Status Effects

This article is about effects which can be inflicted on monsters. For the different kinds of effects which Isaac's primary weapon can have, see Tear Effects.

Status effects are special effects that can be inflicted on an enemy from a variety of sources, such as tears, bombs, and items. Each status effect has a color and symbol/effect associated with them for easy identification. These colorations are not to be confused with champions.

Effects

Effect	Appearance	Description
Burn		Afflicted enemies take 4 to 6 fire damage over time, like poison. Afflicted enemies will be tinted orange for the duration and have a fire symbol above them. Afflicted enemies will sustain double Isaac's tear damage over time.
Charm		Afflicted enemies will temporarily fight on Isaac's side, running toward other enemies and damaging them for 25% of their maximum HP per touch, 5 damage with half heart projectiles and 10 with full heart ones. If no other enemies are in the room, a charmed enemy will instead run towards Isaac. (Charmed enemies can still hurt Isaac.) Afflicted enemies will be tinted pink for the duration and have a heart symbol above them. Most enemies with ranged attacks will not fire them. Charmed enemies will prioritize non-charmed enemies and won't target invincible enemies. Charmed Portals will also spawn friendly enemies.
Confusion		Afflicted enemies are slowed and walk around randomly. While confused, most non-boss enemies will be unable to attack. Afflicted enemies will be tinted pale gray and have stars above them.
Fear		Afflicted enemies are scared of Isaac and will run away from him. While scared, most non-boss enemies will be unable to attack or charge towards Isaac. Afflicted enemies will be tinted purple and have a skull symbol above them.
Petrified		Afflicted enemies are stopped in place. They cannot move or attack. Afflicted enemies will be shaded brown-gray as if turned to stone (unless petrified by Midas' Touch, in which case they will be shaded gold).
Poison		Afflicted enemies sustain 4 to 6 damage over time. Afflicted enemies will be tinted green and have a bubbly effect surrounding them. Afflicted enemies will sustain double Isaac's tear damage over time.
Slow		Afflicted enemies are slowed down. Any projectiles they shoot will also be slowed down. Attacks that end when the enemy runs out of momentum, such as the charging attacks of Gurdy Jr. and Dingle, will be vastly shortened in duration. Depending on the item that triggers the slow effect, afflicted enemies will be tinted black or white with a snail icon above them.
Friendly		Afflicted enemies are permanently charmed and will fight on Isaac's side until they die. Most enemies under this effect will follow Isaac across rooms, like a familiar. Friendly enemies cannot hurt Isaac. Friendly enemies are not tinted but still have heart effects.
Shrink		Afflicted enemies are shrunken and will run away from Isaac. Isaac can walk over shrunken enemies to kill them.
Bleed		Afflicted enemies take damage equal to 10% of their maximum health every 5 seconds.

Notes

• Host-type enemies will take burn and poison damage even if their skull is down, and all status effects can be applied by tears even if their skulls are down.
• After a boss or mini-boss had a status effect applied on them, they will receive immunity against all status effects for 8 seconds. This means that no other status effect can be applied to that enemy during this period.
  • The slow effect is an exception to this rule.

Burn

Passive items that cause burning

Name	ID	Icon	Quote	Description
Fire Mind	257		Flaming tears	Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.

Charm

Activated items that cause charming

Name	ID	Icon	Quote	Description
Kidney Bean	421		Love toots!	Upon use, Isaac farts, charming all nearby enemies.

Passive items that cause charming

Name	ID	Icon	Quote	Description
Ball of Bandages	207		Gotta lick 'em all!	Orbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.
Mom's Eyeshadow	200		Charm tears	Tears have a chance to charm enemies.
Betrayal	391		Turn your enemy	Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
Farting Baby	404		It farts!	A familiar that follows Isaac and blocks tears. If a tear hits Farting Baby, there is a high chance for it to fart, which will either knockback, poison, or charm all nearby enemies.
Glitter Bombs	432		Prize bombs!	Gives Isaac 5 bombs, and makes Isaac's bombs have a chance to drop random pickups or charm enemies when they explode.
Bozo	513		Party time!	Increases damage by a flat 0.1 and grants a Soul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop.

Pills that cause charming

Pill	Effect
Pheromones	Charms all enemies in the room for a short period of time.

Notes

• First stage of Ball of Bandages cannot charm enemies. See Ball of Bandages for details.
• Charmed enemies will still target Isaac if they are the only enemy in the room.

Confusion

Passive items that cause confusion

Name	ID	Icon	Quote	Description
Butt Bombs	209		Toxic blast +5 bombs	+5 bombs. Bombs now cloud up the screen, briefly damaging and confusing all enemies.
Iron Bar	201		Concussive tears	Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.
No. 2	378		Uh oh...	Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 60 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
Camo Undies	497		Camo kid	Isaac becomes camouflaged at the beginning of each room. Until he shoots, all non-boss enemies will be confused.
Glaucoma	460		Blind tears!	Adds a chance to shoot tears that confuse enemies for an extremely long time.

Trinkets that cause confusion

Name	ID	Icon	Quote	Description
Faded Polaroid	69		You feel faded	Occasionally causes Isaac to blend into the ground, which briefly confuses all enemies in the room.

Fear

Activated items that cause fear

Name	ID	Icon	Quote	Description
Mom's Pad	41		Gross...	Upon use, inflicts fear to all enemies in the room for 5 seconds.
The Gamekid	93		Temporary Man-Pac	Upon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed.

Passive Items that cause fear

Name	ID	Icon	Quote	Description
Abaddon	230		Evil + DMG up + fear shot	Increases damage and speed, removes all Red Heart containers, grants six Black Hearts, and adds a chance to shoot fear tears.
Dark Matter	259		Fear shot	Increases damage by 1 and adds a chance to shoot fear tears.
Mom's Perfume	228		Fear shot	Adds a chance to shoot fear tears and decreases tear delay by 1.
My Shadow	433		Me! And my shaaaadow!	Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black friendly Charger that will attack enemies. The Charger will be killed if it is damaged too much.
Spear of Destiny	400		Your destiny	In addition to tears, Isaac now holds a spear in front of him which deals damage equal to 2 times his tear damage, and occasionally inflicts fear. The spear cannot be thrown but deals damage while it is in contact with an enemy.
Bozo	513		Party time!	Increases damage by a flat 0.1 and grants a Soul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop.

Pills that cause fear

Pill	Effect
Power Pill!	Temporarily grants invulnerability, inflicts fear on enemies in the room, and lets Isaac deal contact damage, similar to The Gamekid.

Petrification

Activated items that petrify enemies

Name	ID	Icon	Quote	Description
Mom's Bra	39		Mass Fear	Upon use, petrifies all enemies in the current room for approximately 4 seconds.
The Boomerang	338		It will never leave you	Throws a short-range boomerang which does a bit of damage and has a high chance to stun the enemy for 2 seconds. Can also be used to grab pickups.
Mega Bean	351		Giga fart!	When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies near Isaac, and send a wave of spikes that deals 10 damage across the room in the direction Isaac is facing.

Passive items that petrify enemies

Name	ID	Icon	Quote	Description
Midas' Touch	202		Golden touch	Enemies that touch Isaac are temporarily frozen and turn to gold. Any enemy killed while in this state will drop coins.
Mom's Contacts	110		Freeze effect	Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
Charged Baby	372		Bbbzzzzzt!	A battery familiar that occasionally drops a Lil' Battery, gives an active item charge, or freezes all enemies in the room.
Dad's Ring	546		Father's blessing	Creates a ring of light around Isaac that petrifies enemies in contact.
Eye of Greed	450		Gold tears!	Every 20 tears, Isaac loses 1 penny and shoots an additional gold tear that freezes enemies and turns them into gold. Any enemy killed while in this state will drop coins.

Poison

Activated items that poison enemies

Name	ID	Icon	Quote	Description
Bob's Rotten Head	42		Reusable ranged bomb	Upon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.
The Bean	111		Toot on command	Isaac releases bad gas, poisoning any enemy in close vicinity.
Mega Bean	351		Giga fart!	When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies near Isaac, and send a wave of spikes that deals 10 damage across the room in the direction Isaac is facing.

Passive items that poison enemies

Name	ID	Icon	Quote	Description
Bob's Brain	273		Explosive thoughts	Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Bob's Curse	140		+5 poison bombs	Gives 5 bombs and grants all bombs poison effect.
Ipecac	149		Explosive shots	Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Scorpio	305		Poison tears	Grants poison tears, which deal damage over time when inflicted.
The Black Bean	180		Toot on touch	When taking damage, Isaac farts, causing poison damage to all enemies in range.
The Common Cold	103		Poison Damage	Adds a chance to shoot poison tears, dealing damage over time when inflicted.
The Virus	13		Poison touch	Inflicts poison to enemies who make contact with Isaac. Speed down. Poisoned enemies have a chance to drop a black heart when killed.
Farting Baby	404		It farts!	A familiar that follows Isaac and blocks tears. If a tear hits Farting Baby, there is a high chance for it to fart, which will either knockback, poison, or charm all nearby enemies.
Serpent's Kiss	393		The kiss of death	Tears have a random chance to apply a poison effect to enemies. Isaac now deals poison damage on contact. Enemies that were poisoned have a chance to drop a black heart when killed.
Toxic Shock	350		Mass poison	Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short lasting pool of green creep on the ground.
Acid Baby	491		Pills pills pills!	Spawns a familiar that drops random pills every 3 rooms cleared. Upon using a pill, all enemies in the room are poisoned.
Contagion	466		Outbreak!	The first enemy killed in a room explodes and poisons nearby enemies. Poisoned enemies will also explode upon death.
Dead Tooth	446		Halitosis	While firing, Isaac gains a green aura that poisons nearby enemies.

Trinkets that poison enemies

Name	ID	Icon	Quote	Description
Pinky Eye	30		Poison shots	Adds a 10% chance to shoot a poison tear, dealing damage over time when inflicted.
Black Tooth	95		It looks dead	Adds a chance to fire a black tooth that deals double damage and poisons enemies.
Locust of Pestilence	114		I bring Pestilence	Upon entering a room with enemies, spawns a Green Locust which damages and poisons enemies.

Pills that poison enemies

Pill	Effect
Bad Gas	Isaac farts, poisoning enemies around him.

Slow

Activated items that slow enemies

Name	ID	Icon	Quote	Description
Spider Butt	171		Mass enemy slowdown + damage	Damages all enemies in the room and slows them and their projectiles down.
The Hourglass	66		Temporary enemy slowdown	Upon activation, enemies and their projectiles are slowed down for a short duration.

Passive items that slow enemies

Name	ID	Icon	Quote	Description
Ball of Tar	231		Sticky feet...	Adds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
Broken Watch	337		I think it's broken	Chance upon entering a room to slow down or speed up every enemy and their attacks. The chance to slow enemies is quite higher than the chance to speed them up.
Juicy Sack	266		Sticky babies	A familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.
Little Gish	99		Sticky friend	Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Spider Bite	89		Slow effect	Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Stop Watch	232		Let's slow this down a bit	Automatically inflicts slow to all enemies in every room. Upon taking damage, inflicts slow to all enemies for the current room.
Censer	387		Peace be with you	Gives Isaac a golden censer familiar which creates a huge aura of light that slows down any enemies and enemy shots inside it.
Night Light	425		Scared of the dark?	A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots.
Large Zit	502		Creep shots	Adds a chance to fire a creep shot that deals double damage and leaves a trail of slowing white creep.
Parasitoid	461		Egg tears!	Adds a chance to fire an egg sack which spawns slowing creep and spawns a blue fly or spider upon hitting an enemy.

Trinkets that slow enemies

Name	ID	Icon	Quote	Description
Locust of Famine	115		I bring Famine	Upon entering a room with enemies, spawns a Yellow Locust that damages and slows enemies.

Notes

• The creep from items like Ball of Tar and Juicy Sack only slow enemies for as long as they remain in the creep.
• The Mask + Heart enemy is not affected by the slow effect.

Friendly

Activated items that make enemies friendly

Name	ID	Icon	Quote	Description
Friendly Ball	382		Gotta fetch 'em all!	Throwing the ball at an enemy instantly kills it and captures it. The captured enemy can later be released and will be friendly, fighting for Isaac and persisting between rooms.
Book of the Dead	545		Rise from the grave	Upon use, spawns a friendly Bony or an orbital bone for each enemy killed in the current room.

Passive items that create friendly enemies

Name	ID	Icon	Quote	Description
My Shadow	433		Me! And my shaaaadow!	Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black friendly Charger that will attack enemies. The Charger will be killed if it is damaged too much.
Mystery Egg	539		Sacrificial insemination	Spawns an egg familiar, which cracks and turns into a random friendly enemy when Isaac is hurt. The egg regenerates upon entering a different room.
Poke Go	505		Gotta catch em...	Upon entering a room with enemies in it, has a chance to spawn a random friendly enemy that persists across rooms.
Shade	468		It follows	Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly Chargers.

Shrink

Passive items that grant shrinking tears

Name	ID	Icon	Quote	Description
God's Flesh	398		Shrink shot	Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.

Bleed

Passive items that inflict bleed

Name	ID	Icon	Quote	Description
Backstabber	506		Watch your back!	Isaac's tears deal double damage and inflict bleeding on enemies if they're facing away from Isaac.
Mom's Razor	508		It's sharp!	Spawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.

Random

These items inflict random status effects on enemies.

Passive items that inflict random effects

Name	ID	Icon	Quote	Description
GB Bug	405		Game breaking bug, right away!	A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with and has a chance to re-roll pickups that it passes over.
Spider Mod	403		Mod buddy!	Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.