have lost Teleports the player to the Secret Room. This card will open one random wall once inside the Secret Room, so you can leave even if you don't have any bombs available.
XIX - The Sun 20 XIX - The Sun Icon.png May the light heal and enlighten you Restores full health, deals 100 damage to all enemies in the room, and reveals the map for the current floor, except the Super Secret Room.
XX - Judgement 21 XX - Judgement Icon.png Judge lest ye be judged Spawns a Beggar.
XXI - The World 22 XXI - The World Icon.png Open your eyes and see Reveals the entire floor, except for the Super Secret Room. Has no effect if under the effect of Curse of the Lost or Amnesia.

Playing Cards[edit | edit source]

When on the ground, these cards look like: FaceCard.png


Name ID Icon Message Effect
2 of Clubs 23 2 of Clubs Icon.png Item multiplier Doubles your bombs. If you have no bombs, gives you 2 instead.
2 of Diamonds 24 2 of Diamonds Icon.png Item multiplier Doubles your coins. If you have no coins, gives you 2 instead.
2 of Spades 25 2 of Spades Icon.png Item multiplier Doubles your keys. If you have no keys, gives you 2 instead.
2 of Hearts 26 2 of Hearts Icon.png Item multiplier Doubles Isaac's current number of red hearts. Does not affect Eternal Hearts, Soul Hearts, or Black Hearts. Doesn't add new heart containers, just fills empty ones.
Added in Afterbirth † Ace of Clubs 27 Ace of Clubs Icon.png Convert all Turns all pickups and chests in the room into bombs.
Added in Afterbirth † Ace of Diamonds 28 Ace of Diamonds Icon.png Convert all Turns all pickups and chests in the room into coins.
Added in Afterbirth † Ace of Hearts 30 Ace of Hearts Icon.png Convert all Turns all pickups and chests in the room into random heart pickups.
Joker 31 Joker Icon.png ??? Teleports you to the Devil Room or Angel Room.

Special Cards[edit | edit source]

Magic: The Gathering Card Backs[edit | edit source]

When on the ground, these cards look like: Removed in Afterbirth † FaceCard.png    Added in Afterbirth † MagicCard.png

Name ID Icon Message Effect
Chaos Card 42 Chaos Card Icon.png ??? Throws the card to kill anything in its path. Opens normal doors.
Added in Afterbirth † Huge Growth 52 Huge Growth Icon.png Become immense! Makes Isaac large for the current room, increasing his range and damage.
Added in Afterbirth † Ancient Recall 53 Ancient Recall Icon.png Draw 3 cards Spawns 3 random cards.
Added in Afterbirth † Era Walk 54 Era Walk Icon.png Savor the moment For the current room, enemies are slowed, Isaac's speed is increased, and his shot speed is decreased.

Credit Card Backs[edit | edit source]

When on the ground, this card looks like: Removed in Afterbirth † FaceCard.png    Added in Afterbirth † CreditCard.png

Name ID Icon Message Effect
Credit Card 43 Credit Card Icon.png Charge it! Converts all items in the Shop or Devil Room into pickups or items on pedestals, allowing them to be picked up for free.

Playing Card Backs[edit | edit source]

When on the ground, these cards look like: FaceCard.png

Name ID Icon Message Effect
Rules Card 44 Rules Card Icon.png ??? Displays a cryptic statement on the screen, similar to a Fortune Teller. These messages (often) provide hints on bosses, bonus areas, etc.
Suicide King 46 Suicide King Icon.png A true ending? Kills Isaac and spawns lots of pickups, items, and/or chests in the same room.
Added in Afterbirth ? Card 48 Q Card Icon.png Double active When used, copies the effect of Isaac's currently held activated collectible item.

Card Against Humanity Backs[edit | edit source]

When on the ground, this card looks like: Removed in Afterbirth † FaceCard.png    Added in Afterbirth † HumanityCard.png

Name ID Icon Message Effect
A Card Against Humanity 45 A Card Against Humanity Icon.png Something stinks... Covers the entire room with poop. The process is not instant, and the room will not get filled if you leave it before it's done filling.

Chance Card Backs[edit | edit source]

When on the ground, this card looks like: Removed in Afterbirth † FaceCard.png    Added in Afterbirth † ChanceCard.png

Name ID Icon Message Effect
Added in Afterbirth Get out of Jail Free Card 47 Get out of Jail Free Card Icon.png Open Sesame Upon use, opens all doors in the current room (including the golden door at The Chest / Dark Room), similar to Dad's Key.

Holy Card Backs[edit | edit source]

When on the ground, this card looks like: HolyCard.png

Name ID Icon Message Effect
Added in Afterbirth † Holy Card 51 Holy Card Icon.png You feel protected Grants the Holy Mantle effect for the current room.

Runes[edit | edit source]

Left Pointing Runes[edit | edit source]

When on the ground, these runes look like: Rune2.png


Rune ID Icon Unlock method Message Effect
Hagalaz 32 Hagalaz Icon.png Rune of Hagalaz Complete challenge #1Rune of HagalazRune of Hagalaz Destruction Destroys all breakable objects in the room. Does not affect Key Blocks.
Jera 33 Jera Icon.png Rune of Jera Complete challenge #2Rune of JeraRune of Jera Abundance Clones all pickups and chests in a room (including shop pickups; the clones can then be picked up for free). Cloned chests will contain exactly the same type of items: if the original contains a pickup, so will the clone; the same is true for Collectibles. Cannot clone other Jera runes and trinkets.
Ehwaz 34 Ehwaz Icon.png Rune of Ehwaz Complete challenge #3Rune of EhwazRune of Ehwaz Passage Creates a trapdoor leading to the next floor. Has an estimated 1/12 (8%) chance to spawn a door to a Crawl Space instead.
Dagaz 35 Dagaz Icon.png Rune of Dagaz Complete challenge #4Rune of DagazRune of Dagaz Purity Removes any curses from the current floor and grants a soul heart. (This will not remove Curse of the Labyrinth.)

Right Pointing Runes[edit | edit source]

When on the ground, these runes look like: Rune1.png


Rune ID Icon Unlock method Message Effect
Ansuz 36 Ansuz Icon.png Rune of Ansuz Complete challenge #5Rune of AnsuzRune of Ansuz Vision Reveals the whole map, including the Secret Room and the Super Secret Room.
Perthro 37 Perthro Icon.png Rune of Perthro Complete challenge #6Rune of PerthroRune of Perthro Change Rerolls all pedestal items in the room. (This is the same effect as The D6.)
Berkano 38 Berkano Icon.png Rune of Berkano Complete challenge #20Rune of BerkanoRune of Berkano Companionship Summons 3 friendly blue flies and 3 friendly blue spiders.
Algiz 39 Algiz Icon.png Rune of Algiz Complete challenge #8Rune of AlgizRune of Algiz Resistance Grants a shield which lasts for 30 seconds.
Added in Afterbirth Blank Rune 40 Blank Rune Icon.png Blank Rune Complete challenge #30 (Removed in Afterbirth † The unlock is bugged and actually unlocks Kidney Stone)Blank RuneBlank Rune ??? Grants a random rune effect. Has a 25% chance to spawn another Blank Rune upon use.

Other Runes[edit | edit source]

Rune ID Icon Unlock method Message Effect
Added in Afterbirth † Black Rune 41 Black Rune Icon.png Black Rune Defeat Ultra Greedier as ApollyonBlack RuneBlack Rune Void Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into blue flies and spiders. Consumes all pedestal items in the room and turns them into random stat upgrades.

Other[edit | edit source]

These are items other than cards and runes (and pills) that take up the consumable slot. When on the ground, each of these items are uniquely identifiable by their respective icon.

Name ID Icon Message Effect
Added in Afterbirth Dice Shard 49 Dice Shard Icon.png D6 + D20 Upon use, activates the effects of the D6 and the D20 at the same time.
Added in Afterbirth Emergency Contact 50 Emergency Contact Icon.png Help from above When used, will cause two Mom's Hands to come down and grab two random enemies.

Notes[edit | edit source]

  • The game counts runes as cards for the purposes of Starter Deck, Blank Card, and Added in Afterbirth † Tarot Cloth.
  • Added in Afterbirth Using the Blank Card with the ? Card teleports the player to the I AM ERROR room of the current floor. This consumes both the Blank Card and the ? Card.
  • Using the Joker card in The Womb II or Utero II will instantly teleport the player to the Devil Room or Angel Room with a trapdoor leading to Sheol or to the Cathedral. This can be used to skip Mom's Heart or It Lives and will not count as a kill.
  • Using The Joker card can allow Isaac to encounter Devil Rooms or Angel Rooms on floors they otherwise cannot appear on.
  • If you use the Strength card with only one soul or black heart left, and lose the soul or black heart while in the same room, you retain the full heart container that Strength grants after you leave.
  • Using the Strength card as ??? will give you a permanent soul heart instead of a temporary one. In Afterbirth, when Keeper has only one coin heart, he can use the Strength card to gain a second one which is also permanent.

Unlockable Achievements[edit | edit source]

Trivia[edit | edit source]

  • The runes and their names ingame are based off of Norse runes and/or the runic language. Runes also used to signify that it has or is some kind of magic.
  • The Suicide King card is a reference to the King of Hearts card, which is usually called that way because it depicts a king in a way that he appears to be sticking his sword into his head.
  • Added in Afterbirth The Get out of Jail Free card is a reference to a card with the same name that appears in the table game Monopoly.
  • The "A Card Against Humanity" card is a reference to the card game "Cards Against Humanity".
  • The "XVI - The Tower" card (plus given the fact that there is a Necropolis area in the game) can be a reference to Tower Of Silence
  • Ancient Recall, Era Walk, Huge Growth, and Chaos Card are all based on cards from Magic: The Gathering.
    • The Chaos Card is a reference to the card "Chaos Orb", which also instantly destroys enemies that it touches.
    • Added in Afterbirth † The "Ancient Recall" card is a reference to the card "Ancestral Recall", which also draws three cards.
    • Added in Afterbirth † The "Era Walk" card is a reference to the card "Time Walk", which allows players to take an extra turn.
    • Added in Afterbirth † The "Huge Growth" card is a reference to the card "Giant Growth", which buffs creatures summoned in the game.
  • Added in Afterbirth † Many cards were given new unique back sprites in Booster Pack #5, some originating from Antibirth.


The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op MainPageItems Small.png Items Item Pools Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets