Sisters Vis

Boss Double Trouble (With Larry Jr.) (With The Husk or Lokii) Degraded Boss
Boss
Defeat ??? as 6 different charactersSomething wicked this way comes+!

Sisters Vis are a boss added in the expansion The Binding of Isaac: Afterbirth † that can appear in all environments of Chapters 3 and 4.

Behavior

• Similar to The Cage, Sisters Vis curl up in a ball and roll towards Isaac, bouncing off the walls. One of them leaves a trail of Green Creep while the other leaves behind a trail of Brown Creep. One of them will stop rolling before the other and will either:
  • Fire a Mega BlastUpon use, Isaac fires a laser similar to the one used by Mega Satan. This laser deals massive damage, lasts for approximately 15 seconds, and persists between rooms. Isaac is pushed backwards by the force of the laser while it is active. laser at the player's direction.
    • Alternatively, this Mega Blast laser may rotate nearly 180 degrees.
  • Fire two, three or four lines of blood shots in a V formation at the player's direction.

Any of these attacks will finish a few seconds before the other Sister Vis stops rolling.

• Spawns either two Vis or two Begottens.
• The Sisters Vis will leap into the air and land one on each side of Isaac. They will then open their belly and fire Mega Blast lasers towards where Isaac was when they landed. The two beams will hit each other and block each other, so that the damage field of the Mega Blast only appears between the two Sisters.

When one of the two is about to die or killed, the other will become enraged, and will attack much faster.

• If the Sister Vis that leaves Green Creep dies first, the other will leave Green Creep instead of Brown Creep.

Gallery

• 

  Sisters Vis in-game.

• 

  Sisters Vis as one of Delirium's forms.

Notes

• A possible encounter in Greedier mode may spawn up to 8 Sisters Vis.
• They can be found in The Void even when not unlocked.

Trivia

• Sisters Vis are a cameo from the 2004 PC game Gish, created by Edmund McMillen.
  • In Gish, they are the bosses of the 3rd area: The 7 Planes of Hehenna.
  • As Sisters Vis are originally from Gish, the designs of the Vis enemies and The Cage itself originated from them.
• On the Sisters Vis' bodies there is a Y-shaped mark, commonly known as an autopsy stitch. The stitch is commonly made at the start of a surgery, to get access to the insides of the cadaver. When the autopsy is complete, it's stitched back together
  • The same stitching is seen on The Duke of Flies, The Cage and Conquest.
• Sisters Vis are the only normal boss that shoots the type of laser that is shot by Mega Satan and the item Mega BlastUpon use, Isaac fires a laser similar to the one used by Mega Satan. This laser deals massive damage, lasts for approximately 15 seconds, and persists between rooms. Isaac is pushed backwards by the force of the laser while it is active..
• There are unused textures for Sisters Vis in the base game (no DLC).
  • The unlock condition for Sisters Vis would have been to "beat Sheol 10 times" and would have appeared in Sheol after being unlocked. It is unknown how this would work in-game, as Satan acts as one of the final bosses and always appears in Sheol.

Bugs

Bug! When there are four Sisters Vis (two pairs, which can be seen in Greed Mode) in the same room, there is a chance that three of them will act like normal, but the fourth one won't move or attack at all. However, when three are killed, the fourth one will return to normal.

Bug! Sisters Vis can spawn in the bottom center of a Boss Room. If the entrance to the room is from the bottom, entering the room may cause Isaac to immediately take damage.