Serpent's Kiss

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Item icon
Item altar
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Character appearance

Tear appearance
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Added in Afterbirth †(page 4, column 8, row 2)
Removed in Afterbirth †(page 4, column 8, row 2)

Serpent's Kiss Defeat Satan as Lilith
Added in Afterbirth

Serpent's Kiss is an unlockable passive item added in The Binding of Isaac: Afterbirth.

Effects[edit | edit source]

  • Grants a chance to fire poison tears, each tick dealing damage equal to Isaac's.
    • Poison from the shots will tick 2 times.
  • Inflicts poison on enemies who make contact with Isaac.
    • Contact poison will tick 6 times.
  • Enemies who are killed after they have been inflicted with this type of poison have a 20% chance to drop black hearts.

Notes[edit | edit source]

  • Not affected by luck.
  • The contact poison effect of this item is identical to The Virus The Virus but does not include a Speed down.
  • Enemies and bosses with multiple segments, such as Chub and Larry Jr., have a chance to drop multiple Black Hearts.
  • The enemy does not need to be killed by the poison or still be poisoned when killed for the Black Hearts to drop.
  • Removed in Afterbirth † Although Stonies and Shopkeepers can't be visibly poisoned, they still can drop Black Hearts if destroyed after being touched.
  • If a boss has status immunity due to being inflicted by another status, they can still drop a black heart if they've been touched or hit by a Serpent's Kiss tear.

Synergies[edit | edit source]

  • Dr. Fetus Dr. Fetus / Epic Fetus Epic Fetus: Bombs and missiles may become poisonous, and enemies hit by them may drop black hearts.
  • Invulnerability: Contact while invincible poisons enemies.
  • Mom's Knife Mom's Knife: Enemies poisoned by the knife may drop black hearts.

Interactions[edit | edit source]

  • Athame Athame / Maw of the Void Maw of the Void: The black rings may poison enemies but do not generate black hearts.
  • Brimstone Brimstone: The blood barrage may poison enemies but does not generate black hearts.
  • Godhead Godhead: The Godhead aura cannot inflict poison but the tears themselves may poison enemies on contact.
  • Tech.5 Tech.5 / Tech X Tech X / Technology Technology / Technology 2 Technology 2: The lasers may poison enemies but do not generate black hearts.
  • Added in Afterbirth †Trisagion Trisagion: May poison enemies but does not generate black hearts.

In-game footage[edit | edit source]

Trivia[edit | edit source]

  • Serpent's Kiss is most likely referencing Viper (Madame Hydra) from Marvel Comics, who has green lipstick and has transmitted poison through hollow fangs or poisoned lipstick before.

Seeds[edit | edit source]

 PC  NFMD MEVX (Treasure room adjacent to spawn)

 PC  E14Y Q0Z7 (Treasure room adjacent to spawn)

 PC  QZC2 FNKQ (Treasure room adjacent to spawn)

 PC  7BXL YJFT (Treasure room two down from spawn then one to the left)

 PC  Added in Afterbirth † Normal and hard modes only R77P MR8A (Treasure Room adjacent to spawn)

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