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After picking up three distinct items from the following list, Isaac turns into a buff berserker and a random pill spawns. Isaac gains +2 damage and +0.15 speed / maximum speed. Maximum speed may never exceed 2.0.

(The items in the following list consist of all of the "syringe" items in the game.)

Passive Collectibles[edit | edit source]

Name ID Icon Quote Description
Experimental Treatment 240 Experimental Treatment All stats up, then shuffled Randomly increases and decreases some of the character's stats.
Growth Hormones 70 Growth Hormones Speed + DMG up Increases damage by 1 and speed by 0.4.
Roid Rage 14 Roid Rage Speed and range up Increases speed by 0.6, range by 5.25, and tear height by 0.5.
Speed Ball 143 Speed Ball Speed + shot speed up Increases speed by 0.3 and shot speed by 20%.
Synthoil 345 Synthoil DMG up + range Increases damage by 1, range by 5.25, and tear height by 0.5.
The Virus 13 The Virus Poison touch Inflicts poison to enemies who make contact with Isaac. Speed down. Added in AfterbirthPoisoned enemies have a chance to drop a black heart when killed.
Added in Afterbirth † Adrenaline 493 Adrenaline Panic = power Increases damage based on how many empty Red Heart containers Isaac has.
Added in Afterbirth † Euthanasia 496 Euthanasia Needle shot Adds a chance to fire needles that instantly kill basic enemies and deal triple damage to bosses. If a needle kills an enemy, it bursts into more tears/needles.

Gallery[edit | edit source]

Seeds[edit | edit source]

 PC  Hard mode only KG4F IN87 (First Boss item & first two treasure rooms for a 2nd floor spun)

 PC  Greed mode only AGZ1 DPSX (First item room, first shop item, 2nd shop item (after buying first))

 PC  Added in Afterbirth † 2C1H 8F60 (XL floor, The Virus from Lust, Adrenaline in one of the Treasure Rooms, and Speed Ball by second Boss Room)

Mac VXG4 BN24 (First treasure room, second and third boss room)

Mac Greed mode only 9QYB 6FFL (First two treasure rooms, 2nd Gold treasure room)

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