- x2.3 damage multiplier.
- +1 flat damage.
- +4.125 range.
- +0.75 tear height.
- -0.4 tears.
- -25% shot speed.
- Grants homing tears.
- Grants homing bombs (the effect of Bobby-BombGives Isaac 5 Bombs, and causes all dropped bombs to home towards the closest enemy.).
- Grants one heart container.
- Replenishes all red hearts.
- Sacred Heart has the highest damage multiplier of all passive items.
- Although this item increases range, the reduction of shot speed results in a slight decrease in effective range, not accounting for homing.
- The Sacred Heart (also known as the Most Sacred Heart of Jesus) is a devotion practiced in Catholicism, which represents "the heart of Jesus Christ God, pierced on the cross", and God's "boundless and passionate love for mankind".
K4X2 K1K0 (4th floor angel room)
MJ0A X38C (4th floor angel room)
6FR2 46G3 (4th floor angel room)