Sheol

Sheol is one of two unlockable floors following The Womb/Utero, the other being Cathedral. After defeating Mom's Heart, a devil room may spawn containing a trapdoor leading down to Sheol. Unlocking and defeating It Lives will always spawn a trapdoor leading to Sheol, as well as a Beam of Light leading to the Cathedral. Sheol can also be accessed using the item We Need To Go Deeper during the Womb II, even if Mom's Heart has not been defeated. It can also be entered if a Joker is used on the last floor of Womb II, as it may bring you to the Devil Deal room with a trap door.

Sheol only has one floor, and the boss is always Satan.

Monsters

Monsters	Description
Bony	Wanders around the room and throws a bone at Isaac when he is in sight.
Death's Head	Invulnerable enemy that moves diagonally around the room, dealing contact damage. Dies when the room is cleared.
Evil Twin	Mirrors Isaac's movements and fires three spread blood shots at the same time as Isaac. Can fly over obstacles.
Bloodshot Eye	Slowly turns towards Isaac and fires a Brimstone beam at Isaac if he stands still or is too slow.
Begotten	Starts attached to the wall. After a while, it detaches, firing 6 blood shots in radial directions and turning the room dark and chasing Isaac. Phases in and out of visibility when detached.
Camillo Jr.	Moves around the room diagonally, occasionally firing Technology lasers towards Isaac. Fires more often upon getting damaged.
Globin	Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, which can be killed. Will regenerate after a short period of time if not killed quickly.
Gazing Globin	Quickly chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, which will slide away from Isaac and can be killed. Will regenerate after a short period of time if not killed quickly.
Black Globin	Chases Isaac, dealing a full heart of contact damage and spawning spiders whenever it takes damage. Spawns a spider, Black Globin's Head, and Black Globin's Body upon death.
Black Globin's Body	Walks aimlessly around the room, occasionally spawning spiders.
Host	Stationary enemy that is normally invulnerable. Raises its head up when Isaac gets close, revealing a fleshy stem that can be damaged. Upon raising its head, it will fire 3 blood shots and lower its head again.
Mobile Host	Acts like the Host, but follows Isaac and deals contact damage.
Selfless Knight	Moves erratically around the room and charges toward Isaac very quickly when in line of sight. Can only be damaged from behind.
Bone Knight	Moves erratically around the room, charges toward Isaac when in line of sight, and leaves behind a trail of damaging red creep. Can only be damaged from behind.
Leech	Quickly charges towards Isaac when he gets in its line of sight.
Kamikaze Leech	Quickly charges towards Isaac when he gets in its line of sight. Explodes upon death.
Nerve Ending	Static enemy which acts as a meat shield.
Null	Act like faster Frowning Gapers. When Isaac gets near, they phase in and out of visibility and pursue Isaac faster.
Oob	When Isaac lines up with it horizontally, it charges across the room once. When Isaac is not horizontal to it, it spawns Brains.
Black Maw	When Isaac lines up with it horizontally, it charges in his direction and then doubles back, charging back to its original position. When Isaac is not horizontal to it, it spawns Leeches. Explodes when it dies.
Big Spider	Erratically moves towards Isaac and deals touch damage. Splits into two Spiders upon death.
Ticking Spider	Crawls around the room erratically, following Isaac and dealing touch damage. Can jump small distances. Explodes upon death.
Sucker	Flies slowly towards Isaac, exploding into 4 shots in the cardinal directions upon death.
Soul Sucker	Flies slowly towards Isaac. Spawns a vortex that fires four Brimstone beams in the cardinal directions upon death.
Swarmer	Slowly floats around the room, spawning several Attack Flies. Spawns Pooters upon taking damage. Spawns a Boom Fly upon death.
Wizoob	Disappears, then appears near Isaac and spits a cluster of spectral tears at him.
Red Ghost	Disappears, then reappears near Isaac and fires a brimstone laser.
Lil' Haunt	Follows Isaac erratically and occasionally shoots blood shots toward Isaac's destination, predicting his movements.
Gaping Maw	Stationary and invulnerable monster that sucks Isaac towards it, along with Isaac's tears and enemy projectiles.
Stone Eye	Stationary and invulnerable monster that constantly rotates and fires a flickering Technology laser. Stops firing when the room is cleared.
Brimstone Grimace	Stationary and invulnerable monster that fires Brimstone beams in a specific direction.
Cross Grimace	Stationary and invulnerable monster that continuously fires shots in four directions.
Imp	Slowly drifts towards Isaac, frequently firing 5 blood shots in quick succession towards Isaac. Tries to avoid Isaac's shots and occasionally teleports and reappears elsewhere.
Mr. Red Maw	Walks towards Isaac and attacks by launching its head towards Isaac. Turns into a Red Maw or Gusher upon death depending on the killed body segment. Occasionally separates at will.

Boss

Satan

Trivia

• In Hebrew, Sheol is translated as "place of the dead"; it is described as the common grave of humans in Jewish religious lore (including the Old Testament), making it the Abrahamic version of the underworld.
• Sheol is the 9th level in the game (without there being a Curse of the Labyrinth). The 14th-century novel Dante's Inferno, one of the first books to describe hell in detail, notes that the 9th layer of hell is frozen. On Isaac's last will, it says he died in "a cold place" if he dies in Sheol.
  • In addition, the 9th layer of hell is said to be where Satan is imprisoned, indicating the reason for Satan's presence in the area.
• Like in all chapters, you can find small noninteractive objects on the ground. One of these decorations is a drawing of a triangle that can possibly be a reference to the Triforce, an iconic relic from The Legend of Zelda series.

Music

The music for Sheol is titled Duress. The term duress means intimidation or coercion, and usually denotes violence.

Binding of Isaac: Rebirth OST