Sisters Vis

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Boss Sisters Vis name.png
Boss versus screen image
Table dividing line 1.png

In-game appearance
Table dividing line 2.png

Stage The Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png
Stage The Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png
Stage The Void icon.png
Double Trouble
Stage The Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png
(With Larry Jr.)
Stage The Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png
(With The Husk or Lokii)
Degraded Boss
Stage Sheol icon.png
Stage The Chest icon.pngStage Dark Room icon.png
Table dividing line 3.png

Boss Boss

Something wicked this way comes+! Defeat ??? as 6 different characters
Added in Afterbirth †

Sisters Vis are a pair of bosses added in the expansion The Binding of Isaac: Afterbirth † that can appear in all environments of Chapters 3 and 4.

Behavior[edit | edit source]

  • Similar to The Cage, Sisters Vis curl up in a ball and roll towards Isaac, bouncing off the walls. One of them leaves a trail of Green Creep while the other leaves behind a trail of Brown Creep. One of them will stop rolling before the other and will either:
    • Fire a Mega Blast Mega Blast laser at the player's direction.
      • Alternatively, this Mega Blast laser may rotate nearly 180 degrees.
    • Fire two, three or four lines of blood shots in a V formation at the player's direction.

Any of these attacks will finish a few seconds before the other Sister Vis stops rolling.

  • Spawns either two Vis or two Begottens.
  • The Sisters Vis will leap into the air and land one on each side of Isaac. They will then open their belly and fire Mega Blast lasers towards where Isaac was when they landed. The two beams will hit each other and block each other so that the damage field of the Mega Blast only appears between the two Sisters.

When one of the two is low on health or killed, the other will become enraged and will attack much faster.

  • If the Sister Vis that leaves Green Creep dies first, the other will leave Green Creep instead of Brown Creep.

Gallery[edit | edit source]

Notes[edit | edit source]

  • A possible encounter in Greedier Mode may spawn up to 8 Sisters Vis.
  • They can be found in The Void The Void, even when not unlocked.

Trivia[edit | edit source]

  • Sisters Vis are a cameo from the 2004 PC game Gish, created by Edmund McMillen.
    • In Gish, they are the bosses of the 3rd area: The 7 Planes of Hehenna.
    • As the Sisters Vis are originally from Gish, the designs of the Vis enemies and The Cage itself originated from them.
  • On the Sisters Vis' bodies, there is a Y-shaped mark. During an autopsy, an incision is made into the body and is stitched up afterward. The remaining Y-shaped mark is known as an autopsy stitch.
  • Sisters Vis are the only normal boss that shoots the type of laser that is shot by Mega Satan and the item Mega Blast Mega Blast.
  • There are unused textures for Sisters Vis in the base game (no DLC). [1]
    • The unlock condition for Sisters Vis would have been to "beat Sheol 10 times" and would have appeared in Sheol after being unlocked. It's unknown how this would work in-game, as Satan acts as one of the final bosses and always appears in Sheol.

Bugs[edit | edit source]

Bug Bug! When there are four Sisters Vis (two pairs, which can be seen in Greed Mode) in the same room, there is a chance that three of them will act like normal, but the fourth one won't move or attack at all. However, when three are killed, the fourth one will return to normal.
Bug Bug! Sisters Vis can spawn in the bottom center of a Boss Room. If the entrance to the room is from the bottom, entering the room may cause Isaac to immediately take damage.
Bug Bug! One Sister Vis can become enraged before the other Sister Vis actually dies; if this happens and the one that leaves Brown Creep is the one that becomes enraged, it will continue to leave Brown Creep until the other Sister Vis is killed.

References[edit | edit source]

Bosses Boss Monstro.png
Chapter 1
Stage The Basement icon.pngStage The Cellar icon.pngStage Burning Basement icon.png
GeminiStevenBlighted OvumDingleThe Duke of FliesFamineFistulaGurglingsThe HauntLarry Jr.MonstroPinWidowThe FallenThe Headless Horseman
DangleLittle HornRag ManTurdlings
Chapter 2
Stage The Caves icon.pngStage The Catacombs icon.pngStage Flooded Caves icon.png
ChubC.H.A.D.Carrion QueenDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusThe WretchedThe FallenThe Headless Horseman
The ForsakenThe FrailThe Stain
Big HornRag Mega
Chapter 3
Stage The Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png
The AdversaryThe BloatThe CageThe GateMonstro IIGishLokiMask of InfamyWarThe FallenThe Headless HorsemanMom
Sisters Vis
Chapter 4
Stage The Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png
BlastocystThe BloatConquestDaddy Long LegsTriachnidDeathLokiiMama GurdyMr. FredScolexTeratomaThe FallenThe Headless HorsemanMom's HeartIt Lives
Sisters VisThe Matriarch
Blue Womb
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png
Chapter 6
Stage Dark Room icon.pngStage The Chest icon.png
???The LambMega Satan
The Void
Stage The Void icon.png
Greed Mode
Ultra Greed
Ultra Greed
Ultra Greedier
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets