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|Guppy||Beelzebub||Super Bum||Yes Mother?||Bob||Fun Guy||Leviathan|| Conjoined |
|Spun||Seraphim||Oh Crap||Bookworm||Spider Baby||Adult||Stompy|
Isaac will gain 3 soul hearts and permanent flight after picking up 3 or more of the following items.
Activated Collectibles[edit | edit source]
|The Bible||33||Temporary Flight||Upon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.|
Passive Collectibles[edit | edit source]
|Dead Dove||185||Flight + spectral tears||Grants spectral tears and flight.|
|Guardian Angel||112||Extra protection||Spawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies, and increases the speed of all orbital familiars.|
|The Halo||101||All stats up||Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.|
|Holy Grail||184||Flight + HP up||Grants flight and one heart container.|
|Holy Mantle||313||Holy shield||Automatically negates first taken damage in every room.|
|Mitre||173||You Feel Blessed||Grants a chance of converting any red hearts pickups into soul hearts instead.|
|Rosary||72||Faith up||Adds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.|
|Sworn Protector||363||Protective friend||An orbital angel which does 7 contact damage per tick and blocks enemy shots. Upon blocking 10 shots in a room it drops an eternal heart.|
Notes[edit | edit source]
Despite having the same name, the familiar SeraphimAn angel familiar which follows Isaac and fires homing tears which deal 10 damage at -25% shot speed and a reduced fire rate. does not contribute to the Seraphim transformation.
Seeds[edit | edit source]
QYTQ 9MY6 First two floors
6NKO NW3F (Cellar II boss. Needs to have Guppy's Tail from Curse room on 1st floor to get red chest. Rosary in Treasure room on 1st floor, The Bible from red chest on 2nd floor, The Halo from 2nd boss.)
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|